Core Insights - The first batch of newly registered companies in the Sci-Tech Innovation Board's growth layer was listed on October 28, with two of the three companies being biopharmaceutical firms, He Yuan Bio (688765) and Biobetter (688759) [1][4] - Both companies experienced significant stock price increases on their first trading day, with He Yuan Bio rising by 213.49% and Biobetter by 74.41% [2][3] Company Performance - He Yuan Bio opened at 88 CNY per share, reaching a high of 91.32 CNY before closing at 91.1 CNY, resulting in a total market capitalization of 32.57 billion CNY and a trading volume of 2.782 billion CNY [2][3] - Biobetter opened at 48.9 CNY per share, with a peak increase of 175.03%, ultimately closing at 31.01 CNY, leading to a market capitalization of 13.96 billion CNY and a trading volume of 1.107 billion CNY [2][3] Financial Status - Both He Yuan Bio and Biobetter have not yet achieved profitability, with projected net losses for 2022 to 2025 ranging from approximately -144 million CNY to -1.87 billion CNY for He Yuan Bio and -188 million CNY to -1.73 billion CNY for Biobetter [5][6] Product Pipeline and Innovation - He Yuan Bio has a robust product pipeline with eight drugs under development, including a recombinant human albumin injection that has received regulatory approval, while two drugs are in Phase II clinical trials [6][7] - Biobetter focuses on innovative drug development for major diseases, with one breakthrough therapy already approved and several others in various stages of clinical trials [6][7] Market Sentiment - The significant stock price increases are attributed to optimistic market expectations regarding the high growth potential of the biopharmaceutical industry and the scarcity of new stocks, which has driven investor sentiment [4][6] - The capital market's acceptance of unprofitable biopharmaceutical companies reflects a supportive environment for technology-driven enterprises, facilitating funding for long development cycles and high capital needs [6][7]

Core Viewpoint - He Yuan Bio (688765) is set to be listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on October 28, with an issuance price of 29.06 yuan per share [1] Company Overview - He Yuan Bio is a biopharmaceutical company that meets the fifth listing standard of the Shanghai Stock Exchange's Sci-Tech Innovation Board [1] - The company has a pipeline of 8 drugs under development, with the fastest progressing drug, recombinant human albumin injection (OsrHSA, HY1001), having received approval from the National Medical Products Administration [1] - Currently, 2 drugs are in Phase II clinical trials, 2 drugs are in Phase I clinical trials, and 1 drug has been approved to commence clinical trials [1] - The company has multiple drugs in the research and development stage and has not yet achieved profitability [1]

股票简称：禾元生物 股票代码：688765 武汉禾元生物科技股份有限公司 Wuhan Healthgen Biotechnology Corp. （武汉东湖新技术开发区神墩五路 268 号） 首次公开发行股票 科创板上市公告书 保荐人（联席主承销商） 中国（上海）自由贸易试验区商城路 618 号 联席主承销商 北京市朝阳区安立路 66 号 4 号楼 二〇二五年十月二十四日 武汉禾元生物科技股份有限公司 上市公告书 特别提示 武汉禾元生物科技股份有限公司（以下简称"禾元生物"、"发行人"、"公 司"、"本公司"）股票将于 2025 年 10 月 28 日在上海证券交易所科创板上市。 根据《上海证券交易所科创板上市公司自律监管指引第 5 号——科创成长 层》，上市时未盈利的科创板公司，自上市之日起纳入科创成长层。截至本公告 披露日，禾元生物尚未盈利，自上市之日起将纳入科创成长层。 普通投资者参与科创成长层股票或者存托凭证交易的，应当符合科创板投资 者适当性管理的要求，并按照上海证券交易所有关规定，在首次参与交易前以纸 面或者电子形式签署《科创成长层风险揭示书》，由证券公司充分告知相关风险。 本公司提醒投资者应充分 ...

Core Viewpoint - The first batch of newly registered companies in the Sci-Tech Innovation Growth Sector is set to debut, with three companies, He Yuan Bio, Xi'an Yicai, and Biobetter, expected to be included despite currently being unprofitable [1][2][3] Group 1: Company Details - He Yuan Bio is the first company to initiate the issuance process under the fifth set of standards for the Sci-Tech Innovation Board, focusing on innovative drug development with eight drugs in its pipeline [2][3] - Biobetter has one innovative drug product approved for market and several others in various clinical trial phases, also adhering to the fifth set of standards [2] - Xi'an Yicai, a leading manufacturer of 12-inch silicon wafers, is the first unprofitable company to be accepted and approved under the fourth set of standards [3] Group 2: Financial Performance - As of the first half of 2025, He Yuan Bio, Biobetter, and Xi'an Yicai reported losses of approximately 81.63 million, 73.89 million, and 340 million respectively [3] Group 3: Issuance and Subscription Details - The subscription limits for online purchases are set at 53,500 shares for Xi'an Yicai and 14,000 shares for Biobetter, with corresponding market value requirements of 535,000 and 140,000 respectively [1] - He Yuan Bio's online issuance saw over 3.35 million investors participating, with an initial subscription rate of about 0.036% and a final rate of approximately 0.054% after adjustments [6] Group 4: Regulatory Changes - The new issuance rules allow for differentiated lock-up and allocation arrangements for unprofitable companies, encouraging institutional investors to play a larger role in pricing [4][5] - New registered stocks in the Sci-Tech Innovation Growth Sector will be marked with a special identifier "U" to distinguish them from existing stocks [7]

Core Viewpoint - The article discusses the first batch of newly registered companies entering the Sci-Tech Innovation Growth Tier, highlighting their current unprofitable status and the implications for investors and the market [1][3]. Group 1: Newly Registered Companies - Three companies, He Yuan Bio, Xi'an Yicai, and Biobetter, are set to enter the Sci-Tech Innovation Growth Tier, with their respective issuance prices and subscription limits detailed [1][4]. - As of the prospectus disclosure date, all three companies are unprofitable, with losses reported for the first half of 2025: He Yuan Bio at 81.63 million yuan, Biobetter at 73.89 million yuan, and Xi'an Yicai at 340 million yuan [5]. Group 2: Listing Standards and Approval - He Yuan Bio and Biobetter are listed under the fifth set of standards, while Xi'an Yicai follows the fourth set. He Yuan Bio is noted as the first company to initiate the issuance process after the reactivation of the fifth set of standards [4]. - Xi'an Yicai is recognized as the first unprofitable company to be accepted and approved under the "Eight Articles of Sci-Tech Innovation Board" [4]. Group 3: Subscription and Investor Participation - He Yuan Bio's online issuance saw approximately 3.36 million effective subscription accounts, with an initial winning rate of about 0.036%, which increased to approximately 0.054% after a mechanism was triggered due to high subscription multiples [10][11]. - As of September 22, 500 million investors have opened trading permissions for the Sci-Tech Innovation Growth Tier, with special identifiers added to distinguish new registered stocks [12]. Group 4: Lock-up and Allocation Arrangements - The three companies are the first to adopt differentiated lock-up and allocation arrangements for offline issuance, encouraging professional institutions to play a larger role in new stock pricing [7][8]. - Specific lock-up ratios and periods are set for each company, with He Yuan Bio having a maximum lock-up ratio of 70% for the highest subscription tier [7].

Company Overview - The company is an innovative biopharmaceutical enterprise with a globally leading plant bioreactor technology platform, specifically a rice endosperm cell bioreactor expression system [1][3] - The company has developed multiple products including drugs, pharmaceutical excipients, and research reagents based on its rice endosperm cell bioreactor expression system [1] Product Pipeline - As of now, the company has a total of 8 drug candidates in its pipeline, with the fastest progressing product, recombinant human albumin injection (OsrHSA, HY1001), expected to receive approval by July 2025 for the indication of "hypoalbuminemia due to liver cirrhosis" [2] - Five products are currently in clinical trials, while several others are in preclinical research stages [2] Core Technology - The company has established an internationally leading rice endosperm cell bioreactor expression system, which includes upstream and downstream technologies for efficient recombinant protein expression and purification [3] Production Capacity - The company has built a commercial-scale production line capable of producing 10 tons of OsrHSA raw liquid annually and 1 million dosage forms, with a cGMP intelligent production line [4] - A new production line with a capacity of 120 tons of OsrHSA raw liquid is under construction, expected to be completed by September 2024 [4] Intellectual Property - The company holds a total of 21 domestic invention patents and 62 foreign invention patents [4] Research and Development - The company has strong research capabilities, having independently or led 3 national major science and technology projects and 2 provincial key projects [5] - The company has published 20 SCI papers and books related to its core technologies and products [5] Awards and Recognition - The company's core technology has received national awards, including the Second Prize of National Science and Technology Invention and an Excellent Patent Award from the National Intellectual Property Administration [6] Financial Performance - The company's revenue for the years 2022, 2023, 2024, and the first half of 2025 was 13.40 million, 24.26 million, 25.22 million, and 12.71 million respectively [7] - Research and development expenses for the same periods were 110.50 million, 159.10 million, 116.79 million, and 55.94 million, indicating significant investment in R&D [8] Development Strategy - The company aims to provide green, safe, accessible, and sufficient biopharmaceutical products globally, focusing on unmet clinical needs and leveraging its technological advantages [9] Competitive Advantages - The company’s main competitive advantages include its ideal recombinant protein drug preparation platform, a large potential market for recombinant human albumin, and the safety and environmental benefits of its products [10] Industry Characteristics - The biopharmaceutical industry is characterized by interdisciplinary applications, continuous technological iteration, long R&D cycles, high investment, and regulatory barriers [15] Market Demand - The clinical demand for human serum albumin drugs in China is significant, with a market size projected to grow from 25.8 billion in 2020 to 57 billion by 2030 [16] Future Innovations - The company plans to focus on original innovations in rice endosperm cell expression technology, accelerate the development of long-acting drugs based on recombinant human albumin, and advance multiple therapeutic recombinant biological products [14]

Core Viewpoint - The first company to undergo the listing review under the reactivated fifth set of standards for the Sci-Tech Innovation Board is Wuhan Heyuan Biotechnology Co., Ltd., which focuses on innovative drugs but faces significant financial challenges and ongoing international technical disputes [2][3]. Financial Challenges - Heyuan Biotechnology has been operating at a loss, with revenues increasing from 13.40 million yuan in 2022 to 25.22 million yuan in 2024, but net profits recorded losses of -144 million yuan, -187 million yuan, and -151 million yuan over the same period [3][4]. - As of December 31, 2024, the company had accumulated unremedied losses of 851 million yuan [3]. - The company's cash reserves have significantly decreased from 654 million yuan in mid-2022 to 160 million yuan by the end of 2024 [6]. Debt and Liquidity Issues - The company has seen a rise in debt, with short-term borrowings reaching 10.01 million yuan and long-term borrowings hitting 184 million yuan by the end of 2024, doubling from the previous year [7]. - Key liquidity ratios have deteriorated, with the current ratio dropping from 2.35 in 2022 to 1.02 in 2024, and the quick ratio falling from 2.03 to 0.69 over the same period [7][8]. R&D and Product Pipeline - Heyuan Biotechnology has a pipeline of eight drugs under development, with the most advanced product, recombinant human serum albumin injection (HY1001), expected to receive approval soon [9][10]. - The company has faced delays in the clinical trial phases of its products, particularly HY1002, which has seen its Phase III trial pushed back multiple times, now slated for late 2025 [10][11]. Legal Disputes - The company is embroiled in a long-standing patent infringement lawsuit initiated by Ventria Bioscience, which claims Heyuan's products infringe on its patents [12][13]. - The ongoing legal issues pose a risk to the company's core technology and could lead to significant financial liabilities or restrictions on product sales [14].