Core Insights - The article emphasizes the importance of identifying high-quality growth stocks with a strong track record, particularly focusing on well-known companies that have consistently performed well over the years [1][2] Group 1: Investment Strategy - Investors should look for "hero stocks" that are obvious winners, rather than picking randomly [1] - Cramer highlights the performance of FAANG stocks, which have outperformed the S&P 500 and achieved double-digit gains over the past decade [2] - The article warns against investing in stocks that appear to be doing well without a solid pedigree, as many gains are driven by market enthusiasm rather than fundamental strength [2] Group 2: Historical Performance - Research by economist Hendrik Bessembinder indicates that a small number of stocks account for the majority of market gains from 1925 to 2023, with only 17 stocks delivering substantial returns [2] - Notable high-yielding stocks mentioned include Boeing, IBM, Coca-Cola, Deere, and Johnson & Johnson, which have provided significant returns compared to the broader market [2] Group 3: Future Opportunities - The search for the next big growth stock continues, with the belief that there are always new opportunities waiting to be discovered, similar to the current Magnificent Seven [3] - As long as proven winners like the Magnificent Seven remain strong, they will continue to be favored investments [3]

Core Insights - The article highlights the progress made for Black women founders in Canada over the past five years, indicating a shift in the venture capital landscape, although challenges remain [4][10]. Investment Landscape - Globally, the number of venture capital deals involving female-founded or co-founded companies increased by nearly 60% from 2014 to 2023, yet female-founded startups captured only about 2% of global venture dollars as of 2023 [5]. - In Canada, women-led startups accounted for just 4% of total VC investment in 2021, which tripled to 12% by the first half of 2024, reflecting significant but fragile progress [6]. Institutional Response - The Business Development Bank of Canada (BDC) has initiated several programs to address historical investment gaps, including a $35 million commitment to co-invest alongside women-led businesses and a $50 million initiative to help women acquire or lead established companies [8]. Black Entrepreneurship - In 2023, only 1.3% of Black adults in Canada were entrepreneurs, with Black women at an even lower rate of 0.7%. However, projections suggest that Black entrepreneurs could represent 3.2% of Canada's entrepreneurial base by 2034 [9]. Founders' Impact - Six Black women founders have raised over $1 million each through venture capital and non-dilutive funding, demonstrating a shift in the market and the potential for scalable business models [14]. - Companies founded by these women span various sectors, including technology, healthcare, and sustainability, showcasing their ambition and governance [14][25]. Call to Action - The article emphasizes the need for structural changes to ensure the success of Black women founders becomes the norm rather than the exception, advocating for increased diverse investors and government-backed data collection [28]. - It argues that supporting Black women founders is not just a moral imperative but an economic necessity, as they are addressing critical global challenges [29][30].

All three are buys, but for different reasons.Fears of a recession did not materialize this year. However, it's always worth it for investors to buy shares of companies that can perform well during economic downturns. Solid dividend stocks that routinely increase their payouts are especially attractive in that regard, since they tend to have businesses equipped to withstand challenging times.Let's discuss three stocks to buy to prepare your portfolio for any recession that may lay ahead: Microsoft (MSFT 0.5 ...

Market Performance - Major U.S. indexes ended the Christmas-shortened week higher, with the S&P 500 and Dow reaching new record highs, gaining 0.75% and 0.72% respectively, while the Nasdaq Composite increased by 0.70% [1] - The U.S. GDP growth rate for Q3 2025 was 4.3%, exceeding expectations and marking the fastest growth since Q3 2023 [2] - Despite a decline in consumer confidence, investor optimism is driven by strong corporate earnings outlook and AI enthusiasm [2] Stock Performance - Castle Biosciences, Inc. (CSTL) shares increased by 77.9% since being upgraded to a Zacks Rank 1 (Strong Buy) on October 20, significantly outperforming the S&P 500's 3.8% increase [3][6] - F.N.B. Corporation (FNB) shares rose by 13.4% after its upgrade to Zacks Rank 2 (Buy) on October 21, compared to the S&P 500's 2.8% increase [4] - Hamilton Insurance Group, Ltd. (HG) and Kinross Gold Corporation (KGC) saw gains of 19.8% and 7.7% respectively since their upgrade to Outperform on October 17 [7] Portfolio Performance - A hypothetical portfolio of Zacks Rank 1 stocks returned +14.3% in 2025, slightly underperforming the S&P 500's +14.9% [11] - The Zacks Model Portfolio has outperformed the S&P 500 index by over 12 percentage points since 1988, with an annualized average return of +23.9% compared to +11.5% for the S&P 500 [13] - The Zacks Earnings Certain Admiral Portfolio (ECAP) returned -1.30% in Q3 2025, underperforming the S&P 500's +8.1% gain [15] Dividend Portfolio Performance - Johnson & Johnson (JNJ) returned 14.3% over the past 12 weeks, while 3M Company (MMM) increased by 5.2% during the same period [18] - The Zacks Earnings Certain Dividend Portfolio (ECDP) returned -0.01% in Q3 2025, compared to the S&P 500's +8.1% gain [19]

Summary of Key Points from the Conference Call Industry Overview - **Industry**: Biopharma in North America - **Market Analysis**: The latest weekly Total Prescription (TRx) year-over-year (YoY) growth for the week ending December 19, 2025, was +1.1%, compared to +1.0% the previous week and +0.8% over the past 12 weeks [1][2] Prescription Trends - **Weekly TRx Change**: For the week ended December 19, the US total market weekly TRx YoY change was +1.1%, up from +0.9% a year ago. The rolling 4-week TRx YoY was +1.2%, and the rolling 12-week TRx YoY was +0.8% [2] - **Extended Unit (EUTRx) Growth**: EUTRx weekly YoY growth was +1.4%, which is above the TRx YoY growth [2] - **Sequential Growth**: Sequential weekly TRx growth was +2.3%, a significant increase compared to -1.4% the week before [2] Company-Specific Insights Bristol Myers Squibb (BMY) - **Cobenfy Launch**: Cobenfy was approved for schizophrenia on September 26, 2024. The number of prescriptions (scripts) for the week was approximately 2,800, up from 2,710 the previous week. To meet 2025 consensus expectations, Cobenfy TRx needs to track at approximately 2-3 times the volumes from recent schizophrenia launches [3] - **Sales Estimates**: The consensus estimate for Cobenfy has decreased from $196 million to $161 million, implying that around 104,000 TRx are required to meet these estimates [3] Vertex Pharmaceuticals (VRTX) - **Journavx Launch**: Journavx was approved for acute pain on January 30, 2025. The number of scripts for the week was approximately 13,060, up from 12,570 the previous week. Hospital scripts accounted for about 39% of total scripts in Q3 [4] - **Sales Projections**: To achieve 2025 sales of $68 million, approximately 303,000 total scripts are needed, assuming a net price of $225 per script [4] Gilead Sciences (GILD) - **Yeztugo Launch**: Yeztugo was approved on June 18, 2025. The latest week total TRx was approximately 780, down from 800 the previous week. The analysis suggests that achieving FY25 sales of $150 million requires incremental weekly script growth from current levels [5][9] - **Market Coverage**: Yeztugo has secured 75% commercial coverage, including major payers, and most do not require copays, indicating alignment with USPSTF guidelines [9] Additional Insights - **Market Focus**: Investors are increasingly focused on 2026, with strong PrEP market growth of +14% YoY and sustained Descovy share of over 45% [9] - **Pricing Analysis**: The pricing analysis for immunology drugs such as Stelara and Tremfya has been updated, showing how additional indications impact price per script [10] - **Biosimilar Adoption**: Comprehensive analysis of biosimilar adoption across various branded drugs has been included, indicating trends in market share and sales [12] Conclusion - The biopharma industry in North America is showing positive growth trends in total prescriptions, with specific companies like BMY, VRTX, and GILD launching new products and adjusting sales expectations. The focus on 2026 and the strong market coverage for new drugs indicate potential investment opportunities in this sector.

Core Insights - Johnson & Johnson has successfully completed the acquisition of Halda Therapeutics for $3.05 billion in cash, enhancing its oncology portfolio with innovative therapies for solid tumors, including prostate cancer [1][2] Group 1: Acquisition Details - The acquisition of Halda Therapeutics includes the addition of HLD-0915, a clinical-stage therapy for prostate cancer, which utilizes the proprietary Regulated Induced Proximity TArgeting Chimera (RIPTAC™) platform [2] - The deal is expected to result in a dilution of approximately $0.20 to Adjusted Earnings Per Share (EPS), split equally between 2025 and 2026, due to non-recurring charges related to Halda employee equity awards and integration costs [3] Group 2: Strategic Goals - The acquisition is part of Johnson & Johnson's commitment to redefining cancer treatment through breakthrough science and transformative medicines, aiming to eliminate cancer [2] - The company plans to leverage the RIPTAC™ platform to advance a promising pipeline of novel product candidates and discover more molecules in oncology and beyond [3]

Core Insights - The pharmaceutical industry is experiencing significant performance divergence among major multinational companies in 2025, with some companies thriving while others face substantial challenges [1][2][3][4]. Financial Performance - Novo Nordisk reported Q3 2025 revenues of 74.976 billion Danish Krone (approximately $11.276 billion), a year-on-year increase of 11%, with total revenues for the first three quarters reaching 229.92 billion Danish Krone (approximately $34.58 billion), up 15% [1]. - Key products such as Ozempic, Rybelsus, and Wegovy contributed significantly to Novo Nordisk's revenue, with Wegovy showing a remarkable growth of 54% [1]. - Merck's pharmaceutical revenue for the first three quarters of 2025 was $43.299 billion, with a 68% decline in revenue from China, dropping to $1.452 billion [2]. - Eli Lilly achieved a remarkable turnaround with Q3 revenues of $17.6 billion, a 54% increase year-on-year, driven by the success of its GLP-1 drug [3]. - Pfizer was the only company in the top 10 to experience a decline in both revenue and profit, with Q3 revenues of $16.654 billion, down 6% year-on-year [4]. Strategic Adjustments - Major pharmaceutical companies are actively seeking solutions to address strategic challenges, including layoffs and business divestitures, with 190 layoffs reported in the first three quarters of 2025 [2][9]. - Companies like Merck and Novo Nordisk are implementing significant cost-cutting measures, with Merck aiming to save $3 billion by 2027 and Novo Nordisk planning to cut approximately 9,000 jobs [2][9]. - The trend of divesting mature assets is becoming common, with companies opting to sell off non-core or underperforming business units to focus on innovation [7][9]. Market Dynamics - The Chinese market is no longer a guaranteed success for multinational pharmaceutical companies, with significant performance disparities emerging [5][12]. - The ongoing "patent cliff" is a critical concern, with many companies facing over 20% of their revenue at risk due to expiring patents [5]. - The competitive landscape is shifting, with local investment firms increasingly acquiring mature products from multinational companies, allowing for more localized management and decision-making [8][9]. Future Outlook - The future of multinational pharmaceutical companies will depend on their ability to innovate rapidly, adapt to local market policies, and manage patent expirations effectively [12][14]. - Companies that can successfully transition to innovation-driven models and integrate into China's biopharmaceutical ecosystem are likely to thrive [12][14]. - The restructuring of global pharmaceutical companies is creating both challenges and opportunities for local firms, as they may benefit from the divestiture of mature products and increased collaboration on early-stage innovations [14].

Core Insights - The article discusses the expertise of Fred Piard, a quantitative analyst with over 30 years in technology, focusing on data-driven systematic investment strategies since 2010 [1]. Group 1: Expertise and Background - Fred Piard has authored three books and runs an investing group called Quantitative Risk & Value, which focuses on quality dividend stocks and innovative tech companies [1]. - He provides various market strategies, including market risk indicators, real estate, bond, and income strategies in closed-end funds [1].

Group 1 - The primary goal of the "High Income DIY Portfolios" service is to provide high income with low risk and capital preservation for DIY investors [1] - The service offers seven portfolios designed for income investors, including retirees, featuring three buy-and-hold portfolios, three rotational portfolios, and a conservative NPP strategy portfolio [1] - The portfolios include two high-income portfolios, two dividend growth investing (DGI) portfolios, and a conservative NPP strategy portfolio aimed at low drawdowns and high growth [1] Group 2 - The author of the article has 25 years of investment experience and focuses on dividend-growing stocks with a long-term investment horizon [2] - A unique 3-basket investment approach is applied, targeting 30% lower drawdowns, 6% current income, and market-beating growth over the long term [2] - The service includes a total of 10 model portfolios with varying income targets, buy and sell alerts, and live chat for portfolio management and asset allocation [2]

【深圳商报讯】(记者刘娥)我国生物医用材料领域取得重大突破。近期，由深圳华诺生物科技有限公司 自主研发的"可吸收止血流体凝胶"获得国家药品监督管理局(NMPA)三类医疗器械注册证，成功打破美 国强生公司在该高端止血耗材领域长达10年的市场垄断。华诺生物科技创始人，大连理工大学教授、博 导王华楠表示，截至目前，该产品已实现近千家医院入院，预计到2026年将实现强生产品30%—40%的 市场替代，未来5年完成全面替代。 这一突破性成果源自王华楠团队17年的持续研发。与传统材料依赖稳定的共价键不同，华诺生物创新 的"自愈合分子技术"基于"动态非共价键"原理，使材料在被破坏后能够快速重组恢复结构和强度。该技 术同时具备了流体的可注射性和固体的支撑能力，在微创手术中，医生可以通过腹腔镜将材料精准注入 体内深处出血点，实现快速止血封闭。 业内专家指出，随着国家加大对高端医疗器械产业的支持力度，未来5—10年将是中国医疗器械耗材企 业集中爆发期。华诺生物的成功案例表明，通过产学研深度融合，中国企业在高端医疗耗材领域完全有 能力突破技术壁垒，实现从跟跑到并跑甚至领跑的跨越。 目前，华诺生物已与多家国际机构开展合作，其自主研发 ...