Core Viewpoint - The article discusses the promising future of Structure Therapeutics and its oral GLP-1 drug, aleniglipron, in the obesity treatment market, particularly in light of recent developments and upcoming phase three trials [2][3][4]. Company Overview - Structure Therapeutics is preparing for phase three trials of its daily oral GLP-1 drug, aleniglipron, which has shown significant weight loss results in earlier trials [3][4]. - The company's shares increased by over 100% following the release of midstage data indicating that aleniglipron helped patients lose more than 11% of their weight at 36 weeks [3]. Competitive Landscape - Structure's aleniglipron is positioned as "next in line" in the market after Novo Nordisk's approved pill and an upcoming oral drug from Eli Lilly [4]. - The drug's efficacy is highlighted, with a higher 240-milligram dose showing up to 15.3% weight loss at 36 weeks, compared to competitors reporting similar results over longer periods [6]. Key Advantages - The company emphasizes four competitive advantages: 1. Efficacy demonstrated in trials [6]. 2. Safety, with no drug-related liver injuries reported [7]. 3. Low manufacturing costs, allowing for large-scale production [7]. 4. The ability to combine aleniglipron with other treatments for enhanced effects [8]. Market Potential - There is a significant market opportunity, with 100 million people in the U.S. needing obesity treatment, yet only about 5 million currently receiving injections [9]. - Oral medications like aleniglipron are expected to expand the market, particularly through primary care physicians who prefer prescribing pills [9][10]. Future Outlook - The future of the obesity drug market may focus on combination therapies to address various health conditions alongside obesity [11]. - The company anticipates improvements in access and affordability, with recent price cuts from competitors and upcoming Medicare coverage for obesity drugs [12]. - Structure Therapeutics aims to address a large unmet need globally, even if it means accepting lower prices for their products [13].

Goldman Sachs sets a price target of $102 for NASDAQ:GPCR, indicating a potential increase of approximately 15.07%.Aleniglipron demonstrates a clinically meaningful weight loss of 11.3% in Phase 2b study.The company faces challenges from adverse events and competition from compounded drugs.Structure Therapeutics Inc. (NASDAQ:GPCR) is a biopharmaceutical company focused on developing innovative treatments for obesity. The company is currently seeking approval for its experimental weight-loss pill, aleniglipr ...

Group 1 - Structure Therapeutics Inc. (NASDAQ:GPCR) is involved in developing oral small-molecule drugs aimed at treating chronic conditions such as obesity and pulmonary fibrosis [1] - The company has a partnership with Roche, which is viewed as a positive aspect, but the stock price is perceived to fully reflect this deal, leading to a cautious stance on investment [1] - Comparatively, Eli Lilly is mentioned as the "gold standard" in the industry, suggesting that GPCR may not be the best investment choice at this time [1] Group 2 - There is a belief that certain AI stocks present greater upside potential and lower downside risk compared to GPCR, indicating a shift in investment focus [2] - The article suggests that there are undervalued AI stocks that could benefit from current economic trends, such as tariffs and onshoring, which may be more attractive to investors [2]

Core Viewpoint - Structure Therapeutics Inc. (NASDAQ:GPCR) is recognized as one of the top 14 stocks to buy, with shares increasing over 130% in the last three months due to positive developments related to its oral obesity treatment [1][2]. Group 1: Clinical Developments - A study on aleniglipron, an oral obesity pill, showed a weight loss of 11.3% in obese or overweight patients after 36 weeks at a dosage of 120 mg, marking a significant advancement in the market primarily dominated by injectables [2]. - Ongoing clinical research is testing a 240 mg dose of aleniglipron, which has resulted in an even greater weight loss of 15.3% after 36 weeks [3]. - On December 17, the company announced the initiation of the first human trial for ACCG-2671, an oral small-molecule amylin receptor aimed at treating obesity [3]. Group 2: Market Performance and Analyst Ratings - Wall Street analysts maintain a bullish outlook on GPCR, with a consensus Strong Buy rating and a one-year average price target of $104, indicating a potential upside of 49.94% as of January 12 [4]. - Recent analyst updates include a Buy rating from LifeSci Capital with a price target of $107 and an Outperform rating from BMO Capital with a price target of $130 [4]. Group 3: Company Overview - Structure Therapeutics Inc. is a biotechnology company focused on developing treatments for chronic metabolic conditions [5].

Group 1 - The CEO of GPCR, Raymond Stevens, expressed concerns about the influx of generic versions of their experimental weight loss drug, which has not yet been approved [1] - Following the launch of weight loss injections by Eli Lilly and Novo Nordisk, patients turned to generics due to supply shortages, although these shortages have since ended [1] - The CEO of Novo Nordisk indicated that up to 1.5 million patients in the U.S. are using compounded weight loss drugs, highlighting the ongoing issue of generics in the market [1] Group 2 - Pharmaceutical companies claim that the FDA has not done enough to prevent the spread of generics, with a recent statement indicating plans to publish a list of overseas suppliers that meet FDA standards [2] - Compounding pharmacies utilize these raw materials to produce their own branded generic versions of drugs like Wegovy and Zepbound [2] Group 3 - Stevens noted that GPCR's aleniglipron is a small molecule drug with a more complex manufacturing process, making it harder to replicate compared to peptide drugs like Zepbound and Wegovy from Eli Lilly and Novo Nordisk [1]

Key Points In early December, over 50,000 shares of Structure Therapeutics were indirectly sold by a stakeholding company, valued at nearly $4 million. The stakeholding company is predominantly controlled by the Johnson family, who are highly active in the pharmaceutical sector. These 10 stocks could mint the next wave of millionaires › FMR LLC, a 10% Owner of Structure Therapeutics Inc. (NASDAQ:GPCR), indirectly sold 52,356 shares for a transaction value of approximately $3.8 million on Dec. 8, 2 ...

Core Insights - Structure Therapeutics (NASDAQ: GPCR) ended 2025 positively, with shares rising significantly in December following strong mid-stage data for its weight loss drug, aleniglipron. The company aims to maintain this momentum into 2026 as it progresses in the anti-obesity market [1][7]. Pipeline Overview - Aleniglipron is a once-daily oral GLP-1 candidate that demonstrated a placebo-adjusted mean weight loss of 11.3% at the highest dose in a 36-week phase 2b study. An ongoing mid-stage study has shown even higher mean weight loss of up to 15.3% after 36 weeks. The discontinuation rate due to adverse reactions was 10.4% in the first study, which is typical for GLP-1 medications [4][5]. - Structure Therapeutics plans to initiate a phase 3 study for aleniglipron this year. Additionally, the company has other candidates in its pipeline, including ACCG-2671, an oral weight loss candidate that mimics the action of the amylin hormone [5]. Market Competition - Aleniglipron faces competition from at least two other oral weight loss medications expected to be approved by the time it reaches the market. The FDA has recently approved an oral formulation of Wegovy and is reviewing orforglipron, another oral medicine developed by Eli Lilly [6][7].

Core Insights - Structure Therapeutics Inc. (NASDAQ:GPCR) is gaining attention as a promising investment opportunity, with multiple analysts raising their price targets significantly due to strong growth potential and favorable market conditions [1][2][3] Analyst Ratings and Price Targets - H.C. Wainwright raised its price target on Structure Therapeutics to $90 from $60, citing a validated titration strategy and significant arbitrage opportunity compared to industry metrics [1] - Morgan Stanley increased its price target to $125 from $120, maintaining an Overweight rating, and noted that regulatory uncertainties affecting the biopharma sector are expected to diminish in 2026 [2] - Jefferies also raised its price target to $125 from $79, highlighting the positive Phase 2b data for aleniglipron and positioning Structure Therapeutics as a leader in the oral GLP-1 space [3] Company Overview - Structure Therapeutics is a clinical-stage global biopharmaceutical company focused on developing novel oral small-molecule therapeutics for chronic diseases with unmet medical needs in the US [4] Market Position and Growth Potential - The company is seen as having strong M&A potential and encouraging Phase 2 data, positioning it well for future growth or acquisition opportunities [1]

Industry Overview - The drug and biotech sector regained momentum in the latter part of 2025 after a weak first half, setting the stage for a strong year for select stocks [1] - Improved policy clarity following drug pricing agreements with the Trump administration reduced uncertainty, while a rebound in mergers and acquisitions revived investor appetite for risk [1] - Innovation accelerated across high-growth areas such as obesity, gene therapy, inflammation, and neuroscience, with the FDA approving 43 novel therapies as of December 22, 2025 [2] Company Highlights Ionis Pharmaceuticals - Ionis Pharmaceuticals' shares surged 127.6% in 2025, significantly outperforming the industry growth of 5% [5][6] - The company advanced its wholly-owned portfolio, highlighted by the FDA approval of Tryngolza for familial chylomicronemia syndrome, generating $57.4 million in sales in the first nine months of 2025 [9] - Ionis is evaluating Tryngolza in late-stage studies for severe hypertriglyceridemia, with plans to file for FDA label expansion soon [10] - The FDA approved Ionis' second drug, Dawnzera, for hereditary angioedema, with a regulatory filing in the EU expected in early 2026 [11] Structure Therapeutics - Structure Therapeutics' shares surged 127.2% in the past year, compared to the industry's 15.6% growth [13] - The stock rally was driven by positive data from the ACCESS clinical program for aleniglipron, showing up to 15.3% placebo-adjusted weight loss [15][16] - The company plans to initiate phase III development for aleniglipron in mid-2026 and is also developing other candidates for obesity treatment [18] Monopar Therapeutics - Monopar Therapeutics' shares rallied 185.9% in the past year, significantly outperforming the industry [20] - The stock price increase was fueled by positive expectations regarding its lead candidate ALXN-1840 for Wilson disease, following a licensing agreement with AstraZeneca [22] - Monopar plans to submit a regulatory filing with the FDA in early 2026 based on favorable long-term data for ALXN-1840 [26] Kodiak Sciences - Kodiak Sciences' shares rallied 181.1% in the past year, contrasting with the industry's 15.7% decline [27] - The stock's performance reflects growing investor confidence in its late-stage pipeline assets, particularly tarcocimab and KSI-501 [29] - Kodiak plans to submit a regulatory filing for tarcocimab for multiple indications, with top-line data from pivotal studies expected in 2026 [31][33]

SAN FRANCISCO, Dec. 17, 2025 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic diseases, with a focus on obesity, today announced that it has initiated a first-in-human Phase 1 clinical study of ACCG-2671, the company’s lead oral small molecule amylin receptor agonist for the treatment of obesity. ACCG-2671 was designed via the company’s next generation structure-based drug discove ...