Several pharmaceutical stocks have come under pressure recently, mainly due to concerns surrounding the proposed "Most Favored Nations" (MFN) pricing model. While the HHS announcement appeared sweeping in scope - targeting all branded drugs - we believe any meaningful impact on drug prices is unlikely Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opini ...

特朗普喊话，药价砍30~80% 本文约 3500 字，推荐阅读时长 15 分钟，欢迎关注新财富公众号。 0 1 这不是特朗普第一次抛出药价"最惠国政策"的概念。 早在2020年任内，他就试图通过Medicare Part B项目来推动类似措施，希望压低部分高价注射药物的 政府医保采购成本，并预计未来七年节省850亿美元药费。但当时该政策因未履行完整行政立法程 序，被联邦法院裁定"程序违法"而叫停。 5月11日，特朗普在Truth Social上高调发声，宣布将签署一项重启的行政命令，推动"最惠国政策 （Most Favored Nations, MFN）"——这是一项看起来"很简单"的政策目标：美国的医保药价不能高 于别的国家，尤其是邻国如加拿大和墨西哥。特朗普甚至在公开表态中宣称，该政策一旦生效，美国 药品价格"将立刻下降30~80%"。 此次政策"回锅" 重启 ，同样没有明确的适用范围，也缺乏具体的执行细节 ，比如：是否仅覆盖联邦 老年人医保（Medicare），是否涵盖低收入群体医保（Medicaid），以及具体的价格锚定机制尚未公 开。这一"模糊性"也引发了市场和媒体的广泛质疑。 《华尔街日报》在评论 ...

Johnson & Johnson (NYSE:JNJ) Goldman Sachs 46th Annual Global Healthcare Conference Call June 11, 2025 3:20 PM ET Company Participants Tom Cavanaugh - Company Group Chairman for North America Innovative Medicine Conference Call Participants Asad Haider - Goldman Sachs Group, Inc., Research Division Asad Haider We're just right about at time, so let's get started. Tail end of day 3 of our conference, saving the best for last. Very welcome to Tom Cavanaugh, group -- Company Group Chairman, North American Inno ...

Bristol-Myers Squibb Company (BMY) FY Conference June 11, 2025 10:00 AM ET Speaker0 All right. We're just right about at time. So let's get started. Welcome to day three of our Healthcare Conference. My name is Assad Haidar. I'm The U. S. Pharmaceutical Analyst here at Goldman Sachs. I'm very, very pleased and privileged to have the Bristol Myers team over here, Chris Boerner, Chairman and CEO and Adam Wenkowski, Chief Commercial Officer. Chris and Adam, welcome, and thank you for being with us. It's great ...

Financial Data and Key Metrics Changes - The company is anticipating over $50 billion in revenue by the early to mid-2030s, driven by a diversified set of therapeutic areas including cardiometabolic, immunology, ophthalmology, vaccines, and HIV [4][5] - The company has invested over $12 billion in manufacturing strategy from 2018 to 2024, with an additional $9 billion planned to bring more manufacturing back to the U.S. [16][18] Business Line Data and Key Metrics Changes - The company has nearly 20 new assets and product launches planned over the next few years, marking a significant period of transformation and growth [3][4] - The oral PCSK9, enlicitide, has shown promising results in Phase III studies, with ambitions to be the most potent LDL cholesterol-lowering pill [3][50] Market Data and Key Metrics Changes - The U.S. market for cholesterol management shows that 70% of individuals are not at their cholesterol goals, indicating a significant opportunity for the company's PCSK9 products [49] - The company continues to see elevated inventories in the Chinese market for Gardasil, with expectations for future growth once market conditions improve [36] Company Strategy and Development Direction - The company is focused on executing its pipeline and leveraging its R&D capabilities across both human and animal health sectors, with a strong emphasis on operational synergies [71][72] - The company is committed to addressing drug pricing issues and is engaged in constructive dialogue with the administration regarding the MFN executive order [9][12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the safety and efficacy of their vaccines, particularly klezrovimab, despite regulatory uncertainties [23][24] - The company is optimistic about its growth trajectory, with more product launches planned than ever before in a five-year window [47] Other Important Information - The company is actively pursuing business development opportunities, with a focus on identifying strategic assets that align with its scientific goals [40][41] - The company is expanding its immunology focus, particularly around the TL1A class, which is seen as a significant therapeutic target [42][43] Q&A Session Summary Question: What are the expectations regarding the political environment and MFN pricing? - Management indicated ongoing constructive dialogue with the administration and a willingness to collaborate on drug pricing solutions [7][9] Question: How is the company addressing the manufacturing shift for KEYTRUDA? - The company is bringing back KEYTRUDA manufacturing to the U.S. through a phased approach, with significant investments in infrastructure [18][19] Question: What is the outlook for Gardasil sales in the U.S.? - Management acknowledged potential headwinds from discussions around lower dosing recommendations but remains confident in the vaccine's value [26][34] Question: What is the company's strategy for business development? - Management emphasized that the recent slowdown in business development activity is due to timing rather than a change in strategy or urgency [40][41] Question: How does the company view the competitive landscape in oncology? - The company is focused on advancing its broad ADC program and is committed to moving quickly in the oncology space [62][64]

Pfizer Inc. (NYSE:PFE) Goldman Sachs 46th Annual Global Healthcare Conference June 9, 2025 8:00 AM ET Company Participants Albert Bourla - Chairman of the Board & CEO Conference Call Participants Asad Haider - Goldman Sachs Group, Inc., Research Division Asad Haider Great. Good morning, everyone, and welcome to our 46th Annual Global Healthcare Conference. My name is Asad Haider, I'm the U.S. pharma analyst here at Goldman Sachs and we are very privileged to have Albert Bourla with us to kick off this confe ...

Pfizer (PFE) FY Conference June 09, 2025 08:00 AM ET Speaker0 Great. Good morning, everyone, and welcome to our forty sixth Annual Global Healthcare Conference. My name is Assad Heather. I'm The U. S. Pharma Analyst here at Goldman Sachs. And we are very privileged to have Albert Bula with us to kick up this conference. Albert's the CEO of Pfizer. Albert, thank you for being with us. Speaker1 Great pleasure. Speaker0 Albert, we have about thirty five minutes, so I wanna start with a big picture question for ...

Summary of Alnylam Pharmaceuticals (ALNY) 2025 Conference Call Company Overview - **Company**: Alnylam Pharmaceuticals (ALNY) - **Event**: Bank of America Healthcare Conference - **Date**: May 14, 2025 Key Industry Insights - **Impact of Executive Orders**: The recent executive order regarding most favored nation pricing is still developing, making it difficult to assess its implications for Alnylam. However, the company benefits from having orphan drugs in the U.S., which may exempt them from future price negotiations under the IRA [3][4] - **Tariffs**: Current tariffs do not materially impact Alnylam's guidance, as the majority of their manufacturing is done in the U.S. through contract manufacturing organizations (CMOs) [8][9] Product Launch and Market Dynamics - **Cardiomyopathy Launch**: The launch of the cardiomyopathy product is a significant focus. Initial metrics show that 50% of health systems have completed the PNT process and are on formulary within five weeks of launch, which is faster than anticipated [18][19] - **Revenue Guidance**: Alnylam has guided for TTR revenue between $1.6 billion and $1.725 billion for the year, representing a 36% growth at the midpoint [23] - **Patient Access**: Approximately 70% of patients on the drug have zero out-of-pocket costs, primarily due to Medicare fee-for-service coverage [30] Competitive Landscape - **Market Size and Segmentation**: There are about 18,000 new patients initiating therapy annually, with a significant opportunity to increase diagnosis rates, currently at a 20% diagnosis rate [48] - **First-Line vs. Second-Line Treatment**: Alnylam is focused on first-line treatment due to the progressive nature of the disease and the need for effective early intervention [49] Patient and Physician Engagement - **Patient Compliance**: Alnylam has observed good compliance rates with their injectable therapies, which may be more effective than oral alternatives in ensuring patients receive the necessary treatment [58][60] - **Physician Awareness**: There is a good level of awareness among physicians regarding Alnylam's products, but further education is needed as the company expands its prescriber base [74] Future Outlook - **Revenue Reporting**: Alnylam will not be able to report revenue separately for Ambutra PN and Ambutra Centimeters due to them being the same product under one SKU [67] - **Market Positioning**: Alnylam is uniquely positioned to capture a broad patient base, including both hereditary and wild-type patients, due to its comprehensive label [72][73] Additional Considerations - **Direct-to-Consumer (DTC) Marketing**: Alnylam is engaging in targeted DTC marketing but is not heavily investing in broad campaigns like some competitors [65] - **Value-Based Agreements (VBAs)**: The company is extending its VBAs to ensure adherence and compliance, which is favorable for both patients and payers [60][61]

Company Overview - AbbVie has a strong leadership team with key executives including Jeff Stewart (EVP and Chief Commercialization Officer), Roopal Thakkar (EVP and R&D, Chief Scientific Officer), and Scott Reents (EVP and CFO) [1][2] Current Challenges - The company is experiencing some disruption due to external factors such as MFN (Most Favored Nation) policies and tariffs, which are impacting operational timelines [3][4] - There is an ongoing discussion about the level of disruption and the time it is taking to adapt to these changes, indicating that the company is actively involved in contingency planning [3][4]

AbbVie (ABBV) 2025 Conference Summary Company Overview - **Company**: AbbVie (ABBV) - **Date of Conference**: May 14, 2025 - **Key Speakers**: - Jeff Stewart, Executive Vice President, Chief Commercialization Officer - Rupl Thacker, Executive Vice President, R&D Chief Scientific Officer - Scott Rantz, Executive Vice President, Chief Financial Officer Key Points and Arguments Industry and Market Dynamics - **Disruption and Contingency Planning**: AbbVie acknowledges some disruption due to external factors but emphasizes that it is not affecting business execution. The management team is actively involved in contingency planning and assessing implications of changes in the market [4][6][9]. - **Drug Pricing Policies**: The company is taking the potential impact of new executive orders on drug pricing seriously, indicating that they are closely monitoring developments and preparing for various scenarios [6][8][9]. - **Pricing Equalization**: AbbVie believes that the concept of equalizing drug prices between the US and Europe is complex and may not be feasible due to different healthcare systems and pricing controls in Europe [10][11][12]. Financial Performance and Projections - **Revenue Guidance**: AbbVie has increased its revenue guidance for SKYRIZI and RINVOQ to a combined $31 billion by 2027, with SKYRIZI expected to generate $20 billion and RINVOQ $11 billion [55][56]. - **Immunology Market**: The immunology segment remains a significant revenue driver, with expectations of continued growth despite pricing pressures. The company anticipates low single-digit price degradation over the next five years [51][53]. Research and Development - **M&A Strategy**: AbbVie has been active in M&A, completing over 25 transactions since early 2024, focusing on filling its pipeline in neuroimmunology and oncology [31][32]. - **Obesity Market Entry**: AbbVie has entered the obesity market through a licensing deal with Gubra for an amylin compound, highlighting the potential for differentiation and long-term market opportunities [33][39]. Competitive Landscape - **Direct-to-Consumer Advertising**: AbbVie is the largest DTC advertiser in the pharmaceutical industry. The company is prepared to pivot its marketing strategies if regulations on DTC advertising are imposed [19][21][23]. - **Oral vs. Injectable Therapies**: AbbVie believes that while oral therapies are emerging, injectable products like SKYRIZI and RINVOQ will remain insulated from significant competition due to their efficacy and convenience [64]. Other Important Insights - **Tariffs and Supply Chain**: AbbVie is monitoring the potential impact of tariffs on its supply chain and is implementing mitigation strategies to ensure product availability [26][28][29]. - **Market Growth in Obesity**: The obesity market is expected to grow significantly, with AbbVie anticipating a cash pay component that will support its aesthetics business [48]. Conclusion AbbVie is strategically navigating a complex pharmaceutical landscape with a focus on maintaining growth through innovation, M&A, and effective contingency planning. The company is well-positioned to address challenges related to drug pricing, market competition, and regulatory changes while capitalizing on emerging opportunities in the obesity market and maintaining its leadership in immunology.