Group 1: Company Overview and Sales Performance - The company is actively expanding its low molecular weight heparin calcium injection sales, showing stable growth compared to the same period last year [2] - The sales of Daptomycin injection are expected to see significant growth as the company actively develops the market [2] - The heparin raw material sales are anticipated to experience good growth this year due to negotiations with several large clients [2] Group 2: Product Development and Market Strategy - The company is preparing registration materials for sodium hyaluronate, with strong market demand, particularly in the beauty industry [3] - Plans are in place to develop injectable-grade sodium hyaluronate in the future [3] - The company is preparing registration materials for heparin and low molecular weight heparin formulations for international market entry [3] Group 3: Clinical Trials and New Initiatives - The first phase of clinical trials for Abexinostat is expected to be completed in Q3 of this year, with preparations for the second phase already underway [3] - The company is set to open its first blood dialysis center and is committed to ensuring operational quality [3] - Future collaborations include establishing a specialized oncology hospital in China with a U.S. partner and developing new anti-tumor drugs [3]

Group 1: Company Overview and Operations - Hebei Changshan Biochemical Pharmaceutical Co., Ltd. is focused on the development of hyaluronic acid and heparin series products [1] - The company is currently preparing to apply for production of injectable hyaluronic acid to the National Medical Products Administration [1] - The new hyaluronic acid workshop is designed with a production capacity of 20 tons, while the current capacity for food-grade and cosmetic-grade hyaluronic acid is approximately 1,000 kg [2] Group 2: Product Development and Clinical Trials - The company is collaborating with American Huangxinxiang to develop a new diabetes treatment, Aibennate, which is currently in Phase I clinical trials and progressing well [2] - The company plans to produce pharmaceutical-grade, food-grade, and cosmetic-grade products in the new hyaluronic acid workshop [2] Group 3: Market Strategy and Future Plans - The company is exploring acquisition opportunities in the pharmaceutical, medical services, and medical device sectors to support strategic growth [3] - The company aims to establish a blood dialysis center to meet the demand in Shijiazhuang and surrounding areas, addressing the current shortfall in public hospital capacity [3] - The independent dialysis center will focus on providing superior service and hygiene compared to public hospitals, leveraging collaboration with German D-Med for advanced dialysis standards [3]

证券代码：300255 证券简称：常山药业 编号：2016-3 河北常山生化药业股份有限公司 投资者关系活动记录表 | --- | --- | --- | --- | |------------------------------------|--------------------------------|-----------------------------------------------------------------------------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| | | √ 特定对象调研 | □ 分析师会议 | | | 投资者关系活动 | □ 媒体采访 | □ 业绩说明 ...

Financial Performance - The company's revenue for Q3 2022 was ¥647,277,328.34, a decrease of 12.65% compared to the same period last year[7]. - Net profit attributable to shareholders was ¥2,528,324.29, down 94.96% year-on-year[7]. - The basic earnings per share (EPS) was ¥0.0027, reflecting a decline of 94.96% compared to the previous year[7]. - Total operating revenue for the current period is ¥1,793,779,750.02, a decrease of 17% compared to ¥2,158,441,271.38 in the previous period[28]. - The net profit for the current period is 61,239,360.42, a decrease from 205,052,547.28 in the previous period, representing a decline of approximately 70.1%[30]. - The total comprehensive income for the current period is 56,628,177.82, compared to 196,009,872.74 in the previous period, indicating a decrease of about 71.1%[33]. - The basic and diluted earnings per share for the current period are both 0.0720, down from 0.2215 in the previous period, reflecting a decline of approximately 67.5%[33]. - The operating profit for the current period is 86,207,188.49, a significant decrease from 232,565,881.24 in the previous period, reflecting a decline of about 62.9%[30]. - The total profit for the current period is 83,704,368.74, down from 231,578,978.91 in the previous period, indicating a decrease of approximately 63.8%[30]. Assets and Liabilities - Total assets increased by 11.07% to ¥5,764,437,750.03 compared to the end of the previous year[7]. - The company's total assets reached ¥5,764,437,750.03, up from ¥5,189,848,787.26, showing growth in asset base[27]. - Non-current liabilities increased to ¥701,618,091.58 from ¥383,684,965.68, indicating potential leverage for future investments[27]. - The total liabilities of the company are now ¥2,659,585,565.72, compared to ¥2,117,729,197.94 in the previous period, reflecting increased borrowing[27]. - The company's equity attributable to shareholders increased to ¥3,107,567,055.77 from ¥3,068,784,360.68, showing a slight growth in shareholder value[27]. Cash Flow - The company reported a net cash flow from operating activities of -¥183,723,082.26, a decrease of 29.24% year-to-date[7]. - Cash flow from operating activities shows a net outflow of -183,723,082.26, compared to -142,157,545.23 in the previous period, indicating a worsening cash flow situation[34]. - Cash inflow from financing activities is 1,859,945,742.67, an increase from 1,336,493,978.00 in the previous period, representing a growth of about 39.2%[36]. - The cash and cash equivalents at the end of the period amount to 384,734,470.51, down from 517,516,379.54 in the previous period, a decrease of approximately 25.7%[36]. Shareholder Information - The number of shares held by the largest shareholder, Gao Shuhua, is 333,644,728, representing 35.69% of total shares[14]. - The total number of shares held by the top ten shareholders includes 333,644,728 shares held by Gao Shuhua, representing the largest single holding[17]. - The company repurchased a total of 15,906,000 shares, accounting for 1.70% of the total share capital[17]. - The company plans to unlock 25% of the shares held by executives annually during their tenure, with specific unlock dates set for certain shareholders[18]. - The total number of restricted shares at the end of the period was 2,656,757, with a significant portion being released due to executive departures[20]. - The company reported a total of 11,500,000 shares held in a credit trading guarantee account by shareholder Chen Xi, indicating active participation in financing activities[17]. - The company has not disclosed any related party relationships among the top ten shareholders, nor whether they are acting in concert[17]. Expenses - Sales expenses decreased by 38.72% year-on-year, primarily due to reduced marketing expenses[13]. - Financial expenses increased by 43.25% year-on-year, mainly due to higher interest from increased bank loans[13]. - Research and development expenses increased to ¥115,423,336.21 from ¥106,404,718.54, indicating a continued focus on innovation[28]. Market Outlook - The company plans to expand its market presence and enhance product offerings in the upcoming quarters[29]. - The company reported a net profit margin improvement, indicating better cost management and operational efficiency[29].

Financial Performance - The company's operating revenue for the first half of 2022 was ¥1,146,502,421.68, a decrease of 19.11% compared to ¥1,417,401,504.14 in the same period last year[28]. - The net profit attributable to shareholders of the listed company was ¥64,761,136.23, down 58.74% from ¥156,960,062.38 in the previous year[28]. - The net profit after deducting non-recurring gains and losses was ¥62,378,790.31, a decline of 59.14% compared to ¥152,666,257.93 in the same period last year[28]. - The net cash flow from operating activities was -¥282,443,577.36, a significant decrease of 338.16% from ¥118,591,701.88 in the previous year[28]. - Basic earnings per share were ¥0.07, down 58.82% from ¥0.17 in the same period last year[28]. - The company's operating revenue for the reporting period was ¥1,146,502,421.68, a decrease of 19.11% compared to ¥1,417,401,504.14 in the same period last year, primarily due to a decline in sales of low molecular heparin preparations and heparin raw materials[63]. Assets and Liabilities - Total assets at the end of the reporting period were ¥5,820,185,840.37, an increase of 12.15% from ¥5,189,848,787.26 at the end of the previous year[28]. - The net assets attributable to shareholders of the listed company were ¥3,106,056,745.99, a slight increase of 1.21% from ¥3,068,784,360.68 at the end of the previous year[28]. - The company's total assets included cash and cash equivalents of ¥678,516,099.25, representing 11.66% of total assets, an increase from 10.47% the previous year due to increased bank loans[68]. - The inventory level rose to ¥2,578,695,116.73, accounting for 44.31% of total assets, reflecting an increase in raw material costs[68]. - The company's short-term borrowings increased to ¥1,760,597,759.94, representing 30.25% of total assets, up from 23.74% the previous year, attributed to increased bank loans[68]. Market Position and Product Development - The company maintains a leading position in the domestic low molecular weight heparin market, with its core product, low molecular weight heparin calcium injection, recognized widely and holding a dominant market share[38]. - The company is actively developing a new Class I drug, a long-acting GLP-1 formulation for treating type 2 diabetes, which is currently in phase III clinical trials[39]. - The company is expanding its product line to include new products such as sildenafil citrate, in addition to its heparin and hyaluronic acid products[41]. - The company is focusing on improving the efficiency of fund usage and enhancing the economic benefits of its projects[88]. - The company is committed to balancing generic and innovative drug development to manage risks associated with new product research[121]. Research and Development - The company's R&D investment increased by 15.94% to ¥108,557,893.89 from ¥93,630,517.91 in the previous year, indicating a focus on innovation and product development[63]. - The company plans to increase investment in R&D for heparin series products, hyaluronic acid series products, and new drug development in the coming years[61]. - The company is advancing the clinical trials for Abenatide injection and two new anti-tumor drugs, with all participant enrollments completed as planned[52]. Environmental Compliance - The company processed a total of 21,893.78 tons of wastewater in the first half of 2022, with no instances of exceeding discharge standards[141]. - The wastewater treatment facility at the company operated smoothly throughout the year, ensuring compliance with discharge standards[141]. - The company received environmental impact assessment approvals for multiple projects, including a 35-ton heparin raw material project in October 2021[143]. - The company obtained a national pollutant discharge permit valid until May 6, 2027[144]. - The company has implemented a comprehensive waste gas treatment system that meets regulatory standards throughout its facilities[142]. Risks and Challenges - The company faces risks related to policy and industry changes, intensified market competition, and new business risks[6]. - The company is facing risks from policy changes in the pharmaceutical industry, which could impact operational performance if not adapted to promptly[116]. - The company anticipates increased operating costs due to rising sales and research expenses as it expands its market presence[123]. Subsidiary Performance - The subsidiary Hebei Changshan Jiukang Biotechnology Co., Ltd. reported a net loss of 25,717,141.90 CNY[95]. - The subsidiary Hebei Changshan Kaikede Biotechnology Co., Ltd. reported a net loss of 7,033,615.50 CNY[97]. - The company reported a net profit of 10,394,261.61 yuan from its Hong Kong subsidiary, primarily from the export of raw materials[112]. - The Jiangsu subsidiary achieved a net profit of 998,731.56 yuan, mainly from the sale of low molecular heparin calcium raw materials[111]. Financial Management - The company reported no non-operating fund occupation by controlling shareholders or related parties during the reporting period[176]. - There were no violations regarding external guarantees during the reporting period[177]. - The semi-annual financial report was not audited[178]. - The company did not experience any major litigation or arbitration matters during the reporting period[182]. - There were no significant related party transactions during the reporting period[190].

Financial Performance - The company's operating revenue for Q1 2022 was ¥574,179,074.10, a decrease of 19.18% compared to ¥710,471,945.23 in the same period last year[4] - Net profit attributable to shareholders was ¥29,651,405.14, down 56.75% from ¥68,564,864.13 year-on-year[4] - Basic earnings per share decreased to ¥0.03, down 57.14% from ¥0.07 in the same period last year[4] - Net profit for the current period was ¥28,851,938.26, down 57.5% from ¥67,763,683.84 in the previous period[31] - The total comprehensive income for the current period was ¥27,186,973.03, down from ¥67,650,342.85 in the previous period[34] Cash Flow - The net cash flow from operating activities was -¥158,674,887.67, a decline of 312.95% compared to ¥74,511,494.41 in the previous year[4] - The cash inflow from operating activities totaled ¥570,204,153.47, a decrease of 26.3% compared to ¥773,417,974.82 in the previous period[35] - The cash outflow from operating activities amounted to ¥728,879,041.14, an increase of 4.3% from ¥698,906,480.41 in the prior period[38] - The net cash flow from investment activities was -¥143,068,776.56, compared to -¥26,001,230.73 in the previous period[38] - Cash inflow from financing activities was ¥439,130,477.50, with a net cash flow of ¥359,162,655.61 after outflows[38] Assets and Liabilities - Total assets at the end of the reporting period were ¥5,597,062,348.40, an increase of 7.85% from ¥5,189,848,787.26 at the end of the previous year[4] - Current assets amounted to CNY 3,664,314,908.73, up from CNY 3,408,485,410.19 at the beginning of the year, indicating a growth of approximately 7.5%[21] - Total liabilities increased to ¥2,497,755,786.05 from ¥2,117,729,197.94, representing a growth of 17.9%[27] - Non-current liabilities rose to ¥531,455,411.42 from ¥383,684,965.68, an increase of 38.6%[27] - The company’s total liabilities increased, with short-term borrowings being a significant component of the total liabilities[21] Expenses - Total operating costs decreased to ¥542,640,735.36 from ¥629,075,497.31, reflecting a reduction of 13.7%[28] - The company experienced a 44.69% decrease in selling expenses, attributed to the reduction in sales revenue[9] - Research and development expenses for the current period were ¥36,139,354.53, a decrease of 11.5% from ¥40,999,115.40 in the previous period[28] Other Financial Metrics - The weighted average return on net assets was 0.96%, down 1.42% from 2.38% in the same period last year[4] - The company reported a foreign exchange loss of ¥1,408,421.45, compared to a loss of ¥1,360,520.62 in the previous period[31] - The total equity attributable to shareholders of the parent company was ¥3,096,770,800.59, up from ¥3,068,784,360.68, a growth of 0.9%[27] - The company reported accounts receivable of CNY 282,556,880.93, down from CNY 293,346,231.91, indicating a decrease of approximately 3%[21] Shareholder Information - The company repurchased 15,906,000 shares in 2020, accounting for 1.70% of the total share capital[14] - The total number of restricted shares at the end of the period was 253,514,027, with 168,450 shares released during the period[17]

Financial Performance - The company's total revenue for 2021 was not explicitly mentioned, but the report indicates a focus on growth and expansion strategies [18]. - The company's operating revenue for 2021 was ¥2,968,050,842.32, an increase of 25.56% compared to 2019 [25]. - The net profit attributable to shareholders for 2021 was ¥233,573,840.79, a decrease of 7.62% compared to 2020 [25]. - The net profit attributable to shareholders after deducting non-recurring gains and losses for 2021 was ¥224,748,743.04, down 10.72% from 2020 [25]. - The total revenue for heparin raw materials reached ¥687,397,846.80 in 2021, a significant increase from ¥345,576,139.48 in 2020, reflecting a growth rate of 100% [74]. - The total revenue for water injection preparations was ¥492,852,941.70 in 2021, compared to ¥346,163,899.10 in 2020, indicating a growth rate of 42.36% [74]. - The company reported a significant increase in online sales revenue from its hyaluronic acid and cosmetics business, driven by the successful mass production of the active pharmaceutical ingredient, Ectoin [63]. - The company achieved a net profit of 12,860,074.98 CNY from its Jiangsu subsidiary, primarily from the export of low molecular weight heparin raw materials [133]. - The Hong Kong subsidiary reported a net profit of 18,404,155.91 CNY, mainly from the export of raw materials [133]. - The company reported a significant increase in revenue, achieving a total of 1.5 billion RMB for the fiscal year, representing a 20% growth year-over-year [200]. Shareholder Returns - The company reported a cash dividend of 0.26 CNY per 10 shares for all shareholders, based on a total of 919,060,878 shares [7]. - The company’s board of directors has approved the profit distribution plan, reflecting a commitment to shareholder returns [7]. Research and Development - The company is focused on research and development in biopharmaceuticals, which is crucial for future growth [18]. - The company has developed proprietary technologies for heparin and maintains a strong R&D system, contributing to its competitive edge in the market [42]. - The company is developing a new Class I drug, a long-acting GLP-1 formulation for the treatment of type 2 diabetes, which has entered the clinical phase III [46]. - R&D expenses rose to ¥150,626,662.12 in 2021, an increase of 18.10% from ¥127,543,413.03 in 2020, driven by higher R&D investments [83]. - The total R&D investment amounted to ¥219,515,411.99 in 2021, representing 7.40% of operating revenue, slightly up from 7.18% in 2020 [86]. - The company is focusing on the development of new products, including hyaluronic acid and sildenafil citrate, to drive revenue growth [140]. - The company is advancing the clinical trials for innovative drugs, including Aibennate, and aims to strengthen its R&D capabilities to support future growth [160]. Market Position and Strategy - The company has a leading market share in low molecular weight heparin calcium injection, covering over 3,000 hospitals nationwide [42]. - The company aims to leverage its position in the Hebei Free Trade Zone to enhance the production and export of upstream products like heparin crude and raw materials [43]. - The company plans to increase production and sales of low molecular weight heparin preparations to maintain its market leadership in China [140]. - The company intends to expand its international market presence by enhancing the production of high-value heparin raw materials and preparations [140]. - The company is focusing on both internal development and external expansion through mergers, technology collaborations, and joint ventures to enhance innovation capabilities and sustainable growth [164]. Governance and Compliance - The company emphasizes the importance of accurate financial reporting and has declared that all financial statements are true, accurate, and complete [6]. - The company has established comprehensive governance regulations, including rules for shareholder meetings and board operations, to enhance decision-making transparency [168]. - The governance structure includes a board of directors, supervisory board, and management team, ensuring checks and balances among these entities [167]. - The company prioritizes accurate and timely information disclosure, designating the chairman as the primary responsible person for information disclosure [174]. - The company has a robust governance structure, with a dedicated supervisory board overseeing compliance and operational integrity [193]. Operational Efficiency - The company has a registered address in the Hebei Free Trade Zone, indicating a strategic location for operations [19]. - The company has multiple wholly-owned subsidiaries, enhancing its operational capabilities and market reach [15]. - The company has a total of 4 subsidiaries, with varying levels of profitability and operational focus, including biotechnology and medical device sectors [120]. - The company has a clear asset ownership structure, including land, buildings, machinery, trademarks, and patents, ensuring operational independence [176]. - The company has a complete labor and social security system, with all employees under formal contracts and social insurance [176]. Risks and Challenges - The company recognizes potential risks from government policy changes that could impact operational costs and market competition [143]. - The company is at risk of declining market share for heparin products if it fails to pass consistency evaluations or cannot win bids in national centralized procurement [144]. - Rising procurement costs for heparin crude products significantly affect the company's operating costs, prompting a focus on maintaining reasonable inventory and increasing self-supply [147]. - The company anticipates increased period expenses due to intensified market competition and diverse new product development, which may pressure cost control capabilities [148]. Future Outlook - The company provided a positive outlook for the next fiscal year, projecting a revenue growth of 25% [200]. - New product launches are expected to contribute an additional 300 million RMB in revenue next year [200]. - Market expansion plans include entering three new provinces, targeting a 10% market share in these regions within two years [200]. - The company plans to push forward the international registration of heparin injections, focusing on the U.S. and EU markets, with recent registrations in Bolivia and Uzbekistan [156].

Financial Performance - The company's revenue for Q3 2021 reached ¥741,039,767.24, an increase of 18.04% compared to the same period last year[3] - Net profit attributable to shareholders was ¥50,125,991.97, a decrease of 32.23% year-on-year[3] - The net profit after deducting non-recurring gains and losses was ¥48,816,334.10, down 31.68% from the previous year[3] - Total operating revenue for the period reached ¥2,158,441,271.38, an increase from ¥1,637,611,319.05 in the previous period, representing a growth of approximately 31.8%[26] - Net profit for the period was ¥205,052,547.28, slightly up from ¥203,457,633.07, reflecting a growth of approximately 0.8%[29] - The net profit attributable to the parent company was approximately ¥207.09 million, compared to ¥204.62 million in the previous period, reflecting a slight increase[32] - The total comprehensive income attributable to the parent company was approximately ¥198.04 million, down from ¥212.17 million in the previous period[32] Assets and Liabilities - Total assets at the end of the reporting period were ¥5,120,131,094.26, reflecting an increase of 11.98% from the end of the previous year[3] - The total assets of the company reached ¥5,120,131,094.26, compared to ¥4,572,556,783.14 in the previous period, an increase of approximately 12%[25] - Total liabilities increased to ¥2,070,893,213.91 from ¥1,719,328,775.53, representing a growth of about 20.4%[25] - The company's equity attributable to shareholders rose to ¥3,045,623,851.87 from ¥2,847,580,472.06, indicating an increase of approximately 6.9%[25] Cash Flow - The company's cash flow from operating activities showed a net inflow of ¥-142,157,545.23, a significant improvement of 64.70% year-on-year[3] - Cash inflows from operating activities totaled approximately ¥2.41 billion, up from ¥1.69 billion in the previous period, indicating strong revenue growth[36] - Cash outflows from operating activities increased to approximately ¥2.55 billion from ¥2.09 billion, resulting in a net cash flow from operating activities of approximately -¥142.16 million, an improvement from -¥402.68 million in the previous period[36] - Cash and cash equivalents increased by 126.13% year-on-year, attributed to improved cash flow from operating activities[10] - The cash and cash equivalents at the end of the period amounted to approximately ¥517.52 million, down from ¥578.98 million at the end of the previous period[39] Shareholder Information - Total number of common shareholders at the end of the reporting period was 35,745[12] - The largest shareholder, Guotou High-tech Investment Co., Ltd., holds 35.69% of shares, totaling 333,644,728 shares[12] - The company plans to unlock 25% of the shares held by executives annually during their tenure[16] - The company repurchased 15,906,000 shares in 2020, representing 1.70% of total shares[15] - The total number of restricted shares at the beginning of the period was 250,233,546, remaining unchanged[16] Operational Metrics - The company experienced an 80.78% increase in operating costs, primarily due to higher sales volumes and rising raw material prices[7] - Total operating costs amounted to ¥1,933,766,897.05, up from ¥1,405,472,840.96, indicating a rise of about 37.4%[26] - Gross profit for the period was ¥224,674,374.33, compared to ¥232,138,478.09 in the previous period, showing a slight decrease of around 3.2%[29] - Research and development expenses increased to ¥106,404,718.54 from ¥84,614,578.27, marking a rise of about 25.7%[29] Future Outlook - Future outlook includes continued investment in R&D and potential market expansion strategies to enhance revenue growth[28] - The company has not disclosed any significant new strategies or product developments in the current report[18]

Financial Performance - The company's operating revenue for the first half of 2021 was CNY 1,417,401,504.14, representing a 40.36% increase compared to CNY 1,009,847,609.95 in the same period last year[25]. - Net profit attributable to shareholders of the listed company reached CNY 156,960,062.38, up 20.13% from CNY 130,654,169.65 in the previous year[25]. - The net cash flow from operating activities was CNY 118,591,701.88, a significant improvement of 128.46% compared to a negative cash flow of CNY 416,676,745.13 in the same period last year[25]. - Basic earnings per share increased to CNY 0.17, reflecting a growth of 21.43% from CNY 0.14 in the previous year[25]. - Total assets at the end of the reporting period were CNY 4,583,617,900.37, a slight increase of 0.24% from CNY 4,572,556,783.14 at the end of the previous year[25]. - Net assets attributable to shareholders of the listed company rose to CNY 2,999,468,868.63, marking a 5.33% increase from CNY 2,847,580,472.06 at the end of the previous year[25]. - The weighted average return on net assets was 5.37%, an increase of 0.69% compared to 4.68% in the previous year[25]. - The company reported a net profit after deducting non-recurring gains and losses of CNY 152,666,257.93, which is a 17.04% increase from CNY 130,437,911.69 in the previous year[25]. Market Position and Product Development - The company maintains a leading market share in low molecular weight heparin calcium injection, with widespread recognition in the market[43]. - The company is one of the few in China with a complete heparin product industrial chain, engaging in the R&D, production, and sales of heparin raw materials and preparations[43]. - The company’s core product, low molecular weight heparin calcium injection, accounts for over 10% of its main business revenue[37]. - The company is currently developing a Class I new drug, a GLP-1 long-acting preparation for the treatment of type II diabetes, which has entered the clinical phase III[37]. - The company has been recognized as a national high-tech enterprise and has established a drug research institute to enhance its R&D capabilities[37]. - The company is actively expanding its product range and optimizing management mechanisms to enhance market competitiveness[43]. - The company is focusing on the R&D of heparin series products, hyaluronic acid series products, and new drugs like Aibennapeptide[60]. Revenue Sources - Heparin preparations generated revenue of 803.41 million yuan, a year-on-year increase of 35.90%[44]. - Sales revenue from heparin raw materials reached 575.40 million yuan, up 42.27% year-on-year[45]. - The sales volume and price of heparin raw materials have increased, contributing to the company's revenue growth[43]. Investment and Financial Management - The total investment during the reporting period was ¥5,050,000.00, reflecting a significant increase of 98.04% compared to ¥2,550,000.00 in the previous year[75]. - The total amount raised from the non-public offering was RMB 60,000 million, with a net amount of RMB 58,335.29 million after expenses[78]. - The interest income from the raised funds amounted to RMB 1,377.69 million, with RMB 3,067.14 million utilized from the special account[78]. - The company committed to invest a total of RMB 58,335.2 million in projects, with RMB 1.89 million invested during the reporting period, achieving an investment progress of 28.53%[79]. Environmental Compliance - The company processed a total of 21,750 tons of wastewater in the first half of 2021, with no instances of exceeding discharge standards[126]. - The subsidiary, Kaikede, processed 55,119 tons of wastewater during the same period, also with no exceedances in discharge standards[126]. - The company generated a total of 24.3256 tons of hazardous waste in the first half of 2021, all of which was disposed of by qualified units[132]. - The company achieved a 100% pass rate in the LDAR testing for VOCs, effectively reducing unorganized emissions and air pollution[132]. - The company has maintained stable operations of its wastewater treatment facilities, ensuring compliance with environmental standards throughout the reporting period[126]. - The company has not faced any administrative penalties related to environmental issues during the reporting period[129]. - The company has implemented a comprehensive environmental monitoring plan, with all monitored parameters meeting discharge standards[128]. Shareholder Information - The total number of shares increased from 934,966,878 to 934,966,878, with a slight increase in restricted shares from 253,271,828 to 253,489,328[167]. - The company’s management increased their holdings, with Vice President Li Zhihua acquiring 190,000 shares and CFO Wang Jun acquiring 100,000 shares during the reporting period[167]. - The total number of common shareholders at the end of the reporting period is 32,024[174]. - The largest shareholder, Gao Shuhua, holds 35.69% of the shares, totaling 333,644,728 shares[174]. - The second-largest shareholder, Guotou High-tech Investment Co., Ltd., holds 12.56%, amounting to 117,403,020 shares[174]. Risks and Challenges - The company is facing risks from policy and industry changes, which could impact drug production and competition[104]. - Rising procurement costs for heparin crude products are a concern, prompting the company to monitor market prices closely and enhance self-supply capabilities[107]. - The company reported that the sales growth of heparin preparations was below expectations, leading to a reassessment of investment projects[79]. Legal and Compliance Matters - The company did not engage in any related party transactions during the reporting period[145]. - The company reported a litigation amount of 1.3186 million yuan related to a contract dispute with Beijing Jiacheng Pharmaceutical Co., Ltd.[143]. - There were no significant penalties or rectifications during the reporting period[144]. - The company has not experienced any significant litigation or arbitration matters during the reporting period[141].

Financial Performance - The company's operating revenue for Q1 2021 reached ¥710,471,945.23, representing a 78.36% increase compared to ¥398,337,913.55 in the same period last year[8] - Net profit attributable to shareholders was ¥68,564,864.13, up 40.56% from ¥48,781,306.45 year-on-year[8] - Basic earnings per share increased to ¥0.07, reflecting a 40.00% rise from ¥0.05 in the same quarter last year[8] - The company's operating revenue for Q1 2021 reached 710.47 million CNY, an increase of 78.36% compared to the same period last year[26] - The net profit attributable to the parent company was 68.56 million CNY, reflecting a growth of 40.56% year-on-year[24] - The company's net profit for the first quarter is not explicitly stated, but the increase in revenue and costs suggests a focus on growth despite rising expenses[66] - The net profit for the current period was ¥66,736,639.13, up 51.5% from ¥44,080,297.75 in the previous period[76] - The total comprehensive income for the current period was ¥66,736,639.13, compared to ¥44,080,297.75 in the previous period, indicating a 51.5% increase[79] - The company's operating profit was ¥75,714,852.21, which is a 45.7% increase from ¥51,991,135.14 in the previous period[76] - The company reported a total profit of ¥75,614,852.21, an increase of 54.6% from ¥48,906,306.47 in the previous period[76] Cash Flow - The net cash flow from operating activities was ¥74,511,494.41, a significant recovery from a negative cash flow of ¥-307,050,623.24 in the previous year, marking a 124.27% improvement[8] - Cash flow from operating activities saw a net inflow increase of 124.27% year-on-year, driven by higher cash receipts from sales[25] - The cash flow from operating activities was ¥765,419,716.52, compared to ¥434,520,472.49 in the previous period, marking a 76% increase[80] - The net cash flow from operating activities was CNY 74.51 million, a turnaround from a negative CNY 307.05 million in the previous period[84] - The company reported a significant increase in sales cash receipts to CNY 741.14 million, compared to CNY 454.37 million in the previous period[87] Assets and Liabilities - Total assets at the end of the reporting period were ¥4,606,218,350.24, a 0.74% increase from ¥4,572,556,783.14 at the end of the previous year[8] - The total assets of the company increased from ¥4,522,331,607.46 to ¥4,616,811,957.19, marking a growth of approximately 2.1%[63] - The total liabilities decreased to CNY 1,685,339,999.78 from CNY 1,719,328,775.53, a decline of about 2.0%[53] - Total liabilities rose from ¥1,664,068,858.42 to ¥1,691,812,569.02, an increase of about 1.7%[63] Shareholder Information - The top shareholder, Gao Shuhua, holds 35.69% of the shares, with a total of 333,644,728 shares[12] - The company did not engage in any repurchase transactions among the top 10 shareholders during the reporting period[15] Research and Development - Research and development expenses rose by 72.83% compared to the previous year, indicating increased investment in R&D[23] - Research and development expenses for the first quarter were ¥40,999,115.40, up from ¥23,722,505.21, indicating a significant increase of about 72.6% as the company invests in innovation[66] - Research and development expenses rose to ¥36,681,300.67, up 55.2% from ¥23,614,703.22, highlighting the company's commitment to innovation[73] Other Income and Expenses - The company reported a government subsidy of ¥3,180,483.63 during the reporting period[8] - Other income increased by 84.22% year-on-year, mainly due to higher government subsidies related to operating activities[23] - The income tax expense for the current period was ¥8,878,213.08, compared to ¥4,826,008.72 in the previous period, reflecting a 83.5% increase[76] - The company recorded other income of ¥2,847,937.70, which is an increase from ¥1,046,471.19 in the previous period, indicating a growth of 172.5%[73] Inventory and Accounts Receivable - Accounts receivable financing increased by 122.24% from the beginning to the end of the period, primarily due to an increase in outstanding bills[22] - Accounts receivable decreased to CNY 360,573,362.98 from CNY 387,300,920.58, indicating a reduction of about 6.9%[47] - Inventory increased to CNY 1,901,517,923.91 from CNY 1,886,950,438.19, showing a growth of approximately 0.8%[47] - Accounts receivable increased from ¥397,924,112.88 to ¥417,083,134.30, reflecting a rise of about 4.3%[57] - Inventory levels remained stable, with a slight increase from ¥1,757,827,045.66 to ¥1,758,844,500.20, indicating a focus on maintaining stock levels[57]