香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完 整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內 容而引致的任何損失承擔任何責任。 微創醫療科學有限公司* （於開曼群島註冊成立的有限公司） （股份代號：00853） 自願公告 有關擬進行心律管理業務之策略性重組而訂立合併協議 茲提述微創醫療科學有限公司（「本公司」，連同其附屬公司統稱為「本集團」）日期為二零二五年七月 十六日的公告（「該公告」），內容有關本集團心律管理業務之擬議重組。除非文義另有所指外，本公 告所用詞彙與該公告所界定者具有相同涵義。 本公司董事會（「董事會」）欣然宣佈，於二零二五年九月二十九日，CRM Cayman、微創心通及 MicroPort CardioFlow CRM Limited（「合併附屬公司」）訂立了一份合併協議（「合併協議」）。合併附屬 公司為一間於開曼群島註冊成立的獲豁免有限公司，並為微創心通間接全資擁有之附屬公司。 根據合併協議，微創心通將透過合併附屬公司以合併方式收購CRM Cayman。於該合併生效時， CRM Cayman將成為微創心通之間 ...

来源：金杜研究院 在本项目中，金杜作为大冢方的法律顾问，为其提供了高效、一站式的专业法律服务。金杜全程参与了 项目的交易方案设计、法律尽职调查、股权转让过程中的交易文件起草、谈判及签署等各个环节，并协 助完成了本次交易所需的监管审批及交割等事宜。金杜各个团队跨司法辖区、跨专业领域通力协作，充 分体现了金杜的一体化优势和在重大跨境交易中的综合服务能力。本项交易的顺利完成，再次展现了金 杜在医药健康、跨境投资和资本市场等核心业务领域的专业实力和丰富经验。 本项目由金杜上海办公室合伙人陈青东牵头，香港办公室合伙人刘正富、上海办公室合伙人王臻婷主 办，团队成员包括顾问黄慧明、律师龚智彦和沈冠婕。 项目负责人 陈青东 合伙人 上海办公室 chenqingdong@cn.kwm.com 近日，大冢控股株式会社（Otsuka Holdings Co., Ltd.，简称大冢控股）旗下全资子公司大冢医疗器械有 限公司（Otsuka Medical Devices Co., Ltd.）与上海生物医药并购基金等投资方就转让微创医疗科学有限 公司（MicroPort Scientific Corporation，股票代码：00853 ...

Group 1 - The top three companies with the highest short positions as of September 19 are ZTE Corporation (00763) at 15.35%, COSCO Shipping Holdings (01919) at 14.10%, and CATL (03750) at 13.44% [1][2] - The companies with the largest absolute increase in short positions are China Education Holdings (00839) with an increase of 2.61%, Dongfang Electric (01072) with an increase of 2.06%, and Xiexin Technology (03800) also with an increase of 2.06% [1][2] - The companies with the largest absolute decrease in short positions are Hua Hong Semiconductor (01347) with a decrease of -2.52%, Chifeng Jilong Gold Mining (06693) with a decrease of -1.77%, and Laikai Pharmaceutical-B (02105) with a decrease of -1.72% [1][2] Group 2 - The latest short position data shows that ZTE Corporation maintained 116 million shares, COSCO Shipping Holdings had 406 million shares, and CATL had 20.95 million shares [2] - The companies with the largest increase in short positions include China Education Holdings, which rose from 3.73% to 6.33%, and Dongfang Electric, which rose from 7.34% to 9.40% [2] - The companies with the largest decrease in short positions include Hua Hong Semiconductor, which fell from 9.00% to 6.48%, and Chifeng Jilong Gold Mining, which fell from 3.30% to 1.53% [2][3]

Core Viewpoint - The shares of MicroPort group companies have declined significantly, with MicroPort Medical (00853) down 6.8% to HKD 12.59, MicroPort Robotics-B (02252) down 5.29% to HKD 26.52, MicroPort NeuroScience (02172) down 4.46% to HKD 12.21, and HeartLink Medical-B (02160) down 2.34% to HKD 1.25 due to a planned share reduction by major shareholder Otsuka [1] Group 1: Shareholder Actions - Otsuka plans to reduce its holdings by 92.3 million shares at a price range of HKD 12.44 to HKD 12.71 per share, representing a discount of 5.99% to 7.98% compared to the closing price on September 25 of HKD 13.52 [1] - The total cash raised from this share reduction is estimated to be between HKD 11.48 billion and HKD 11.73 billion [1] - There were significant pre-market transactions involving 92.3 million shares at a price of HKD 12.58 per share, amounting to approximately HKD 11.61 billion [1] Group 2: Analyst Insights - Morgan Stanley's recent report indicates that MicroPort Medical faces ongoing domestic regulatory challenges, but it has strong export momentum in surgical robotics, cardiovascular, and vascular intervention businesses [1] - The company is expected to achieve breakeven by 2026, as the obligations related to cardiac rhythm management (CRM) have been resolved and Otsuka has completed its exit [1] - Morgan Stanley has raised the target price for MicroPort Medical from HKD 8.6 to HKD 16, which corresponds to a projected price-to-earnings ratio of approximately 20 times for 2027, while maintaining a "market perform" rating [1]

消息面上，昨日晚间有媒体报道称，微创医疗股东Otsuka(大冢)计划减持9230万股，每股作价12.44- 12.71港元，较9月25日收盘价13.52元折让5.99-7.98%。合计套现11.48-11.73亿港元。值得注意的是，微 创医疗今日盘前现多宗大手成交，涉及9232.37万股，每股作价12.58港元，涉资约11.61亿港元。 智通财经APP获悉，微创系全线走低，截至发稿，微创医疗(00853)跌6.8%，报12.59港元；微创机器人- B(02252)跌5.29%，报26.52港元；微创脑科学(02172)跌4.46%，报12.21港元；心通医疗-B(02160)跌 2.34%，报1.25港元。 摩根士丹利近期发布研报称，微创医疗面临持续的国内监管挑战，但在手术机械人、心血管和血管介入 业务的出口动能强劲，预期2026年有望实现收支平衡；又因心律管理(CRM)义务已解决，主要股东 Otsuka已完成撤出，因此将该股目标价由原先8.6港元上调至16港元，相当于预测2027年市盈率约20 倍。维持"与大市同步"评级。 ...

( 於開曼群島註冊成立的有限公司) (股票代碼: 00853) 2025 中期報告 公司概況 微創醫療科學有限公司（「本公司」或「微創®」）及其附屬公司（統稱「本 集團」）是一家領先的醫療器械集團，專注於在全球範圍內創新、製 造及銷售高端醫療器械。憑藉目前已在全球20,000*多家醫院使用的 多樣化產品組合，本集團在全球運營多個業務分部，包括心血管介 入業務、骨科醫療器械業務、心律管理（「心律管理」）業務、大動脈 及外周血管介入業務、神經介入業務、結構性心臟病業務、手術機 器人業務等。 本集團以人為本，我們堅定地信仰人人都有生而平等的醫療權、健 康權和追求活得更久的權利，並希冀與社會各界通力合作，為人人 享有這種權利而積極創造各種各樣的變革性醫療手段。我們通過創 新科學的實際應用，不斷開發出領先的科技與產品服務，為患者提 供能延長和重塑生命的可普惠化真善美方案。在世界範圍內，平 均每5秒就有一個微創®的產品被用於挽救和延長生命或提升生命品 質。 我們擁有一個大型且不斷豐富的知識產權庫以及一支強大的研究與 開發（「研發」）團隊。我們在全世界與國際知名醫生及科學家緊密合 作，開發出符合最高質量及臨床最高標準的一系 ...

Core Viewpoint - MicroPort Medical's stock transfer indicates a strategic shift among shareholders, with a market capitalization of HKD 18.57 billion, representing 7.40% of the company [1] Group 1: Company Performance - Morgan Stanley's report highlights ongoing domestic regulatory challenges faced by MicroPort Medical, but notes strong export momentum in surgical robots (Medbot), cardiovascular, and vascular intervention businesses [1] - The company is expected to achieve breakeven by 2026, driven by resolved obligations in cardiac rhythm management (CRM) [1] Group 2: Shareholder Actions - The transfer of shares from Citibank to Shanghai International Securities suggests a reallocation of investment among major stakeholders [1] - Major shareholder Otsuka has completed its exit from the company, which may influence future strategic directions [1] Group 3: Price Target and Valuation - Morgan Stanley has raised the target price for MicroPort Medical from HKD 8.6 to HKD 16, implying a projected price-to-earnings ratio of approximately 20 times for 2027 [1] - The rating remains "in line with the market," indicating a neutral outlook on the stock's performance relative to the broader market [1]

Core Viewpoint - MicroPort Medical's stock transfer from Citibank to Silver International Securities indicates a significant market movement, with a total value of HKD 18.57 billion, representing 7.40% of the company's shares [1] Group 1: Company Performance - Morgan Stanley's report highlights ongoing domestic regulatory challenges faced by MicroPort Medical, but notes strong export momentum in surgical robots (Medbot), cardiovascular, and vascular intervention businesses [1] - The company is expected to achieve breakeven by 2026, driven by resolved obligations in cardiac rhythm management (CRM) and the completion of major shareholder Otsuka's exit [1] Group 2: Stock Valuation - Morgan Stanley has raised the target price for MicroPort Medical from HKD 8.6 to HKD 16, which corresponds to a projected price-to-earnings ratio of approximately 20 times for 2027 [1] - The firm maintains a "Market Perform" rating for the stock, reflecting a cautious but optimistic outlook on the company's future performance [1]

Core Viewpoint - Morgan Stanley reports that MicroPort Medical (00853) faces ongoing domestic regulatory challenges but has strong export momentum in surgical robots (Medbot), cardiovascular, and vascular intervention businesses, with a projected break-even in 2026. The target price for the stock has been raised from HKD 8.6 to HKD 16, reflecting a forecasted price-to-earnings ratio of approximately 20 times for 2027. The rating remains "in line with the market" [1] Group 1 - MicroPort Medical's sales forecasts for 2025 to 2027 have been reduced by approximately 2%, indicating an 11% compound annual growth rate from 2024 to 2027 [1] - The expectation for net profit to break even in 2026 remains unchanged, with net profit forecasts for 2026 and 2027 being raised by 151% and 15% respectively from a low base [1] - The discount on the holding company has been narrowed from 40% to 30%, reflecting reduced liquidity concerns, and gross margin forecasts have been adjusted upwards based on guidance [1] Group 2 - Continuous cost-saving measures have led to a corresponding reduction in operating expense forecasts [1] - The company is now projected to achieve operational break-even in 2025 from a low base, with net losses expected to narrow by 93% to approximately USD 55 million in 2025 [1]

Core Viewpoint - Morgan Stanley reports that MicroPort Medical (00853) faces ongoing domestic regulatory challenges, but strong export momentum in surgical robots, cardiovascular, and vascular intervention businesses is expected to lead to breakeven by 2026. The target price is raised from HKD 8.6 to HKD 16, reflecting a projected 2027 P/E ratio of approximately 20 times [1] Group 1 - MicroPort Medical's sales forecasts for 2025 to 2027 have been reduced by about 2%, indicating an 11% CAGR from 2024 to 2027 [1] - The net profit forecast for 2026 remains at breakeven, with net profit estimates for 2026 and 2027 raised by 151% and 15% respectively from a low base [1] - The discount on the holding company has been narrowed from 40% to 30%, reflecting reduced liquidity concerns, and gross margin forecasts have been adjusted upwards based on guidance [1] Group 2 - Continuous cost-saving measures have led to a reduction in operating expense forecasts, with the company expected to achieve breakeven at the operating level in 2025 [1] - The net loss for 2025 is projected to narrow by 93% to approximately USD 55 million [1]