Summary of Kanghong Pharmaceutical Conference Call Company Overview - **Company**: Kanghong Pharmaceutical - **Date**: October 29, 2025 Key Points Industry and Company Performance - **Biopharmaceutical Segment**: Revenue reached 2.04 billion CNY, a year-on-year increase of 11.36% [2][6] - **Traditional Chinese Medicine Segment**: Revenue was approximately 1.138 billion CNY, up 8.87% year-on-year, mainly driven by products Songling Xuebai Kang and Shugan Jieyu [2][5] - **Chemical Generic Drugs Segment**: Revenue fell to 440 million CNY, a decline of 14.2%, primarily due to the impact of the centralized procurement of Hydrobromide Vortioxetine [2][5][6] - **Overall Revenue**: For the first three quarters of 2025, total revenue was 3.62 billion CNY, reflecting a growth of 6.23% year-on-year [4][17] - **Net Profit**: The net profit attributable to shareholders was 1.033 billion CNY, an increase of 6.08% year-on-year [4] Clinical Trials and Product Development - **Ophthalmology**: - High-concentration Kangbai Xip (KH902/R10) is in Phase II trials for diabetic macular edema and will soon enter Phase III [2][7] - Gene therapy products KA7,631 and KH658 for NAMD are undergoing clinical trials in both China and the US [2][7][25] - **Oncology**: - KH617 for advanced solid tumors and adult diffuse glioma is in Phase II trials, with two subjects enrolled showing promising results [2][8] - The first ADC product KH815 has entered Phase I trials in China and Australia, with 15 subjects enrolled [10][19] - **Neuroscience**: - KH607 for major depressive disorder is in Phase II with over 100 subjects enrolled [11][24] - KH702, a non-addictive pain relief drug, has completed Phase I with 66 subjects [12] Future Outlook - **Revenue and Profit Growth**: The company expects a revenue and profit growth of 5-15% for the full year, although facing pressure in Q4 [5][17] - **Market Positioning**: Kanghong aims to maintain its leadership in the Chinese ophthalmology market, particularly in the anti-VEGF segment, despite increasing competition [18][21] - **R&D Focus**: The company will continue to invest in innovative therapies in ophthalmology, oncology, and neuroscience, with a strong emphasis on gene therapy and ADC technologies [9][14][26] Competitive Landscape - **Ophthalmology Market Trends**: The market is shifting towards anti-VEGFR therapies, with increasing competition from both domestic and international players [13][18] - **Strategic Response**: Kanghong plans to leverage its innovative products and academic promotion teams to navigate market challenges and enhance its competitive edge [18][21] Additional Insights - **Gene Therapy Innovations**: The company is exploring gene therapy for non-ophthalmic indications, focusing on chronic diseases and innovative R&D [14][15] - **Clinical Data Disclosure**: Data for K763 and KH658 is expected to be disclosed in mid-2026, with plans to present findings at major global ophthalmology conferences [25] This summary encapsulates the key insights from the conference call, highlighting Kanghong Pharmaceutical's performance, clinical advancements, future strategies, and market dynamics.

Group 1: Market Position and Product Development - Kanghong Pharmaceutical's KANGBAIXIPU has established a leading position in the Chinese ophthalmology market, with expectations for high-concentration KANGBAIXIPU to launch by 2028, further solidifying market presence [2][3] - The company's gene therapy platform is projected to receive approval for its ophthalmic products around 2030, enhancing its product lineup in the retinal disease sector [2][3] Group 2: Clinical Trials and Safety Data - KH631's Phase I clinical trial data shows excellent safety, with results expected in the first half of 2026 for all subjects, indicating no significant racial differences in safety and preliminary efficacy signals [3][4] - KH607 is currently advancing to Phase II clinical trials, with Phase I and IIa trials demonstrating good safety and efficacy [7] Group 3: Financial Guidance and Investment - For the first half of 2025, sales expenses are projected to increase by approximately 7.85%, management expenses by about 1.41%, and R&D investment by around 16.45% [8] - R&D investment is expected to account for approximately 9.26% of revenue in the first half of 2025, up from 8.51% in the same period last year [8] Group 4: Future Projections - The company anticipates a revenue growth of 5%-15% for 2025 compared to 2024, with net profit expected to increase by the same percentage [8] - The commercialization prospects for innovative drugs depend on various factors, including efficacy, safety, and market competition [7]

Core Insights - The pharmaceutical industry is witnessing a shift towards "long-termism," with companies like Kanghong Pharmaceutical focusing on existing products and breakthroughs in research and development [2][3] Group 1: Innovation Acceleration - Kanghong Pharmaceutical's eye drop product, Lifisfene (brand name "Langyueming"), has been approved as the first 3rd category new drug for dry eye treatment in China, addressing a significant market need [4] - Lifisfene shows clinical efficacy, alleviating symptoms in two weeks and significantly improving corneal damage in 12 weeks, catering to over 300 million potential patients [4] - The dry eye medication market in China is projected to reach approximately 4.79 billion yuan in 2024, with a compound annual growth rate of 16% from 2020 to 2024 [4] Group 2: Strengthening the Core - Kanghong's flagship product, Conbercept, generated 1.345 billion yuan in revenue in the first half of 2025, accounting for 54.83% of total revenue, maintaining its leading market share despite competition [7] - The company employs a strategy of "cost-effectiveness + treatment convenience," enhancing patient adherence through innovative treatment regimens [7] - Kanghong is advancing its high-concentration formulation KH902-R10 into phase II clinical trials, aiming to further solidify its market position [7] Group 3: Expanding Product Portfolio - In the oncology sector, Kanghong's KH815, a dual payload ADC, has shown superior anti-tumor activity in preclinical studies, particularly in drug-resistant models [5][6] - The company is also developing HER3 (KHN922) dual payload ADCs, positioning itself competitively in the next-generation ADC market [6] - The company’s mental health product, Shugan Jieyu capsules, is experiencing double-digit growth and is expanding into anxiety treatment, indicating strong market potential [8] Group 4: Industrial Development - Kanghong has completed the construction of its gene drug production base in Chengdu, which will support clinical research and commercial product manufacturing [9] - The market perception of Kanghong is shifting from a stable company reliant on Conbercept to a more dynamic platform with diverse growth opportunities in dry eye, ADC, and gene therapy [9] - The company is evolving from a "product" focus to a "platform" approach, with Conbercept providing a stable revenue base while new technologies offer future growth potential [9]

Core Viewpoint - Chengdu Kanghong Pharmaceutical Group Co., Ltd. is focusing on innovation and clinical needs to enhance its research and development efforts for its product pipeline in 2025 [1][2] Financial Performance - In 2024, the company achieved operating revenue of 4.453 billion yuan and a net profit attributable to shareholders of 1.191 billion yuan, representing year-on-year growth of 12.51% and 14.02% respectively [1] - In the first quarter of this year, the company reported operating revenue of 1.199 billion yuan and a net profit of 400 million yuan, with year-on-year increases of 9.7% and 7.09% respectively [1] Strategic Focus - The core competitive advantage of the company lies in its strategic layout and continuous innovation capabilities, which encompass product layout, research and development capacity, production capability, talent reserve, international development, and brand building [2] - The company has developed a diversified research and development system covering traditional Chinese medicine, antibody drugs, gene therapy, and small molecule drugs [2] Product Development - The company is advancing several innovative projects, including the "Shu Gan Jie Yu Capsule" for anxiety disorder in phase III clinical trials, and KH607 for depression in phase II clinical trials, as well as KH110 for Alzheimer's disease in phase III clinical trials [2] - KH815, a dual payload ADC drug, is the first of its kind to enter clinical trials globally, targeting advanced solid tumors with a dual mechanism of action [2] Future Direction - The company will continue to adhere to the business philosophy of "innovation as the core, quality as life" and will drive sustainable high-quality development through product innovation and industrial collaboration [3]