Core Insights - The company has made significant progress in the development of its innovative drug SYN045, which has received approval for Phase I clinical trials in three different dosages from the National Medical Products Administration of China [1] - The results from the completed clinical trials indicate favorable pharmacokinetic characteristics, enhanced safety, and tolerability compared to similar drugs, supporting the potential for long-term oral administration [1] - The company has submitted a total of 18 invention patents related to the SYN045 project, including 5 international patents and 13 domestic patents, with some already granted [1] Group 1: SYN045 Development - SYN045 is a highly selective PGI2 receptor agonist showing significant anti-pulmonary arterial hypertension effects in animal studies [1] - The company plans to conduct Phase IIa clinical trials based on the final results of Phase I to determine the dose-response relationship and explore efficacy and safety in patients [1] Group 2: Other Drug Developments - The company is developing an innovative anti-epileptic drug targeting the potassium ion channel KCNQ2/3, currently in the compound screening phase and preparing for toxicity evaluation [2] - An innovative drug for diabetic peripheral neuropathic pain is also under development, targeting AAK1, with compound screening currently underway [2] - The company is working on three new drug reformulation projects, with two completing pharmacokinetic-based formulation studies and one planned for IND submission within the year [2]

Group 1 - Xiansheng Pharmaceutical has entered into a licensing agreement with NextCure for the ADC drug SIM0505, with a potential transaction value of up to $745 million [1] - SIM0505 targets CDH6 for the treatment of solid tumors, and NextCure will gain access to Xiansheng's TOPOi payload technology for its new ADC product in preclinical development [1] - The National Medical Products Administration has proposed a 30-day review process for innovative drug clinical trial applications to enhance the efficiency of drug development [1] Group 2 - Rongchang Biopharmaceutical's product Tai Tasi Pi has received orphan drug designation from the European Commission for the treatment of myasthenia gravis [2] - Myasthenia gravis is a rare autoimmune disease with a global prevalence of approximately 15-25 cases per 100,000 people [2] Group 3 - Shishi Pharmaceutical Group's caffeine has received the European Pharmacopoeia suitability certificate, facilitating its entry into the European and American markets [3] - The CEP certification indicates compliance with high standards for production processes and quality control, enhancing the brand's international image [3] Group 4 - Saintno Biopharmaceutical expects a significant increase in net profit for the first half of 2025, projecting a year-on-year growth of 253.54% to 332.10% [4] - The growth is attributed to the strong performance of its peptide raw material business and expanded marketing efforts [4]

3. 中国恒大(03333.HK)附属公司委任清盘人，股份自2024年1月29日星期一上午10时18分起暂停买卖， 并将继续停牌，直至另行通知。 4. 市场传闻称泡泡玛特(09992.HK)要进军AI玩具，泡泡玛特相关人士回应称："没听说过"。 5. 一脉阳光(02522.HK)：附属公司湖南一脉拟收购众雅诊断100%股权。 6. 亿纬锂能：拟发行 H 股股票并在香港联合交易所有限公司主板挂牌上市。 7. 龙湖集团(00960.HK)在港交所公告，5月实现总合同销售金额人民币64.7亿元，合同销售面积49.2万平 方米。 金十数据整理：每日港股市场要闻速递（6月10日 周二） 个股新闻： 1. 四环医药(00460.HK)吡洛西利片新增适应症的新药上市申请获受理。 2. 石四药集团(02005.HK)：取得0.3ml马来酸噻吗洛尔滴眼液药品生产注册批件。 ...

Market Overview - The Hang Seng Index fell by 0.21%, down 49 points, closing at 23,857 points, while the Hang Seng Tech Index decreased by 0.59% [1] - The early trading volume in the Hong Kong stock market reached HKD 102.1 billion [1] Sector Performance - The non-ferrous metal sector showed strong performance, with institutions optimistic about sustained profitability; Luoyang Molybdenum Co. rose by 4% and Jiangxi Copper Co. increased by 3.11% [1] - The three major telecom operators in Hong Kong experienced gains, with China Unicom, China Mobile, and China Telecom all rising over 2% [1] Notable Stock Movements - China Silver Group surged over 23%, with spot silver prices reaching nearly USD 36, marking a 13-year high [1] - Longpan Technology saw a rise of 3.35% after signing a large order for 150,000 tons of lithium iron phosphate, indicating a boost in solid-state battery production [1] - Dongyue Group increased by 1.54% as prices for third-generation refrigerants continued to rise, positioning the company as a leader in R22 and R32 quotas [1] - Youjia Innovation rose by 7% after securing a key model for a new energy brand under Changan Automobile [1] - Shijiazhuang Pharmaceutical Group increased by 4.27% after obtaining production registration for calcium gluconate and sodium chloride injection [1] - Zhongxu Future surged over 11% as the issuance of domestic game licenses reached a new high, with multiple new titles planned for release within the year [1] Company-Specific Challenges - Dongfeng Group's stock fell over 3% amid clarification from its controlling shareholder that there are no current restructuring plans, with a reported 17.1% year-on-year decline in vehicle sales for the first five months [2] - Alibaba Health dropped by 3.46% as its profits for the fiscal year 2025 fell short of expectations, with UBS suggesting the company may struggle to maintain its current valuation [3] - The automotive sector faced renewed declines, with analysts predicting an unavoidable new round of price wars, leading to a trend of increased revenue without profit growth; XPeng Motors fell by 2.9% and Li Auto decreased by 1.46% [3]

Core Viewpoint - Stone Four Pharmaceutical Group has obtained the drug production registration certificate for Calcium Gluconate and Sodium Chloride Injection (100ml), which is classified as a Class 3 chemical drug and is considered to have passed the consistency evaluation [1] Group 1 - The Calcium Gluconate and Sodium Chloride Injection is primarily used for the treatment of acute hypocalcemia, magnesium poisoning, and fluoride poisoning [1]

Summary of Key Points Core Viewpoint - On June 2, 39 Hong Kong-listed companies conducted share buybacks, totaling 35.36 million shares and an amount of HKD 1.273 billion [1][2]. Group 1: Buyback Details - Tencent Holdings repurchased 1.013 million shares for HKD 500.53 million, with a highest price of HKD 498.40 and a lowest price of HKD 490.00, accumulating HKD 26.531 billion in buybacks for the year [1][2]. - AIA Group repurchased 5.448 million shares for HKD 354.23 million, with a highest price of HKD 65.75 and a lowest price of HKD 64.15, accumulating HKD 11.009 billion in buybacks for the year [1][2]. - Kuaishou Technology repurchased 6 million shares for HKD 311.91 million, with a highest price of HKD 52.55 and a lowest price of HKD 50.30, accumulating HKD 1.809 billion in buybacks for the year [1][2]. Group 2: Buyback Rankings - The highest buyback amount on June 2 was from Tencent Holdings at HKD 500.53 million, followed by AIA Group at HKD 354.23 million [1][2]. - In terms of buyback volume, the largest was from CSPC Pharmaceutical Group with 7.55 million shares, followed by Kuaishou Technology with 6 million shares and AIA Group with 5.448 million shares [1][2]. Group 3: Additional Buyback Activities - Hengan International conducted its first buyback of the year, repurchasing shares for HKD 14.89 million [2]. - The report includes a detailed table of buybacks by various companies, showing the number of shares repurchased, total amounts, and price ranges [3].

Summary of Key Points Core Viewpoint - A total of 36 companies conducted share buybacks on June 2, 2025, with Tencent Holdings (00700) leading in both the number of shares repurchased and the total amount spent on buybacks. Group 1: Buyback Details - Tencent Holdings (00700) repurchased 1.013 million shares for a total of 501 million CNY, with a year-to-date cumulative buyback of 10.797 million shares, representing 0.118% of its total share capital [1][2] - AIA Group (01299) repurchased 5.448 million shares for 354 million CNY, with a cumulative buyback of 29.266 million shares, accounting for 0.274% of its total share capital [2] - Kuaishou-W (01024) repurchased 6 million shares for 312 million CNY, with a cumulative buyback of 12.3 million shares, representing 2.826% of its total share capital [2] Group 2: Other Notable Buybacks - Times Electric (03898) repurchased 320,700 shares for 10.528 million CNY, with a cumulative buyback of 53.301 million shares, accounting for 9.823% of its total share capital [2] - Stone Four Pharmaceutical Group (02005) repurchased 7.55 million shares for approximately 20.984 million CNY, with a cumulative buyback of 7.55 million shares, representing 0.263% of its total share capital [2] - Modern Dental Group (03600) repurchased 100,000 shares for 4.181 million CNY, with a cumulative buyback of 200,000 shares, accounting for 0.021% of its total share capital [3] Group 3: Additional Companies - China Eastern Airlines (00670) repurchased 2 million shares for 596,650 CNY, with a cumulative buyback of 66.088 million shares, representing 1.277% of its total share capital [2] - Mengniu Dairy (02319) repurchased 300,000 shares for 5.225 million CNY, with a cumulative buyback of 24.596 million shares, accounting for 0.625% of its total share capital [2] - Huazheng Medical (01931) repurchased 20,000 shares for 4.260 million CNY, with a cumulative buyback of 1.824 million shares, representing 0.135% of its total share capital [3]

Group 1: Hong Kong Stock Market Highlights - Mixue Group (02097) rose over 7%, reaching a new high, with Daiwa raising its target price to HKD 608, optimistic about same-store sales growth and store opening speed [1] - Lianlian Digital (02598) increased nearly 10% following the official enactment of the "Stablecoin Regulation" in Hong Kong [1] - Automotive stocks collectively declined, with Li Auto-W, Great Wall Motors, and GAC Group all dropping over 2%, as the Ministry of Industry and Information Technology and the China Association of Automobile Manufacturers opposed "involution-style" price wars [1] - CSPC Pharmaceutical Group (02005) fell over 7% after reporting a 36.9% year-on-year decline in revenue and a 59.5% drop in net profit attributable to shareholders for Q1, with expectations of a 45%-60% decline in profit for the first half of the year due to demand drop and intensified competition [1] - Solar energy stocks dropped across the board, with New Special Energy, Xinyi Energy, Fuyao Glass, and Xinyi Solar all declining over 4%, as the anticipated "531" rush in May did not materialize following the April rush [1] - Chinese property stocks fell collectively in early trading, with R&F Properties, Sunac China, New City Development, and Agile Group all dropping over 4%, as data showed a 10.8% year-on-year decline in sales for the top 100 real estate companies from January to May, with a 17.3% drop in May alone [1] Group 2: Other Notable Stocks - Chongqing Rural Commercial Bank (03618) rose nearly 5% after being included in the CSI 300 Index, becoming the first local financial institution from Chongqing to be included, with a 6.25% year-on-year increase in net profit attributable to shareholders for Q1 [2] - Baker Hughes (02149) increased over 8%, reaching a new high after completing a placement of 3 million new H-shares, raising approximately HKD 117 million [2] - Giant Bio (02367) fell over 4% amid ongoing controversies regarding its product components, with the company stating it received an apology from the relevant testing agency and will pursue accountability for the rumors [2] - Chip stocks declined across the board, with Hua Hong Semiconductor, Jingmen Semiconductor, SMIC, and Shanghai Fudan all dropping over 2%, influenced by fluctuating U.S. policies and a decline in the Philadelphia Semiconductor Index [2] - Beike-W (02423) dropped nearly 6% as Huaxi Securities reported a significant slowdown in second-hand housing transaction growth, with a mere 8% year-on-year increase in 15 cities for the first 29 days of May, the lowest since October of the previous year [2] Group 3: U.S. Stock Market Highlights - AstraZeneca (AZN.US) rose over 2% after its cancer drug Imfinzi received EU approval for specific muscle-invasive bladder cancer treatments [3] - Trump Media & Technology Group (DJT.US) increased over 2.4% after announcing the completion of approximately USD 2.44 billion in financing, planning to use about USD 2.32 billion for Bitcoin reserves, potentially becoming one of the largest Bitcoin holders among U.S. public companies [3] - Nvidia (NVDA.US) fell over 2.92% after the CEO announced plans to sell up to 6 million shares by the end of 2025 [3] - Palantir (PLTR.US) rose over 7.73% as reports indicated the Trump administration relies on its technology for inter-agency data sharing, with over USD 113 million in government contracts since Trump took office [3] - Costco (COST.US) increased over 3.12% after reporting Q3 earnings that exceeded expectations, with revenue of USD 63.2 billion, an 8% year-on-year increase, and EPS of USD 4.28, demonstrating its scale advantage and member loyalty [3]

Core Viewpoint - The National Healthcare Security Administration (NHSA) has initiated an investigation into six companies for collusion and price negotiation during the national drug procurement process, marking the first instance of such violations since the implementation of centralized drug procurement in China [1][4]. Group 1: Investigation and Penalties - Six companies have been disqualified from the seventh round of national drug procurement due to collusion in bidding and have been placed on a "blacklist," facing a suspension of participation for 6 to 12 months [3][7]. - This incident is referred to as the "largest collusion case" in national drug procurement history [4]. - The involved companies include Chengdu Xinjie High-tech Development Co., Ltd., Renhe Yikang Group Co., Ltd., Guangzhou Yipin Hong Pharmaceutical Co., Ltd., Shijiazhuang Fourth Pharmaceutical Co., Ltd., Shanghai Xudong Haipu Pharmaceutical Co., Ltd., and Jiangxi Yiyou Pharmaceutical Co., Ltd. [7]. Group 2: Financial Impact - The collusion has resulted in a loss of approximately 266 million yuan for the procurement side, with Yipin Hong committing to refund the entire amount based on sales data from 2022 to present [8]. - The average winning price for the involved drug, Ambroxol Hydrochloride Injection, was 17.95 yuan, with a price drop of 22%, making it one of the least reduced products in the procurement [9]. Group 3: Market Implications - The blacklisting of these companies may lead to increased competition among other firms for the market share of Ambroxol Hydrochloride Injection, as the involved companies accounted for over 90% of its sales in public hospitals [11]. - The NHSA has emphasized the importance of compliance with laws and regulations in drug procurement, warning that collusion will lead to penalties and damage to corporate reputation [11].

Core Viewpoint - Shijiazhuang Four Pharmaceutical has received approval for its generic drug, Deferasirox dispersible tablets (125mg), marking it as the third domestic company to pass the consistency evaluation for this product in China [1][8]. Group 1: Product Information - Deferasirox, developed by Novartis, is primarily used to treat chronic iron overload due to blood transfusions in patients aged 2 and above, as well as in non-transfusion-dependent thalassemia (NTDT) patients aged 10 and above [3]. - It is the first FDA-approved oral iron chelator that is routinely used, and it has been approved in over 80 countries globally [3]. - In 2022, the global sales of Deferasirox exceeded $300 million [3]. Group 2: Market Performance - In the domestic market, Deferasirox dispersible tablets were included in the national medical insurance directory in 2019 and entered the regular medical insurance directory in 2021 [5]. - In 2023, the total sales of Deferasirox dispersible tablets in hospitals across China reached 168 million yuan, representing a year-on-year growth of 15.03% [5]. - Original drug manufacturers hold a dominant market share of 96.76% in the hospital sales sector [5]. Group 3: Competitive Landscape - The first generic version of Deferasirox dispersible tablets was approved by Aosaikang in June 2021, followed by the second approval from China Medical Huashitong Biopharmaceutical in August 2024 [8]. - Shijiazhuang Four Pharmaceutical is now the third domestic company to pass the evaluation for Deferasirox dispersible tablets [8]. Group 4: Company Strategy - Shijiazhuang Four Pharmaceutical emphasizes a "combination of innovation and generics," supported by a strong innovation team and mechanisms, leading to a robust product pipeline and enhanced research outcomes [11]. - As of now, the company has had 112 products approved or deemed to have passed the consistency evaluation [11]. - In 2024, Shijiazhuang Four Pharmaceutical has already had 45 products approved, with six being the first to pass the evaluation [12].