Core Viewpoint - CloudBreak Therapeutics has successfully listed on the Hong Kong Stock Exchange, marking a significant milestone as the first international ophthalmic innovation drug company to go public in Hong Kong, with a market capitalization of HKD 84.73 billion and net fundraising of approximately HKD 5.22 billion [2][4] Company Overview - Founded in 2015 in Irvine, California, CloudBreak Therapeutics is a clinical ophthalmic biotechnology company focused on innovative and differentiated therapies, with a mission to ensure that no one is hindered by poor eye health [4] - The company has developed a broad and innovative pipeline, including eight drug candidates targeting major diseases of the anterior and posterior segments of the eye, with four in clinical stages and four in preclinical stages [4] Product Pipeline - The core product CBT-001 is a pioneering drug for the treatment of pterygium, currently undergoing global Phase III clinical trials across multiple countries, showing significant efficacy and good tolerability [6][10] - Other products in the pipeline include CBT-004 for treating vascularized pterygium, CBT-006 for dry eye syndrome, and CBT-009 for myopia in adolescents, all demonstrating promising clinical results [12][13] Market Opportunity - The global prevalence of pterygium is 10.2%, with rural areas in China reaching as high as 33%, indicating a significant unmet medical need in this area [7][10] - The global ophthalmic drug market is projected to reach USD 73.9 billion by 2030, highlighting the growth potential for innovative therapies in this sector [16] Investment and Support - Since 2018, CloudBreak Therapeutics has raised a total of HKD 11.3 billion, receiving support from various institutions, including Yi Feng Capital, which participated in its C-round financing in 2022 [14][15] - The successful IPO is seen as a validation of the company's core value and clear development path, with expectations for its innovative products to capture significant market share in the global ophthalmic drug market [15][18]

Core Viewpoint - The initial public offering (IPO) of Bokan Vision Pharmaceutical Co., Ltd. (02592.HK) on the Hong Kong Stock Exchange faced a significant decline, with shares opening at HKD 9.50 and closing at HKD 6.20, representing a drop of 38.61% [1] Group 1: Company Overview - Bokan Vision is a clinical-stage ophthalmic biotechnology company focused on developing various therapies, with its core product being CBT-009, an atropine eye preparation for treating myopia in adolescents [1] - The total number of shares issued at the time of listing was 838,892,874 [2] Group 2: IPO Details - The final offer price for the shares was HKD 10.10, raising a total of HKD 611.88 million, with a net amount of HKD 522.21 million after deducting estimated listing expenses of HKD 89.67 million [2] - The number of shares offered was 60,582,000, with 12,115,500 shares allocated for public offering in Hong Kong and 48,466,500 shares for international offering [2] Group 3: Use of Proceeds - The net proceeds from the global offering are intended for ongoing clinical research and development activities for core products CBT-001 and CBT-009, as well as funding for production facilities, commercialization activities, and general corporate purposes [2] Group 4: Financial Performance - Bokan Vision has not recorded any revenue and has faced significant business failure risks, with net losses of USD 66.84 million, USD 129.42 million, and USD 99.13 million for the years 2022 to 2024, totaling USD 295.39 million [5] - Research and development expenditures for the years 2022, 2023, and 2024 were USD 15.3 million, USD 27.5 million, and USD 37.9 million, respectively [5] - The net cash used in operating activities for the same years was USD 20.05 million, USD 22.51 million, and USD 26.52 million [6][7]

Core Viewpoint - Cloudbreak Pharma Inc. (拨康视云) successfully listed on the Hong Kong Stock Exchange on July 3, 2025, raising approximately HKD 612 million through its IPO, with a strong demand reflected in the subscription rates [3][6]. Group 1: IPO Details - The IPO involved a global offering of 60.582 million shares, representing 7.22% of the total shares post-issue, priced at HKD 10.10 per share [3]. - The public offering was oversubscribed by 78.78 times, while the international offering saw a subscription rate of 0.89 times [3]. - Two cornerstone investors participated, committing a total of approximately USD 28.8 million, which accounted for 29.25% of the global offering [3]. Group 2: Shareholder Structure - The largest single shareholder is Dr. Ni Jinsong, holding approximately 20.86%, followed by his wife, Ms. Bing Leng, with 1.32%, totaling 22.18% [4]. - Other significant shareholders include Van Son Dinh (7.14%), Yang Rong (1.76%), and Li Jun Zhi (4.14%), along with various institutional investors [4][5]. Group 3: Company Overview - Established in 2015, Cloudbreak Pharma is an innovative clinical-stage ophthalmic biotechnology company focused on developing novel and differentiated therapies [6]. - The company has a pipeline of eight candidate drugs targeting major eye diseases, with four in clinical stages and four in preclinical stages [6]. - Key products include CBT-001 and CBT-004, which may be the first global treatments for pterygium and vascularized eyelid lesions, respectively [6]. Group 4: Market Performance - As of the midday close, Cloudbreak Pharma's stock was priced at HKD 7.04, with a total market capitalization of approximately HKD 5.906 billion [7][8].

Group 1: Company Developments - Bolekan Vision Cloud-B has launched its IPO on the Hong Kong Stock Exchange, with approximately 60.58 million shares available for global sale at a price of HKD 10.10 per share, indicating the company's confidence in its value [1] - Stand Robot has submitted its listing application to the Hong Kong Stock Exchange, focusing on industrial intelligent mobile robot solutions, despite currently being in a loss-making position [2] - Chengtai Technology has filed its prospectus with the Hong Kong Stock Exchange, specializing in millimeter-wave radar products, with projected revenues increasing from 0.58 billion to 3.48 billion from 2022 to 2024 [4] Group 2: Financial Performance - China Wangwang reported revenues of approximately 23.51 billion for the fiscal year ending March 31, 2025, a slight decrease of 0.3% year-on-year, while profit attributable to equity holders increased by 8.6% to 4.34 billion [3]

Group 1 - Cloudbreak Pharma Inc. (referred to as "Cloudbreak") plans to issue 60.582 million H-shares from June 24 to June 27, with an expected listing date on the Hong Kong Stock Exchange on July 3, 2025 [1][3] - The offering price is set at HKD 10.10 per share, aiming to raise approximately HKD 612 million, with a net fundraising amount of about HKD 522 million [3] - Key investors include Fuzhi Holdings Limited and The Reynold Lemkins Group (Asia) Limited, which collectively subscribed for approximately USD 28.8 million worth of shares [3] Group 2 - Cloudbreak is a clinical-stage ophthalmic biotechnology company focused on developing various therapies, with two core products: CBT-001 for treating pterygium and CBT-009 for juvenile myopia [5] - The company has other candidate drugs in early development stages, including two clinical-stage candidates and four preclinical-stage candidates [5] - Revenue projections for Cloudbreak are approximately zero for 2022 and 2023, with an expected revenue of USD 10 million in 2024; net losses are projected at USD 66.838 million, USD 129 million, and USD 99.13 million for the respective years [5] Group 3 - The funds raised from the IPO will be allocated to the continued clinical development of core product CBT-001, regulatory filing, and approval-related research, as well as costs associated with the development of CBT-009 [5]