前沿生物药业（南京）股份有限公司 1、公司全部在有效期内的股权激励计划所涉及的标的股票总数累计未超过公司股本总额的 20.00%。上述任何一名激励对象通过全部在有效期内的股权激励计划获授的公司股票数量累计未 超过公司股本总额的 1.00%。 2、本激励计划首次授予激励对象不包括公司独立董事、监事、单独或合计持有公司 5%以上 股份的股东或实际控制人及其配偶、父母、子女。 3、预留部分的激励对象应当在本激励计划经股东大会审议通过后 12 个月内确定，经董事会 提出、薪酬与考核委员会/监事会发表明确意见、律师发表专业意见并出具法律意见书后，公司在 指定网站按要求及时准确披露激励对象相关信息。 4、合计数与各明细数直接相加之和在尾数上如有差异，是由于四舍五入所造成。 2025 年限制性股票激励计划首次授予激励对象名单 （截至授予日） 一、 2025 年限制性股票激励计划的分配情况 | 姓名 | 职务 | 国籍 | 获授的第二类限 制性股票数量 （万股） | 占本激励计划拟 授出全部权益数 量的比例 | 占首次授予日股 本总额的比例 | | --- | --- | --- | --- | --- | --- | | ...

证券代码：688221 证券简称：前沿生物 公告编号：2025-036 前沿生物药业（南京）股份有限公司 关于 2025 年限制性股票激励计划内幕信息知情人及 激励对象买卖公司股票情况的自查报告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 前沿生物药业（南京）股份有限公司（以下简称"公司"）于 2025 年 9 月 17 日召开第四届董事会第六次会议、第四届监事会第六次会议审议通过了《关 于公司<2025 年限制性股票激励计划（草案）>及其摘要的议案》等议案，并于 2025 年 9 月 18 日在上海证券交易所网站（www.sse.com.cn）披露了相关公告。 1 卖公司股票情况进行了查询，并由中国证券登记结算有限公司上海分公司出具 了查询证明。 二、核查对象买卖公司股票情况说明 根据中国证券登记结算有限公司上海分公司出具的《信息披露义务人持股 及股份变更查询证明》及《股东股份变更明细清单》，在本激励计划自查期间， 共 3 名激励对象存在买卖公司股票的行为。经公司核查，上述人员在自查期间 进行的股票交易系其个人基于二 ...

北京国枫律师事务所 GRANDWAY 北京国枫律师事务所 Grandway Law Offices 北京市东城区建国门内大街 26 号新闻大厦 7 层 邮编: 100005 电话（Tel）: 010-88004488/66090088 传真（Fax）: 010-66090016 北京国枫律师事务所 关于前沿生物药业(南京) 股份有限公司 2025 年限制性股票激励计划首次授予相关事项的 关于前沿生物药业（南京）股份有限公司 2025 年限制性股票激励计划首次授予相关事项的 法律意见书 国枫律证字[2025]AN147-2 号 法律意见书 国枫律证字|2025|AN147-2号 致: 前沿生物药业(南京) 股份有限公司 根据本所与前沿生物签订的律师服务协议,本所接受前沿生物的委托,担任 前沿生物本次激励的专项法律顾问。根据《公司法》《证券法》《管理办法》《上 市规则》等法律、法规、规章、规范性文件及《公司章程》的有关规定,本所律 师已出具了《北京国枫律师事务所关于前沿生物药业(南京)股份有限公司 2025 年限制性股票激励计划(草案)的法律意见书》(以下简称"原法律意见书"), 现就本次激励计划首次授予限制性股 ...

南京市鼓楼区集庆门大街 270 号苏宁环球国际中心 43 层 电话：025-85803866 传真：025-85803680 邮编：210003 北京国枫（南京）律师事务所 关于前沿生物药业（南京）股份有限公司 2025 年第二次临时股东大会的 法律意见书 国枫律股字[2025]H0044 号 致：前沿生物药业（南京）股份有限公司（贵公司） 北京国枫（南京）律师事务所（以下简称"本所"）接受贵公司的委托，指派律师 出席并见证贵公司 2025 年第二次临时股东大会（以下简称"本次会议"）。 本所律师根据《中华人民共和国公司法》（以下简称"《公司法》"）、《中华人 民共和国证券法》（以下简称"《证券法》"）、《上市公司股东会规则》（以下简称 "《股东会规则》"）、《律师事务所从事证券法律业务管理办法》（以下简称"《证券法律 业务管理办法》"）、《律师事务所证券法律业务执业规则（试行）》（以下简称"《证券法 律业务执业规则》"）等相关法律、行政法规、规章、规范性文件及《前沿生物药业（南 京）股份有限公司章程》（以下简称"《公司章程》"）的规定，就本次会议的召集与召开 程序、召集人资格、出席会议人员资格、会议表决程序 ...

本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 前沿生物药业（南京）股份有限公司（以下简称"公司"）于 2025 年 9 月 17 日 召开第四届董事会第六次会议，审议通过了《关于公司<2025 年限制性股票激励计划 （草案）>及其摘要的议案》及相关议案。根据《上市公司股权激励管理办法》（以下 简称"《管理办法》"）等有关法律、法规及规范性文件的相关规定，公司对 2025 年限 制性股票激励计划（以下简称"本激励计划"）拟首次授予激励对象的姓名和职务在 公司内部进行了公示。公司董事会薪酬与考核委员会（以下简称"薪酬委员会"）结 合公示情况对首次授予激励对象人员名单进行了核查，相关公示情况及核查情况如下： 一、公示情况说明 证券代码：688221 证券简称：前沿生物 公告编号：2025-034 前沿生物药业（南京）股份有限公司 董事会薪酬与考核委员会关于公司 2025 年限制性股票激励计划 首次授予激励对象名单的公示情况说明及核查意见 公司薪酬委员会根据《管理办法》《激励计划（草案）》的规定，对《激励对象名 1 单》进行了 ...

Core Viewpoint - The report from Open Source Securities indicates that small RNA drugs targeting weight loss are focusing on two main targets: INHBE and ALK7, with Arrowhead and Wave making the fastest progress in this area [1][2]. Group 1: Market Potential - The small RNA drug sector is expected to break into the billion-dollar weight loss market, with a focus on INHBE and ALK7 as key targets [1]. - INHBE is expressed in liver cells and plays a role in fat metabolism by encoding and secreting Activin E, which interacts with ALK7 [1]. Group 2: Company Progress - Arrowhead and Wave are leading in the development of INHBE siRNA molecules, with phase 1 trial data expected within the next six months [2]. - Alnylam, while slightly behind, has a comprehensive approach covering INHBE, ALK7, and GeneD for muscle targeting [2]. Group 3: Clinical Insights - Preclinical data shows that Arrowhead's ALK7 siRNA combined with Tirzepatide can enhance weight loss effects and provide longer-lasting efficacy, allowing for less frequent dosing [3]. - Genetic studies suggest that individuals with loss of function in INHBE or ALK7 exhibit healthier metabolic profiles, indicating that targeting these pathways may reduce visceral fat rather than just overall weight [3]. Group 4: Investment Recommendations - Short-term focus is recommended on Arrowhead and Wave's data readouts, particularly regarding safety, pharmacokinetics, dosing intervals, biomarker knockdown levels, early efficacy, and metabolic changes [4]. - Recommended stocks include Yuyuan Pharmaceutical (688658.SH), Sunshine Novo Nordisk (688621.SH), Rejuve Biotech (688068.SH), and Shiyao Group (01093), with beneficiaries including Frontier Biotech-U (688221.SH) and Hengrui Medicine (600276) (01276) [4].

Group 1 - The core viewpoint of the article highlights the target price increases for several listed companies, with notable gains for Dongcai Technology, Seres, and Gree Electric, showing target price increases of 51.97%, 37.62%, and 36.96% respectively [1][3] - On September 25, a total of 12 target price adjustments were made by brokerages, with the highest target price set at 32.43 yuan for Dongcai Technology [1][3] - A total of 35 listed companies received brokerage recommendations on September 25, including Sanyuan Shares, Anhui Weaving High-tech, and Yixin Pharmacy [1][3] Group 2 - On the same date, two companies had their ratings upgraded, with Renfu Pharmaceutical's rating raised from "Hold" to "Buy" by Shouchuang Securities, and Sanhuan Group's rating upgraded from "Hold" to "Buy" by Huazheng Securities [4][6] - A total of 10 companies received initial coverage from brokerages, with Frontier Biotech receiving a "Buy" rating from Kaiyuan Securities and Jiete Biotech also receiving a "Buy" rating from Xinda Securities [4][7] - Other companies receiving initial coverage include Bowei Alloy with a rating of "Hold" and Leisai Intelligent with a "Buy" rating, indicating a diverse range of sectors being covered [4][7]

Core Insights - The report highlights the potential of small nucleic acid drugs in the weight loss market, focusing on two key targets: INHBE and ALK7, which are involved in fat metabolism regulation [5][11][12] - The UCO-SAF industry is experiencing tight supply and increasing prices due to high global demand and reduced overseas supply, with significant profit margins for SAF in China [6][17][18] - The company, Daotong Technology, is recognized as a global leader in digital repair, with strong growth prospects in its AI and robotics solutions, maintaining a "buy" rating [7][21][22] Industry Analysis - The small nucleic acid drug sector is positioned to address unmet clinical needs in weight management, with promising data from ongoing trials [12][13][14] - The SAF market is expected to grow rapidly due to increasing global demand and regulatory support, particularly in Europe and China, despite challenges in overseas supply [17][18] - The digital repair market is expanding, driven by regulatory requirements for TPMS installation and a growing vehicle population, with Daotong Technology poised to capitalize on this trend [21][24][25] Company Insights - Arrowhead and Wave are leading the development of small nucleic acid drugs, with upcoming trial data expected to provide insights into their efficacy and safety [12][14] - Frontline Bio is enhancing its competitive edge through a diversified pipeline that includes innovative drugs and high-end generics, with a focus on HIV treatment [8][27][28] - Daotong Technology's recent achievements in North America solidify its market leadership and open new opportunities in emerging markets [21][22][25]

Group 1 - The company, established in 2013 and listed on the Shanghai Stock Exchange in 2020, has developed a core self-researched HIV drug, Aikening (Aibowei Tai), which was approved in 2018, marking a significant milestone in its development [1] - The company is focusing on an innovative pipeline that combines innovative drugs and high-end generics, covering long-acting HIV drugs, small nucleic acid drugs, high-end generics, and medical devices, enhancing its core competitiveness [1] - The company anticipates steady growth in sales of HIV medications and potential growth from its small nucleic acid innovation pipeline, projecting net profits of -176 million, -171 million, and -164 million yuan for 2025-2027, with corresponding EPS of -0.47, -0.46, and -0.44 yuan, and a current PE ratio of -31.6, -32.6, and -33.8 times [1] Group 2 - The company is advancing in the small nucleic acid field, focusing on chronic disease treatment with self-researched ACORDE delivery carrier siRNA drugs, targeting diseases such as IgA nephropathy and dyslipidemia, with selected targets showing First-in-Class (FIC) or Best-in-Class (BIC) potential [2] - In the IgA nephropathy area, the company has three siRNA drugs targeting complement mechanisms, with FB7013 (single target MASP-2) expected to submit an IND application by the end of 2025, and FB7011 (dual targets MASP-2 and CFB) showing promising preclinical results [2] - The company has developed an innovative siRNA delivery carrier, ACORDE, and is exploring kidney and central nervous system delivery, which may further open growth opportunities [2] Group 3 - Aikening (injection form of Aibowei Tai) is the core product for long-acting HIV treatment, approved in 2018 as the first long-acting HIV fusion inhibitor globally, with potential for expanded market coverage and penetration into lower-tier markets [3] - The company is actively advancing the research and development of new long-acting HIV formulations and is assembling a complete long-acting treatment regimen [3] - The strategic layout of high-end generics and medical devices is expected to continuously contribute to the company's revenue growth [3]

Investment Rating - The investment rating for the company is "Buy" (initial coverage) [2] Core Views - The company is focusing on innovative drug development, particularly in small nucleic acid technology and long-acting HIV treatments, which are expected to drive future growth [5][30] - The core product, Aikening (艾可宁), has shown stable sales growth and is positioned to expand its market presence, especially in the HIV treatment sector [7][26] - The company has a clear and stable shareholding structure, with a significant stock incentive plan aimed at enhancing long-term growth [16][21] Summary by Sections 1. Company Overview - Founded in 2013 and listed on the Shanghai Stock Exchange in 2020, the company has developed Aikening, a key HIV treatment, which was approved in 2018 [5][14] - The company is building a pipeline that combines innovative drugs and high-end generics, enhancing its competitive edge [5][30] 2. Financial Performance - Revenue has grown from 0.47 billion yuan in 2020 to an estimated 1.43 billion yuan in 2025, with a CAGR of approximately 29.1% [22] - The net profit attributable to shareholders is projected to improve from a loss of 329 million yuan in 2023 to a loss of 176 million yuan in 2025 [8][22] - The gross margin is expected to stabilize around 32.7% in 2025, reflecting improved operational efficiency [8][27] 3. Product Pipeline - The company is advancing its small nucleic acid drug pipeline, targeting chronic diseases with several candidates in clinical development, including treatments for IgA nephropathy and dyslipidemia [6][34] - Aikening is the first long-acting HIV drug approved globally, and the company is working on a comprehensive long-acting treatment regimen [7][30] 4. Strategic Initiatives - The company has launched a stock incentive plan to align the interests of management and shareholders, focusing on innovation and commercialization [21][19] - The research team is experienced, with a strong background in drug development, which supports the company's long-term innovation strategy [19][20]