Summary of Tempus AI FY Conference Call (September 08, 2025) Company Overview - **Company**: Tempus AI (NasdaqGS:TEM) - **Industry**: Genomics and Data Analytics in Healthcare Key Points Financial Performance - **Q2 Growth**: - Genomics business experienced a growth acceleration from 20% year-over-year in Q1 to 26% in Q2 [2] - Genomics revenue exceeded 30% growth due to reimbursement tailwinds [2] - Adjusted EBITDA improved by approximately $10 million quarter-over-quarter, with expectations to achieve positive adjusted EBITDA in 2025 [2] Business Expansion and Strategy - **Revenue Milestone**: Company is approaching $1.3 billion in revenue, with both main business segments growing at around 30% [3] - **Acquisition of Amri**: - Expected to enhance growth rates, particularly in rare diseases and pediatrics [5] - Q2 growth for Amri was over 30%, with half attributed to market share gains [14] - **Portfolio Expansion**: Focus on expanding beyond oncology into areas like rare diseases, with expectations of positive reimbursement trends [5] Market Dynamics - **Oncology Landscape**: - There are nearly 15,000 oncologists in the U.S., indicating a significant market for holistic solutions [4] - The company believes that the largest players in minimal residual disease (MRD) will also dominate treatment selection [4] - **Reimbursement Trends**: - Positive trends in securing commercial payer reimbursement, although the landscape remains fragmented [9] - MRD tests currently lack reimbursement, with expectations for improvement by the end of the year [10] Data Infrastructure and Technology - **Data Investments**: - Tempus has invested heavily in building a robust technology stack, employing around 700 software engineers [18] - The company has developed proprietary tools to make healthcare data actionable for clients [19] - **Foundation Model**: - A significant project involving over 350 petabytes of data and 1,800 GPUs aimed at generating insights for oncology [28] - The model is expected to enhance the personalization and contextualization of tests, improving clinical decision-making [29] AI and Healthcare - **AI Integration**: - The company is a leader in applying AI to diagnostics, with several FDA-approved algorithms [37] - There is a recognized need for reimbursement mechanisms for AI-driven solutions in healthcare [36] - **Future Outlook**: - AI is anticipated to have a transformative impact on healthcare, with significant potential for cost savings and improved outcomes [61] Challenges and Considerations - **Market Competition**: - The company faces competition in securing reimbursement and market share, particularly in the MRD space [10] - **Long-term Growth**: - While current growth rates are strong, the sustainability of share gains from competitors is uncertain [14] Additional Insights - **Client Engagement**: - The company has established long-term contracts with major pharmaceutical clients, indicating strong demand for its data services [33] - **Product Differentiation**: - Tempus aims to differentiate its genomic tests through integrated data insights, enhancing the value proposition for physicians [27] This summary encapsulates the key insights and developments discussed during the Tempus AI FY Conference Call, highlighting the company's growth trajectory, strategic initiatives, and the evolving landscape of genomics and data analytics in healthcare.

Core Insights - Tempus AI, Inc. (TEM) is rapidly expanding its partnerships in oncology and neuroscience, utilizing its AI platforms, Lens and Next, to enhance precision medicine [1] Partnerships and Collaborations - Tempus has initiated a multi-year collaboration with The Abrams Research Center at Northwestern University to utilize its AI-powered Lens platform for genomic data analysis in Alzheimer's research [2] - In February, Tempus partnered with the Institute for Follicular Lymphoma Innovation to create a deidentified data library in Lens, aimed at accelerating treatment development for follicular lymphoma [2] - In May, Tempus formed a strategic collaboration with Boehringer Ingelheim to advance cancer pipeline research, building on previous joint efforts [3] - Earlier this year, Tempus and Stemline Therapeutics announced a collaboration to enhance oncology treatments using the AI-enabled Next platform [3] - In January, Tempus partnered with Genialis to leverage its multimodal dataset for developing new RNA-based algorithms across various cancer types [4] Industry Comparisons - Sophia Genetics expanded its partnership with AstraZeneca to utilize its AI Factories for breast cancer therapy research, while also collaborating with Result Laboratorium for pharmacogenomics insights [5] - AbbVie announced collaborations with ADARx Pharmaceuticals and Gubra A/S to develop therapeutics across multiple disease areas, including oncology [6] Stock Performance - Over the past year, Tempus AI shares have increased by 35.9%, outperforming the industry growth of 21.4% and the S&P 500's 15.9% improvement [7] Valuation Metrics - Tempus currently trades at a forward 12-month Price-to-Sales (P/S) ratio of 9.38, significantly higher than the industry average of 5.87 [10] Earnings Estimates - Recent estimates for Tempus AI's loss per share have shown mixed movements for 2025 and 2026, with current estimates at -0.16 for Q3 2025 and -0.70 for the current year [11][12]

Core Insights - Hims & Hers Health, Inc. (HIMS) is leveraging artificial intelligence (AI) to transform healthcare delivery, aiming for a more personalized, scalable, and accessible approach [1][6] - The company appointed Mo Elshenawy as CTO to lead AI integration, focusing on creating an AI-powered healthcare platform that enhances diagnosis, treatment, and delivery [1][6] - Hims & Hers raised $870 million in convertible notes to fund AI tools and expand personalized treatment options, reflecting its commitment to modernizing healthcare infrastructure [2][6] AI Integration and Innovations - Hims & Hers is developing an AI-driven healthcare platform that includes initiatives like the intelligent MedMatch routing system to improve diagnostic accuracy and patient experience [2] - Teladoc Health, Inc. (TDOC) is also utilizing AI to enhance its virtual care ecosystem, focusing on intelligent triage and predictive analytics to improve patient outcomes [3] - Tempus AI, Inc. (TEM) is embedding AI in precision medicine, particularly in oncology and neurogenomics, to optimize clinical workflows and support real-time clinical decision-making [4] Financial Performance and Estimates - Hims & Hers shares have increased by 95.7% year-to-date, significantly outperforming the industry growth of 19.7% [5] - The Zacks Consensus Estimate predicts a 174.1% improvement in HIMS' earnings per share from 2024 to 2025 [7] - HIMS' forward 12-month price-to-sales ratio is 4.1X, lower than the industry average of 5.8X but higher than its three-year median of 2.3X [9]

Group 1 - The shift from traditional user inputs to agentic AI in travel planning is significant, enhancing personalization by providing context-aware recommendations [2][4] - Natural language chat AI agents are more effective in understanding user needs and preferences, allowing for a more tailored travel experience [3][4] - The collaboration between Amadeus, Microsoft, and Accenture has led to the development of a trip planning agent that utilizes conversational interfaces for business travel bookings [7] Group 2 - The implementation of agentic AI aims to autonomously make decisions and adapt to changing environments, posing both opportunities and threats to traditional travel intermediaries [8][10] - AI agents are expected to interact with travel suppliers' AI systems, allowing for comprehensive data access and improved customer service [11][12] - The ultimate goal of these AI agents is to negotiate and present the best travel options, focusing on achieving the best price for consumers [12]