- AMBROSIA is the largest study to evaluate the impact of Medical Nutrition Therapy (MNT) on diet quality and the gut microbiome, with 546 participants enrolled - - Topline results from the study identified three enterotypes, one of which was associated with increased BMI and poorer diet, and demonstrated that MNT can successfully improve microbiome composition and enable patients to switch enterotypes - - The U.S.-based study was run in collaboration with Kroger Health, the healthcare division of The Kroge ...

Gut Health & Market Opportunity - 80% of chronic diseases are linked to poor gut health, resulting in $100 billion in direct medical costs annually in the US alone [4] - Current gut health testing methods are costly, inconvenient, slow, and fail to capture daily shifts in the gut microbiome [7] - The company aims to provide a home-based, real-time gut health monitoring solution [11][13] Technology & Solution - The company is developing a "homeable" for gut health, enabling users to sample, sense, act, and repeat, turning gut feelings into hard data [13][14] - The solution combines daily gut health data with AI to bring a lab to the user's home [11] - The device aims to provide personalized feedback on diet, probiotics, and potential illness detection [14][15] Competitive Advantage - The company emphasizes the importance of frequency, context, privacy, and agency in gut health monitoring [12] - Daily loops of testing at home can change everything [12] - The company is building the first female athlete microbiome data set [17] Personal Motivation & Vision - The founder's personal experience as an athlete with gut issues drives the development of the solution [2][11] - The company's vision is to enable individuals to measure their normal gut health and adjust gently to improve longevity [18] - The founder is undertaking a 365-day sprint to measure her gut health and optimize her training and diet [15][16]

Curcumin & Turmeric Benefits - A 2016 study found curcumin comparable to ibuprofen for pain relief [1] - Early studies show curcumin from turmeric may impact brain health [1] - Turmeric is considered an extraordinary remedy [1] - Turmeric and curcumin are beneficial for the microbiome [2] Curcumin Absorption & Toxicity - Curcumin absorption into the body is very low, around 1-2% [2] - Low absorption is likely due to curcumin toxicity at high doses [2] Microbiome Importance - The microbiome, consisting of trillions of bugs in the gut, plays a significant role in bodily functions [3] - The microbiome has more cells than the body's own cells [3]

Regulatory Transparency & Flexibility - The FDA emphasizes regulatory flexibility, tailoring processes to specific conditions, especially rare and incurable ones, considering limited alternatives [1][2] - Drug developers and pharmaceutical companies deserve predictability, as highlighted by the framework for COVID vaccine regulation published in the New England Journal of Medicine [4][5] - The FDA aims for transparency by releasing decision letters to the public and drug developers, modernizing the agency, and addressing misinformation, including rewriting dietary guidelines with USDA [12][13] Vaccine & Booster Recommendations - While the CDC sets the vaccine schedule, the FDA has approved vaccines for high-risk populations; booster shots for low-risk individuals require more research [5][6] - There are scientific unknowns and polarizing views regarding the necessity and frequency of COVID boosters, especially for healthy young individuals, alongside concerns about vaccine injuries [8][9] Public Trust & Misinformation - Public trust in health institutions has significantly declined, with trust in doctors and hospitals dropping from 71% to 40% in the last four years, necessitating rebuilding efforts [10][11] - The FDA is addressing misinformation by rewriting the food pyramid with USDA, ending the "war on natural saturated fat," and clarifying the difference between whole grains and ultra-processed foods [13] Food & Dietary Guidelines - The FDA is taking action to remove petroleum-based food dyes, inspired by previous discussions on removing "poisons and chemicals" from the food supply [17][18] - The FDA acknowledges the addictive nature of processed foods, designed by food scientists, contributing to chronic diseases and insulin resistance in children [20][21] - The SNAP program now has waivers for states to restrict taxpayer dollars from being used for junk food and sugary drinks [22] Women's Health - Women's health issues have been historically overlooked, prompting the FDA to host a roundtable on hormone replacement therapy for perimenopausal women [25][26] - The NIH is refocusing its funding to study root causes of chronic diseases, including school lunch programs, sleep medicine, and environmental exposures [29] Opioid Crisis & Supplements - The FDA, along with the DEA, is taking action to schedule 7-hydroxy mitragynine (7-OHM), a synthetic opioid found in vape stores, which is 13 times more potent than morphine [35][36] - The FDA is concerned about the unregulated nature of supplements and the need for regulation to ensure Americans are taking trustworthy and healthy products [33]

Biological Composition & Symbiosis - The human body is composed of approximately 30 trillion human cells and 39 trillion microbial cells, indicating humans are outnumbered by microbes within their own bodies [1] - Symbiosis, or cooperation, is a fundamental aspect of biology, as important as competition in evolution [3] - Mitochondria, essential for eukaryotic life, evolved from bacteria through a symbiotic relationship [4] - Microbes in the digestive tract aid in breaking down indigestible foods and enhancing nutrient absorption [5][6] - E coli on the skin protect against harmful pathogens by providing a barrier against invaders [7] Genetic Diversity & Microbiome Impact - The human genome contains approximately 22,000 protein-coding genes, a surprisingly low number compared to other organisms [8] - Human biodiversity is significantly influenced by the microbiome, which shapes individual experiences throughout life [9][10] Ecological Perspective - Viewing the human body as a collective of organisms highlights the importance of balance and strength within this ecosystem [10] - Humans, like microbes on the planet's skin, have a responsibility to protect and preserve the Earth as a superorganism [11]

Core Argument - The gut microbiome, consisting of trillions of microorganisms, significantly influences human feelings, decisions, memory, immunity, and cravings [1][2][3][4] - The gut and brain are connected via a highly active communication pathway, impacting decision-making processes [4][5] Research & Experimentation - A research study is being conducted with patients undergoing digestive tract surgery, using kombucha as a probiotic and a placebo to study the impact on the microbiome [8][9] - Placebo effects are crucial in microbiome research to differentiate the impact of probiotics from the psychological effects of treatment [10][11][12] - Studies show that altering the microbiome with probiotics can influence risk-taking behavior, patience, and reactions to unfairness [13][14][15][16][17][18][19][31] Microbiome & Lifestyle - Urban living can reduce the diversity of the gut microbiome by approximately fourfold compared to living closer to nature [33] - A diet beneficial for the microbiome includes natural, unprocessed foods, vegetables (ideally not perfectly cleaned), and fermented foods like kimchi and kombucha [35] - Alcohol consumption, even in small amounts, can harm the gut microbiome [35][36]

To keep the microbiome healthy, diet is key. Microbes thrive on foods rich in fibre and digestion-resistant starch, so munching on fresh fruit, vegetables, legumes and nuts is a good place to start https://t.co/BmgXuK66Xb ...

To keep the microbiome healthy, diet is key. Microbes thrive on foods rich in fibre and digestion-resistant starch, so munching on fresh fruit, vegetables, legumes and nuts is a good place to start https://t.co/X9TdwjNFQy ...

Health Crisis & Inflammation - The health industry recognizes a crisis of inflammation, with half of the deaths globally linked to inflammatory conditions like heart disease, diabetes, and dementia [1][2] - The food industry suggests that the scale of suffering from inflammatory conditions might be a byproduct of a broken food system [2] Gut Microbiome & Diet - The scientific community highlights the importance of gut bacteria, noting that humans host trillions of these microorganisms in their gut [6] - The scientific community indicates that gut bugs thrive on fiber from plants, producing beneficial neurotransmitters and supporting the immune system [7][8] - The food industry observes a decline in gut microbial diversity, linking it to the consumption of processed foods lacking fiber and containing chemicals that inhibit bacterial growth [13][14] Food System Transformation - The food industry reports a significant shift in dietary habits, with processed foods now constituting two-thirds of the average diet, a reversal from the 1980s [11] - The food industry warns that ultra-processed foods, while convenient and palatable, are pro-inflammatory and contribute to obesity and illness, with one in four 11-year-olds being overweight or obese [13] - The agricultural sector notes that 50% of human calorie intake comes from just three crops, highlighting a lack of biodiversity in food production [15] Solutions & Future Outlook - The food industry advocates for a shift towards fresh, natural foods in various settings, emphasizing their role in reconnecting individuals with nature and supporting gut health [16][17] - The food industry promotes the idea of becoming "food rebels" by making conscious food choices to protect inner and outer ecosystems, fostering hope for a healthier future [18][19]

Industry Trend - Awareness of the microbiome has grown, leading to increased availability of products designed to boost good bacteria in health-food shops [1] Product Analysis - The report questions the effectiveness of products claiming to boost good bacteria [1]