Group 1: Core Insights - CRISPR gene editing technology is being increasingly applied in the genetic improvement of animals such as horses, sheep, and pigs, enhancing traits for safer and higher-quality meat products [1][2] - The use of CRISPR in horses has faced resistance from traditional sports organizations, highlighting the tension between technological advancement and traditional practices [2] - Companies like Acceligen are utilizing CRISPR to develop livestock that can better withstand climate change, such as the PRLR-SLICK cows, which have been recognized as safe for consumption by the FDA [3] Group 2: Industry Applications - The development of CRISPR-edited animals is showing potential in agriculture, with applications aimed at improving meat and dairy production efficiency [3][4] - The GalSafe pig, developed by Revivicor, aims to reduce allergic reactions in humans and has potential applications in organ transplantation [4] - The emergence of CRISPR-edited animals is also driven by the need for disease resistance, as seen in the genetically modified pigs that can resist specific viral infections [3] Group 3: Ethical and Safety Considerations - The rise of gene-edited animals raises ethical concerns, particularly regarding the potential health impacts on both the animals and consumers [5][6] - There are worries about unintended consequences, such as off-target mutations that could lead to health issues or early mortality in edited animals [6] - Continuous monitoring of the health impacts of gene editing on animals is deemed necessary to ensure their welfare and long-term health [6]

Core Viewpoint - The article discusses the birth of the world's first CRISPR gene-edited horses, highlighting the implications of this technology in animal breeding and the controversies surrounding it [3][5][7]. Group 1: CRISPR Gene-Edited Horses - The first CRISPR gene-edited horses were born in Argentina, created by Kheiron Biotech, using CRISPR-Cas9 technology to enhance muscle growth by knocking out the myostatin gene [7]. - These horses are clones of the award-winning racehorse Polo Pureza and exhibit stronger muscles and faster speeds compared to ordinary horses [5][7]. - The introduction of these gene-edited horses has sparked controversy, particularly in the equestrian community, with concerns about the impact on traditional breeding practices and livelihoods [8]. Group 2: Broader Applications of CRISPR Technology - Prior to the CRISPR horses, gene editing had been widely applied in agriculture and disease treatment, such as the development of PRLR-SLICK cattle, which are more heat-resistant due to a gene edit [9]. - The FDA approved PRLR-SLICK for meat production in 2022, showcasing the regulatory acceptance of gene-edited animals [9]. - Other examples include CRISPR sheep for increased meat yield and CRISPR pigs that are resistant to diseases like PRRS, with FDA approval for market sale expected by 2026 [10]. Group 3: Ethical and Health Concerns - The rise of CRISPR gene-edited animals raises ethical questions, particularly regarding animal health and the potential unforeseen consequences of genetic modifications [11]. - Concerns include the long-term health effects on the animals and the possibility of genetic changes being passed to future generations or affecting wild populations [12]. - There is a call for further research to monitor any adverse health impacts resulting from gene editing in animals [12].