Core Viewpoint - The article discusses the birth of the world's first CRISPR gene-edited horses, highlighting the implications of this technology in animal breeding and the controversies surrounding it [3][5][7]. Group 1: CRISPR Gene-Edited Horses - The first CRISPR gene-edited horses were born in Argentina, created by Kheiron Biotech, using CRISPR-Cas9 technology to enhance muscle growth by knocking out the myostatin gene [7]. - These horses are clones of the award-winning racehorse Polo Pureza and exhibit stronger muscles and faster speeds compared to ordinary horses [5][7]. - The introduction of these gene-edited horses has sparked controversy, particularly in the equestrian community, with concerns about the impact on traditional breeding practices and livelihoods [8]. Group 2: Broader Applications of CRISPR Technology - Prior to the CRISPR horses, gene editing had been widely applied in agriculture and disease treatment, such as the development of PRLR-SLICK cattle, which are more heat-resistant due to a gene edit [9]. - The FDA approved PRLR-SLICK for meat production in 2022, showcasing the regulatory acceptance of gene-edited animals [9]. - Other examples include CRISPR sheep for increased meat yield and CRISPR pigs that are resistant to diseases like PRRS, with FDA approval for market sale expected by 2026 [10]. Group 3: Ethical and Health Concerns - The rise of CRISPR gene-edited animals raises ethical questions, particularly regarding animal health and the potential unforeseen consequences of genetic modifications [11]. - Concerns include the long-term health effects on the animals and the possibility of genetic changes being passed to future generations or affecting wild populations [12]. - There is a call for further research to monitor any adverse health impacts resulting from gene editing in animals [12].