Core Insights - The market has experienced significant price movements among various companies, indicating a mix of company-specific developments and broader market trends [1] Company-Specific Developments - John Hancock ESG Large Cap Core Fund Class A (JHJAX) saw a dramatic price drop to $12.56, reflecting a -42.01% change, potentially due to shifts in investor sentiment towards ESG investments [2][8] - Immuneering Corporation (IMRX) experienced a stock price decline to $4.92, a -40.94% change, likely influenced by market reactions to updates from its Phase 2a trial of atebimetinib for pancreatic cancer [3][8] - MSP Recovery, Inc. (MSPR) had its price decrease to $0.05, translating to a -38.29% change, with a notable increase in short interest indicating growing bearish sentiment among investors [4][8] - CorMedix Inc. (CRMD) saw a decrease to $7.43, a -33.47% change, possibly due to challenges related to its lead product candidate and recent leadership changes [5] - Locafy Limited (LCFYW) experienced a price drop to $3, a -31.03% change, which may be linked to updates on its technology platform and market positioning [6] Market Trends and Investor Sentiment - The significant trading volumes for these companies suggest active investor engagement, likely in response to recent announcements or broader market conditions [3][4][5][6] - Understanding the underlying causes of these price changes is crucial for investors, as they reflect the dynamic nature of the stock market influenced by clinical trial results, financial performance, and strategic shifts [7]

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U.S. stocks traded mixed midway through trading, with the Dow Jones index gaining more than 250 points on Thursday.The Dow traded up 0.54% to 49,261.60 while the NASDAQ declined 0.62% to 23,437.73. The S&P 500 also fell, dropping, 0.05% to 6,917.76.Check This Out: Delta Air Lines Earnings Are Imminent; These Most Accurate Analysts Revise Forecasts Ahead Of Earnings CallLeading and Lagging SectorsIndustrials shares gained by 1.4% on Thursday.In trading on Thursday, information technology stocks dipped by 1.4 ...

Immuneering Corporation (NASDAQ:IMRX) stock is trading lower on Thursday after the company shared updated data from its ongoing Phase 2a trial of atebimetinib (IMM-1-104) with a modified chemotherapy combination (gemcitabine/nab-paclitaxel (mGnP) in first-line pancreatic cancer.Thirty-four (34) patients in the trial had over 13 months median follow-up time.Overall survival on the chemotherapy regimen after 12 months was 35%, compared to 64% in the atebimetinib combo trial.The survival was 83% in the atebime ...

此外，该联合疗法的12个月总缓解率为39%，而标准疗法为23%。其中位无进展生存期为8.5个月，优于 标准疗法的5.5个月。Immuneering特别指出，在超过10%的患者中仅观察到两种3级不良事件，即中性粒 细胞减少症和贫血。 尽管atebimetinib的数据表现良好，但投资者可能将其与处于开发阶段的其他胰腺癌一线疗法进行对比， 例如Verastem的avutometinib联合defactinib方案以及Revolution Medicines的daraxonarasib。其中， avutometinib联合疗法此前报告的总缓解率达83%，daraxonarasib则为55%。不过，Verastem和Revolution Medicines所公布结果的中位随访时间相对较短。 该公司报告称，接受atebimetinib联合改良版吉西他滨/白蛋白结合型紫杉醇治疗的患者，12个月总生存 率为64%。公司指出，目前标准疗法在12个月的总生存率基准为35%。 生物技术公司Immuneering Corp.(IMRX.US)在周三盘后交易中暴跌约21%，此前其公布了atebimetinib作 为胰腺癌一线疗法的2 ...

PresentationWelcome to the Immuneering conference call to discuss the positive 12-month overall survival update from the company's ongoing Phase IIa trial of atebemetinib in first-line pancreatic cancer patients. [Operator Instructions] As a reminder, this call is being recorded today, Wednesday, January 7, 2026. I would now like to turn the conference over to Courtney Dugan, Vice President, Head of Investor Relations. Please go ahead.Courtney Dugan Thank you, operator. Joining us on the call today from Imm ...

Immuneering Conference Call Summary Company Overview - **Company**: Immuneering - **Focus**: Development of atebumetanib for treating first-line pancreatic cancer Key Industry Insights - **Industry**: Oncology, specifically pancreatic cancer treatment - **Current Treatment Landscape**: Standard of care includes gemcitabine plus nab-paclitaxel (GNP), with overall survival rates significantly lower than those reported for atebumetanib Core Points and Arguments 1. **Overall Survival Data**: - 12-month overall survival rate for patients treated with atebumetanib plus chemotherapy is 64% [7][21] - Historical benchmark for standard of care (GNP) is approximately 35%, indicating a 29-point absolute separation [8][21] - Median overall survival for standard of care is about 8.5 months, while median for atebumetanib has not yet been reached [8][11] 2. **Quality of Life Improvements**: - Significant improvements in quality of life reported, with specific case studies highlighting patients regaining independence and experiencing less severe side effects [5][18] - Functional Assessment of Anorexia Cachexia Therapy (FAACT) score improved from 96 to 141 in a patient case study [18] 3. **Safety and Tolerability**: - Favorable safety profile with few severe side effects; only anemia and neutropenia occurred in over 10% of patients [10] - No harsh side effects observed with atebumetanib monotherapy, differentiating it from traditional chemotherapy [10] 4. **Clinical Trial Plans**: - Upcoming pivotal phase 3 trial (MapKeeper 301) will enroll approximately 510 patients, comparing atebumetanib plus modified gemcitabine nab-paclitaxel against standard GNP [20] - Primary endpoint will be overall survival, with dosing expected to begin mid-year [20] 5. **Expanded Cohort Data**: - An expanded cohort of over 50 patients is being reported, with overall survival trending consistently with the original cohort of 34 patients [12][49] - The expanded cohort includes additional patients who started treatment later, but results remain robust [49] 6. **Market Positioning**: - Immuneering aims to position atebumetanib as a best-in-class treatment for pancreatic cancer, with the potential to become the new standard of care [52] - The company emphasizes the importance of both quality and quantity of life for patients, aiming to provide effective treatment without debilitating side effects [34][52] Additional Important Content - **Patient Demographics**: The trial population is older, with a median age of 69, which reinforces the significance of the survival benefits observed [12] - **Future Milestones**: Upcoming milestones include sharing circulating tumor DNA analyses and updated survival data, as well as the initiation of phase 2 combination studies in lung cancer [21][22] This summary encapsulates the key points discussed during the Immuneering conference call, highlighting the promising data surrounding atebumetanib and its potential impact on the treatment of pancreatic cancer.

- Reported 12-month overall survival (OS) in Phase 2a clinical trial nearly double the benchmark from pivotal study of standard of care gemcitabine/nab-paclitaxel (GnP) - - Atebimetinib consistently demonstrates impressive overall survival advantage at all time periods reported; Median overall survival remains unreached as of data cutoff, suggesting encouraging durability of clinical benefit - - Anticipate dosing first patient in pivotal Phase 3 clinical trial, MAPKeeper 301, in mid-2026 - - Company to host ...

U.S. stocks were mixed, with the Dow Jones index falling around 0.2% on Wednesday.Shares of Monte Rosa Therapeutics Inc (NASDAQ:GLUE) rose sharply during Wednesday's session after the company announced interim data from an ongoing Phase 1 clinical study evaluating MRT-8102.Monte Rosa Therapeutics shares jumped 45.2% to $23.25 on Wednesday.Here are some other big stocks recording gains in today’s session.Ventyx Biosciences Inc (NASDAQ:VTYX) gained 37.5% to $13.82 following reports that Indianapolis-based Eli ...

Core Viewpoint - Immuneering Corporation (IMRX) has received a Zacks Rank 2 (Buy) upgrade, indicating a positive outlook based on rising earnings estimates, which are a significant factor influencing stock prices [1][3]. Earnings Estimates and Stock Price Impact - The Zacks rating system emphasizes the correlation between changes in earnings estimates and stock price movements, particularly influenced by institutional investors who adjust their valuations based on these estimates [4][6]. - For Immuneering, the increase in earnings estimates suggests an improvement in the company's underlying business, which is expected to drive the stock price higher [5]. Earnings Estimate Revisions - Immuneering is projected to earn -$1.35 per share for the fiscal year ending December 2025, with no year-over-year change anticipated [8]. - Over the past three months, the Zacks Consensus Estimate for Immuneering has risen by 13.4%, indicating a positive trend in earnings expectations [8]. Zacks Rank System - The Zacks Rank system categorizes stocks into five groups based on earnings estimates, with a strong historical performance, particularly for Zacks Rank 1 stocks, which have averaged a +25% annual return since 1988 [7]. - Immuneering's upgrade to Zacks Rank 2 places it in the top 20% of Zacks-covered stocks, suggesting a strong potential for market-beating returns in the near term [10].