机器之心PRO · 会员通讯 Week 28 --- 本周为您解读 ③ 个值得细品的 AI & Robotics 业内要事 --- 1. 下一代 AI 系统怎么改？让 AI 自己改？! 人类数据为何不足以支撑「经验时代」？DGM 验证了怎样的路径？「自进化」范式有哪些特征？让 AI 自我改进的框架和 RL 有 何异同？「自进化」有哪些研究视角？未来的「自进化」方案来自模块的排列组合？ ？... 2. 智元启动「买买买」，路径未明，资本抢跑，主流技术范式下谁在领跑具身智能赛道？ 相比端到端，双系统架构是否在高复杂场景下更稳定？大多数具身智能公司都倾向「自研本体+定制模型」的路径？从轮式、四 足到人形，不同本体背后有哪些模型设计差异？2025 年上半年，具身行业谁最受资本青睐？智元收购上纬新材，具身智能技术 未成却资本先行？ ... 3. Brett Adcock：装可爱的机器人没有未来？! Figure AI 已经在筹备量产了？Brett Adock 的飞机公司为做机器人带来了哪些经验？哪些要素促成了机器人能力的指数级突 破？Figure AI 也在「沿途下蛋」？为什么装可爱的机器人无法被社会接受？为什么没有机 ...

戴德梁行：上海二季度写字楼区域分化明显 零售商业迭代升级 大宗交易韧性中见新机 上海，2025年7月 2日——享誉全球的房地产服务和咨询顾问公司戴德梁行成功举办2025年上海二季度市场回顾媒体发布 会，针对写字楼市场、零售商业市场、大宗交易市场、产业地产市场以及资产管理市场进行多维度的解 读。 上海写字楼市场：甲级写字楼平稳过渡 区域分化明显 结构性机遇仍存 2025年二季度，上海甲级写字楼市场呈现量价继续承压。数据显示，本季度净吸纳量仅8.53万平方米， 环比、同比分别下滑18.4%与67.6%。受新增供应冲击，市场空置率持续攀升，至季度末达23.6%；甲级 写字楼平均租金承压下行，降至6.99元/平方米/天，环比跌幅1.9%。 供应端方面，二季度迎来4个新项目集中入市，为市场注入约24万平方米新增供应，核心商圈与新兴商 圈各占2席。分别为浦东竹园板块的"世纪财富广场"、长宁核心板块的"AFA上海融侨中心"、浦东洋泾 板块"恒基新岸商业中心"、闵行莘庄板块的"天荟云洲"，集中入市进一步加剧市场竞争压力。 从租赁需求结构来看，零售贸易制造与TMT行业成为租赁主力，合计占据市场半壁江山，占比分别为 28%、23 ...

Group 1 - The 2025 World Artificial Intelligence Conference aims to focus on 10 key areas including AI infrastructure, scientific intelligence, smart terminals, AI-enabled new industrialization, and AI+finance [1] - The conference will feature a structure of "1+1+2+10+N," which includes one opening ceremony and main forum, one high-level meeting on global AI governance, two plenary sessions on scientific frontiers and development safety, over ten ministerial forums, and multiple ecological forums [1] - Over 1,200 guests from more than 30 countries and regions have confirmed their attendance, including 12 Turing Award and Nobel Prize winners, over 80 academicians, and representatives from top international laboratories [1] Group 2 - The exhibition area for the conference will exceed 70,000 square meters, attracting over 800 participating companies, with more than 50% of them being from outside the city and international [2] - Major domestic AI leading companies, over 60 top foreign enterprises such as Siemens and Schneider, and more than 30 central state-owned enterprises will showcase their ecological partners [2] - More than 3,000 cutting-edge exhibits will be presented, including over 40 large models, 50 AI terminal products, 60 intelligent robots, and over 100 significant new products making their global or Chinese debut, marking the largest scale in the history of the event [2]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 碱基编辑器 （ Base editor， BE） 是胞嘧啶脱氨酶 （ cytosine deaminase ） 或腺嘌呤脱氨酶 （ adenine deaminase ） 与核酸酶活性丧失的 CRISPR 蛋白 （dCas） 共价融合而成的，其中，胞嘧啶碱基编辑器 （CBE） 可在基因组中实现 C:G 到 T:A 的碱基转换，腺嘌呤碱基编辑器（ABE）可在基因组中实现 A:T 到 G:C 的碱基转换。 然而，现有的碱基编辑器会修改编辑窗口内的所有胞嘧啶或腺嘌呤，这限制了它们碱基编辑的精确性。 2025 年 7 月 7 日，芝加哥大学 汤玮欣 团队在 Nature Biotechnology 期刊发表了题为： High-precision cytosine base editors by evolving nucleic-acid- recognition hotspots in deaminase 的研究论文。 该研究聚焦于开发高精度的 胞嘧啶碱基编辑器 （CBE） ，通过定向进化改造大肠杆菌的 tRNA 特异性腺苷脱氨酶 （TadA） ， 解决了现有碱基编辑器存在 的 ...

SynBio团队 | 陈国强教授 在生物技术领域，蛋白质定向进化技术作为一项关键工具，通过模拟自然进化过程，能够快速优化蛋白质功能，这为生物技术的诸多应用场景提供了可能 性。然而，传统的定向进化方法如易错 PCR 等存在效率低下、耗时较长以及突变库多样性受限等问题。 近年来，基于 CRISPR-Cas 或 T7 RNA 聚合酶的突变系统虽取得了一定进展，但仍面临突变范围局限、宿主兼容性较差等挑战，尤其在非模式生物中， 缺乏高效的蛋白质定向进化工具，极大地限制了其在工业生物技术领域的广泛应用。 【SynBioCon】 获 悉， 在此背景下， 清华大学 陈国强 教授团队 成功开发出 一种新型正交转录突变系统（OTM），用于加速体内蛋白质进化 。相关 文章以题为"An orthogonal transcription mutation system generating all transition mutations for accelerated protein evolution in vivo"发表在 Nature Communications 期刊。 图 | 正交转录突变系统的设计、开发、优化和应用 总的 ...

编辑丨王多鱼 排版丨水成文 蛋白质定向进化 是生物技术领域的重要工具，通过模拟自然进化过程，在实验室中快速优化蛋白质功能。 然而，传统方法如易错 PCR 存在耗时长、效率低、突变库多样性受限等问题。 近年来，基于 CRISPR -Cas 或 T7 RNA 聚合酶的突变系统虽取得进展，但仍面临 突变范围小、 宿主 普 适性 窄等挑战。在非模式生物 （例如 嗜盐单胞菌 Halomonas bluephagenesis ） 中， 缺乏高效的蛋白 质定向进化 工具，限制了其在工业生物技术中的应用。如何开发一种高效、 高特异性、 广宿主兼容且能 同时引入多种突变类型的系统，成为亟待解决的难题。 近日， 清华大学 陈国强 教授团队在 Nature Communications 期刊 发表了题为： An orthogonal transcription mutation system generating all transition mutations for accelerated protein evolution in vivo 的研究论文。 该开发了一种 正交转录突变系统 （ OTM ） 。该系统通过将 三种广宿 ...

更精妙的是，不同鱼类的"平衡策略"各具特色：胸鳍位置靠后的鱼类仿佛拥有更长的"操控杆"，能 更高效地调整姿态；体型修长的鱼类则需要付出更多能量对抗水流扰动；而那些圆润可爱的鱼，却凭借 紧凑的体型成为悬停界的"节能高手"。 原标题：鱼儿悬停水中为何要消耗更多能量 悬停时的鱼类代谢率比静止或休息时高出整整两倍。这种高耗能的生存策略，实则是数百万年进化 的结晶。譬如那些擅长高速巡游的鱼类，悬停效率更低些，但看似静止的身体，实则是积蓄力量的弹 簧，能像箭般在水域中疾驰；而那些生活在复杂珊瑚礁的鱼类，进化出了更圆润的体型，牺牲速度换取 悬停时的稳定性，可以静静等待猎物上门——这都是它们用身体写出的生存智慧密码。 在南加州圣克莱门特岛附近，一条加里波第鱼在水中悬停。图片来源：斯克里普斯海洋研究所 你在水族箱里见过这样的画面吗：鱼儿静止悬停在水中，仿佛被施了魔法般一动不动，连水流拂过 鱼鳍都纹丝不动。长久以来，科学家都认为这是鱼类最省力的休息姿势，但最新研究却颠覆了这一认知 ——悬停时的鱼儿，其实正在默默燃烧着两倍于休息状态的能量！这背后，是一场关于平衡、进化与流 体力学精妙博弈的故事。 几乎所有硬骨鱼体内都藏着一个神奇的 ...

Investment Rating - The report does not provide specific investment ratings for the industry segments [2]. Core Insights - The overall strategy emphasizes the evolution of the supply side in the new energy sector, focusing on innovation and avoiding "involution" in the market [3][5]. - The new energy vehicle supply chain is entering a new cycle, with companies like CATL benefiting from collaborations with tech giants like Xiaomi and Huawei [3][21]. - The lithium battery sector is expected to see a positive outlook, with production forecasted to exceed 130 GWh in July, marking a nearly 40% year-on-year increase [4][35]. - The photovoltaic industry is facing challenges due to overcapacity and competition, but recent government measures aim to optimize supply and stabilize the market [5][25]. Summary by Sections New Energy Vehicle Supply Chain - The downstream landscape is evolving, with companies like CATL collaborating with automakers to enhance production efficiency and shorten delivery times [3][27]. - The launch of Xiaomi's YU7 has exceeded expectations, indicating a shift in consumer behavior towards valuing emotional and intelligent experiences in vehicles [21][22]. Lithium Battery Sector - The lithium battery production is projected to grow, with significant investments in high-end products and solid-state technologies [4][35]. - Companies like Fulin Precision and Enjie are expanding their production capabilities, focusing on high-performance lithium iron phosphate and solid-state battery materials [4][31]. Photovoltaic Industry - The photovoltaic sector is expected to confirm a mid-term bottom as supply-side optimization measures are implemented [5][25]. - Major glass manufacturers in the photovoltaic industry plan to reduce production by 30% starting in July to address overcapacity issues [5][25]. Offshore Market Opportunities - Leading companies like EVE Energy are investing in overseas projects, such as a new energy storage project in Malaysia worth up to 8.654 billion yuan [4][22]. - The establishment of independent pricing systems and production capacities in overseas markets is seen as a strategy to enhance profitability [4][22]. AI and New Energy Integration - The integration of AI with new energy sectors is highlighted, with companies exploring innovative applications and market breakthroughs [8][21]. - The report notes the acceleration of controlled nuclear fusion technology, with companies like CFS partnering with Google for future energy supply [8][34].

Group 1 - The Guangdong Heyuan Dinosaur Museum houses over 20,000 dinosaur egg fossils, the largest collection in the world, providing insights into the mysteries of the Cretaceous period [1][3] - The museum features a variety of dinosaur eggs, including crystal-like eggs and thin-shelled eggs, each containing unique historical information [3] - The museum serves as a significant base for scientific research and public education about dinosaurs and Earth's evolutionary history [9] Group 2 - The Xiamen Science and Technology Museum has become a popular destination this summer, averaging over 10,000 visitors daily, with nearly 400 interactive exhibits [11] - The museum showcases the first public display of a 10-meter-long adult beaked whale specimen, which was salvaged and preserved after stranding in 2021 [13] - The exhibition includes interactive experiences that educate visitors about whale evolution and biology, enhancing engagement through immersive storytelling [19] Group 3 - The Shandong Museum is currently hosting the "Silver Sparrow Mountain Han Bamboo Slip Culture Exhibition," featuring nearly 5,000 bamboo slips unearthed from a Han tomb [21][23] - The exhibition presents significant historical artifacts, including the "Art of War" by Sun Tzu and Sun Bin, resolving long-standing historical debates [23] - The exhibition will last for three months and includes academic lectures and bamboo slip-making experiences for visitors [23] Group 4 - The National Museum's "Cosmic Archaeology: Time Exploration" exhibition opened on July 3, showcasing the visualization of data related to cosmic exploration [24][26] - The exhibition features various interactive displays, including a simulator for the Square Kilometer Array radio telescope and ancient astronomical maps [28] - This exhibition aims to merge science and art, making the invisible aspects of the universe visible to the public [26][28]

Group 1 - The core viewpoint of the articles emphasizes Shanghai's commercial market is experiencing a transformation driven by policy initiatives and market dynamics, focusing on enhancing consumption quality and quantity [1][5] - The Shanghai Municipal Commission of Commerce released the "2025 Consumption Expansion Action Plan," which aims to leverage the city's advantages as an international consumption center through supply-side innovation and consumer incentives [1] - In the first five months of 2025, retail sales in monitored commercial districts in Shanghai grew by 2.1% year-on-year, surpassing the overall growth rate of social retail sales [2] Group 2 - The average rent in Shanghai's core commercial districts was reported at 1,877 RMB per month per square meter, with an average occupancy rate of 94.71% in the second quarter of 2025 [2] - New shopping centers are emerging with a focus on ecological integration and thematic experiences, particularly in non-core districts, targeting younger consumers [2][3] - The Labubu series from Pop Mart saw a revenue surge of 106.92% year-on-year, contributing significantly to the brand's overall performance [3] Group 3 - The opening of the new LV landmark "Louis Number" in Shanghai represents a blend of art and commerce, featuring a total area of 1,600 square meters and various experiential offerings [3] - The Taikoo Group is collaborating with the Jing'an District government to enhance the Nanjing West Road area into a global retail destination, focusing on both historical preservation and modern retail [4] - The commercial market in Shanghai is expected to enter a "differentiated upgrade" phase, with new high-end commercial supply projected to reach 880,000 square meters by 2028 [5] Group 4 - Shanghai is the first city in China to officially launch a pilot program for retail innovation enhancement, focusing on diverse commercial formats and digital empowerment [6][8] - Key commercial districts participating in the pilot program include Nanjing East Road, Huaihai Middle Road, and Lujiazui, among others [8]