Core Insights - Eli Lilly's Zepbound (tirzepatide) demonstrated superior efficacy in weight loss compared to Wegovy (semaglutide) in the SURMOUNT-5 trial, achieving an average weight loss of 20.2% versus 13.7% at 72 weeks [1][2][3] Group 1: Trial Results - Zepbound participants lost an average of 50.3 lbs (22.8 kg), while Wegovy participants lost an average of 33.1 lbs (15.0 kg), indicating a 47% greater relative weight loss with Zepbound [2] - In key secondary endpoints, 64.6% of Zepbound participants achieved at least 15% weight loss compared to 40.1% for Wegovy [2][5] - Zepbound also showed a greater average waist circumference reduction of 7.2 inches (18.4 cm) compared to 5.1 inches (13.0 cm) for Wegovy [2][5] Group 2: Safety and Tolerability - The safety profile of Zepbound was consistent with previous trials, with gastrointestinal-related adverse events being the most common and generally mild to moderate [5] - 6.1% of Zepbound participants discontinued treatment due to adverse events, compared to 8.0% for Wegovy [5] Group 3: Product Information - Tirzepatide is marketed as Zepbound in the U.S. for adults with obesity or overweight with weight-related medical problems, and as Mounjaro for type 2 diabetes [6][10] - Zepbound is FDA-approved for adults with moderate-to-severe obstructive sleep apnea and obesity [10]

Core Viewpoint - LifeMD, Inc. is enhancing its weight management program by integrating access to Wegovy (semaglutide) through NovoCare Pharmacy, providing cash-pay patients with streamlined access to this FDA-approved medication [1][2][3] Group 1: Company Overview - LifeMD is a leading provider of virtual primary care services, offering telemedicine, lab testing, and pharmacy services across more than 200 conditions [5] - The company utilizes a vertically integrated digital care platform, a 50-state affiliated medical group, and a national diagnostic lab network to improve access to affordable healthcare [5] Group 2: Product Offering - The integration with NovoCare Pharmacy allows LifeMD to offer all FDA-approved dose strengths of Wegovy directly within its virtual care platform [1][4] - Wegovy is the first GLP-1 therapy approved in the U.S. for chronic weight management and cardiovascular risk reduction in adults with obesity [4] Group 3: Market Position and Strategy - LifeMD's weight management program is one of the fastest-growing cash-pay offerings in the U.S., providing virtual consultations, lab testing, and prescriptions for anti-obesity medications [2][3] - The company aims to reduce barriers for patients seeking access to life-changing medications like Wegovy, enhancing the overall patient experience [3]