Core Viewpoint - Moderna's stock surged 16% following positive clinical trial results for its experimental skin cancer vaccine, mRNA-1893/V940, which showed a 49% reduction in the risk of melanoma recurrence when combined with Keytruda immunotherapy [2][3]. Company Performance - Moderna's revenues have declined at an average annual rate of 52.3% over the last three years, with a 56.4% drop in the latest twelve-month period from $5.1 billion to $2.2 billion [7]. - The most recent quarter reported a 46% year-over-year revenue decline, down to $1.0 billion [7]. - The company is currently trading at a price-to-sales ratio of 7.9x, significantly higher than the S&P 500's 3.3x, indicating that investors are paying nearly $8 for each dollar of revenue generated [6]. Financial Health - Moderna's operating income over the past four quarters was negative $3.5 billion, resulting in an operating margin of -157.3%, compared to the S&P 500's average operating margin of 18.8% [9]. - The company has a solid balance sheet with $734 million in debt against a market capitalization of $19 billion, yielding a debt-to-equity ratio of 4.2% [11]. - Cash and cash equivalents total $4.5 billion out of $12 billion in total assets, resulting in a cash-to-assets ratio of 37.1% [11]. Cash Flow and Sustainability - At the current burn rate of about $2 billion annually in operating cash flow, Moderna has approximately two years of runway before needing to achieve commercial success or raise additional capital [12]. - The company is heavily investing in R&D for its product pipeline while generating minimal revenue from offerings outside of COVID vaccines [10]. Market Resilience - Moderna has shown poor resilience during market declines, with its stock plummeting 85.7% from its peak in August 2021 to November 2023, compared to the S&P 500's 25.4% drop [13]. - The stock has not returned to previous highs and is currently trading near $50 after reaching $166.61 in May 2024 [13]. Investment Outlook - While the cancer vaccine shows promise, it is years away from commercialization and will face regulatory hurdles [8]. - The overall evaluation indicates very weak growth, very weak profitability, very strong financial stability, and weak downturn resilience, suggesting that the risk-reward profile is unfavorable for investors [16].

Core Viewpoint - Moderna's stock has experienced a significant decline of 91% since its peak during the pandemic, but recent positive developments in cancer vaccine trials may signal a potential recovery for the company [2][10]. Group 1: Stock Performance and Market Sentiment - Shares of Moderna rose by 16% on January 21 following encouraging results from a skin cancer vaccine developed in partnership with Merck [3]. - The stock is currently trading 40% above Wall Street's average price target of approximately $30, indicating skepticism about further price increases [6]. - 18.8% of Moderna's shares are sold short, suggesting that if the company can diversify its offerings beyond its declining Covid franchise, there may be upward pressure on the stock price [6]. Group 2: Clinical Trials and Product Pipeline - Moderna and Merck are conducting multiple clinical trials to explore the potential of their mRNA technology in treating various cancers, including lung, kidney, and bladder cancers [4]. - The Phase 3 trial results for a personalized skin cancer vaccine showed a 49% reduction in recurrence or death after five years among high-risk melanoma patients [8]. - The market potential for the skin cancer vaccine is substantial, with peak sales projected to reach billions, particularly as the American Cancer Society estimates that around 112,000 people in the U.S. will be diagnosed with melanoma in 2026 [9]. Group 3: Future Scenarios and Analyst Perspectives - Analysts present three potential scenarios for Moderna's stock: a status quo scenario with stock prices stabilizing between $30 and $50, a pessimistic scenario with prices dropping to $15 to $20 if the cancer vaccine fails, and an optimistic scenario where prices could rise to between $100 and $190 if the cancer vaccine is successful [12][13]. - The average price target among analysts is $29, reflecting mixed views on the company's future performance [14]. - An optimistic outlook hinges on the effectiveness of the cancer vaccine, with potential implications for commercialization in other cancer types [15]. However, some analysts remain cautious, citing challenges in similar treatments and logistical hurdles [16].

Group 1 - Global stock markets experienced a slight increase following Trump's withdrawal of trade threats against Europe, alleviating concerns about a trade war [2][28] - As of the report, Dow futures rose by 0.35%, S&P 500 futures increased by 0.56%, and Nasdaq futures climbed by 0.83% [3][29] - The European Stoxx 600 index rose by 1.1%, with the automotive sector leading gains, particularly Volkswagen which surged by 5.2% [3][29] Group 2 - Gold prices remained stable near record highs, indicating that risk appetite in the stock market has not fully translated into a significant drop in safe-haven demand [4][30] - The market interpreted Trump's statements as a sign of easing geopolitical and trade tensions, leading to a renewed preference for stock assets [4][30] Group 3 - Semiconductor stocks strengthened, with Nvidia's CEO comments at Davos boosting enthusiasm for AI investments, leading to a 17% surge in Disco Corp. and a 2.3% increase in Samsung Electronics [6][31][32] - The Korean benchmark index, a tech stock indicator, reached a historical high [32] Group 4 - The VIX volatility index, known as the "Wall Street fear gauge," saw a significant decline, indicating a reduction in market panic [34] - Japanese government bonds rebounded for the second consecutive trading day, while Bitcoin traded around $90,000 [33] Group 5 - Focused stocks included Western Digital, which rose over 4%, Micron Technology up over 3%, and Seagate Technology increasing by 2.5% [40] - Moderna continued to rise by 5.6% following positive data on its mRNA cancer vaccine [41] - GE Aerospace saw a pre-market increase of over 5%, with adjusted earnings per share expected to be between $7.10 and $7.40 for 2026, exceeding market expectations [42]

Core Viewpoint - Wall Street is optimistic that a new pipeline of cancer drugs will lead to earnings growth, especially as the respiratory vaccine sector is currently underperforming [1] Group 1: Industry Outlook - The cancer drug pipeline is seen as a potential driver for earnings growth in the pharmaceutical industry [1] - The respiratory vaccine business is struggling, which has shifted focus towards oncology products [1] Group 2: Company Implications - Companies involved in cancer drug development may benefit from increased investor interest and potential revenue growth [1] - The performance of respiratory vaccines may impact overall company earnings, necessitating a strategic pivot towards oncology [1]

U.S. stock futures rose on Thursday following Wednesday’s gains. Futures of major benchmark indices were higher.The indices settled higher on Wednesday, gaining more than 1% during the session after President Donald Trump abruptly withdrew his latest round of tariff threats. He stated that planned tariffs on European Union countries will no longer take effect following what he described as a “very productive” meeting with NATO Secretary General Mark Rutte. Meanwhile, the 10-year Treasury bond yielded 4.24%, ...

莫德纳(MRNA.US)盘前续涨5.6%，报52.6美元，该股昨日大幅收涨近16%。消息面上，近日，默沙东与 莫德纳联合披露mRNA肿瘤疫苗mRNA-4157联合K药的二期临床五年随访数据，显示联合疗法较 Keytruda单药治疗将高危III/IV期黑色素瘤患者复发或死亡风险显著降低49%，且疗效持久，有力支持了 mRNA肿瘤疫苗诱导持久免疫应答的科学假设。(格隆汇) ...

Market Overview - The stock market experienced a significant rally due to positive developments in international trade, particularly the suspension of planned tariffs on EU countries by President Trump [1] - Major U.S. stock indexes saw notable gains, with the Dow Jones Industrial Average increasing by 1.2% to 49,077.23, the S&P 500 rising by 1.16% to 6,875.62, and the Nasdaq adding 1.18% to 23,224.82 [1] Company Highlights - **Intel Corporation (NASDAQ:INTC)**: - Intel's stock rose by 11.72% to close at $54.25, nearing its 52-week high of $54.41, with an after-hours gain of 1.2% to $54.92 [2] - Anticipation builds for Intel's fourth-quarter earnings report, expected to show earnings per share of 8 cents and revenue of $13.38 billion, following a previous quarter where revenue was $13.65 billion and earnings per share were 23 cents [3] - **Moderna Inc (NASDAQ:MRNA)**: - Moderna shares surged by 15.84% to $49.81, reaching a 52-week high of $50, with an after-hours increase of 4.4% to $52 [4] - Investor enthusiasm is driven by a recent update on a cancer therapy study in collaboration with Merck & Co, which showed significant improvements in recurrence-free survival for melanoma patients [5] - **The Metals Company Inc (NASDAQ:TMC)**: - TMC's stock climbed by 13.31% to $8.17, with an after-hours increase of 9.4% to $8.94 [6] - The company welcomed a new rule from the National Oceanic and Atmospheric Administration that modernizes regulations for deep seabed mining permits, aligning with TMC's strategy for transitioning to commercial production [7] - **Microsoft Corporation (NASDAQ:MSFT)**: - Microsoft's stock fell by 2.29% to $444.11, remaining below its 52-week high of $555.45 [8] - CEO Satya Nadella emphasized the need for artificial intelligence to deliver tangible benefits to maintain public trust, particularly in sectors like healthcare and education [8] - **Lucid Group Inc (NASDAQ:LCID)**: - Lucid's stock jumped by 17.88% to $11.47, with an expansion of its manufacturing partnership in Saudi Arabia enhancing its growth outlook [9] - The collaboration with Rockwell Automation aims to implement advanced manufacturing systems at Lucid's plant, providing real-time visibility and control over production lines [10]

Key Points Moderna's and Merck's partnership could help to advance cancer care. A promising skin cancer trial might have broader implications for other types of tumor treatments. 10 stocks we like better than Moderna › Shares of Moderna (NASDAQ: MRNA) popped on Wednesday after the biotech leader announced positive clinical trial results for its experimental skin cancer vaccine, developed with healthcare giant Merck. By the close of trading, Moderna's stock price was up more than 15%. Image source ...

Core Insights - The collaboration between Merck and Moderna on the mRNA cancer vaccine mRNA-4157 has shown promising results, significantly reducing the risk of recurrence or death by 49% in high-risk melanoma patients when combined with the PD-1 inhibitor Keytruda [1][2] - The mRNA-4157 vaccine utilizes a personalized neoantigen therapy mechanism, which designs synthetic mRNA encoding up to 34 neoantigens based on the unique mutations in a patient's tumor DNA [2] - The market potential for mRNA cancer vaccines is substantial, with projections indicating that they could become a new class of cancer immunotherapy, combining accessibility and personalization [4] Company Developments - Moderna plans to increase investment in the oncology sector, with the Phase III clinical trial for mRNA-4157 fully enrolled and expanding its indications beyond melanoma [2] - EVM16, a personalized cancer vaccine developed by the domestic company, has entered human trials, marking a significant milestone in the application of mRNA technology combined with AI for neoantigen selection [3] - The clinical data from EVM16 is expected to be released in the next 6-12 months, with the company aiming to initiate Phase Ib studies thereafter [3] Industry Trends - The success of mRNA-4157 highlights the unmet needs in cancer treatment, with the industry recognizing the potential of mRNA cancer vaccines to address these gaps [4] - The competitive landscape for personalized cancer vaccines is evolving, with domestic companies like EVM16 accelerating their development efforts in response to the advancements made by global players [4]

1月20日，默沙东与莫德纳联合披露的mRNA肿瘤疫苗mRNA-4157(intismeran autogene)联合K药的二期 临床五年随访数据，为全球肿瘤免疫治疗领域注入"强心剂"。受消息影响，莫德纳当天股价上涨2.8%， 随着mRNA产品临床推进，其股价重拾升势，最新价已逼近近一年高点。 这项代号为KEYNOTE-942/mRNA-4157-P201的研究显示，在完全切除后的高危III/IV期黑色素瘤患者 中，mRNA-4157联合PD-1抑制剂帕博利珠单抗(Keytruda)的联合疗法，较Keytruda单药治疗将复发或死 亡风险显著降低49%。 该数据不仅体现疗效显著，更凸显其持久性。此前，该研究在随访两年时数据显示将复发或死亡风险降 低44%，三年时为49%，至第五年随访节点风险降低比例仍维持在49%的高位，有力地支持了mRNA肿 瘤疫苗机制可提供诱导持久免疫应答的科学假设。 尽管PD-1抑制剂已成为多种肿瘤治疗的重要基石，但复发风险依然困扰着相当比例的患者。在此背景 下，"个体化疫苗+免疫检查点抑制剂"的组合方案被视为突破现有治疗瓶颈的癌症治疗重要方向。 作为全球首个获FDA突破性疗法认证的mRN ...