Summary of WuXi Biologics Earnings Review Company Overview - **Company**: WuXi Biologics (2269.HK) - **Market Cap**: HK$130.4 billion / $16.7 billion - **Current Price**: HK$30.62 - **12-Month Price Target**: HK$29.30 - **Downside**: 4.3% from current price Financial Performance - **1H25 Revenue**: Rmb9.95 billion, up 16.1% year-over-year (y/y), or 9% y/y excluding XDC [1] - **Net Profit**: Rmb2.34 billion, up 56% y/y; adjusted non-IFRS net profit increased by 12% y/y [1] - **Gross Margin**: Expanded by 3.6 percentage points y/y to 42.7%, attributed to reduced share-based employee incentives and improved capacity utilization [1] - **SG&A Ratio**: Stable at 10.6%, compared to 11.6% in 1H24 [1] - **3-Year Service Backlog**: Grew to US$4.21 billion, up 15.3% from 2H24, exceeding expectations [1][2] Revenue Guidance and Projections - **FY25 Revenue Guidance**: Raised to 14-16% y/y from previous 12-15% y/y, implying 19-21% growth for continuing operations [1] - **Long-term Gross Margin Target**: Management aims for a gross margin of 50% [1] - **Singapore Site Gross Margin Expectation**: Anticipated to reach ~45% due to large-scale capacity and advanced technologies [1] Project and Backlog Insights - **Total Backlog**: Increased to US$20.3 billion from US$18.5 billion at YE24 [2] - **Client Retention**: Over 90% retention in the R segment and more than 95% D-to-M conversion [2] - **New Projects**: 86 new projects signed in 1H25, with 25 PPQs scheduled for FY25, primarily in bi/multi-specific antibodies and ADCs [2][16] New Revenue Streams - **Milestone Backlog**: Increased to US$9.0 billion, with potential sales royalties and cell line royalties expected to contribute significantly to profits in the long term [17] - **IP-based Income Potential**: Could contribute 30% of profit in 5-6 years, driven by royalties and milestone payments [17] Capital Expenditure and Expansion Plans - **FY25 Capex Guidance**: Lowered to Rmb5.3 billion from Rmb6 billion, with significant allocation for biologics capacity expansion [18] - **Global Expansion Progress**: Notable advancements in manufacturing sites in Ireland, the U.S., and Singapore [18] Risks and Valuation - **Valuation Adjustments**: EPS estimates for 2025-2027 adjusted upwards by 15.9%, 11.9%, and 13.5% respectively due to better-than-expected margin improvements [20] - **Key Risks**: Legislative outcomes affecting revenue, cooling biotech funding, and increasing competition [20] Conclusion WuXi Biologics demonstrates strong financial performance with significant growth in revenue and backlog, alongside strategic plans for expansion and new revenue streams. However, potential risks from legislative changes and market competition remain critical considerations for investors.

Core Viewpoint - WuXi Biologics reported a 16% year-on-year increase in sales for the first half of the year, with adjusted net profit growing by 12%, aligning with market expectations [1] Financial Performance - The management raised the full-year revenue growth guidance from 12%-15% to 14%-16%, anticipating accelerated growth in unfulfilled orders to support long-term growth [1] - The revenue forecast for 2025 to 2027 has been increased by 2% to 9%, while net profit forecasts for 2026 to 2027 have been raised by 6% to 12%, reflecting strong mid-term performance and robust order growth [1] Strategic Insights - Beyond development and production, potential royalties and milestone payments are expected to be key drivers of WuXi Biologics' long-term growth [1] - The target price has been adjusted from HKD 28.8 to HKD 34.8, maintaining an "outperform" rating [1]

Core Viewpoint - The company has raised its profit forecasts for 2025/2026 due to smooth project progress and improved operational efficiency, maintaining an outperform rating in the industry [1] Financial Performance - The company reported 1H25 revenue of 9.95 billion, a year-on-year increase of 16.1%, with a continuous operating business revenue growth of 20.2% [2] - Gross margin reached 42.7%, up 3.6 percentage points year-on-year, while adjusted EBITDA was 4.31 billion, reflecting a 20.6% increase [2] - Adjusted net profit for 1H25 was 2.84 billion, a year-on-year increase of 11.6%, with a corresponding profit margin of 28.5% [2] Business Model and Growth - The CRDMO business model is fully operational, with over 50 molecular projects enabled, and potential milestone payments reaching 9 billion [3] - Revenue from preclinical stage projects was 4.15 billion, up 35.2% year-on-year, driven by research services and preclinical development project conversions [3] - Revenue from clinical phase III and commercialization reached 4.29 billion, a 24.9% increase, supported by the advancement of early projects and ongoing commercialization [3] Project and Order Status - The company signed 86 new projects in 1H25, with over 70% being complex molecules, showcasing its technical capabilities [4] - The company secured 9 new molecular projects, including 2 clinical phase III projects, primarily from the U.S. [4] - The total unfulfilled orders reached 20.3 billion, with approximately 4.2 billion in orders expected to be completed within three years [4] Capacity Expansion - Capital expenditure for 1H25 was approximately 1.9 billion, with an expected total of 5.3 billion for the year [5] - In Singapore, the modular biopharmaceutical production facility has commenced construction, while the modular bulk production facility is in the design phase [5] - In Ireland, the MFG6.2 facility has completed its first engineering batch and PPQ production, and MFG7 has completed its second 12kL scale PPQ production [5]

Core Viewpoint - The company has raised its net profit forecasts for 2025 and 2026 by 5.5% and 1.6% to 4.21 billion and 4.71 billion yuan respectively, due to smooth project progress and improved operational efficiency [1] Financial Performance - The company reported 1H25 revenue of 9.95 billion yuan, a year-on-year increase of 16.1%, with a continuous operating business revenue growth of 20.2% [2] - Gross margin reached 42.7%, up 3.6 percentage points year-on-year, while adjusted EBITDA was 4.31 billion yuan, reflecting a 20.6% increase [2] - Adjusted net profit for 1H25 was 2.84 billion yuan, an 11.6% year-on-year increase, exceeding expectations due to successful project advancements and improved efficiency [2] CRDMO Business Model - As of 1H25, the company has empowered over 50 molecular projects, with potential milestone payments and sales shares amounting to 9 billion USD [3] - Revenue from preclinical stage reached 4.15 billion yuan, a 35.2% increase, driven by research services and preclinical development project conversions [3] - Revenue from clinical phase III and commercialization reached 4.29 billion yuan, a 24.9% increase, supported by the advancement of early projects and ongoing commercialization [3] Project and Order Status - The company signed 86 new projects in 1H25, with over 70% being complex molecules, showcasing its technical capabilities [4] - The company secured 9 new molecular projects, including 2 clinical phase III projects, primarily from the U.S. [4] - As of 1H25, the total unfulfilled orders reached 20.3 billion USD, with approximately 4.2 billion USD in orders expected to be completed within three years [4] Global Capacity Expansion - Capital expenditure for 1H25 was approximately 1.9 billion yuan, with an expected total of 5.3 billion yuan for the year [5] - In Singapore, the modular biopharmaceutical production facility has commenced construction, while the modular bulk production facility is in the design phase [5] - In Ireland, the MFG6.2 has completed its first engineering batch and PPQ production, and MFG7 has completed its second 12kL scale PPQ production [5]

花旗发表研报指，将药明生物列为委托开发制造商(CDMO)领域首选标的之一，考虑收入增长加快及盈 利能力改善，目标价由35港元上调至40港元，予"买入"评级。另外，该行将2025至27年各年收入预测分 别上调2%、2%及1%，净利润预测分别上调15%、10%及11%。 ...

Core Insights - WuXi Biologics reported a 16.1% year-on-year revenue growth to 9.95 billion yuan for the first half of 2025, driven by the successful execution of its "Follow and Win Molecule" strategy and expansion of service offerings in the biopharmaceutical industry [1] - The company's IFRS net profit increased by 54.8% to 2.76 billion yuan, with profit attributable to shareholders rising by 56.0% to 2.34 billion yuan, primarily due to gross profit growth and returns from investments and asset optimization [1] - WuXi Biologics added 86 comprehensive development projects in the first half of 2025, with over 70% of new projects involving bispecific/multispecific antibodies and ADCs [1] Financial Performance - The company supported 67 clinical phase III projects and 24 commercial production projects as of June 30, 2025, with a 24.9% year-on-year increase in revenue from clinical phase III and commercial production, indicating a maturation of early projects and ongoing growth of existing commercial projects [2] - WuXi Biologics has a total unfulfilled order backlog of 20.34 billion USD, with unfulfilled service orders and potential milestone payment orders amounting to 11.35 billion USD and 9 billion USD, respectively [2] - The unfulfilled orders over the next three years increased from 3.65 billion USD in December 2024 to 4.21 billion USD, reinforcing expectations for near-term revenue growth [2] Future Outlook - Based on current performance, WuXi Biologics has raised its full-year revenue guidance for 2025 [3]

Core Viewpoint - The CRO (Contract Research Organization) industry is expected to enter a new development phase as adjustments are largely completed, with several broker reports indicating a recovery in the domestic pharmaceutical investment landscape in the second half of 2025 [1][4]. Company Summary - WuXi Biologics reported a revenue of 9.95 billion yuan for the first half of 2025, representing a year-on-year growth of 16.1%, and a net profit of 2.76 billion yuan, up 54.8% year-on-year [1][2]. - As of June 30, 2025, the total value of uncompleted orders reached 20.34 billion USD, with a three-year increase of 4.21 billion USD, reinforcing revenue growth expectations [2][3]. - The CEO of WuXi Biologics highlighted a robust performance with 86 new comprehensive projects signed, marking a record high for the same period [2]. - The company’s revenue from preclinical services grew by 35.2% year-on-year, benefiting from the transition of R&D service projects to the development phase [2][3]. - WuXi Biologics supported 67 clinical phase III projects and 24 commercial production projects, with revenues from these areas increasing by 24.9% year-on-year [2]. Industry Summary - Multiple broker reports suggest that the CRO industry has completed its adjustments and is poised for a new growth phase, with a recovery in global pharmaceutical investment expected by the end of 2023 [4]. - The domestic investment landscape is anticipated to recover in the second half of 2025, driven by a combination of internal and external demand, which may lead to continuous valuation recovery in the industry [4]. - The CRO industry returned to positive growth in the first quarter of this year, with expectations for this trend to continue throughout the year [4]. - Certain sub-sectors, such as peptides and ADCs, are benefiting from high demand, while the CDMO (Contract Development and Manufacturing Organization) sector is expected to maintain rapid growth [4].

Financial Data and Key Metrics Changes - Revenue reached nearly RMB 10 billion, representing a 16.1% increase year-over-year [28] - Adjusted EBITDA increased by 20.6% to RMB 4.3 billion, with an adjusted EBITDA margin of 43.3% [35][36] - Adjusted net profit exceeded RMB 2.8 billion, reflecting an 11.6% year-over-year increase [36] - Gross profit margin improved from 39.1% to 42.7%, with adjusted gross profit margin at 45.6% [7][40] Business Line Data and Key Metrics Changes - Research and Development (R&D) revenue grew over 35% year-over-year, driven by a strong pipeline of projects [30] - Late-phase and commercial manufacturing revenue grew close to 25%, representing over 43% of the total portfolio [30] - Early-phase revenue saw a decline due to timing issues with large-scale clinical manufacturing projects transitioning from phase two to phase three [30][31] Market Data and Key Metrics Changes - North America accounted for nearly 60% of revenue, with a growth rate of 20% [23] - Europe contributed close to 20% of revenue, showing modest growth as the company shifts focus from CMO projects to early-phase programs [24] - China represented 13% of revenue, experiencing a single-digit decline primarily due to out-licensing of programs to global partners [25] - Asia, particularly Japan, Korea, and Singapore, showed significant growth, now accounting for nearly 7% of revenue with more than double the growth rate [26] Company Strategy and Development Direction - The company emphasizes a unique CRDMO model, focusing on both service-based and IP-driven revenue streams [50][57] - The strategy includes expanding capacity globally, with significant investments in facilities in the US, Ireland, and Singapore [47][79] - The company aims to leverage its strong portfolio in ADCs and bispecifics, which now account for over 40% of its project portfolio [22] Management's Comments on Operating Environment and Future Outlook - Management noted that the company has absorbed post-COVID industry adjustments and is positioned for accelerated growth [28] - The backlog has shown significant growth, with milestone backlog increasing from RMB 7 billion to RMB 9 billion and service backlog from RMB 10 billion to RMB 11.3 billion [16][17] - The company expects to continue benefiting from global biotech trends, including M&A activities and out-licensing of Chinese assets to global partners [63][64] Other Important Information - The company achieved a 100% success rate in regulatory inspections, hosting 44 inspections [6] - Employee retention rate remains high at 98.8%, with no increase in total employee numbers over the past 18 months [42] - The company has a strong cash position with RMB 12.5 billion on hand and a conservative debt level of RMB 2.7 billion [43][47] Q&A Session Summary Question: What are the key drivers for revenue growth in the upcoming quarters? - Management highlighted the successful execution of the follow and win molecule strategies, with a strong pipeline of late-phase projects expected to ramp up [29] Question: How does the company plan to address the decline in early-phase revenue? - The decline is attributed to timing issues with large-scale projects transitioning to manufacturing, which is expected to be replenished by new projects in the pre-IND space [30][31] Question: What is the company's outlook on the global market trends? - Management expressed confidence in continued growth driven by M&A activities and the out-licensing of Chinese biotech programs to global partners, which typically results in significant revenue amplification [63][64]

Financial Data and Key Metrics Changes - Revenue reached nearly RMB 10 billion, representing a 16.1% increase year-over-year [27] - Adjusted EBITDA increased by 20.6% to RMB 4.3 billion, with an adjusted EBITDA margin of 43.3% [34] - Adjusted net profit exceeded RMB 2.8 billion, an 11.6% increase year-over-year [35] - Gross profit margin improved from 39.1% to 42.7%, with a gross profit increase of RMB 900 million [32][38] Business Line Data and Key Metrics Changes - Early phase R&D revenue grew over 35%, while late phase manufacturing revenue increased by nearly 25% [28][29] - The company added a record 86 new projects in the first half of the year, continuing strong momentum from the previous year [4][28] - The backlog grew significantly, with milestone backlog increasing from RMB 7 billion to RMB 9 billion and service backlog from RMB 10 billion to RMB 11.3 billion [16][17] Market Data and Key Metrics Changes - North America accounted for nearly 60% of revenue, with a growth rate of 20% [22] - Europe contributed close to 20% of revenue with modest growth, while China accounted for 13% with a single-digit decline [24] - Asia, particularly Japan, Korea, and Singapore, saw revenue growth exceeding 100% [25] Company Strategy and Development Direction - The company emphasizes its unique CRDMO model, which integrates R&D, development, and manufacturing [50][58] - Focus on expanding capabilities in ADCs and bispecifics, with over 300 projects in the pipeline [19][21] - Plans to enhance global capacity, with significant expansions in the US, Ireland, and Singapore [76][80] Management's Comments on Operating Environment and Future Outlook - Management noted that the company has absorbed post-COVID industry adjustments and is positioned for accelerated growth [27][28] - The company expects to continue benefiting from the increasing number of projects moving through its golden funnel [28] - Management expressed confidence in achieving positive free cash flow for the fourth consecutive year [48] Other Important Information - The company maintained a high employee retention rate of 98.8% and stable employee numbers despite revenue growth [6] - The company has a strong balance sheet with RMB 12.5 billion in cash and a conservative debt level of RMB 2.7 billion [42][47] - The company achieved a 100% success rate in regulatory inspections, reinforcing its quality assurance [6][81] Q&A Session Summary Question: What are the key drivers of revenue growth? - Revenue growth was primarily driven by successful execution of the follow and win the molecule strategies, with late phase and commercial manufacturing revenue growing close to 25% [28][29] Question: How is the company addressing the decline in early phase revenue? - The decline in early phase revenue is attributed to timing issues as several large-scale projects progressed from phase two to phase three, which is expected to be replenished by new projects [29] Question: What is the company's strategy for expanding its market presence? - The company aims to leverage its strong market share in China and capitalize on global licensing trends, expecting revenue to grow significantly as projects are out-licensed to global partners [64][65]

Financial Performance - Revenue increased by 16.1% year-over-year to RMB 10 billion[7], with adjusted EBITDA up 20.6% to RMB 4.3 billion[7] and adjusted net profit up 11.6% to RMB 2.8 billion[7] - Gross profit margin improved by 360 basis points to 42.7%[7], with adjusted EBITDA margin at 43.3% and adjusted net profit margin at 28.5%[7] - Basic earnings per share (EPS) increased by 56.8% to RMB 0.58[7] Business Growth and Backlog - Integrated projects increased by 16.4% year-over-year to 864[8] with 86 new projects added in 1H 2025[9] - Commercial projects increased by 50% year-over-year to 24[9] - Total backlog reached US$20.3 billion[9, 16], including US$11.4 billion in service backlog[17] and US$4.2 billion within 3 years[17] Revenue Breakdown and Geography - Pre-IND revenue rose 35.2% year-over-year in 1H 2025[11] - Late-stage + CMO revenue increased by 24.9% year-over-year[12] - North America revenue grew 20.1% year-over-year, accounting for 60.5% of total revenue[21, 22] Capacity and Quality - The company completed 44 regulatory inspections with a 100% success rate[9, 66] - The company has 16 drug substance facilities and DP facilities with ~500,000L bioreactor capacity[51] Technology and Innovation - The company has enabled 50+ programs with potential milestone & sales royalty[13, 40] - The company is scaling out single-use technology to large batch sizes, with 339 batches across 5 manufacturing facilities[99] WBS and ESG - The company is improving gross margin through WBS initiatives[105] - The company is committed to sustainability and has received several ESG ratings and awards[108]