证券代码：688221 证券简称：前沿生物 公告编号：2025-024 前沿生物药业（南京）股份有限公司 1、审议通过《关于公司<2025 年半年度报告>及摘要的议案》 具 体 内 容 详 见 公 司 于 同 日 披 露 于 上 海 证 券 交 易 所 网 站 （http://www.sse.com.cn/）的《前沿生物药业（南京）股份有限公司 2025 年 半年度报告》及《前沿生物药业（南京）股份有限公司 2025 年半年度报告摘要》。 监事会的审核意见为：公司 2025 年半年度报告的编制和审议程序符合法律、 法规、公司章程及监管机构的规定；公司 2025 年半年度报告的内容与格式符合 相关规定，公允地反映了公司 2025 年半年度的财务状况和经营成果等事项；2025 年半年度报告编制过程中，未发现公司参与报告编制和审议的人员有违反保密规 定的行为；监事会全体成员保证公司 2025 年半年度报告披露的信息真实、准确、 完整，不存在任何虚假记载、误导性陈述或重大遗漏，并对其内容的真实性、准 确性和完整性依法承担法律责任。 关于第四届监事会第四次会议决议的公告 本公司监事会及全体监事保证本公告内容不存在任何虚 ...

中信证券股份有限公司 关于前沿生物药业（南京）股份有限公司 变更部分募集资金投资项目的核查意见 中信证券股份有限公司（以下简称"中信证券"或"保荐机构"）作为正在 履行前沿生物药业（南京）股份有限公司（以下简称"前沿生物"或"公司"） 持续督导工作的保荐机构，根据《证券发行上市保荐业务管理办法》《上市公司 募集资金监管规则》《上海证券交易所科创板上市公司自律监管指引第 1 号—— 规范运作》等有关规定，对前沿生物变更部分募集资金投资项目的事项进行了 审慎核查，核查情况如下： 一、募集资金及募投项目基本情况 根据中国证券监督管理委员会《关于同意前沿生物药业（南京）股份有限公 司首次公开发行股票注册的批复》（证监许可[2020]2232 号文），公司获准向社会 公开发行人民币普通股 8,996 万股，每股发行价格为人民币 20.50 元，共募集资 金 184,418.00 万元；扣除发行费用（不含增值税）12,688.99 万元后，募集资金净 额 171,729.01 万元。上述募集资金到位情况已经毕马威华振会计师事务所（特殊 普通合伙）审验并出具了毕马威华振验字第 2000756 号《验资报告》。 根据中国证券 ...

前沿生物药业（南京）股份有限公司2025 年半年度报告 公司代码：688221 公司简称：前沿生物 前沿生物药业（南京）股份有限公司 2025 年半年度报告 2025 年 8 月 1/185 前沿生物药业（南京）股份有限公司2025 年半年度报告 重要提示 一、 本公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实性、准确 性、完整性，不存在虚假记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 二、 重大风险提示 本报告包含涉及重大风险和不确定性的前瞻性陈述。公司的前瞻性声明主要基于公司对未来 事件及趋势的当前预期及预测，公司认为此类未来事件及趋势可能会影响公司的业务、财务状况 及经营业绩。除历史信息外，本报告中的所有陈述，均属前瞻性陈述。该等陈述涉及风险和不确 定因素，包括"第三节管理层讨论与分析"之"四、风险因素"下所描述的内容，可能导致实际 业绩和结果与所预计的情况存在重大差异。鉴于上述不确定性，广大投资者不应过度依赖该等前 瞻性陈述。除非法律另有要求，公司不承担任何因新信息或其他原因而更新任何前瞻性陈述的义 务。 三、 公司全体董事出席董事会会议。 四、 本半年度报告未经审计 ...

Group 1 - The stock of Frontline Bio (688221.SH) closed at 18.25 yuan, with a decline of 4.4%, currently in a state of breaking issue [1] - Frontline Bio was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on October 28, 2020, with an issuance of 89.96 million shares, accounting for 25.01% of the total share capital after issuance, at a price of 20.50 yuan per share [1][2] - The total amount raised from the issuance was 184.418 million yuan, with a net amount of 171.729 million yuan, intended for various clinical research projects and working capital [2][4] Group 2 - The highest stock price of Frontline Bio on the listing day was 35.53 yuan, marking the peak since its listing [2] - The underwriting and sponsorship fees for the initial public offering amounted to 12.689 million yuan, with the underwriting and sponsorship fee being 11.613 million yuan [2] - The actual controller of Frontline Bio is Dong Xie, who holds U.S. nationality and has permanent residency in China [3]

Group 1 - The A-share market has seen a decline in several biopharmaceutical stocks, with notable drops including Nanmo Bio down 9%, Shanghai Yizhong down over 7%, and Nuocheng Jianhua down over 5% [1] - Other companies experiencing declines include Yangguang Nuohuo and Guangshengtang down over 4%, and Haichuang Pharmaceutical, Baicheng Pharmaceutical, Yaokang Bio, and Qianyan Bio down over 3% [1] Group 2 - Specific stock performance includes: - Nanmo Bio (688265) down 9.06% with a market cap of 5.027 billion and a year-to-date increase of 178.89% - Shanghai Yizhong (688091) down 7.23% with a market cap of 15.7 billion and a year-to-date increase of 89.98% - Nuocheng Jianhua (688428) down 5.25% with a market cap of 56 billion and a year-to-date increase of 158.55% - Yangguang Nuohuo (688621) down 4.57% with a market cap of 8.727 billion and a year-to-date increase of 107.29% - Guangshengtang (300436) down 4.26% with a market cap of 26.3 billion and a year-to-date increase of 404.68% [2]

Group 1 - A-share market sees weakness in certain biopharmaceutical stocks, with notable declines in several companies [1] - Nanmo Bio falls by 9%, while Shanghai Yizhong drops over 7% [1] - Nocare Health declines by over 5%, and Sunshine Nuohe and Guangshengtang both decrease by over 4% [1] - Haichuang Pharmaceutical, Baicheng Pharmaceutical, Yaokang Bio, and Qianyan Bio all experience declines of over 3% [1]

Core Viewpoint - Frontline Bio (688221.SH) is currently trading at 19.63 yuan, reflecting a decline of 1.90% and is in a state of post-IPO price drop [1] Group 1: IPO Details - Frontline Bio was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on October 28, 2020, with an issuance of 89.96 million shares, accounting for 25.01% of the total share capital post-issuance, at a price of 20.50 yuan per share [1] - The total funds raised from the IPO amounted to 184.418 million yuan, with a net amount of 171.729 million yuan after expenses [2] - The company planned to use the raised funds for various projects, including the development of an HIV fusion inhibitor, clinical research for a combined therapy, and marketing network construction [2] Group 2: Financials and Shareholder Information - The actual controller of Frontline Bio is Dong Xie, who holds U.S. nationality and has permanent residency in China [3] - In a subsequent issuance on September 22, 2022, Frontline Bio issued 14.818 million shares at a price of 13.51 yuan per share, raising a total of approximately 200.2 million yuan, with a net amount of about 195.67 million yuan after deducting issuance costs [3] - The total amount raised from both fundraising rounds is approximately 2.044 billion yuan [4]

Market Overview - On August 8, the chemical pharmaceutical sector rose by 0.24% compared to the previous trading day, with Lianhuan Pharmaceutical leading the gains [1] - The Shanghai Composite Index closed at 3635.13, down 0.12%, while the Shenzhen Component Index closed at 11128.67, down 0.26% [1] Stock Performance - Notable declines in individual stocks include: - Shanghai Yizhong: closed at 72.23, down 5.42% with a trading volume of 80,000 shares and a turnover of 573 million yuan - Yifang Bio: closed at 39.80, down 5.37% with a trading volume of 203,000 shares and a turnover of 818 million yuan - Qianhong Pharmaceutical: closed at 10.19, down 4.77% with a trading volume of 1,197,800 shares and a turnover of 1.23 billion yuan [1] Capital Flow Analysis - The chemical pharmaceutical sector experienced a net outflow of 230 million yuan from institutional investors and a net outflow of 93.16 million yuan from retail investors, while retail investors saw a net inflow of 323 million yuan [1] - Key stocks with significant capital flow include: - Meinuohua: net inflow of 236 million yuan from institutional investors, with a 18.01% share - Lianhuan Pharmaceutical: net inflow of 197 million yuan from institutional investors, with a 13.40% share [2] - Other notable stocks include Han Yu Pharmaceutical and Bo Rui Pharmaceutical, with net inflows of 171 million yuan and 131 million yuan from institutional investors, respectively [2]

Core Viewpoint - The A-share market shows a slight increase with the Shanghai Composite Index at 3630.45 points, reflecting a gain of 0.36% as of 14:02, with a total trading volume of 14153.35 billion yuan [1] Group 1: Market Performance - The A-share market has a total trading volume of 14153.35 billion yuan [1] - The Shanghai Composite Index is at 3630.45 points, indicating a 0.36% increase [1] Group 2: Stocks with Death Cross - A total of 13 A-shares have experienced a death cross, where the 5-day moving average falls below the 10-day moving average [1] - Notable stocks with significant distance between their 5-day and 10-day moving averages include: - Information Development: 5-day MA at 44.98 yuan, 10-day MA at 45.61 yuan, a difference of -1.39% [2] - Zhun Oil Shares: 5-day MA at 7.31 yuan, 10-day MA at 7.41 yuan, a difference of -1.34% [2] - Xin Nuo Wei: 5-day MA at 52.60 yuan, 10-day MA at 53.19 yuan, a difference of -1.11% [2]

Market Performance - The three major indices collectively strengthened, with the Shanghai Composite Index rising by 0.96% to surpass the 3600-point mark, the Shenzhen Component Index increasing by 0.59%, and the ChiNext Index up by 0.39%. The total trading volume in the Shanghai and Shenzhen markets was approximately 1.60 trillion yuan [2]. Military Industry - The military sector showed outstanding performance, with North China Long Dragon (301357.SZ) rising over 14%, Great Wall Military Industry (601606.SH) hitting the daily limit of 10%, and other companies like Construction Industry (002265.SZ) and Aileda (300696.SZ) also experiencing significant gains. The "14th Five-Year Plan" is entering its final phase, and events like the August 1st Army Day and the September 3rd military parade are driving a reshaping of the military industry [3]. PEEK Materials and Robotics - PEEK materials and robotics concepts gained strength, with Xinhan New Materials (301076.SZ) rising by 20%, Huami New Materials (836247.BJ) up over 12%, and Zhongxin Fluorine Materials (002915.SZ) increasing by 10%. The stock Weixin New Materials (688585.SH) resumed trading and hit the daily limit of 20%, having accumulated over 1300% growth since July [3]. Communication Equipment and AI Demand - The communication equipment sector and liquid cooling server concepts also performed well, with Changxin Bochuang (300548.SZ) rising over 13% to reach a historical high, and Yidong Electronics (301123.SZ) increasing by over 10%. Major tech companies like Microsoft, Google, Meta, and Amazon reported high capital expenditures (CAPEX) for Q2 2025, totaling approximately $95 billion, a year-on-year increase of 67% and a quarter-on-quarter increase of 24% [4]. Banking and Securities Sector - The banking and securities sectors performed well, with companies like Shanghai Pudong Development Bank (600000.SH) and Xinda Securities (601059.SH) experiencing significant gains. Recent government policies aimed at personal consumption loan interest subsidies and service industry loan interest subsidies are expected to boost consumption and small businesses, indicating a supportive stance towards bank interest margins [5]. Weak Performers - The traditional Chinese medicine and film sectors showed weakness, with Qizheng Tibetan Medicine (002287.SZ) dropping by 9.98% and Xingfu Blue Ocean (300528.SZ) declining over 6%. Some innovative drug concepts also faced downturns, with companies like Qianfang Biology (688221.SH) and Hite Biology (300683.SZ) experiencing declines [5].