Core Viewpoint - Changshan Pharmaceutical experienced a 5.07% increase in stock price, reaching 50.99 CNY per share, with a trading volume of 976 million CNY and a market capitalization of 46.863 billion CNY as of October 15 [1] Company Overview - Hebei Changshan Biochemical Pharmaceutical Co., Ltd. is located in the Hebei Free Trade Zone and was established on September 28, 2000, with its listing date on August 19, 2011 [1] - The company's main business involves the research, production, and sales of heparin series products, with revenue composition as follows: 47.47% from water injection preparations, 39.24% from heparin raw materials, and 13.29% from other products [1] Fund Holdings - According to data, one fund under Bosera Asset Management holds a significant position in Changshan Pharmaceutical. The Bosera National Index 2000 ETF (159505) held 1,400 shares in the second quarter, accounting for 0.55% of the fund's net value, ranking as the fifth-largest holding [2] - The Bosera National Index 2000 ETF (159505) was established on November 23, 2023, with a latest scale of 11.7815 million CNY. Year-to-date returns are 37.61%, ranking 997 out of 4,220 in its category, while the one-year return is 49.48%, ranking 579 out of 3,857 [2] Fund Manager Information - The fund manager of Bosera National Index 2000 ETF (159505) is Tang Yibing, who has been in the position for 3 years and 87 days. The total asset size of the fund is 9.874 billion CNY, with the best return during his tenure being 72.49% and the worst being -41.93% [3]

Investment Rating - The report assigns an "Overweight" rating to the pharmaceutical and biotechnology industry, indicating that the industry index is expected to outperform the CSI 300 index by 10% or more over the next six months [1][33]. Core Insights - The pharmaceutical and biotechnology sector experienced an overall decline of 1.20% from October 6 to October 10, 2025, ranking 25th among 31 industries in the Shenwan index, underperforming the CSI 300 index by 0.69 percentage points. Year-to-date, the sector has risen by 21.87%, ranking 12th among the 31 industries and outperforming the CSI 300 index by 4.54 percentage points [3][14]. - The current PE valuation for the pharmaceutical and biotechnology sector stands at 30.87 times, which is at the historical median level, with a valuation premium of 129% compared to the CSI 300 index [22][14]. - Notable stock movements include a 21.00% increase in Zhendemedical, a 12.01% rise in Wanbangde, and a 1.51% increase in the Traditional Chinese Medicine II sub-sector [27][3]. Market Performance - The pharmaceutical and biotechnology sector's performance for the week of October 6 to October 10, 2025, showed a decline of 1.20%, with Traditional Chinese Medicine II and pharmaceutical commerce sub-sectors increasing by 1.51% and 0.64%, respectively [13][3]. - Year-to-date, the sector has increased by 21.87%, with the top-performing sub-sectors being medical services (41.37%), chemical pharmaceuticals (36.28%), and biological products (16.22%) [14][3]. Industry News - On October 10, 2025, the State Council released regulations for the management of clinical research and application of new biomedical technologies, effective from May 1, 2026, establishing a clear framework for the sector's development [4][29]. - The National Medical Products Administration announced on October 9, 2025, that companies with Traditional Chinese Medicine injections approved before 2019 must accelerate post-marketing research and evaluation [4][30]. - Novo Nordisk announced on October 9, 2025, a $47 billion acquisition of Akero Therapeutics, gaining access to a potential best-in-class therapy for metabolic dysfunction-related fatty liver disease [5][30]. Investment Recommendations - The report suggests that the pharmaceutical and biotechnology sector has been underperforming recently, but the acquisition by Novo Nordisk indicates a long-term trend of multinational corporations enriching their R&D pipelines through mergers and acquisitions. The upcoming ESMO conference is anticipated to provide new data on domestic innovative drugs and potential business development opportunities [6][31]. - The report emphasizes that domestic innovative drug companies are rapidly gaining global competitiveness, and innovative drugs remain a key investment theme in the medium to long term. The innovative drug sector is expected to continue showing high revenue growth and reducing losses [6][31]. - Recommended stocks include Teabo Bio, Betta Pharmaceuticals, Kelun Pharmaceutical, KAILI Medical, Pumen Technology, and Huaxia Eye Hospital, with a watchlist including Zhongsheng Pharmaceutical, Rongchang Bio, Qianhong Pharmaceutical, Yifeng Pharmacy, Baipusais, and Lingrui Pharmaceutical [6][31].

Core Insights - The financing buy-in for Changshan Pharmaceutical (300255) on October 10 was 97.42 million yuan, with a net buy of 1.32 million yuan, indicating a positive investor sentiment [1][3] - The financing balance reached 1.95 billion yuan, showing a slight increase of 0.07% from the previous day [3][4] - Over the past three trading days, the cumulative net buy amounted to 29.49 million yuan, with 11 out of the last 20 trading days showing net buying activity [1][2] Financing Activity Summary - On October 10, the net financing buy was 1.32 million yuan, with a financing balance of 1.95 billion yuan, representing 4.29% of the circulating market value [2] - The financing balance has shown fluctuations, with a previous day's net buy of 23.43 million yuan and a balance of 1.949 billion yuan [2][4] - The financing balance has increased from 1.921 billion yuan on September 29 to 1.95 billion yuan on October 10, reflecting a general upward trend in investor activity [4] Market Sentiment Analysis - An increase in financing balance typically indicates a bullish market sentiment, suggesting that investors are leaning towards buying [5] - The recent net buying activity suggests a growing confidence among investors in Changshan Pharmaceutical's stock performance [1][5]

Market Overview - The chemical pharmaceutical sector experienced a decline of 0.66% on October 9, with Nanjing New Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3933.97, up 1.32%, while the Shenzhen Component Index closed at 13725.56, up 1.47% [1] Stock Performance - Notable gainers in the chemical pharmaceutical sector included: - Haichen Pharmaceutical (300584) with a closing price of 63.81, up 13.76% and a trading volume of 155,800 shares, totaling 973 million yuan [1] - Changshan Pharmaceutical (300255) closed at 49.29, up 8.21% with a trading volume of 394,400 shares, totaling 1.916 billion yuan [1] - Conversely, Nanjing New Pharmaceutical (688189) saw a significant drop of 19.96%, closing at 9.10 with a trading volume of 32,300 shares, totaling 29.426 million yuan [2] Capital Flow - The chemical pharmaceutical sector experienced a net outflow of 1.108 billion yuan from institutional investors, while retail investors saw a net inflow of 544 million yuan [2] - The capital flow for specific stocks showed: - Changshan Pharmaceutical had a net inflow of 14.6 million yuan from institutional investors, but a net outflow of 14 million yuan from retail investors [3] - Haichen Pharmaceutical recorded a net inflow of 85.3 million yuan from institutional investors, with retail investors showing a net outflow of 68 million yuan [3]

证券代码：300255 证券简称：常山药业 公告编号：2025-40 河北常山生化药业股份有限公司 关于控股股东进行股票质押的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 河北常山生化药业股份有限公司（以下简称"公司"）近日接到控股股东高 树华先生函告，获悉高树华先生将其所持有本公司的部分股份进行质押，新增累 计质押股份数超过公司总股本的 5%。具体事项如下： 截至公告披露日，上述股东及其一致行动人所持质押股份情况如下： | | | | 累计质押 | 占其所 | 占公司 | 已质押股份情况 已质押股 | | 未质押股份情况 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 股东名称 | 持股数量 （股） | 持股比例 | 股份数量 （股） | 持股份 比例 | 总股本 比例 | 份限售和 | 占已质 押股份 | 未质押股 份限售和 | 占未质 押股份 | | | | | | | | 冻结、标 记数量 | 比例 | 冻结数量 | 比例 | | 高树华 | 280,644 ...

Core Points - In 2025, Hebei Changshan Biochemical Pharmaceutical Co., Ltd. approved a guarantee limit of up to 360 million yuan for its wholly-owned subsidiary Kaikede at the 2024 annual general meeting [1] - The company recently signed a guarantee contract with Agricultural Bank of China Zhengding County Branch to provide joint liability guarantee for Kaikede's principal and interest of 13.6625 million yuan, which does not require further review within the approved limit [1] - As of the announcement date, the company and its controlling subsidiaries have a total guarantee limit of 2.06 billion yuan, which accounts for 131.86% of the most recent audited net assets [1] - After this guarantee, the actual guarantee balance is 1.3103551 billion yuan, representing 83.88% of the total limit, with no overdue or abnormal guarantee situations reported [1]

证券代码：300255 证券简称：常山药业 公告编号：2025-39 河北常山生化药业股份有限公司 关于为全资子公司提供担保的进展公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 一、担保情况概述 河北常山生化药业股份有限公司（以下简称"公司"）于 2025 年 5 月 19 日 召开的 2024 年度股东大会审议并通过《关于提供担保额度预计的议案》，同意公 司为全资子公司河北常山凯库得生物技术有限公司（以下简称"凯库得"）借款 融资提供不超过 3.6 亿元的担保额度，上述额度期限自股东大会审议通过之日起 至 2025 年度股东大会之日。具体内容详见公司刊登于巨潮资讯网的《关于提供 担保额度预计的公告》（公告编号：2025-14）。 二、担保进展 2025 年 9 月 29 日，公司与中国农业银行股份有限公司正定县支行（以下简 称"农业银行"）签订了《保证合同》，公司为凯库得与农业银行签订的固定资 产借款合同下 1,366.25 万元的本金及利息提供连带责任保证。 本次担保事项在已经审议的年度担保额度范围内，无需再提交公司董事会或 股东大会审议。 2．企业 ...

Group 1 - The core viewpoint of the news is that Changshan Pharmaceutical experienced a stock price increase of 5.22%, reaching 46.80 CNY per share, with a trading volume of 677 million CNY and a turnover rate of 1.62%, resulting in a total market capitalization of 43.012 billion CNY [1] - Changshan Pharmaceutical, established on September 28, 2000, and listed on August 19, 2011, is primarily engaged in the research, production, and sales of heparin series products [1] - The company's main business revenue composition includes 47.47% from water injection preparations, 39.24% from heparin raw materials, and 13.29% from other products [1] Group 2 - From the perspective of fund holdings, one fund under Bosera Fund has a significant position in Changshan Pharmaceutical, with the Bosera National Index 2000 ETF holding 1,400 shares, accounting for 0.55% of the fund's net value, ranking as the fifth-largest holding [2] - The Bosera National Index 2000 ETF, established on November 23, 2023, has a latest scale of 11.7815 million CNY and has achieved a year-to-date return of 38.28%, ranking 1165 out of 4220 in its category [2] - The fund manager, Tang Yibing, has a cumulative tenure of 3 years and 66 days, with the fund's total asset scale at 9.874 billion CNY, achieving the best return of 83.84% and the worst return of -41.93% during his tenure [2]

Group 1: Changshan Pharmaceutical - The company is preparing for clinical trials of Aibennate peptide for weight loss, with no current plans for oral formulation development [1] - Aibennate peptide is a long-acting GLP-1 receptor agonist, developed through chemical modification of exenatide [1] - The marketing preparation includes team building, product knowledge training, and marketing strategy formulation [1] Group 2: Fosun Pharma - Four innovative drugs approved in the first half of the year are expected to gradually increase sales in the coming months [2] - Innovative drug revenue exceeded 4.3 billion yuan, a year-on-year increase of 14.26%, accounting for over 30% of total drug revenue [2] - The company is actively participating in negotiations for the inclusion of its innovative drugs in insurance and national basic medical insurance directories [2] Group 3: Tiantan Biological Products - The company has established an international cooperation department to enhance its global market presence [3] - Products such as tetanus immunoglobulin and rabies immunoglobulin have already been exported [3] - The company is focused on international certification and registration of key products [3] Group 4: Kangtuo Medical - The US-based subsidiary BIOPLATE has launched a local production line for PEEK plates [4] - The company has completed market access in nearly 40 countries and regions [4] - The marketing of "4D bioactive plates" and PEEK fixation systems is underway in the US [4] Group 5: Tailong Pharmaceutical - The company is focusing on the development of modified new drugs across various therapeutic areas including respiratory, digestive, and oncology [5] - Projects in progress include treatments for Alzheimer's disease and schizophrenia [5] Group 6: Heng Rui Pharmaceutical - The HRS-5635 injection has been included in the list of proposed breakthrough therapies [6][7] - Chronic hepatitis B infection affects approximately 257 million people globally, with a significant mortality rate [7] - There is a pressing need for more effective treatments to achieve functional cure for chronic hepatitis B [7]

Market Overview - As of 10:30 AM, the Shanghai Composite Index is at 3827.97 points, with a decline of 0.10% [1] - The total trading volume of A-shares today is 113.62 billion yuan [1] Technical Analysis - A total of 162 A-shares have seen their 5-day moving average cross below the 10-day moving average [1] - Notable stocks with significant distance between their 5-day and 10-day moving averages include: - Changshan Pharmaceutical: 5-day MA is 1.52% lower than the 10-day MA [1] - Zero Point: 5-day MA is 1.19% lower than the 10-day MA [1] - Xiyu Co.: 5-day MA is 1.15% lower than the 10-day MA [1] Individual Stock Performance - Changshan Pharmaceutical (300255): Today's decline of 2.60%, with a 5-day MA of 47.08 yuan and a 10-day MA of 47.81 yuan, showing a distance of -1.52% [1] - Zero Point (301169): No change in price today, with a 5-day MA of 45.38 yuan and a 10-day MA of 45.92 yuan, showing a distance of -1.19% [1] - Xiyu Co. (000960): Today's increase of 1.22%, with a 5-day MA of 21.25 yuan and a 10-day MA of 21.50 yuan, showing a distance of -1.15% [1] Additional Stock Insights - ST Lifang (300344): Decline of 0.79%, with a 5-day MA of 5.15 yuan and a 10-day MA of 5.21 yuan, showing a distance of -1.08% [1] - Dongxin Peace (002017): Decline of 2.81%, with a 5-day MA of 26.14 yuan and a 10-day MA of 26.42 yuan, showing a distance of -1.06% [1] - Other stocks with notable performance include: - Yihua New Materials (301176): Decline of 0.87% [1] - Sanguang (002110): Decline of 0.71% [1]