以下文章来源于肥胖世界ObesityWorld ，作者肥胖世界 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 生物制剂(尤其是重组蛋白)已成为现代医学的核心支柱。虽然这类药物在多种疾病治疗中展现出色疗效，但其短暂的体内半衰期始终是一大掣 肘，而将精准工程化的细胞作为药物递送平台或许能彻底解决这一难题。 慢性疾病因其渐进性且往往不可逆转的特性，使得蛋白类药物通常需要长期(甚至终身)反复注射，才能维持稳定治疗效果。以风靡全球的司美 格鲁肽和替尔泊肽等GLP-1类药物为例，它们虽然重塑了糖尿病和肥胖治疗格局，但作为多肽类生物制剂，仍需每周注射，且必须长期坚持才 能保持效果，一旦停药，减掉的体重会迅速反弹。 近年来，以CAR-T细胞为代表的细胞药物在血液肿瘤和自身免疫性疾病等相对罕见病症中展现出"治愈级"效果。不同于传统药物，CAR-T细 胞是一种"活体"药物，能在患者体内自我复制和长期生存，从而有望实现"一次治疗、长期有效"的理想目标。 2024年3月，彭敏团队在《实验医 ...

Core Viewpoint - The article discusses a groundbreaking research study that introduces a long-lasting CAR-T cell platform for the delivery of biologics, specifically targeting chronic diseases like obesity and diabetes, offering a potential solution for patients requiring lifelong treatment [7][8][20]. Group 1: Research Breakthroughs - The research team from Tsinghua University developed a revolutionary long-lived CAR-T cell, named GD2TIF, which can achieve sustained release of GLP-1, a key drug for obesity and diabetes, with a single injection [8][18]. - This innovative approach allows for long-term management of chronic diseases, potentially eliminating the need for repeated injections that are common with current peptide/protein biologics [7][20]. Group 2: Mechanism and Advantages - The GD2TIF cells can maintain stable levels in the body without the need for chemotherapy pre-treatment, which is often risky for non-cancer patients [16][17]. - The platform targets GD2, a tumor-associated antigen, ensuring safety by minimizing off-target effects, as GD2 is highly expressed in certain tumors but not in normal tissues [16][17]. Group 3: Clinical Implications - In animal models, a single infusion of GD2TIF cells secreting GLP-1 resulted in sustained weight management and normal blood sugar levels, meeting clinical "cure" standards for obesity and diabetes [18][20]. - The research indicates that this method could provide a cost-effective alternative to traditional biologic therapies, which often require ongoing treatment and frequent medical visits [20].