日前，武汉禾元生物科技股份有限公司（以下简称"禾元生物"）成功通过上交所科创板上市委审议。作 为科创板重启第五套上市标准后首家过会的企业，禾元生物的成功，标志着武汉生物医药产业实现了 从"实验室到临床"的科技创新与产业创新融合（以下简称"科产融合"）新跨越。 在武汉，更多创新力量正沿着科产融合的道路加速奔跑。启钠新能的生产线上，一场"元素魔术"正在上 演：磷、铁、钠等基础原材料经过精确配比，在自动化生产线上流转。研磨、喷雾干燥、高温烧结、精 密粉碎……一系列工序后，定制化的钠离子电池正极产品稳定产出。 "武汉已构建起完整的新材料产业链条，强大的产业协同能力，为初创公司提供了广阔的市场空间和无 限可能。"武汉启钠新能源科技有限公司创始人、董事长胡培表示。 武汉正以其"宽容失败、赋能梦想"的独特创新生态，吸引并转化着无数像胡培这样的青年才俊。他们从 单纯的"求职者"或"创业者"，成长为深度参与科产融合的"创新合伙人"。 "来这里，做新质生产力的定义者！来这里，做前沿产业的破局者！来这里，让你的梦想与城市共生 长！"在武汉市"建设支点当好龙头"系列形势政策宣讲之"推动科技创新和产业创新深度融合"主题报告 会上，武汉 ...

Core Viewpoint - The first company to undergo the listing review under the reactivated fifth set of standards for the Sci-Tech Innovation Board is Wuhan Heyuan Biotechnology Co., Ltd., which focuses on innovative drugs but faces significant financial challenges and ongoing international technical disputes [2][3]. Financial Challenges - Heyuan Biotechnology has been operating at a loss, with revenues increasing from 13.40 million yuan in 2022 to 25.22 million yuan in 2024, but net profits recorded losses of -144 million yuan, -187 million yuan, and -151 million yuan over the same period [3][4]. - As of December 31, 2024, the company had accumulated unremedied losses of 851 million yuan [3]. - The company's cash reserves have significantly decreased from 654 million yuan in mid-2022 to 160 million yuan by the end of 2024 [6]. Debt and Liquidity Issues - The company has seen a rise in debt, with short-term borrowings reaching 10.01 million yuan and long-term borrowings hitting 184 million yuan by the end of 2024, doubling from the previous year [7]. - Key liquidity ratios have deteriorated, with the current ratio dropping from 2.35 in 2022 to 1.02 in 2024, and the quick ratio falling from 2.03 to 0.69 over the same period [7][8]. R&D and Product Pipeline - Heyuan Biotechnology has a pipeline of eight drugs under development, with the most advanced product, recombinant human serum albumin injection (HY1001), expected to receive approval soon [9][10]. - The company has faced delays in the clinical trial phases of its products, particularly HY1002, which has seen its Phase III trial pushed back multiple times, now slated for late 2025 [10][11]. Legal Disputes - The company is embroiled in a long-standing patent infringement lawsuit initiated by Ventria Bioscience, which claims Heyuan's products infringe on its patents [12][13]. - The ongoing legal issues pose a risk to the company's core technology and could lead to significant financial liabilities or restrictions on product sales [14].

Group 1 - The first company to be reviewed under the restarted fifth set of standards for the Sci-Tech Innovation Board is Wuhan Heyuan Biotechnology Co., Ltd. (Heyuan Bio) [1][3] - Heyuan Bio is an innovative biopharmaceutical company known for its "rice-derived blood" technology and has established a unique plant expression system and two technical platforms [3][4] - The company has adjusted its fundraising target down by approximately 1.1 billion yuan, from an initial 3.502 billion yuan to 2.4 billion yuan, due to steady progress in R&D and business operations [5][6] Group 2 - Heyuan Bio's asset-liability ratio is projected to increase significantly in 2024, with ratios of 18.81%, 23.96%, and 43.37% for the years 2022 to 2024 respectively [6][7] - The company has not yet achieved profitability, with reported revenues of approximately 13.4 million yuan, 24.3 million yuan, and 25.2 million yuan for the years 2022 to 2024, and net losses of approximately 144 million yuan, 187 million yuan, and 151 million yuan for the same period [7] - Heyuan Bio's core product, HY1001, is expected to be approved for market launch soon, having completed its Phase III clinical trials with promising results [7][8] Group 3 - The recent policy changes by the China Securities Regulatory Commission aim to enhance the inclusivity and adaptability of the Sci-Tech Innovation Board, facilitating the listing of unprofitable companies [4] - Other companies currently in the review process under the fifth set of standards include Beixin Life, Hengrun Da, Sizherui, and Bibete, with some making faster progress than others [8][9]

作为禾元生物的核心产品，HY1001获批上市将有效缓解我国人血清白蛋白长期依赖进口 的局面。 本文为IPO早知道原创 作者｜ Eric 微信公众号｜ipozaozhidao 在生物医药领域的激烈竞争中，武汉禾元生物科技股份有限公司（以下简称 "禾元生物"）正以其独 特的技术优势和深厚的研发实力，逐渐崭露头角。即将上会的禾元生物，不仅在稻米造血技术上取得 显著进展，其背后更蕴含着一系列值得关注的创新亮点，为行业发展带来新的思考与方向。 禾元生物自 2006 年成立以来，便专注于重组蛋白表达技术研究与产品开发。经过多年耕耘，公司 构建起了一套完整且先进的技术体系，其中水稻胚乳细胞生物反应器高效重组蛋白表达平台（ Oryz HiExp ）和重组蛋白纯化技术平台（ Oryz Pur ）是其核心竞争力所在。 Oryz HiExp 平台利用水稻胚乳细胞作为生物反应器，通过胚乳细胞特异性表达的启动子、人工定点突 变增强启动子转录水平、蛋白定向储存、内质网减负和密码子优化等综合技术，实现了重组蛋白在水 稻胚乳细胞中的特异性表达与高效储存。这一平台的优势在于，能够将重组蛋白产量从传统的 mg 级别大幅提升至 30g 级别，极大 ...