There are good scientific reasons to tend to your microbiome. Having a diverse assortment of gut bugs, with plenty of the good kind, seems to confer broad health benefits. Here is how to go about it https://t.co/hK562a7j6a ...

There are good scientific reasons to tend to your microbiome. Having a diverse assortment of gut bugs, with plenty of the good kind, seems to confer broad health benefits. Here is how to go about it https://t.co/J8Mx5w4nej ...

There are good scientific reasons to tend to your microbiome. Having a diverse assortment of gut bugs, with plenty of the good kind, seems to confer broad health benefits. Here is how to go about it https://t.co/gHY1f0NuML ...

Studies showed that if you are flossing, you can reduce your risk of dementia by nearly half, which is quite impressive. So I started to research the brain much more and it made me realize this link with the brain and the gut is absolutely crucial and how that influences many things in our brain. For example, things like depression, mood changes, fatigue and energy. But for 40 years, we've been going down the wrong path. We've got so distracted by treating the brain as something so different to the rest of ...

Core Insights - Persephone Biosciences announced topline results from the AMBROSIA Food as Medicine clinical study, which investigated the impact of diet and lifestyle on the microbiome in collaboration with Kroger Health [1][2] - The study identified three enterotypes, with one linked to increased BMI and poorer diet, and demonstrated that Medical Nutritional Therapy (MNT) can improve microbiome composition and facilitate enterotype switching [5][6] Study Overview - The AMBROSIA study is the largest to evaluate the impact of MNT on diet quality and gut microbiome, enrolling 546 participants aged 18-64 at high risk of colorectal cancer [2][5] - Participants were randomized into two groups: one receiving MNT for 4 months and the other serving as a control group with no dietary modifications [3] Key Findings - Enterotype 3, dominated by Prevotella, was associated with higher BMI, lower diet scores, and lower microbial diversity [6] - The MNT cohort showed higher final diet scores and greater movement between enterotypes compared to the control group after 4 months [6] - The study found a direct correlation between the number of MNT visits and the percentage of goals attained with diet scores [6] Implications for Healthcare - The findings suggest that MNT, combined with microbiome analysis, could enhance personalized nutrition and lead to better health outcomes [6] - The data from the AMBROSIA trial will also be used to assess the relationship between gut bacteria and colorectal cancer risk, which is a leading cause of cancer-related deaths in the U.S. [7]

Gut Health & Market Opportunity - 80% of chronic diseases are linked to poor gut health, resulting in $100 billion in direct medical costs annually in the US alone [4] - Current gut health testing methods are costly, inconvenient, slow, and fail to capture daily shifts in the gut microbiome [7] - The company aims to provide a home-based, real-time gut health monitoring solution [11][13] Technology & Solution - The company is developing a "homeable" for gut health, enabling users to sample, sense, act, and repeat, turning gut feelings into hard data [13][14] - The solution combines daily gut health data with AI to bring a lab to the user's home [11] - The device aims to provide personalized feedback on diet, probiotics, and potential illness detection [14][15] Competitive Advantage - The company emphasizes the importance of frequency, context, privacy, and agency in gut health monitoring [12] - Daily loops of testing at home can change everything [12] - The company is building the first female athlete microbiome data set [17] Personal Motivation & Vision - The founder's personal experience as an athlete with gut issues drives the development of the solution [2][11] - The company's vision is to enable individuals to measure their normal gut health and adjust gently to improve longevity [18] - The founder is undertaking a 365-day sprint to measure her gut health and optimize her training and diet [15][16]

Curcumin & Turmeric Benefits - A 2016 study found curcumin comparable to ibuprofen for pain relief [1] - Early studies show curcumin from turmeric may impact brain health [1] - Turmeric is considered an extraordinary remedy [1] - Turmeric and curcumin are beneficial for the microbiome [2] Curcumin Absorption & Toxicity - Curcumin absorption into the body is very low, around 1-2% [2] - Low absorption is likely due to curcumin toxicity at high doses [2] Microbiome Importance - The microbiome, consisting of trillions of bugs in the gut, plays a significant role in bodily functions [3] - The microbiome has more cells than the body's own cells [3]

Regulatory Transparency & Flexibility - The FDA emphasizes regulatory flexibility, tailoring processes to specific conditions, especially rare and incurable ones, considering limited alternatives [1][2] - Drug developers and pharmaceutical companies deserve predictability, as highlighted by the framework for COVID vaccine regulation published in the New England Journal of Medicine [4][5] - The FDA aims for transparency by releasing decision letters to the public and drug developers, modernizing the agency, and addressing misinformation, including rewriting dietary guidelines with USDA [12][13] Vaccine & Booster Recommendations - While the CDC sets the vaccine schedule, the FDA has approved vaccines for high-risk populations; booster shots for low-risk individuals require more research [5][6] - There are scientific unknowns and polarizing views regarding the necessity and frequency of COVID boosters, especially for healthy young individuals, alongside concerns about vaccine injuries [8][9] Public Trust & Misinformation - Public trust in health institutions has significantly declined, with trust in doctors and hospitals dropping from 71% to 40% in the last four years, necessitating rebuilding efforts [10][11] - The FDA is addressing misinformation by rewriting the food pyramid with USDA, ending the "war on natural saturated fat," and clarifying the difference between whole grains and ultra-processed foods [13] Food & Dietary Guidelines - The FDA is taking action to remove petroleum-based food dyes, inspired by previous discussions on removing "poisons and chemicals" from the food supply [17][18] - The FDA acknowledges the addictive nature of processed foods, designed by food scientists, contributing to chronic diseases and insulin resistance in children [20][21] - The SNAP program now has waivers for states to restrict taxpayer dollars from being used for junk food and sugary drinks [22] Women's Health - Women's health issues have been historically overlooked, prompting the FDA to host a roundtable on hormone replacement therapy for perimenopausal women [25][26] - The NIH is refocusing its funding to study root causes of chronic diseases, including school lunch programs, sleep medicine, and environmental exposures [29] Opioid Crisis & Supplements - The FDA, along with the DEA, is taking action to schedule 7-hydroxy mitragynine (7-OHM), a synthetic opioid found in vape stores, which is 13 times more potent than morphine [35][36] - The FDA is concerned about the unregulated nature of supplements and the need for regulation to ensure Americans are taking trustworthy and healthy products [33]

Biological Composition & Symbiosis - The human body is composed of approximately 30 trillion human cells and 39 trillion microbial cells, indicating humans are outnumbered by microbes within their own bodies [1] - Symbiosis, or cooperation, is a fundamental aspect of biology, as important as competition in evolution [3] - Mitochondria, essential for eukaryotic life, evolved from bacteria through a symbiotic relationship [4] - Microbes in the digestive tract aid in breaking down indigestible foods and enhancing nutrient absorption [5][6] - E coli on the skin protect against harmful pathogens by providing a barrier against invaders [7] Genetic Diversity & Microbiome Impact - The human genome contains approximately 22,000 protein-coding genes, a surprisingly low number compared to other organisms [8] - Human biodiversity is significantly influenced by the microbiome, which shapes individual experiences throughout life [9][10] Ecological Perspective - Viewing the human body as a collective of organisms highlights the importance of balance and strength within this ecosystem [10] - Humans, like microbes on the planet's skin, have a responsibility to protect and preserve the Earth as a superorganism [11]

Core Argument - The gut microbiome, consisting of trillions of microorganisms, significantly influences human feelings, decisions, memory, immunity, and cravings [1][2][3][4] - The gut and brain are connected via a highly active communication pathway, impacting decision-making processes [4][5] Research & Experimentation - A research study is being conducted with patients undergoing digestive tract surgery, using kombucha as a probiotic and a placebo to study the impact on the microbiome [8][9] - Placebo effects are crucial in microbiome research to differentiate the impact of probiotics from the psychological effects of treatment [10][11][12] - Studies show that altering the microbiome with probiotics can influence risk-taking behavior, patience, and reactions to unfairness [13][14][15][16][17][18][19][31] Microbiome & Lifestyle - Urban living can reduce the diversity of the gut microbiome by approximately fourfold compared to living closer to nature [33] - A diet beneficial for the microbiome includes natural, unprocessed foods, vegetables (ideally not perfectly cleaned), and fermented foods like kimchi and kombucha [35] - Alcohol consumption, even in small amounts, can harm the gut microbiome [35][36]