Core Viewpoint - The article discusses the rise of Chinese pharmaceutical companies in innovation and the challenges they face in collaborating with research institutions, highlighting a trust crisis in early-stage academic innovations [4][5][6]. Group 1: Innovation in Chinese Pharmaceutical Industry - In 2023, the total amount of new drug licensing transactions from Chinese pharmaceutical companies has exceeded $100 billion, indicating a significant rise in innovation capabilities [4]. - The market's increasing demand for innovation is leading to a more competitive international landscape for Chinese pharmaceutical companies [4]. Group 2: Challenges in Collaboration - Domestic research universities and institutions often face difficulties in industrial collaboration, with most partnerships occurring only after projects have reached advanced stages [5][6]. - There is a notable contrast with the U.S., where academic innovations are more readily supported by venture capital, reflecting a conservative approach in China towards early-stage academic innovations [5][6]. Group 3: Trust Issues and Funding - Trust issues arise when early-stage academic research fails to meet expectations, leading to terminated collaborations and a lack of investment in promising projects [7][12]. - The funding required for preclinical research ranges from 30 million to 50 million yuan, which poses a significant barrier for many projects [12]. Group 4: Need for Differentiated Investment - It is suggested that venture capital and large pharmaceutical companies allocate 5% to 10% of their R&D budgets to support early-stage, differentiated innovations, which could lead to breakthrough results [13]. - The article emphasizes the importance of nurturing both immediate and long-term innovations in the pharmaceutical industry, akin to planting seeds for future growth [13].