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科伦博泰生物-B(06990.HK):和宜联生物的纠纷已达成和解 创新性构建收益共享模式
Ge Long Hui· 2025-12-24 21:16
Core Viewpoint - The company has reached a settlement agreement with Yilian Biopharmaceuticals and several doctors to resolve disputes, establishing a profit-sharing model for six ADC drug pipelines, which is a departure from traditional compensation methods [1]. Group 1: Settlement Agreement - The settlement includes revenue sharing from six ADC drug pipelines: YL201, YL202, YL211, YL212, YL221, and YL222, with profits generated before and after the settlement date being shared according to an agreed ratio [1]. - This innovative profit-sharing model aims to create a long-term benefit-sharing mechanism rather than a simple compensation and withdrawal approach [1]. Group 2: Drug Development and Partnerships - Yilian Biopharmaceuticals has secured global rights for YL211 with Roche, receiving an upfront payment of $50 million and potential milestone payments of $1 billion; YL202's overseas rights were granted to BioNtech for $70 million upfront and $1 billion in milestones [2]. - The company has also established collaboration plans for YL212 with Zai Lab in 2023 and has previously partnered on YL221 and YL222 with Junshi Biosciences [2]. Group 3: Clinical Trials and Efficacy - YL201 has received breakthrough therapy designation for SCLC indications in both China and the U.S., with ongoing global clinical studies showing promising results [3]. - In a study of 72 patients with ES-SCLC, YL201 demonstrated an overall response rate (ORR) of 68.1% and a median progression-free survival (mPFS) of 6.2 months [3]. - The drug also showed low central nervous system toxicity, with only 0.9% of patients reporting grade 3 or higher neurological adverse events [3]. Group 4: Future Prospects and Financial Forecast - The company anticipates steady revenue growth, projecting revenues of 2.084 billion, 2.876 billion, and 4.663 billion yuan for 2025-2027, with net profits expected to improve from a loss of 622 million yuan in 2025 to a profit of 561 million yuan by 2027 [4]. - The company maintains a "buy" rating based on the successful commercialization progress of its core products [4].
科伦博泰生物:与宜联生物达成和解后后者6款ADC管线收入需按比例分成
Cai Jing Wang· 2025-12-17 05:27
Core Viewpoint - The company has reached a settlement agreement with Suzhou Yilian Biopharmaceutical Co., Ltd. and other parties to resolve several disputes, including criminal accusations and civil lawsuits related to business secrets and company interests [1] Group 1: Settlement Agreement - The settlement aims to save time and costs associated with legal proceedings [1] - Yilian Biopharmaceutical is required to share a certain percentage of revenue and net profit from specific products (YL201, YL202, YL211, YL212, YL221, and YL222) generated before and after the effective date of the settlement [1] - The board believes that the settlement will not have a significant adverse impact on the company's financial condition and operations [1]