Key Takeaways Cal-Maine Foods (CALM) is moving ahead with its $60 million expansion plan, aimed at expanding capacity for 1.1 million cage-free layer hens and 250,000 pullets by end of 2025. This is part of CALM's multi-year strategy to capitalize on shifting consumer preference for cage-free eggs. With ten U.S. states enforcing cage- free egg production by 2030, around 73% of U.S non-organic laying hens will need to be transitioned to cage- free systems to meet demand. To address this evolving market, Cal- ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 本周，国际顶尖学术期刊 Cell 上线了 5 篇研究论文，其中 3 篇来自中国学者。这些来自中国学者的 研究 包括、 AI 驱动的体内蛋白质激活平台 、 核应激小体的动态组装及其对急性炎症的调控机制 、 新型菌源性 胆汁酸改善血糖稳态。 AI 驱动的体内蛋白质激活平台 2025 年 5 月 27 日，北京大学化学与分子工程学院 、北大 - 清华生命科学联合中心 陈鹏 团队 与 王初 团队合作 ，在国际顶尖学术期刊 Cell 期刊发表了题为： Machine-learning-assisted universal protein activation in living mice 的研究论文 【1】 。 该研究利用 人工智能 （AI） 辅助，开发 了一种名为 CAGE-Prox vivo 的邻近激活策略，用于在活体动物 中按需激活蛋白质以及调控蛋白-蛋白相互作用，为在活体条件下的时间分辨生物学研究和按需治疗干预提 供了一个通用平台。 在活体动物体内精确控制蛋白质激活的通用策略，对于在体内环境中研究蛋白质的功能获得至关重要。在 这项最新研究中，研究团队开发了一种计算机辅助的 ...

Core Viewpoint - Melco Resorts & Entertainment has successfully achieved its goal of sourcing 100% cage-free eggs by 2025 across its global portfolio, reflecting its commitment to sustainability and responsible sourcing [1][3]. Group 1: Sustainability Commitment - The initiative to source cage-free eggs began in 2020 as part of Melco's broader sustainability efforts, which include restoring the environment and empowering local communities [2]. - Melco collaborates with the Lever Foundation to ensure a reliable supply of cage-free eggs and to create economies of scale for this transition [2][3]. Group 2: Impact and Industry Influence - Mr. Lawrence Ho, Chairman and CEO, emphasized that small actions can lead to significant impacts, and the company aims to enhance transparency and supplier engagement in its sourcing practices [3]. - The shift to cage-free eggs is expected to influence other food companies in the region, promoting animal welfare and sustainable food practices [3]. Group 3: Health and Safety Benefits - Cage-free eggs are produced under more humane conditions and are associated with reduced food safety risks, as evidenced by research indicating a significantly higher risk of salmonella contamination in battery cage farms [3].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在活体动物体内精确控制蛋白质激活的通用策略，对于在体内环境中开展蛋白质功能增益 （gain-of-function） 研究至关重要。 2025 年 5 月 27 日，北京大学化学与分子工程学院 、北大 - 清华生命科学联合中心 陈鹏 团队 与 王初 团队合作 ，在国际顶尖学术期刊 Cell 期刊发表了题为： Machine-learning-assisted universal protein activation in living mice 的研究论文。 该研究利用 人工智能 （AI） 辅助，开发 了一种名为 CAGE-Prox vivo 的邻近激活策略，用于在活体动物中按需激活蛋白质以及调控蛋白-蛋白相互作用，为在活 体条件下的时间分辨生物学研究和按需治疗干预提供了一个通用平台。 $${\mathcal{O}}\;\mathbf{C e l P r e s s}$$ 对生物分子进行高选择性和高时间分辨率的功能增益 （gain-of-function ） 研究具有优势且至关重要，有助于剖析各种生物过 程以及揭示疾病病理。人们已开 展了大量的蛋白质工程研究来操控感兴趣 ...

Core Viewpoint - The company is experiencing significant growth driven by the demand for high-speed communication connectors, particularly in the context of AI development, with a strong focus on new product advancements such as liquid cooling solutions and 224G connectors [1][3]. Group 1: Financial Performance - In 2024, the company reported a revenue of 1.032 billion yuan, representing a year-on-year increase of 51.12%, and a net profit of 110 million yuan, up 65.74% [1]. - For Q1 2025, the company achieved a revenue of 379 million yuan, marking a year-on-year growth of 95.25% and a quarter-on-quarter increase of 15.24%, with a net profit of approximately 52.9 million yuan, up 190.12% year-on-year and 65.32% quarter-on-quarter [1][2]. Group 2: Product Development and Market Demand - The company is focusing on liquid cooling solutions and 224G connectors, which have received customer certification and are in small-batch trial production, with mass production expected in Q2 and Q3 of this year [1]. - The main growth driver for the company is the demand for high-speed communication products, particularly in AI applications across various sectors such as internet, rail transportation, healthcare, autonomous driving, data storage, and data transmission [3]. - The company’s high-speed communication product series includes Cage, backplane connectors, and copper cable connectors, with speed upgrades from 112G to 224G [3]. Group 3: Customer Base and Partnerships - The company supplies liquid cooling products primarily to renowned connector companies such as Amphenol, Molex, TE Connectivity, and Luxshare [1]. - In the automotive sector, BYD is a major customer, with the company providing various types of automotive connectors, including control system connectors and high-voltage interlock connectors [3][4]. Group 4: Production Capacity and Order Status - The company maintains a busy production line with saturated orders and strong product demand, indicating a robust operational capacity [2]. - The production of automotive connectors emphasizes high precision and stability, with a focus on quality control and effective collaboration across design and manufacturing processes [4].

尽管当前房价下滑，购房依旧是一门复杂的艺术，市面上那些似乎便宜的"低价房"背后，往往藏着重重陷阱。业内人士透露，以下四种类型的房产正在被暗 中甩售，您是否还在傻傻接盘？ 1. 老旧顶楼小房：居住不舒心，转手反亏无数。曾被视作"价格洼地"的顶楼小房，到了2025年，这种房子将成为噩梦般的烫手山芋。冬冷夏热的极端气候， 漏水和墙壁潮湿几乎是常态，修缮费用高昂，往往动辄超过一万元。而更让人心痛的是，老旧小区内电梯故障频频，一次性爬上20层的楼梯堪比高强度锻 炼，根本不适合老人和小孩。数据显示，这类房产二手挂牌周期一般超过两年，成交价格普遍比同小区其他房源低出30%。 2. 高层密闭"鸽子笼"：居住环境压迫，紧急时刻也难以逃生。位于40层以上的超高层住宅，曾是城市天际线的骄傲，如今却已然成为安全隐患的重灾区。早 晚高峰时段，等待电梯的时间动辄超过半小时，火灾或地震来临时的逃生通道几乎形同虚设。更令人无奈的是，超高层的维护成本极其高昂，外墙脱落、管 道老化等问题频繁发生，物业费年年上涨，居民不得不在心惊肉跳中度日。 3. 阴暗无光的地下室：短命又贬值。光线不足的房屋可谓是健康的隐形杀手！全年都无法接受阳光暴晒，霉菌滋生 ...

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