Company Overview - 欧林生物 is a global, innovation-driven biopharmaceutical company focused on the research, development, production, and commercialization of innovative vaccines, particularly in the areas of "superbug vaccines" and "adult vaccines" [2][3] - Unlike many biotechnology companies that have yet to generate revenue, 欧林生物 has a mature commercialization platform with three products already commercialized: Tetanus Toxoid Vaccine, Hib Conjugate Vaccine, and AC Conjugate Vaccine [2] Market Position - The company's Tetanus Toxoid Vaccine holds a leading market position in China, with a market share exceeding 80% from 2022 to 2024 [2] - 欧林生物 possesses the most comprehensive pipeline targeting "superbugs" globally, addressing significant public health challenges due to antibiotic resistance [2][3] Product Pipeline - The company is developing a 1.1 class innovative superbug candidate vaccine targeting five pathogens, including: - Recombinant Staphylococcus aureus Vaccine (rFSAV) - Oral Recombinant Helicobacter pylori Vaccine (rHPV) - Recombinant Pseudomonas aeruginosa Vaccine (rFPAV) - Recombinant Acinetobacter baumannii Protein Vaccine (rABV) - Group A Streptococcus Vaccine (GAS Vaccine) [2] Financial Performance - Revenue for 欧林生物 is projected as follows: - 2022: approximately 547 million RMB - 2023: approximately 494 million RMB - 2024: approximately 586 million RMB - 2024 (first half): approximately 225 million RMB - 2025 (first half): approximately 305 million RMB [4][6] - Profit figures are as follows: - 2022: approximately 26.58 million RMB - 2023: approximately 11.44 million RMB - 2024: approximately 15.72 million RMB - 2024 (first half): approximately -30.72 million RMB - 2025 (first half): approximately 13.23 million RMB [5][6] Industry Overview - The global vaccine market (excluding COVID-19 vaccines) is expected to grow from 52.9 billion USD in 2019 to 73.8 billion USD by 2024, with a CAGR of 6.9% [8] - The Chinese vaccine market (excluding COVID-19 vaccines) is projected to grow from 42.5 billion RMB in 2019 to 102 billion RMB by 2024, with a CAGR of 19.1% [8] - The Tetanus vaccine market in China is experiencing rapid growth, expected to increase from 200 million RMB in 2019 to 800 million RMB by 2024, with a CAGR of 40.2% [10]

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香港聯合交易所有限公司與證券及期貨事務監察委員會對本申請版本的內容概不負責，對其準確性或完整 性亦不發表任何意見，並明確表示概不就因本申請版本全部或任何部分內容而產生或因倚賴該等內容而引 致的任何損失承擔任何責任。 Chengdu Olymvax Biopharmaceuticals Inc. 成都歐林生物科技股份有限公司 （於中華人民共和國註冊成立的股份有限公司） 的申請版本 警告 本申請版本乃根據香港聯合交易所有限公司（「聯交所」）及證券及期貨事務監察委員會（「委員 會」）的要求而刊發，僅用作提供資訊予香港公眾人士。 本申請版本為草擬本，當中所載資訊並不完整，亦可能會作出重大變動。 閣下閱覽本文件， 即代表 閣下知悉、接納並向成都歐林生物科技股份有限公司（「本公司」，及其附屬公司統稱 為「本集團」）、其獨家保薦人、整體協調人、顧問或包銷團成員表示同意： 本公司招股章程根據香港法例第32章公司（清盤及雜項條文）條例送呈香港公司註冊處處長登記 前，本公司不會向香港公眾人士提出要約或邀請。倘在適當時候向香港公眾人士提出要約或邀 請，有意投資者務請僅依據向香港公司註冊處處長登記的本公司招股章程作出投資決定。招股 ...

Investment Rating - The investment rating for the company is "Buy-A" with a 6-month target price of 27.72 CNY, compared to the current stock price of 23.52 CNY [4]. Core Insights - The company reported a significant revenue increase of 31.11% year-on-year, reaching 507 million CNY in the first three quarters of 2025, with a remarkable net profit growth of 1079.36% to 47 million CNY [1]. - The company is leading globally in the clinical progress of its recombinant Staphylococcus aureus vaccine, with the Phase III clinical trial expected to unblind in the first half of 2026 [3]. - The company has optimized its expense ratio, resulting in a notable improvement in profitability, with a net profit margin increase of 9.32 percentage points to 9.30% [2]. Financial Performance - In Q3 2025, the company achieved a revenue of 201 million CNY, a year-on-year increase of 25.38%, and a net profit of 34 million CNY, up 7.22% [1]. - The gross profit margin for the first three quarters of 2025 was 93.10%, with a slight year-on-year decrease of 1.62 percentage points, while the expense ratio decreased by 13.08 percentage points to 79.30% [2]. - The company’s operating cash flow turned positive, reaching 33 million CNY in the first three quarters of 2025, compared to a negative cash flow of 6.2 million CNY in the same period of 2024 [1]. Research and Development - The company invested 143 million CNY in R&D during the first three quarters of 2025, accounting for 28.19% of its revenue, focusing on vaccines for "superbugs" and "adult vaccines" [4]. - The company is advancing multiple innovative vaccine pipelines, including a recombinant Helicobacter pylori vaccine and a recombinant Pseudomonas aeruginosa vaccine, among others [7]. Future Projections - Revenue growth is projected at 23.8%, 18.7%, and 15.2% for 2025, 2026, and 2027 respectively, with net profit growth expected at 224.7%, 20.1%, and 19.1% for the same years [7].

Core Viewpoint - The company, Chengdu Olin Biological Technology Co., Ltd., is focusing on enhancing its market position through medical education and product promotion while advancing its vaccine research and clinical trials for Staphylococcus aureus and influenza vaccines [1][2]. Financial Performance - In the first half of 2025, the company achieved a revenue of 306 million yuan, representing a year-on-year growth of 35.17% [1]. - The net profit attributable to shareholders was 13.2 million yuan, with a net profit of 7.72 million yuan after deducting non-recurring gains and losses, marking a turnaround from losses in the previous year [1]. R&D Pipeline - The company is focusing on two strategic directions: "super bacteria" vaccines and "adult vaccines," continuously enriching its pipeline and enhancing innovation capabilities [2]. - The company is researching four "super bacteria" vaccines, including recombinant Staphylococcus aureus vaccine, oral recombinant Helicobacter pylori vaccine, recombinant Pseudomonas aeruginosa vaccine, and recombinant Acinetobacter baumannii protein vaccine, all classified as global Class 1 new drugs [2]. Clinical Trials - The recombinant Staphylococcus aureus vaccine has completed Phase I and II clinical trials, with Phase III trials currently ongoing and leading globally [2]. - The vaccine aims to prevent Staphylococcus aureus infections post-surgery, with no similar products available globally, indicating a broad application potential in hospital infection prevention [3]. - The company’s Helicobacter pylori vaccine received Phase I clinical trial approval in Australia in 2024, and further optimization of the oral formulation is underway for future domestic clinical trial applications [3]. Technological Advancements - The company is expanding its technological platforms and has made significant progress in the field of viral vaccines, having initiated Phase I clinical trials for trivalent and quadrivalent influenza virus split vaccines in the first half of 2025 [3].

Core Viewpoint - Chengdu Olin Biological Technology Co., Ltd. plans to issue RMB ordinary shares (A shares) to specific investors to raise a total of RMB 125.2929 million for the technical transformation project of its vaccine research and production base, enhancing its capital strength and profitability [1][2][6]. Group 1: Background and Purpose of the Issuance - The global pharmaceutical market is experiencing growth, with 2023 drug spending estimated at approximately USD 1.6 trillion, and expected to reach about USD 2.2 trillion by 2028, driven by increased drug usage and new product launches [2]. - In China, the pharmaceutical manufacturing industry achieved revenue of RMB 252.057 billion in 2023, with a projected market size of RMB 299.11 billion by 2030, reflecting a compound annual growth rate of 9.6% from 2020 to 2025 [3][4]. - The vaccine industry is a strategic focus for China's biopharmaceutical sector, supported by various government policies aimed at promoting high-quality development in disease prevention and control [5][6]. Group 2: Use of Proceeds - The funds raised will be used for the technical transformation of production lines that are currently outdated, aiming to improve production efficiency and reduce operational costs through automation and smart manufacturing upgrades [6][7]. - The company has established a dual-driven product development strategy focusing on upgrading traditional vaccines and developing innovative vaccines, particularly targeting "super bacteria" and adult vaccines [7][8]. Group 3: Financial Impact and Measures - The issuance is expected to enhance the company's production capacity and financial strength, optimizing its capital structure and reducing financial risks, thereby improving long-term profitability [6][8]. - The company has committed to measures to mitigate the dilution of immediate returns for existing shareholders, including ongoing product development and market expansion efforts [21][24]. Group 4: Compliance and Fairness of the Issuance - The issuance process has been authorized by the company's annual general meetings and complies with relevant legal regulations, ensuring fairness and protecting the interests of all shareholders [16][17]. - The selection of specific investors for the issuance adheres to regulatory requirements, ensuring that the chosen investors possess adequate risk recognition and financial capability [10][11].