-Â Utilizing Ascletis' Peptide Oral Transport ENhancement Technology (POTENT), ASC37 oral tablets achieved average absolute oral bioavailability of 4.2%, approximately 9-, 30-, and 60-fold higher than semaglutide, tirzepatide, and retatrutide in the oral SNAC formulation, respectively, in head-to-head non- human primate (NHP) studies. -Â ASC37 oral tablets' drug exposure, as measured by the area under curve (AUC), was approximately 57-fold of retatrutide's drug exposure in head-to-head NHP studies. -Â Avera ...

Market Overview - November experienced a significant late-month rally, transforming initial market fears into a strong comeback story, showcasing resilience despite early selling pressure [2][6][10] - The broader market showed strength, with almost all major indices closing higher for the month, defying expectations of a potential correction [10][20] AI Sector Impact - The sell-off in early November was triggered by Palantir Technologies' quarterly results, which, while good, raised concerns about AI valuations, leading to a broader decline in AI-linked stocks [3][4][5] - Following Palantir's report, other high-priced AI stocks like Nvidia and Microsoft also faced selling pressure, contributing to a temporary downturn in the technology sector [5][6] Market Resilience - Despite fears of an "AI bubble" and valuation resets, the market demonstrated resilience, with a strong rally in the last trading days of November [7][20] - The rally was attributed to various factors, including easing Treasury yields and improving technical conditions, but most importantly, it reflected the underlying demand for equities [9][20] Sector Rotation - November highlighted a rotation in market leadership, with cyclicals and value stocks gaining traction as tech stocks paused [17][18] - Financials, healthcare, and energy sectors saw renewed interest, while smaller-cap stocks also rebounded, indicating a healthier market tone [17][18] Technical Observations - The Nasdaq 100's failure to close positively in November raised questions, as it had been a leader in previous months, suggesting a potential "Great Mini Rotation" where the index took a breather while other sectors advanced [11][12][18] - Some analysts noted the potential formation of a "head and shoulders" pattern in the Nasdaq 100, which could indicate a shift in market dynamics if confirmed [13][20] Future Outlook - Heading into December, the market momentum appears strong, with expectations of Fed rate cuts and the seasonal "Santa Claus rally" effect potentially supporting further gains [19][20] - The broader market's ability to hold firm amidst uncertainty suggests a strong underlying strength, with bulls remaining in control as long as November's lows are maintained [22][23]

This major corporation is proving its resilience.This year has been challenging for major retailers, as President Donald Trump's tariffs have impacted their operations and consumer behavior. Walmart (WMT +1.29%), one of the largest of them all, hasn't completely escaped this problem. However, the company has navigated them better than most of its similarly sized peers. Walmart's latest financial results once again reminded the market why it is such a reliable company to invest in for the long haul. Let's lo ...

I am Steven Cress, Head of Quantitative Strategies at Seeking Alpha. I manage the quant ratings and factor grades on stocks and ETFs in Seeking Alpha Premium. I also lead Alpha Picks , which selects the two most attractive stocks to buy each month, and also determines when to sell them.Steven Cress is VP of Quantitative Strategy and Market Data at Seeking Alpha. Steve is also the creator of the platform’s quantitative stock rating system and many of the analytical tools on Seeking Alpha. His contributions f ...

The next Nvidia could be hiding in plain sight -- and it's not making GPUs.Wall Street loves chasing the next artificial intelligence (AI) darling. But the truly patient investors are already looking beyond today's graphics processing unit (GPU) shortage to a more fundamental shift in computing itself. Quantum computing has graduated from physics labs to Fortune 500 pilot programs -- and three publicly traded pure-play quantum companies are leading the charge.The search for the next Nvidia (NVDA 1.81%) requ ...

If you are thinking in decades and not days, this trio of dividend stocks could be the perfect starting point for your fledgling portfolio.If investing were easy, everyone would be doing it. Don't feel bad or give up before you start because investing is a daunting task. World famous investor Warren Buffett has extolled the virtues of temperament, saying its more important for investors than high intellect.Here are three stocks that can help you learn about investing as you go, providing you with "training ...

Analysts like this high-flying streaming stock.Imagine investing $10,000 in a stock and never selling a share. After 23 years, you check your portfolio. Your initial investment is now valued at approximately $8.9 million. You don't have to use your imagination if you bought shares of Netflix (NFLX +1.36%) in 2002. This stock, which recently conducted a 10-for-1 stock split, is up 88,600% since its IPO. Is Netflix still an excellent stock to buy? Wall Street thinks so. Streaming and soaringNetflix was a soli ...

Core Insights - The individual has a B.Tech degree in Mechanical Engineering and nearly twenty-five years of experience in the oil and gas sector, primarily in the Middle East [1] - The investment strategy is informed by traits of efficiency, carefulness, and discipline, developed through extensive industry experience [1] - There is a sustained interest in U.S. equity markets, focusing on technology, energy, and healthcare sectors [1] - The investment approach has evolved from growth investing to a blend of value and growth, emphasizing the understanding of business economics and competitive advantages [1] - The individual believes in the importance of allowing time and compounding to enhance investment returns, particularly in high-quality businesses [1] - A moderately conservative orientation is adopted, with a focus on minimizing downside risk as retirement approaches [1] - Recent rebalancing towards income-generating assets such as dividend-paying equities and REITs reflects a shift in investment priorities [1] - Investing is viewed as a means to achieve peace of mind, not just high returns [1] - The individual aims to engage with a community of investors interested in the intersection of business fundamentals and intelligent investing [1] - There is a commitment to investing in ecologically sensitive businesses, highlighting a focus on sustainability [1]

Core Viewpoint - The content emphasizes the importance of conducting personal due diligence and consulting competent advisors before making any financial decisions, particularly in the context of investments and trading [1]. Group 1 - The website provides general news, personal analysis, and third-party content intended for educational and research purposes [1]. - It explicitly states that the information does not constitute any recommendation or advice for investment actions [1]. - Users are advised to perform their own research and consider their financial situation before making decisions [1]. Group 2 - The website includes information about complex financial instruments such as cryptocurrencies and contracts for difference (CFDs), which carry a high risk of losing money [1]. - It encourages users to understand how these instruments work and the associated risks before investing [1].

Core Viewpoint - Shopify has historically provided significant returns for long-term investors, with a $1,000 investment at its IPO in May 2015 now worth approximately $60,000, although recent five-year performance has been less favorable compared to the S&P 500 [1][2]. Shopify's Five-Year Performance - Over the past five years, Shopify's stock has increased by 58%, which is underwhelming compared to the S&P 500's more than 100% increase during the same period [2]. - Shareholders who held the stock for five years experienced significant volatility, including a peak increase of 60% in the first year after buying in November 2020, followed by a decline of up to 87% due to a bear market and strategic missteps [4][5]. Recent Developments - By early 2023, the bear market was concluding, and Shopify sold its fulfillment network to Flexport in June 2023, which helped the company return to profitability and led to an increase in share price [5][6]. - Shopify's decision to exit the fulfillment business allowed it to refocus on its core software competencies, maintaining a competitive advantage in the e-commerce platform ecosystem [6][7]. Historical Context - The 2022 bear market was the only significant downturn in Shopify's over 10-year history, with previous sell-offs being relatively shallow and typically recovering quickly [7][8]. - Current trends indicate that with rising revenue and profits, another sustained sell-off like that of 2022 is becoming increasingly unlikely [8]. Investment Outlook - Despite underperforming the market over the last five years, Shopify stock is still considered a good investment, with the potential for continued outperformance due to ongoing revenue and profit growth [9][10]. - Historical instances of significant losses are rare, and Shopify has generally outperformed the market over most time periods, suggesting resilience even if purchased at a short-term peak [10].