CHARLESTOWN, Mass., Jan. 06, 2026 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced that Bo Cumbo, President and CEO, will present at the 44th Annual J.P. Morgan Healthcare Conference on Tuesday, January 13, 2026, at 5:15 p.m. PT (8:15 p.m. ET). A live webcast of the presentation will be available on the Events page of the Investors section of the Company ...

Summary of Key Points from Biotechnology Equity Research Conference Call Industry Overview - The report focuses on the biotechnology sector, specifically highlighting companies with significant potential for growth and upcoming catalysts in 2026. Key Companies and Their Outlook 1. **Dianthus Therapeutics, Inc. (DNTH)** - Market Cap: $1.82 billion - Price Target: $66 - Key catalysts include: - CIDP Phase III interim analysis in Q2 2026 - Initiation of gMG Phase III study in mid-2026 - Phase II MMN topline data in 2H26 - Potential for significant upside based on peak revenue estimates of ~$2 billion across neuromuscular diseases [19][20][24] 2. **Taysha Gene Therapies, Inc. (TSHA)** - Market Cap: $1.50 billion - Price Target: $11 - Focus on pivotal study for TSHA-102 in Rett syndrome with potential for a 6-month interim readout by YE26/1Q27 [26][27] 3. **Tyra Biosciences (TYRA)** - Market Cap: $1.36 billion - Price Target: $32 - Major catalysts include: - Phase III data for achondroplasia in early 2026 - Initial data for IR-NMIBC in 1H26 - Potential to disrupt the market with oral FGFR3 inhibitors [31][35] 4. **Tango Therapeutics, Inc. (TNGX)** - Market Cap: $1.15 billion - Price Target: $14 - Expected to show de-risking data for vopimetostat in combination with RVMD's RAS inhibitors in 2026 [37][40] 5. **ORIC Pharmaceuticals (ORIC)** - Market Cap: $783 million - Price Target: $23 - Key catalysts include dose-optimization data for prostate cancer and validating data from PFE's MEVPRO-1 trial [42][48] 6. **Solid Biosciences (SLDB)** - Market Cap: $463 million - Price Target: $15 - Focus on DMD program with key regulatory feedback expected in 1H26 [49][53] Major Catalysts and Events - **Upcoming Catalysts:** - RARE and MREO Phase III ORBIT final analysis expected in Dec'25/Jan'26 with potential stock movements of +100%/-30% [2] - ALNY, CRSP, and others expected to provide revenue guidance and business plans early in 2026 [1] - Regulatory events including FDA's Rare Disease Day on 2/23/26 [12] - **Drug Launches:** - Expected launches in 2026 include drugs from ALNY, ARWR, KALV, and others targeting various conditions [3] Financial Updates - **Price Target Changes:** - ARWR raised from $67 to $90 - KOD raised from $24 to $39 [6][10] Market Dynamics - **Pricing Stability:** - 2026 net pricing expected to remain stable with current Medicare contracts influencing high gross-to-net (GTN) guidance [12] - **Strategic Interest:** - Potential for M&A activity as companies like ORIC attract interest due to their prostate cancer programs [43] Conclusion - The biotechnology sector is poised for significant developments in 2026, with multiple companies presenting strong investment opportunities based on upcoming catalysts, drug launches, and strategic positioning in the market.

Core Insights - Jefferies has released a report on the outlook for the U.S. biotech industry in 2026, highlighting key clinical trial data disclosures, new drug approvals, and policy dynamics that could lead to value re-evaluation for companies in the sector [1] Six Preferred Stocks - Jefferies identified six companies as core recommendations for 2026 based on market catalysts and valuation potential: - Dianthus Therapeutics (DNTH.US), target price $66: Focused on claseprubart for various neuromuscular diseases, with peak revenue estimated at $2 billion [2] - Taysha Gene Therapies (TSHA.US), target price $11: TSHA-102 for Rett syndrome, with peak revenue potential of $2 billion and a key trial data disclosure expected by the end of 2026 [2] - Tyra Biosciences (TYRA.US), target price $32: Dabogratinib for bladder cancer and achondroplasia, with critical data expected next year [3] - Tango Therapeutics (TNGX.US), target price $14: Collaboration with Revolution Medicines for a pancreatic cancer treatment, with data expected in mid-2026 [3] - ORIC Pharmaceuticals (ORIC.US), target price $23: Two potential assets targeting prostate cancer and lung cancer, with key data expected next year [4] - Solid Biosciences (SLDB.US), target price $15: Focused on gene therapy for Duchenne muscular dystrophy, with critical meetings with the FDA planned for 2026 [4] Seven Undervalued Companies - The report also highlighted seven undervalued companies with significant catalysts: - Ultragenyx Pharmaceutical (RARE.US), target price $114: Expected key catalysts in 2026, including data for treatments for osteogenesis imperfecta and Angelman syndrome [5] - Beam Therapeutics (BEAM.US), target price $41: Updates on AATD therapy and SCD therapy expected in 2026, showcasing strong potential [5] - Aurinia Pharmaceuticals (AUPH.US), target price $21: Steady growth in lupus nephritis treatment, with new drug development paths expected to expand growth [6] - Kodiak Sciences (KOD.US), target price $39: Anticipated data from three pivotal trials in 2026, with significant potential for stock volatility [7] - Intellia Therapeutics (NTLA.US), target price $45: Key data for hereditary angioedema therapy expected in mid-2026, with sufficient cash reserves to support operations [7] - Compass Therapeutics (CMPX.US), target price $8: Data for cholangiocarcinoma therapy expected in early 2026, with a significant market opportunity [8] - KalVista Pharmaceuticals (KALV.US), target price $38: First oral treatment for hereditary angioedema expected to see rapid growth in 2026 [8] Five Potential Acquisition Targets - Jefferies identified five companies that may become acquisition targets in 2026 due to their unique assets or market positions: - Arrowhead Pharmaceuticals (ARWR.US): Strong RNAi product line for cardiovascular and metabolic diseases [9] - Celcuity (CELC.US): Unique efficacy of gedatolisib in breast cancer [9] - ORIC Pharmaceuticals: High-value prostate and lung cancer projects [9] - Travere Therapeutics (TVTX.US): Potential for significant market expansion in rare kidney diseases [9] - KalVista Pharmaceuticals: First-mover advantage in oral HAE treatment [9]

Core Insights - Several small- and mid-cap stocks experienced notable gains in after-hours trading, driven by investor sentiment and sector momentum rather than new company news [1][2][3][4][5] Company Summaries - **Spyre Therapeutics, Inc. (SYRE)**: Closed at $34.71, up $1.65 or 4.99%, leading the list of gainers despite no new updates [1] - **The Oncology Institute, Inc. (TOI)**: Ended at $3.65, up $0.19 or 5.49%, with steady share price increase without new announcements [2] - **Aurora Cannabis Inc. (ACB)**: Closed at $5.70, gaining $0.13 or 2.33%, benefiting from renewed momentum in the cannabis sector [2] - **Solid Biosciences Inc. (SLDB)**: Finished at $5.45, up $0.07 or 1.30%, supported by the recent addition of Duchenne muscular dystrophy to the Recommended Uniform Screening Panel [3] - **EUDA Health Holdings Limited (EUDA)**: Closed at $2.74, gaining $0.12 or 4.58%, attracting buyers in after-hours trading [4] - **Lexeo Therapeutics, Inc. (LXEO)**: Ended at $9.50, up $0.39 or 4.28%, continuing a trend of strength in the biotech sector [4] - **Eledon Pharmaceuticals, Inc. (ELDN)**: Closed at $1.59, up $0.02 or 1.27%, managing a modest gain without new news [5]

CHARLESTOWN, Mass., Dec. 16, 2025 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today shared that the U.S. Department of Health and Human Services (HHS) officially added Duchenne muscular dystrophy (Duchenne) to the Recommended Uniform Screening Panel (RUSP), the list of conditions recommended for universal newborn screening across the United States. For nearly a dec ...

Solid Biosciences Inc. (NASDAQ:SLDB) is one of the stocks that will double in 2026. On December 4, Needham analyst Gil Blum initiated coverage of Solid Biosciences with a Buy rating and $16 price target. Blum noted that the recent deaths of two non-ambulatory Duchenne muscular dystrophy patients who received Sarepta’s drug, Elevidys, raise concerns about the treatment’s benefit-risk profile. This safety issue may create a significant opportunity for competing gene therapies, specifically citing Solid Biosc ...

Market Outlook - Kevin Mahn of Hennion & Walsh discussed the potential for a bullish year in 2026, despite expected volatility, citing historical data that shows the S&P 500 has risen by an average of just under 14% following 23 Fed interest rate cuts when the index was within 2% of its all-time high since 1950 [1] - Mahn anticipates that if the Fed cuts interest rates, the target rate would fall to a range of 3.5% to 3.75%, with only 50 basis points remaining to reach the Fed's neutral rate of 3% [2] Company Analysis: Bitfarms Ltd. (NASDAQ:BITF) - Bitfarms is projected to have an average upside potential of 104.08% by 2026, with 25 hedge funds holding stakes in the company [7] - The company reported Q3 2025 revenue of $83.66 million, an 86.52% increase year-over-year, although it missed Street expectations by $998.78K, and incurred a quarterly loss of $0.15 per share [10] - Bitfarms is transitioning from Bitcoin mining to becoming a leading North American HPC and AI infrastructure provider, which involves significant capital expenditure and operational changes, leading to execution risks [9] Company Analysis: Solid Biosciences Inc. (NASDAQ:SLDB) - Solid Biosciences has an average upside potential of 155.10% by 2026, with 25 hedge funds holding stakes in the company [11] - The company ended Q3 2025 with $236.1 million in cash and equivalents, up from $148.9 million at the end of 2024, which is expected to fund operations into H1 2027 [12] - Solid Biosciences' SGT-003 gene therapy trial has shown strong efficacy, with plans to meet with the FDA in H1 2026 to discuss accelerated approval pathways [13]

Core Insights - Solid Biosciences Inc. is presenting data on its proprietary capsid AAV-SLB101 and cardiac gene therapy pipeline at the Global CardioVascular Clinical Trialists Forum from December 8-10, 2025 [1][2] - The company aims to showcase the potential of its precision genetic approach to treat cardiac diseases, emphasizing the benefits of AAV-SLB101 [3][6] - Key personnel, including Dr. Gabriel Brooks and Dr. Nicolas Christoforou, will deliver presentations and participate in panel discussions at the forum [1][5][6] Company Overview - Solid Biosciences focuses on developing precision genetic medicines targeting rare neuromuscular and cardiac diseases, with a diverse pipeline including candidates for Duchenne muscular dystrophy and catecholaminergic polymorphic ventricular tachycardia [8] - The company is committed to advancing innovative genetic regulators and technologies to enhance gene therapy delivery across the industry [8] - Founded by individuals affected by Duchenne, Solid's mission is to improve the lives of patients with rare diseases [8]

Summary of Solid Biosciences FY Conference Call Company Overview - **Company**: Solid Biosciences (NasdaqGS:SLDB) - **Focus**: Gene therapy, primarily targeting Duchenne muscular dystrophy (DMD), Friedreich's ataxia, catecholaminergic polymorphic ventricular tachycardia (CPVT), and TNNT2-related cardiac diseases [5][6] Key Points and Arguments Pipeline and Differentiation - Solid Biosciences is developing a next-generation gene therapy platform, emphasizing the importance of delivery systems, including custom capsids and dual plasmids for improved purity [5][6] - The lead program, SGT-003, is a gene therapy for DMD, utilizing a novel capsid (SLB101) that has not been previously tested in humans [7][9][13] - The company has rebuilt its gene therapy program from the ground up, focusing on safety and efficacy, with early data showing promising results in cardiac output improvements in treated patients [14][15][46] Clinical Trials and FDA Interaction - The company plans to meet with the FDA in early 2026 to discuss data from 30 patients and the use of external controls for regulatory approval [17][18][32] - Solid Biosciences aims to initiate a registrational trial soon, with hopes of filing for accelerated approval based on the FDA's guidance [18][33] - The company is cautious about dosing older, sicker patients and intends to work closely with the FDA to ensure safety and efficacy [44][45] Safety and Efficacy Data - As of the latest update, 23 patients have been dosed, with plans to reach 28-30 by year-end [15][26] - No drug-induced liver injuries have been reported, although there was one case of grade three myositis linked to a specific genetic mutation [46][49] - The company is committed to excluding certain mutations from future dosing to mitigate risks [51] Future Developments - Solid Biosciences is preparing to dose patients in additional programs for Friedreich's ataxia and CPVT, with expectations to release safety data in early 2026 [72][75] - The company believes its gene therapy could significantly impact the treatment landscape for DMD and other conditions, with a potential market value of $4.5 billion based on competitor pricing [42] Research and Innovation - The company is exploring the unique properties of its capsid, which may have implications for gene therapy beyond its current applications [59][60] - Solid Biosciences is pursuing method of use patents related to its dosing strategies, which could influence future gene therapy protocols [62] Additional Important Insights - The company is focusing on younger patient cohorts (ages 0-3) for DMD, which presents a significant opportunity given the lack of existing treatments for this age group [41][42] - Solid Biosciences is also adapting its dosing strategies based on findings from ongoing trials, indicating a responsive approach to clinical data [64][70] - The company anticipates that its findings will not only benefit its own programs but could also influence the broader field of gene therapy [59][60] This summary encapsulates the key discussions and insights from the Solid Biosciences FY Conference Call, highlighting the company's strategic focus, clinical developments, and future opportunities in the gene therapy landscape.

Core Insights - Solid Biosciences has received FDA Rare Pediatric Disease and Fast Track designations for SGT-212, a gene therapy for Friedreich's ataxia [1][3] - SGT-212 is the only dual route gene therapy in development for Friedreich's ataxia, utilizing both intradentate nucleus and intravenous infusions [1][5] - The FALCON Phase 1b clinical trial is currently screening participants [1][3] FDA Designations - The Rare Pediatric Disease designation is for serious diseases affecting individuals under 18, potentially allowing the company to receive a pediatric priority review voucher (PRV) [2][4] - The PRV can expedite future Biologic License Applications and may be sold or transferred [2][4] Clinical Development - SGT-212 aims to restore therapeutic levels of the frataxin protein to address neurological, cardiac, and systemic manifestations of Friedreich's ataxia [1][5] - The therapy employs a dual route of administration, confirmed in real-time via MRI-enhancing contrast agent [5] Disease Overview - Friedreich's ataxia is a life-threatening degenerative disease caused by defects in the frataxin gene, affecting approximately 5,000 people in the U.S. and 15,000 in Europe [6] - The disease leads to progressive nervous system damage and cardiac dysfunction, with no current treatments available to halt its progression [6] Company Background - Solid Biosciences focuses on developing gene therapies for rare neuromuscular and cardiac diseases, including SGT-003 for Duchenne muscular dystrophy and SGT-501 for catecholaminergic polymorphic ventricular tachycardia [7][8] - The company aims to improve the lives of patients with rare diseases through innovative genetic medicine [8]