深圳翰宇药业股份有限公司 关于2025年度向金融机构申请综合授信 及担保额度的进展公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别风险提示： 截至本公告披露日，公司及控股子公司累计对外提供担保总额占最近一期经 审计净资产125.64%、对资产负债率超过70%的单位担保金额占公司最近一期经 审计净资产69.99%；公司及子公司无对合并报表范围外的对外担保事项，也不存 在逾期担保。敬请广大投资者注意风险。 一、授信及担保审议程序 证券代码：300199 证券简称：翰宇药业 公告编号：2025-032 深圳翰宇药业股份有限公司（以下简称"公司"或"翰宇药业"）于2025年2月 28日召开第六届董事会第二次会议、2025年3月17日召开2025年第一次临时股东 大会，审议通过了《关于2025年度申请综合授信及担保额度的议案》，同意公司 及子公司2025年度向金融机构申请综合授信及担保额度总计不超过3.5亿元。其 中：公司为子公司、子公司之间提供综合授信及担保额度5,000万元；子公司为本 公司提供综合授信及担保额度不超过30,000万元。该授信自2025年3 ...

证券代码：300199 证券简称：翰宇药业 公告编号：2025-031 深圳翰宇药业股份有限公司 根据《上市公司独立董事管理办法》《深圳证券交易所自律监管指引第2号 ——创业板上市公司规范运作》等相关规定，许立勇先生已书面承诺参加最近一 次独立董事培训并取得深圳证券交易所认可的独立董事资格证书。 近日，公司收到许立勇先生的通知，其已按照相关规定参加了深圳证券交易 所举办的上市公司独立董事培训，并取得了由深圳证券交易所创业企业培训中心 颁发的《上市公司独立董事培训证明》。 特此公告。 深圳翰宇药业股份有限公司董事会 2025年6月17日 关于独立董事取得培训证明的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 深圳翰宇药业股份有限公司（以下简称"公司"或"翰宇药业"）因第五届 董事会任期已届满，按照相关法律程序进行了董事会换届选举。2024年12月19日， 公司召开2024年第四次临时股东大会，审议通过了《提名许立勇先生为第六届董 事会独立董事候选人》，会议选举许立勇先生为公司第六届董事会独立董事，任 期自股东大会审议通过之日起三年。 ...

Core Insights - Hanyu Pharmaceutical (300199) has recently conducted investor research, discussing the progress of the HY3003 new drug project, its layout in the innovative drug field, and overseas market expansion [1][2] Group 1: HY3003 New Drug Project - The HY3003 project has completed preclinical candidate compound screening and raw material process development, officially entering the raw material pilot scale-up phase, which validates the producibility of the molecular structure for subsequent IND application and clinical transformation [1] - HY3003 is a GLP-1R/GIPR/GCGR receptor agonist developed using AI peptide chip technology, aimed at weight loss indications [1] - The project employs a multi-formulation parallel development strategy, including weekly, ultra-long-acting monthly, and oral formulations, with the ultra-long-acting formulation designed to reduce dosing frequency and improve medication adherence [1] Group 2: siRNA and Other Drug Developments - The company is also developing siRNA drugs such as Inclisiran and Zilebesiran for treating high cholesterol and hypertension, as well as Pegcetacoplan for treating geographic atrophy [1] Group 3: Overseas Market Expansion - Currently, the company's raw materials are sold to over 20 countries and regions, with formulations licensed in over 90 countries and regions [2] - The company has signed cooperation agreements for the semaglutide injection (weekly formulation) and oral tablets in markets including China, Brazil, Egypt, Mexico, Eurasian Union, GCC member countries, and North Africa [2] - The company has completed the enrollment of all participants in the Phase III clinical trial for semaglutide injection as of January this year, with plans to submit for approval in China by 2026, followed by the US and other global markets [2] Group 4: Future Pipeline - Hanyu Pharmaceutical has a rich pipeline of peptide and small nucleic acid formulations, planning to launch no less than 20 formulations over the next 10 years, including innovative drugs, micro-innovative drugs, and ANDA [2]

Group 1 - The core viewpoint of the article highlights the collaboration between Shenzhen Hanyu Pharmaceutical Co., Ltd. and Zhuhai Carbon Cloud Peptide Pharmaceutical Technology Co., Ltd. on the HY3003 project, which has successfully completed preclinical candidate screening and raw material process development, entering the raw material pilot scale-up phase [2][3] - The HY3003 project is a GLP-1R/GIPR/GCGR tri-target receptor agonist for weight loss, utilizing AI peptide chip technology for high-throughput screening [2] - The project employs a parallel development strategy for multiple dosage forms, including weekly, ultra-long-acting monthly, and oral formulations [2] Group 2 - The management of Hanyu Pharmaceutical emphasizes the complementary strengths in technology and resources between the two companies, with Carbon Cloud Peptide possessing silicon-based peptide chip technology and AI algorithms, while Hanyu has extensive experience in peptide drug synthesis, purification, formulation development, and clinical translation [3] - A strategic cooperation was established in October 2024, followed by a joint development agreement in May 2025, aiming to incubate China's first tri-target peptide weight loss innovative drug [3] - Hanyu Pharmaceutical's Wuhan raw material production base passed FDA inspection with "zero defects" in November 2024, and the production line for Glatiramer Acetate Injection also successfully passed FDA inspection in 2025, with both products expected to launch in the U.S. market soon [3]

Core Insights - Hanyu Pharmaceutical has entered the dosage maintenance phase for its Semaglutide injection project, with plans to apply for market approval in China by 2026 [1] Company Developments - The company is developing HY3003, a GLP-1R/GIPR/GCGR receptor agonist for weight loss, utilizing AI peptide chip technology for candidate selection [1] - Hanyu has completed preclinical candidate screening and raw material process development, now moving into the raw material pilot scale-up phase [1] - In addition to the weight loss drug, the company is also working on an innovative drug, HY3000 nasal spray, aimed at preventing coronavirus infections, which is currently in Phase III clinical trials [1] Collaborations and Innovations - Hanyu is collaborating with China National Pharmaceutical Group on the research and commercialization of Cannabidiol (CBD) innovative drugs, integrating peptide and small nucleic acid drug technologies [1] - The company has completed enrollment of all participants in the Phase III clinical trial for Semaglutide injection as of January this year and is currently in the follow-up phase [1]

Group 1: Project Development and Strategy - The HY3003 project is a GLP-1R/GIPR/GCGR receptor agonist for weight loss, currently in the raw material drug pilot scale-up phase, laying the groundwork for IND application and clinical transformation [2][4]. - The company employs a multi-formulation parallel development strategy for HY3003, including weekly and ultra-long-acting monthly formulations, aiming to enhance patient compliance and reduce gastrointestinal side effects [3][4]. - The ultra-long-acting monthly formulation reduces injection frequency from weekly to monthly, alleviating patient burden and stabilizing drug concentration levels [4]. Group 2: Technology and Innovation - The AI peptide chip technology enables high-throughput screening of lead compounds, utilizing semiconductor processes to achieve rapid and accurate identification of active peptides [5][7]. - The collaboration with Carbon Cloud focuses on leveraging AI and peptide chip technology for drug development, aiming to create China's first multi-target peptide weight loss drug [7][8]. Group 3: Market Expansion and Product Pipeline - The company has authorized raw materials to over 20 countries and formulations to more than 90 countries, with ongoing negotiations for additional partnerships [9]. - The product pipeline includes innovative drugs such as the HY3000 nasal spray for coronavirus prevention, currently in phase III clinical trials, and ongoing exploration of CBD-based drugs [8][9]. - Upcoming products expected to launch include Glatiramer acetate injection and Acetate of Cetrorelix, targeting multiple sclerosis and assisted reproductive technology, respectively [11]. Group 4: Future Directions and Business Model - The company plans to introduce at least 20 new formulations over the next decade, including innovative and micro-innovative drugs [9]. - The CRDMO business model integrates research, development, and production services, enhancing collaboration and market expansion opportunities [11].

Group 1 - The company plans to apply for a total credit and guarantee limit of up to 350 million yuan for the year 2025, which includes 50 million yuan for the company to provide guarantees for its subsidiaries and 300 million yuan for subsidiaries to provide guarantees for the company [1][2] - The company intends to apply for an additional fixed asset loan of 28 million yuan from Bohai Bank, secured by equipment from a fixed asset project, with its wholly-owned subsidiary providing joint liability guarantee [2][4] - As of the announcement date, the total external guarantee balance provided by the company and its subsidiaries is 727 million yuan, which accounts for 125.64% of the latest audited net assets [4] Group 2 - The company's total assets as of December 31, 2024, were approximately 3.01 billion yuan, while the total liabilities were approximately 2.41 billion yuan, resulting in net assets of approximately 578.63 million yuan [3] - The company's operating income for the year 2025 (unaudited) was approximately 309.97 million yuan, with a total profit of approximately 76.35 million yuan and a net profit of approximately 69.44 million yuan [3]

证券代码：300199 证券简称：翰宇药业 公告编号：2025-030 深圳翰宇药业股份有限公司 关于2025年度向金融机构申请综合授信 一、授信及担保审议程序 深圳翰宇药业股份有限公司（以下简称"公司"或"翰宇药业"）于2025年2月 28日召开第六届董事会第二次会议、2025年3月17日召开2025年第一次临时股东 大会，审议通过了《关于2025年度申请综合授信及担保额度的议案》，同意公司 及子公司2025年度向金融机构申请综合授信及担保额度总计不超过3.5亿元。其 中：公司为子公司、子公司之间提供综合授信及担保额度5,000万元；子公司为本 公司提供综合授信及担保额度不超过30,000万元。该授信自2025年3月17日起12 个月内有效，同时授权公司管理层实施具体相关事宜。具体内容详见公司披露于 中国证监会指定的创业板上市公司信息披露网站巨潮资讯网的相关公告。 二、授信及担保情况概述 为支持公司业务快速发展与战略布局，进一步拓展多元化融资渠道、优化融 资结构，公司拟向渤海银行股份有限公司深圳分行申请新增固定资产借款2,800 万元。本次贷款以该固贷项目的设备作为抵押物，由全资子公司翰宇药业（武汉） 有限 ...

深圳翰宇药业股份有限公司董事会审计委员会 关于续聘公司 2025 年度会计师事务所的审核意见 深圳翰宇药业股份有限公司审计委员会 2025 年 6 月 7 日 公司董事会审计委员会对立信会计师事务所的执业情况进行了充分的了解， 在查阅了其有关资格证照、相关信息和诚信记录后，一致认为立信会计师事务所 具有证券、期货等相关业务执业资格，具备为上市公司提供审计服务的经验与能 力，能够为公司提供公正、公允的审计服务，在 2024 年度执业过程中，立信会 计师事务所切实履行了审计机构应尽的职责，能够客观地评价公司的财务状况和 经营成果，较好地完成了 2024 年度报告的审计工作，具备足够的独立性、专业 胜任能力、投资者保护能力。因此，我们同意续聘立信会计师事务所为公司 2025 年度审计机构，并向董事会提议续聘立信会计师事务所作为公司 2025 年度审计 机构。 根据《中华人民共和国公司法》《深圳证券交易所创业板股票上市规则》《深 圳证券交易所上市公司自律监管指引第 2 号——创业板上市公司规范运作》《深 圳翰宇药业股份有限公司董事会审计委员会实施细则》以及《公司章程》等相关 规定，公司董事会审计委员会认真核查了拟聘任 ...

深圳翰宇药业股份有限公司 关于拟续聘会计师事务所的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 证券代码：300199 证券简称：翰宇药业 公告编号：2025-029 深圳翰宇药业股份有限公司（以下简称"公司"或"翰宇药业"）于2025年 6月6日召开第六届董事会第五次会议审议通过了《关于拟续聘公司2025年度审计 机构的议案》，同意续聘立信会计师事务所（特殊普通合伙）（以下简称"立信"） 为公司2025年度审计机构，本议案将在年度内择机提交至公司股东大会审议，现 将有关事项公告如下： 一、拟续聘会计师事务所的基本情况 （一）机构信息 1、基本信息 立信会计师事务所（特殊普通合伙）由我国会计泰斗潘序伦博士于 1927 年 在上海创建，1986 年复办，2010 年成为全国首家完成改制的特殊普通合伙制会 计师事务所，注册地址为上海市，首席合伙人为朱建弟先生。立信是国际会计网 络 BDO 的成员所，长期从事证券服务业务，新证券法实施前具有证券、期货业 务许可证，具有 H 股审计资格，并已向美国公众公司会计监督委员会（PCAOB） 注册登记。 截至 2024 ...