NEW YORK, Dec. 29, 2025 (GLOBE NEWSWIRE) -- Royalty Pharma plc (Nasdaq: RPRX) today announced that it has acquired the final portion of PTC Therapeutics’ remaining royalty on Roche’s Evrysdi for $240 million upfront and up to $60 million in sales-based milestones. Evrysdi, marketed by Roche, is an orally administered survival motor neuron-2 (SMN2) splicing modifier for the treatment of spinal muscular atrophy. Evrysdi was approved by the FDA in 2020 and has treated over 21,000 patients worldwide. In 2024, E ...

Summary of Royalty Pharma FY Conference Call (December 03, 2025) Company Overview - **Company**: Royalty Pharma (NasdaqGS:RPRX) - **Key Speakers**: Terrance Coyne (CFO), Marshall Urist (EVP of Investments) - **Year**: 2025 described as a transformational year for the company with significant strategic transactions and financial performance improvements [2][37] Core Industry Insights - **Strategic Transactions**: Internalization of external management to consolidate operations, enhancing strategic and financial positioning [2][37] - **Financial Performance**: Record capital returned to shareholders and strong financial results, indicating positive momentum and a robust pipeline [2][37] Financial Metrics - **Leverage**: Total debt to EBITDA ratio is around 3 times, indicating a conservative financial strategy. The company has the flexibility to increase leverage to 4 times if necessary [4][40] - **Portfolio Growth**: Projected portfolio receipts growth to exceed $4.7 billion by 2030, reflecting a 9% annual CAGR, with $2 billion to $2.5 billion in annual capital deployment [7][43] Growth Drivers - **Existing Portfolio**: Approximately 50% of growth expected from existing products, with key contributors including Voranigo, Tremfya, Trelegy, Cobenfy, Trodelvy, and Imdelltra [10][47] - **New Investments**: The remaining growth will come from new investments, with a conservative approach to capital deployment [8][44] Key Products and Pipeline - **Frexalimab**: A Sanofi product for multiple sclerosis with a peak sales potential of over $5 billion and a double-digit royalty [12][49] - **LP(a) Products**: Two royalties from Novartis (Pelacarsen) and Amgen (Olpasiran), with the latter expected to have significant market impact by 2027 [16][54] - **RevMed**: Focus on pancreatic cancer treatments with a unique deal structure that may set a precedent for future partnerships [27][63] Market Dynamics - **China Market**: Royalty Pharma is exploring opportunities in China, recognizing the potential for royalty monetization and the need for local operations [32][69] - **Synthetic Royalties**: The company is innovating in synthetic royalty funding, which could provide a viable alternative to traditional pharma partnerships [28][65] Upcoming Milestones - **Vertex Resolution**: Expected by the end of 2026 [34][70] - **RevMed Phase 3 Data**: Anticipated in 2026 [35][71] - **LP Little A Data**: Expected in 2026 [35][71] Conclusion Royalty Pharma is positioned for continued growth through strategic internalization, a strong existing portfolio, and innovative deal structures. The company is actively exploring new markets, particularly in China, and is focused on maintaining financial flexibility to capitalize on future opportunities.

Core Insights - Drug pricing is a significant concern for pharmaceutical companies and investors, particularly in light of the Inflation Reduction Act and President Trump's push for lower medicine prices [1][11] - The U.S. market is crucial for large-cap pharmaceutical companies due to higher prices for branded medicines, with a substantial portion of their sales originating from this market [7] Drug Pricing Legislation - The Inflation Reduction Act (IRA), enacted in 2022, allows the Centers for Medicare & Medicaid Services (CMS) to negotiate drug prices for Medicare patients, impacting global pharmaceutical companies [2][4] - Newly negotiated prices for 15 blockbuster drugs, including significant discounts for Novo Nordisk's Ozempic (71% discount) and GSK's Trelegy (73% discount), are set to take effect in 2027, with overall discounts ranging from 38% to 85% [4][9] Company Responses and Market Reactions - European pharmaceutical companies, including AstraZeneca and Novo Nordisk, are making substantial U.S. investments to adapt to the changing market dynamics and pricing pressures [3][11] - Stock market reactions have been muted, with AstraZeneca and GSK shares rising less than 1%, while Novo shares increased by 4.7% following the announcement of price negotiations [8][9] Future Considerations - The CMS is expected to publish a list of 15 drugs selected for negotiations for 2028 by February 1, 2026, indicating ongoing scrutiny and potential changes in drug pricing [9] - Companies are exploring ways to mitigate the impact of price reductions, including voluntary price cuts and investments in U.S. manufacturing to avoid tariffs [11][13]

Financial Data and Key Metrics Changes - Theravance Biopharma achieved non-GAAP break-even in Q3 2025, reflecting strong execution and financial discipline [2][18] - The company ended the quarter with approximately $333 million in cash and no debt, indicating a robust financial position [4][18] - Collaboration revenue increased to $20 million, up 19% year-over-year, driven by YUPELRI's strong operating leverage [18] Business Line Data and Key Metrics Changes - YUPELRI net sales increased 15% year-over-year to $71.4 million, supported by strong demand growth and favorable net pricing [6][7] - Profit margins for YUPELRI reached record levels, with hospital volume increasing 29% year-over-year [7][9] - The hospital channel's share in the long-acting nebulized market reached approximately 21%, a new high since launch [7] Market Data and Key Metrics Changes - The strong growth trends for Trelegy are expected to lead to a $100 million milestone in 2026, with current sales performance exceeding required thresholds [4][17] - The company is on track to achieve near-term milestones totaling $75 million in Q4 2025, including $50 million for Trelegy and $25 million for YUPELRI [4][19] Company Strategy and Development Direction - Theravance is focused on advancing the pivotal phase III CYPRESS trial of ampreloxetine, with data readout expected in early 2026 [3][15] - The company aims to position ampreloxetine as the first precision therapy for symptomatic neurogenic orthostatic hypotension in patients with multiple system atrophy [4][15] - A new disease education campaign for healthcare professionals was launched to raise awareness of neurogenic orthostatic hypotension associated with MSA [5] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the execution of the CYPRESS study and the potential of ampreloxetine to be a significant value inflection point for the company [3][20] - The company is optimistic about the upcoming CYPRESS data readout, viewing it as a transformational catalyst with meaningful upside potential [20] - Management emphasized the importance of financial strength and operational efficiency in supporting future growth and capital returns to shareholders [22][23] Other Important Information - The company plans to host a KOL event for investors on December 8th to discuss the unmet medical needs of patients with MSA and the potential of ampreloxetine [4][16] - The operational execution of the CYPRESS study has been aligned with FDA guidelines, ensuring adequate powering for the trial [40] Q&A Session Summary Question: How is the company thinking about capital return to shareholders in light of Trelegy's performance? - Management highlighted the importance of financial strength and the need to evaluate capital return timing based on the execution of the CYPRESS study [22][23] Question: Are there any pipeline assets being considered for future development? - Management reiterated the focus on YUPELRI and ampreloxetine, stating that future options will be evaluated post-ampreloxetine success [25][26] Question: How does the recently published manuscript inform expectations for CYPRESS data? - Management noted that a one-point difference in the composite score is considered clinically meaningful and is crucial for the CYPRESS study [30][33] Question: Can the company share enrollment numbers for the CYPRESS study? - Management confirmed confidence in enrollment numbers and operational execution, stating that the study is adequately powered [40][41]

Financial Data and Key Metrics Changes - Theravance Biopharma achieved non-GAAP break-even in Q3 2025, reflecting strong execution and financial discipline [2][18] - The company ended the quarter with approximately $333 million in cash and no debt, indicating a solid financial position [4][18] - Collaboration revenue increased to $20 million, up 19% year-over-year, driven by UPELRI's strong performance [18] Business Line Data and Key Metrics Changes - UPELRI net sales increased 15% year-over-year to $71.4 million, supported by strong demand growth and favorable net pricing [6][18] - UPELRI's profit margins reached record levels, with hospital volume increasing 29% year-over-year [7][9] - The company is on track to achieve a $25 million milestone from Viatris based on UPELRI's year-to-date sales [3][6] Market Data and Key Metrics Changes - UPELRI's share in the long-acting nebulized hospital market reached approximately 21%, a new high since launch [7] - Strong growth trends for Trelegy are expected to lead to a $100 million milestone in 2026 [4][17] Company Strategy and Development Direction - Theravance is focused on advancing the pivotal phase III Cypress trial of ampraloxetine, with top-line results expected in early 2026 [3][15] - The company aims to position ampraloxetine as the first precision therapy for symptomatic neurogenic orthostatic hypotension in patients with multiple system atrophy [4][15] - A new disease education campaign for healthcare professionals was launched to raise awareness of neurogenic orthostatic hypotension associated with MSA [5] Management Comments on Operating Environment and Future Outlook - Management expressed confidence in the execution of the Cypress study and the potential of ampraloxetine to be a significant value inflection point for the company [3][20] - The company is optimistic about achieving near-term milestones totaling $75 million in Q4 2025 [4][19] - Management highlighted the importance of the upcoming Cypress data readout as a transformational catalyst for the company [20] Other Important Information - The company plans to host a KOL event for investors on December 8 to discuss the unmet medical need for patients with MSA and the potential of ampraloxetine [4][16] - The operational execution of the Cypress study has been aligned with FDA requirements, ensuring adequate powering for the trial [39] Q&A Session Summary Question: How does the company plan to balance returning capital to shareholders with the potential launch of ampraloxetine? - Management emphasized the importance of financial strength and the need to evaluate capital return timing based on the execution of the Cypress study [22][23] Question: Are there any pipeline assets being considered for future development? - Management stated that the current focus is on UPELRI and ampraloxetine, with potential evaluation of other options post-ampraloxetine success [25][27] Question: How does the recently published manuscript inform expectations for the Cypress data? - Management indicated that the publication is important for understanding the minimally clinically important difference needed for the Cypress study [30][33] Question: Can the company share enrollment numbers for the randomized withdrawal portion of the Cypress study? - Management confirmed confidence in enrollment numbers and operational execution, stating that the study is adequately powered [39][40]

Financial Data and Key Metrics Changes - Theravance Biopharma achieved non-GAAP break-even in Q3 2025, reflecting strong execution and financial discipline [3][19] - The company ended the quarter with approximately $333 million in cash and no debt, indicating a robust financial position [4][19] - Collaboration revenue increased to $20 million, up 19% year-over-year, driven by UPELRI's strong operating leverage [19] Business Line Data and Key Metrics Changes - UPELRI net sales increased 15% year-over-year to $71.4 million, supported by strong demand growth and favorable net pricing [6][19] - UPELRI's profit margins reached record levels, with hospital volume increasing 29% year-over-year [8][10] - The company is on track to achieve a $25 million milestone from Viatris based on UPELRI's year-to-date sales performance [3][4] Market Data and Key Metrics Changes - UPELRI's share in the long-acting nebulized hospital market reached approximately 21%, a new launch-to-date high [8] - The strong growth trends for Trelegy are expected to lead to a $100 million milestone in 2026, with GSK reporting $1 billion in sales for the quarter [4][18] Company Strategy and Development Direction - The company is focused on advancing the pivotal phase III Cypress trial of ampraloxetine, with top-line results expected in early 2026 [3][16] - Theravance is committed to raising awareness of neurogenic orthostatic hypotension (NOH) associated with multiple system atrophy (MSA) through a new disease education campaign [5] - The management emphasizes the importance of executing the Cypress study and preparing for the potential launch of ampraloxetine [24][26] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the upcoming Cypress data readout, viewing it as a significant milestone for the company [16][21] - The company remains optimistic about the transformational potential of ampraloxetine for patients with MSA-related NOH [4][21] - The management highlighted the importance of financial strength and operational execution in maximizing shareholder value [24][26] Other Important Information - The company plans to host a KOL event for investors on December 8 to discuss the unmet medical need for patients with MSA and the potential of ampraloxetine [4][17] - The company reiterated its expense guidance for 2025, expecting results to remain broadly consistent in Q4 [20] Q&A Session Summary Question: How is the company thinking about returning capital to shareholders while preparing for the launch of ampraloxetine? - Management emphasized the importance of financial strength and the need to evaluate capital return timing based on the execution of the Cypress study [24] Question: Are there any pipeline assets being considered for future opportunities? - Management stated that the focus remains on the success of ampraloxetine and UPELRI, with potential evaluations of other options post-launch [26] Question: How does the recently published manuscript inform expectations for the Cypress data? - The publication is important as it establishes a clinically meaningful difference that the company aims to replicate in the Cypress study [32][34] Question: Can the company share enrollment numbers for the randomized withdrawal portion of the Cypress study? - Management expressed confidence in the operational execution and stated that they believe the study is adequately powered [39][40]

29 October 2025 Q3 2025 Results Conference call and webcast for investors and analysts gsk.com Agenda Q3 2025 strong performance improves further Emma Walmsley Performance: growth drivers 2 Cautionary statement regarding forward-looking statements Luke Miels and Deborah Waterhouse Q3 2025 financial performance Julie Brown Summary and Q&A Emma Walmsley, Luke Miels, Deborah Waterhouse, Julie Brown, Tony Wood and David Redfern This presentation may contain forward-looking statements. Forward-looking statements ...

Core Points - Royalty Pharma's board of directors has approved a dividend of $0.22 per Class A ordinary share for the fourth quarter of 2025 [1] - The dividend payment date is set for December 10, 2025, with a record date of November 14, 2025 [1] Company Overview - Royalty Pharma, founded in 1996, is the largest buyer of biopharmaceutical royalties and a significant funder of innovation in the biopharmaceutical industry [2] - The company collaborates with various entities, including academic institutions, research hospitals, non-profits, small and mid-cap biotechnology companies, and leading global pharmaceutical companies [2] - Royalty Pharma's portfolio includes royalties from over 35 commercial products and 17 development-stage product candidates, entitling it to payments based on the top-line sales of leading therapies [2]

Core Points - Royalty Pharma plc has appointed Dr. Ted W. Love as Lead Independent Director, a role he will assume while continuing to chair the Nominating and Corporate Governance Committee [1][2] - Dr. Love brings extensive biopharma experience, having served in various leadership roles, including as President and CEO of Global Blood Therapeutics and as a board member of Gilead Sciences [2][3] - Royalty Pharma is recognized as the largest buyer of biopharmaceutical royalties and a significant funder of innovation in the biopharmaceutical industry, with a portfolio that includes royalties on over 35 commercial products [4] Company Overview - Founded in 1996, Royalty Pharma collaborates with a range of innovators from academic institutions to leading global pharmaceutical companies [4] - The company funds innovation both directly by co-funding late-stage clinical trials and indirectly by acquiring existing royalties from original innovators [4] - Current portfolio includes royalties from notable therapies such as Vertex's Trikafta, Johnson & Johnson's Tremfya, and Gilead's Trodelvy, among others [4]

Summary of Royalty Pharma FY Conference Call Company Overview - **Company**: Royalty Pharma (NasdaqGS:RPRX) - **Industry**: Biopharmaceutical royalties - **Market Position**: Largest buyer of biopharmaceutical royalties globally with over 50 products in its portfolio [7][9] - **Financial Metrics**: - Portfolio receipts guidance for 2025: $3.1 billion - Cash flow guidance for 2025: $2.5 billion - Market capitalization: over $20 billion - CAGR of royalty receipts: 12% since IPO [9][10][21] Core Business Model - **Investment Strategy**: Focus on high-quality, important medicines with strong data; operates as a generalist team to evaluate diverse therapeutic areas [16][27][29] - **Capital Allocation**: - $14 billion deployed since IPO - $4 billion returned through buybacks and repurchases [10][11] - **Royalty Types**: - Traditional royalties from licensing transactions - Synthetic royalties created through direct investments in companies [19][20] Growth and Market Dynamics - **Market Expansion**: Significant growth in biotech innovation leading to increased demand for diverse capital sources [11][12] - **Financial Targets**: - Portfolio receipt CAGR target of 10% or more from 2020 to 2030, currently tracking at 12% [21] - Capital deployment target of $10 billion to $12 billion over five years, already exceeding this target [22] - **Investment Returns**: - Unlevered IRR targets: high single to low double digits for approved products, teens for development stage products [23][24] Recent Transactions and Innovations - **Revolution Medicines Deal**: - $2 billion partnership allowing Revolution Medicines to maintain independence while providing significant capital for development [45][50] - Unique structure with upfront and milestone-based funding, including senior secured debt [51][52] - **Investment in Diverse Areas**: - Focus on underrepresented therapeutic areas such as migraine and psychiatry, with investments in CGRP and long-acting injectable products [36][37] Competitive Landscape - **Market Positioning**: - Unique evergreen business model allowing for lower cost of capital and flexibility in investments [40][41] - Emphasis on creating a vibrant marketplace for royalties, welcoming competition while maintaining a leadership position [43][44] Future Outlook - **Market Opportunities**: - Fragmentation in the biotech sector and increased innovation create ongoing opportunities for royalty transactions [58][59] - Potential for new royalties from licensing activities in emerging markets like China [62] - **Deal Structure Innovations**: - Plans to explore earlier-stage investments and innovative funding structures to adapt to market needs [71][72] Key Takeaways - Royalty Pharma is well-positioned in a growing market with a strong track record of capital allocation and investment returns - The company is focused on maintaining its leadership in the biopharmaceutical royalty space through innovative deal structures and strategic partnerships - Future growth is anticipated through continued investment in diverse therapeutic areas and adapting to market dynamics