Market Performance - The market showed mixed performance from January 19 to January 23, with the Shanghai Composite Index rising by 0.84% and the Shenzhen Component Index increasing by 1.11%[5] - The average daily trading volume was 2.80 trillion yuan, a decrease compared to the previous week[5] Healthcare Sector - At the JPM 2026 conference, over 20 Chinese innovative pharmaceutical companies showcased their products, with significant business development (BD) transactions announced[16] - In 2025, the value of China's innovative drug patent licensing transactions reached approximately $135.7 billion, a 143% increase year-on-year, with 157 total transactions[20] Consumer Sector - The Qianwen APP integrated with Alibaba's ecosystem, achieving over 100 million monthly active users within two months of launch, marking its entry into the "billion-level club"[25] - This integration allows for a seamless process from search to decision-making and payment, establishing a comprehensive AI application ecosystem[26] Hard Technology Sector - The supply of storage and logic chips remains tight, leading to widespread price increases across the industry[32] - The price of enterprise SSDs continues to rise, with a projected increase of 33-38% for NAND Flash products due to supply constraints[36] High-end Manufacturing - The State Grid announced a total fixed asset investment of 4 trillion yuan for the 14th Five-Year Plan period (2026-2030), a 40% increase from the previous period, averaging 800 billion yuan annually[42] - The goal is to achieve a 30% share of renewable energy in total power generation by 2030, indicating significant growth potential for the solar and wind energy sectors[46]

证 券 研 究 报 告 行业周报 重视供给端的变量 医药行业周报 投资评级： 报告日期： 推荐 （ 维持 ） 2026年01月26日 分析师：胡博新 SAC编号：S1050522120002 分析师：吴景欢 SAC编号：S1050523070004 医 药 行 业 观 点 1.重视供给端的变量，关注原料药开工率 根据亚太易和监测的高频兽药原料药报价数据，2026第3周阿莫西林市场价格166元，环比涨幅0.5%，阿莫西林钠和青霉素 钾工业盐价格环比持平。受国内需求不足和潜在产能进入的压力，以6-APA代表的青霉素产业链自2025年Q1开始快速下跌， 目前价格已处于近5年（2019-2026）以来的低位。低价竞争挤压了产业的利润空间，2025Q3单季度川宁生物和国药现代 其扣非净利润分别同比下降51.01%和58.01%，但低价也有效的制约了新产能的释放和新的潜在进入者。除了青霉素产业 链之外，氟苯尼考等兽药价格也处于近年来的最低位，市场价格在170元，2023~2025年1月份，氟苯尼考价格为450元、 217元和193元。展望2026年，来自医用和兽用抗生素需求将基本稳定，供给端出于竞争格局和竞争关系的转变， ...

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry as of January 26, 2026 [1] Core Insights - The report emphasizes the importance of supply-side variables, particularly the operating rates of raw material drugs, and highlights the potential for price recovery in the antibiotic market due to changes in competition and supply dynamics [2] - Multi-departmental policy support is enhancing the value positioning of pharmacies, transforming them from mere sales points to comprehensive health service platforms [3] - The trend of Chinese innovative drugs going global is gaining momentum, with significant licensing deals and the need for continuous clinical data validation to support long-term investment confidence [4] - Major companies are increasingly investing in the small nucleic acid field, which is expected to accelerate the development of the supporting industrial chain [5] - A new pricing system for GLP-1 drugs is forming in China, with expectations for market growth driven by a large patient population [6] - The report highlights the market value of oral autoimmune drugs, with promising clinical trial results for new treatments [7] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry outperformed the CSI 300 index by 0.23 percentage points in the last week, ranking 27th among 31 sectors [20] 2. Pharmaceutical Sector Trends and Valuation - The pharmaceutical sector index increased by 4.98% over the past month, outperforming the CSI 300 index by 3.21 percentage points [37] - The current PE (TTM) for the pharmaceutical sector is 38.51, above the five-year historical average of 31.06 [43] 3. Recent Research Achievements - The report includes various deep-dive studies on topics such as the growth of the blood products industry and the impact of policies on inhalation formulations [45] 4. Recent Industry Policies and News - Recent policies include the approval of numerous medical device registrations and the promotion of high-quality development in the pharmaceutical retail sector [46][48]

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry as of January 19, 2026 [1] Core Insights - 2025 marked a significant year for Chinese innovative drugs going global, with a total transaction amount of $135.655 billion, including $7 billion in upfront payments and 157 deals, setting historical highs. The trend continues into 2026, with notable licensing agreements from companies like Yilian Biotech and Rongchang Biotech, indicating strong global competitiveness for Chinese innovative drugs [2] - Major companies are increasingly investing in the small nucleic acid field, with significant acquisitions and clinical approvals. For instance, China National Pharmaceutical Group acquired Hangzhou Hejiya Biopharmaceutical for 1.2 billion RMB, while international firms like Novartis and GSK are also advancing in this area [3] - The GLP-1 market is expected to grow despite new pricing systems, with ongoing collaborations and new product launches anticipated in 2026. The market for GLP-1 drugs is projected to remain robust due to the large patient population for weight loss and diabetes [4] - The oral autoimmune drug market is gaining attention, with promising results from Takeda's new TYK2 inhibitor for psoriasis. Other domestic companies are also advancing in this space, exploring new targets for oral small molecules [5] - The brain-computer interface sector is poised for industrialization, with companies like Neuralink set to produce devices in 2026. Domestic advancements and regulatory support are enhancing the potential for this technology in medical applications [6] - The ZAP-X radiation therapy device is expected to capture a significant market share in China, with rapid growth projected in non-invasive tumor radiation treatment, driven by increasing clinical recognition and adoption [8] Summary by Sections Industry Trends - The pharmaceutical sector is witnessing a resurgence in interest towards innovative drugs, with a notable increase in the innovative drug index by 8.97% since early January 2026, outperforming the CSI 300 index by 6.77 percentage points [2] Company Recommendations - Recommended companies include: - **Yuekang Pharmaceutical** and **Sunshine Nuohua** in the small nucleic acid space - **Yahong Pharmaceutical** and **Yifang Biotechnology** in the autoimmune sector - **Zhongsheng Pharmaceutical** in the GLP-1 market - **Baiyang Pharmaceutical** for ZAP-X radiation therapy - **Meihao Medical** for brain-computer interface technology [10] Market Opportunities - The non-invasive tumor radiation treatment market is projected to grow from 27.2 billion RMB in 2018 to 59.4 billion RMB by 2024, with a compound annual growth rate of 13.9% [8]

Group 1 - The Hong Kong Stock Connect Innovative Drug ETF (Southern, 159297) has seen a rise of 1.48% as of January 14, 2026, with a turnover of 2.21% and a transaction volume of 37.37 million yuan [1] - The ETF's latest scale reached 1.671 billion yuan and the latest share count reached 1.883 billion, both hitting record highs since its inception [1] - The 44th JPMorgan Healthcare Conference is being held from January 12 to 15, 2026, in San Francisco, focusing on biotechnology, biopharmaceuticals, and AI in medicine, marking it as a significant investment and trading window for the global pharmaceutical industry [1] Group 2 - Yilian Biotech announced a new exclusive licensing agreement with Roche for the YL201 project, which includes an upfront payment of $570 million and potential milestone payments [2] - Haizhi Science signed a licensing agreement with AirNexis for the HSK39004 project, with a total transaction value exceeding $1 billion, currently in Phase II clinical trials in China [2] - Zhongsheng Peptide has reached a global licensing and collaboration agreement with Novartis for an undisclosed peptide asset in the field of radioligand therapy [2] Group 3 - The Hong Kong Stock Connect Innovative Drug Index aims to reflect the operational characteristics of listed companies in the innovative drug sector within the Hong Kong Stock Connect [3] - The top ten weighted stocks in the index include CSPC Pharmaceutical Group, BeiGene, CanSino Biologics, China National Pharmaceutical Group, Innovent Biologics, 3SBio, Hansoh Pharmaceutical, Kelun-Biotech, Kangzheng Pharmaceutical, and Ascentage Pharma-B [3]

Investment Rating - The report indicates a positive investment outlook for the pharmaceutical and biotechnology sector, with a focus on AI-enabled strategic upgrades in pharmaceutical manufacturing [2]. Core Insights - The pharmaceutical and biotechnology sector experienced a 5.6% increase from December 29, 2025, to January 9, 2026, outperforming the Wind All A index (4.76%) and the CSI 300 index (2.18%). Key segments leading this growth include hospitals (12.95%), medical research outsourcing (9.25%), and medical devices (7.96%) [2][7]. - The report highlights the rapid development of AI in healthcare, emphasizing the government's initiative to foster AI in drug development, supply chain management, surgical robotics, and intelligent diagnostic systems by 2027. This initiative aims to cultivate 2-3 leading ecological enterprises and a number of specialized companies [2][11]. - The upcoming JPM Healthcare Conference from January 12 to 15, 2026, is expected to boost the sentiment in the innovative drug sector, with over 500 listed companies and thousands of startups participating [2][11]. Market Weekly Review - The pharmaceutical and biotechnology sector rose by 5.6% during the last interval, with hospitals, medical research outsourcing, and medical devices leading the gains. Notably, the stock of Sanbo Brain Science surged by 63.53%, while *ST Changyao saw a decline of 44.9% [7][10]. - The report provides detailed performance metrics for various sub-sectors, with hospitals showing a 12.95% increase, medical research outsourcing at 9.25%, and medical devices at 7.96% [8][9]. Industry News and Key Company Announcements - On January 7, eight departments jointly issued the "AI + Manufacturing" action plan, marking AI drug development and medical supply chain intelligence as national priorities [11]. - Notable company announcements include: - Yilian Bio's exclusive licensing agreement with Roche for the YL201 project, which includes a $570 million upfront payment [11]. - Merck's discussions to acquire Revolution Medicines for $28 billion to $32 billion [11]. - Structure Therapeutics' agreement with Roche and Genentech for a non-exclusive patent license, resulting in a $100 million upfront payment [11][12]. - Eli Lilly's acquisition of Ventyx Biosciences for $1.2 billion [14].

Investment Rating - The investment rating for the industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index increased by 5.60%, ranking 8th among 31 primary industries, outperforming the CSI 300 index which rose by 2.18% [4][16] - The PE (TTM overall method, excluding negative values) for the pharmaceutical and biotechnology industry as of January 9, 2026, is 30.56x, up from 29.20x at the end of the previous period, indicating an upward valuation trend [4][21] - The top three sub-industries in terms of PE are vaccines (47.64x), hospitals (43.33x), and medical devices (39.44x), while pharmaceutical circulation has the lowest valuation at 15.42x [4][21] Industry Review - The report highlights significant developments in the pharmaceutical sector, including the release of the "Fourth Batch of Encouraged Generic Drug Catalog" aimed at optimizing the drug supply guarantee system and enhancing industry structure [6][26] - The report notes that 43 listed companies in the pharmaceutical and biotechnology sector experienced a net reduction in shareholder holdings amounting to 2.779 billion yuan, with 8 companies increasing holdings by 20 million yuan and 35 companies reducing holdings by 2.799 billion yuan [4] Important Industry News - The National Health Commission and other departments released the "Fourth Batch of Encouraged Generic Drug Catalog," which includes 21 varieties and 47 specifications, focusing on clinical needs and disease burdens [26][27] - The NMPA announced measures to strengthen the supervision and management of entrusted drug production, aiming to enhance drug quality assurance levels [29][30] - The NMPA also optimized the review and approval process for urgently needed overseas drugs, encouraging simultaneous global development and submission [31][32] Investment Recommendations - The report suggests focusing on innovative pharmaceutical companies with strong pipeline differentiation, rapid clinical advancement, and robust overseas collaboration capabilities [7][8] - In the medical device sector, it recommends paying attention to companies with solid technical foundations and deep collaborations with leading hospitals and research institutions [8]

Investment Rating - The report maintains a "Recommended" rating for the pharmaceutical industry as of January 11, 2026 [3] Core Insights - 2025 marked a significant year for Chinese innovative drugs going overseas, with total transaction amounts reaching $135.655 billion, including $7 billion in upfront payments and 157 deals, setting historical highs [4] - The innovative drug index saw a 35.31% increase in 2025, outperforming the CSI 300 index by 17.65% [4] - The trend of Chinese innovative drugs going global is expected to strengthen in 2026, with significant deals such as the one between Yilian Biotech and Roche for the YL201 project, which includes a $570 million upfront payment [4] - The small nucleic acid drug sector is experiencing breakthroughs, with GSK's Bepirovirsen showing positive results in Phase III trials for chronic hepatitis B, potentially becoming the first drug to achieve functional cure [5] - The report highlights the importance of oral autoimmune drugs, with Takeda's TYK2 inhibitor showing promising results in treating moderate to severe plaque psoriasis [6] - The brain-computer interface technology is entering a critical industrialization phase, with companies like Neuralink set to produce devices in 2026, supported by favorable policies and clinical trials in China [8] - The ZAP-X radiotherapy device is expected to capture a significant market opportunity in China, with the non-invasive tumor radiotherapy market projected to grow from RMB 27.2 billion in 2018 to RMB 59.4 billion by 2024 [10] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry index underperformed the CSI 300 index by 2.13% over the past week, ranking 25th among 31 industry indices [28] - Over the past month, the pharmaceutical industry index also lagged behind the CSI 300 by 5.42%, ranking 27th [29] 2. Pharmaceutical Sector Trends and Valuation - The current PE (TTM) for the pharmaceutical industry index is 36.95, above the five-year historical average of 31.12 [52] 3. Recent Research Achievements - The report includes various deep-dive studies on topics such as the growth of biological agents and oral drugs, and the impact of policy support on the inhalation drug industry [55] 4. Important Industry Policies and News - Recent policies include the issuance of the fourth batch of encouraged generic drug directories by the National Medical Products Administration [57] - Significant news includes GSK's announcement of positive Phase III results for Bepirovirsen and Yilian Biotech's licensing agreement with Roche [58][59]

Core Viewpoint - Yilian Bio has entered into a new exclusive licensing agreement with Roche to jointly advance the development and commercialization of the candidate innovative antibody-drug conjugate (ADC) YL201 targeting B7H3 for various solid tumor indications [1] Group 1: Licensing Agreement Details - Under the terms of the agreement, Yilian Bio grants Roche exclusive rights to develop, manufacture, and commercialize the YL201 project globally, excluding mainland China, Hong Kong, and Macau [1] - Yilian Bio will receive an upfront payment of $570 million and milestone payments, along with additional payments based on development, registration, and commercialization milestones, as well as tiered royalties based on net sales after YL201 is approved for sale overseas [1] Group 2: Collaboration Background - This exclusive licensing agreement builds on the successful collaboration initiated in January 2024 regarding the YL211 (c-MetADC) project [1] - The partnership aims to leverage the strengths of both companies to accelerate the registration process of the YL201 project globally [1] Group 3: Commitment to Innovation - Both Yilian Bio and Roche are committed to scientific innovation and patient welfare, aiming to make this promising innovative therapy available to patients as soon as possible [1]

Core Viewpoint - The company has reached a settlement agreement with Yilian Biopharmaceuticals and several doctors to resolve disputes, establishing a profit-sharing model for six ADC drug pipelines, which is a departure from traditional compensation methods [1]. Group 1: Settlement Agreement - The settlement includes revenue sharing from six ADC drug pipelines: YL201, YL202, YL211, YL212, YL221, and YL222, with profits generated before and after the settlement date being shared according to an agreed ratio [1]. - This innovative profit-sharing model aims to create a long-term benefit-sharing mechanism rather than a simple compensation and withdrawal approach [1]. Group 2: Drug Development and Partnerships - Yilian Biopharmaceuticals has secured global rights for YL211 with Roche, receiving an upfront payment of $50 million and potential milestone payments of $1 billion; YL202's overseas rights were granted to BioNtech for $70 million upfront and $1 billion in milestones [2]. - The company has also established collaboration plans for YL212 with Zai Lab in 2023 and has previously partnered on YL221 and YL222 with Junshi Biosciences [2]. Group 3: Clinical Trials and Efficacy - YL201 has received breakthrough therapy designation for SCLC indications in both China and the U.S., with ongoing global clinical studies showing promising results [3]. - In a study of 72 patients with ES-SCLC, YL201 demonstrated an overall response rate (ORR) of 68.1% and a median progression-free survival (mPFS) of 6.2 months [3]. - The drug also showed low central nervous system toxicity, with only 0.9% of patients reporting grade 3 or higher neurological adverse events [3]. Group 4: Future Prospects and Financial Forecast - The company anticipates steady revenue growth, projecting revenues of 2.084 billion, 2.876 billion, and 4.663 billion yuan for 2025-2027, with net profits expected to improve from a loss of 622 million yuan in 2025 to a profit of 561 million yuan by 2027 [4]. - The company maintains a "buy" rating based on the successful commercialization progress of its core products [4].