证券日报网1月9日讯，欧林生物在接受调研者提问时表示，公司已于2025年5月底完成了重组金葡菌疫 苗全部入组，正在积极推进数据清理等相关研究工作，根据目前进展，预计2026年上半年完成揭盲相关 工作。由于疫苗临床试验易受多种因素的影响，最终临床试验进展及结果请以公司公开信息为准。 ...

证券日报网1月9日讯 ，欧林生物在接受调研者提问时表示，公司开展重组金葡菌疫苗期中分析的主要 目的是为减少1类新药的研发风险，通过DSMB独立的专业判断来评估是否应继续推进临床试验，而非 依据期中分析数据提前申请新药上市。根据公司与CDE沟通确定的临床试验方案，新药上市申报需在全 部受试者完成入组并达到观察终点后方可进行，期中分析结果不作为申报依据。因此，公司选择仅向 DSMB揭盲，研究团队始终保持盲态，这样既能实现风险管控，又可避免因提前揭盲而消耗样本量、影 响最终统计效力和试验完整性。 （编辑 王雪儿） ...

Core Viewpoint - Chengdu Olin Biological Technology Co., Ltd. has submitted its application for a mainboard listing on the Hong Kong Stock Exchange, marking a significant step towards a dual listing in both A-share and H-share markets [1] Group 1: Company Overview - Olin Bio, established in 2009 and headquartered in Chengdu, specializes in the research, development, and production of human vaccines, with its main product being the adsorbed tetanus vaccine, which dominates the domestic market [1] - The company has shifted its strategic focus towards the development of innovative vaccines targeting multi-drug resistant bacteria [1] Group 2: Financial Performance - Olin Bio's financial performance shows a duality; while revenue has been stable due to a nearly 70% market share of its core product, the net profit margin remains low, fluctuating between 2% and 5% [2] - In the first half of 2025, the company achieved a revenue of 305 million yuan and a net profit of 13.23 million yuan, successfully turning around from losses [2] - The company's sales and distribution expenses have consistently exceeded 50% of revenue, and R&D expenses have remained above 20%, with 134 million yuan allocated for R&D in 2024 [2] Group 3: Revenue Dependency and Risks - The adsorbed tetanus vaccine is the primary revenue driver, contributing 80.1% to 93.7% of total income from 2022 to 2024, with projected sales of 536 million yuan in 2024, accounting for 90.99% of total revenue [3] - The reliance on a single product poses significant risks, as any fluctuations in market demand or competition could severely impact the company's performance [3] - Market forecasts for the adsorbed tetanus vaccine have been downgraded, with projections for 2030 reduced from 2.434 billion yuan to 1.5 billion yuan [3] Group 4: Accounts Receivable and Liquidity Issues - The company's accounts receivable rose from 524 million yuan in 2022 to 694 million yuan by mid-2025, with over 53.2% of receivables aging over one year [4] - The lengthening collection period has negatively impacted cash flow, with accounts receivable turnover days increasing from 272 days in 2022 to 328 days in 2025 [4] - The accumulated impairment losses on accounts receivable exceeded 46 million yuan during the reporting period, further eroding already thin net profits [4] Group 5: Capital Market Activities - Olin Bio terminated a planned A-share private placement aimed at raising 175 million yuan, later reduced to 125 million yuan, due to market conditions and company development plans [5] - The controlling shareholder reduced their stake by approximately 12.18 million shares, cashing out around 279 million yuan, leading to a decrease in their ownership percentage [5][6] Group 6: Future Prospects and Challenges - To mitigate reliance on a single product, Olin Bio is focusing on developing a "super bacteria vaccine," with its core candidate, a recombinant Staphylococcus aureus vaccine, currently in Phase III clinical trials [7] - The company aims to launch this product by 2027, alongside other vaccines targeting antibiotic-resistant bacteria [7] - However, the high costs and risks associated with R&D pose significant challenges, as historical precedents indicate potential pitfalls in vaccine development [7]

Core Viewpoint - Chengdu Olin Biological Technology Co., Ltd. has submitted its listing application to the Hong Kong Stock Exchange, aiming to become another "A+H" listed vaccine company, following its listing on the Sci-Tech Innovation Board in June 2021 [1] Financial Performance - The company has shown an upward trend in revenue, with figures of 547 million, 494 million, 586 million, and 305 million RMB for the years 2022, 2023, 2024, and the first half of 2025 respectively [2][3] - Net profit figures for the same periods were 26.58 million, 11.44 million, 15.72 million, and 13.23 million RMB, indicating a significant improvement in the first half of 2025 with a profit of 13.20 million RMB, reversing previous losses [2][3] - The gross margin has consistently remained above 92%, reflecting strong pricing power and cost control [2] Market Position - Olin Biological holds approximately 70% market share in the domestic tetanus vaccine sector, with its main product, the adsorbed tetanus vaccine, being a significant revenue contributor [1][4] - The company has established a strong sales network covering 30 provinces and municipalities in China, with over 2,000 direct commercial relationships with district and county-level disease control centers [4] Research and Development - The company is focusing on developing vaccines for "super bacteria" and adult vaccines, with a comprehensive pipeline that includes the recombinant Staphylococcus aureus vaccine, which is in Phase III clinical trials [4][9] - R&D investment is projected to reach 134 million RMB in 2024, a 17% increase year-on-year, with the R&D team expanding from 59 to 136 members since 2020 [4][11] Market Growth Potential - The tetanus vaccine market in China is expected to grow from 2 billion RMB in 2019 to 8 billion RMB by 2024, with a compound annual growth rate (CAGR) of 40.2% [6] - The global incidence of tetanus is around 1 million cases annually, with 300,000 to 500,000 deaths, highlighting the ongoing public health challenge [6] Cash Flow and Financial Health - The company is experiencing cash flow pressure, with a net cash flow from operating activities of -9.73 million RMB in 2024 and -20 million RMB in the first half of 2025 [5] - Despite raising 95.91 million RMB through financing activities, the company’s self-sustaining ability remains a concern [5]

Core Viewpoint - Chengdu Olin Biological Technology Co., Ltd. has submitted a listing application to the Hong Kong Stock Exchange, aiming to become another "A+H" listed vaccine company, following its listing on the Sci-Tech Innovation Board in June 2021 [2] Financial Performance - The company's revenue has shown an upward trend, with figures of 547 million, 494 million, 586 million, and 305 million RMB for the years 2022 to the first half of 2025 respectively [3][4] - Net profit figures for the same period were 26.58 million, 11.44 million, 15.72 million, and 13.23 million RMB, indicating a significant improvement in the first half of 2025 with a profit of 13.20 million RMB, marking a turnaround from losses [3][4] - The gross margin has consistently remained above 92%, reflecting strong pricing power and cost control [3] Market Position - Olin Biological holds a dominant position in the domestic tetanus vaccine market, with its main product, the adsorbed tetanus vaccine, capturing approximately 70% of the market share [2][5] - The company has established a comprehensive pipeline for "super bacteria vaccines" and "adult vaccines," focusing on unmet medical needs [5][12] Research and Development - The company is heavily investing in the development of vaccines targeting "super bacteria," with the recombinant Staphylococcus aureus vaccine entering Phase III clinical trials, expected to be the first of its kind globally [5][12] - R&D expenditure is projected to reach 134 million RMB in 2024, a 17% increase year-on-year, with the R&D team expanding from 59 to 136 members since 2020 [5][12] Market Growth Potential - The tetanus vaccine market in China is expected to grow from 2 billion RMB in 2019 to 8 billion RMB by 2024, with a compound annual growth rate (CAGR) of 40.2% [7] - The market is projected to further expand to 26 billion RMB by 2035, maintaining a CAGR of 10.8% from 2024 to 2035, indicating long-term growth potential [7] Challenges - The company faces significant cash flow pressures, with negative operating cash flow reported for 2024 and the first half of 2025, highlighting concerns over its financial sustainability [6][13] - The reliance on a single product for revenue generation poses risks, as market demand fluctuations or competition could impact performance stability [5][13]

Core Viewpoint - Chengdu Olin Biological Technology Co., Ltd. has submitted its listing application to the Hong Kong Stock Exchange, aiming to become another "A+H" listed vaccine company, following its listing on the Sci-Tech Innovation Board in June 2021 [1] Financial Performance - The company has shown an upward trend in revenue, with figures of 547 million RMB in 2022, 494 million RMB in 2023, 586 million RMB in 2024, and 305 million RMB in the first half of 2025 [2][3] - Net profit figures for the same periods were 26.58 million RMB, 11.44 million RMB, 15.72 million RMB, and 13.23 million RMB, indicating a significant improvement in the first half of 2025 with a profit of 13.20 million RMB, compared to a loss in the previous year [2][3] - The gross margin has consistently remained above 92%, reflecting strong pricing power and cost control [2] Market Position - Olin Biological holds approximately 70% market share in the domestic tetanus vaccine sector, with its main product, the adsorbed tetanus vaccine, being a significant revenue contributor [1][4] - The company has established a comprehensive and rapidly progressing pipeline for "super bacteria vaccines," with its core product, the recombinant Staphylococcus aureus vaccine, entering Phase III clinical trials [1][9] Research and Development - The company is focusing on developing vaccines for "super bacteria" and "adult vaccines," with a robust pipeline that includes five innovative candidates targeting various pathogens [9][11] - R&D investment is projected to reach 134 million RMB in 2024, a 17% increase year-on-year, with the R&D team expanding from 59 members in 2020 to 136 by the end of 2024 [4][11] Cash Flow and Financial Health - The company is experiencing significant cash flow pressure, with a net cash flow from operating activities of -9.73 million RMB in 2024 and -20 million RMB in the first half of 2025 [5] - Despite raising 95.91 million RMB through financing activities, the company’s ability to generate cash internally remains a concern [5] Industry Context - The tetanus vaccine market in China is rapidly growing, with a projected increase from 200 million RMB in 2019 to 800 million RMB by 2024, reflecting a compound annual growth rate of 40.2% [6][8] - The global challenge of antibiotic resistance has heightened the demand for vaccines targeting "super bacteria," positioning Olin Biological favorably within a high-potential market [9][11]

Core Viewpoint - Olin Bio is seeking to list on the Hong Kong Stock Exchange to become an "A+H" listed company, aiming to raise funds for innovative vaccine research and to reduce reliance on its core product, the adsorbed tetanus vaccine [1][5]. Group 1: Company Overview - Olin Bio, founded by industry veteran Fan Shaowen and his daughter Fan Fan, has become a key player in the vaccine market, particularly with its adsorbed tetanus vaccine, which has significantly contributed to its revenue [2][3]. - The company achieved a revenue of 589 million yuan in 2024, representing an 18.7% year-on-year increase, and a net profit of 20.76 million yuan, also up by 18.2% [3]. Group 2: Financial Performance - In the first half of 2025, Olin Bio reported a revenue of 306 million yuan, a 35.17% increase year-on-year, and a net profit of approximately 13.2 million yuan, marking a turnaround from previous losses [3]. - The adsorbed tetanus vaccine accounted for 90.99% of total revenue in 2024, with a sales revenue of 536 million yuan, indicating a 15.7% increase [3]. Group 3: Challenges and Risks - Olin Bio faces significant challenges, including a high dependency on the adsorbed tetanus vaccine, which has consistently contributed over 90% of its revenue, exposing the company to market fluctuations and competitive pressures [7]. - The company is also under financial strain, with negative cash flows from operating activities and substantial funding needs for ongoing vaccine development and international expansion [7]. - The competitive landscape is intensifying, with both price competition in traditional vaccines and technological competition in innovative vaccines, potentially compressing profit margins [7].

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Investment Rating - The investment rating for the company is "Buy-A" with a 6-month target price of 27.72 CNY, compared to the current stock price of 23.52 CNY [4]. Core Insights - The company reported a significant revenue increase of 31.11% year-on-year, reaching 507 million CNY in the first three quarters of 2025, with a remarkable net profit growth of 1079.36% to 47 million CNY [1]. - The company is leading globally in the clinical progress of its recombinant Staphylococcus aureus vaccine, with the Phase III clinical trial expected to unblind in the first half of 2026 [3]. - The company has optimized its expense ratio, resulting in a notable improvement in profitability, with a net profit margin increase of 9.32 percentage points to 9.30% [2]. Financial Performance - In Q3 2025, the company achieved a revenue of 201 million CNY, a year-on-year increase of 25.38%, and a net profit of 34 million CNY, up 7.22% [1]. - The gross profit margin for the first three quarters of 2025 was 93.10%, with a slight year-on-year decrease of 1.62 percentage points, while the expense ratio decreased by 13.08 percentage points to 79.30% [2]. - The company’s operating cash flow turned positive, reaching 33 million CNY in the first three quarters of 2025, compared to a negative cash flow of 6.2 million CNY in the same period of 2024 [1]. Research and Development - The company invested 143 million CNY in R&D during the first three quarters of 2025, accounting for 28.19% of its revenue, focusing on vaccines for "superbugs" and "adult vaccines" [4]. - The company is advancing multiple innovative vaccine pipelines, including a recombinant Helicobacter pylori vaccine and a recombinant Pseudomonas aeruginosa vaccine, among others [7]. Future Projections - Revenue growth is projected at 23.8%, 18.7%, and 15.2% for 2025, 2026, and 2027 respectively, with net profit growth expected at 224.7%, 20.1%, and 19.1% for the same years [7].

Core Insights - The company reported a total revenue of 510 million yuan for the first three quarters of 2025, representing a year-on-year increase of 31.1% [1] - The net profit attributable to shareholders reached 50 million yuan, showing a significant year-on-year growth of 1079.4% [1] - The non-recurring net profit attributable to shareholders was 40 million yuan, with an extraordinary year-on-year increase of 12157.5% [1] Revenue Growth and Cost Management - Revenue for Q1, Q2, and Q3 of 2025 was 90 million, 220 million, and 200 million yuan respectively, with year-on-year growth rates of 23.6%, 40.4%, and 25.4% [2] - The company optimized its expense ratio, achieving a total expense ratio of 79.3%, a decrease of 13.1 percentage points year-on-year [2] - The overall gross margin for the first three quarters was 93.1%, down by 1.6 percentage points year-on-year, while the net margin was 9.3%, up by 9.3 percentage points [2] Innovation and Development - The company is advancing in the development of innovative vaccines, including those for superbugs and influenza, which are expected to drive future growth [3] - The phase III clinical trial for the recombinant Staphylococcus aureus vaccine is nearing completion, with global progress leading to an expected unblinding in the first half of 2026 [3] - The company has initiated phase III clinical trials for the quadrivalent influenza virus split vaccine, with the first subject enrolled [3] Revenue Forecast - Revenue projections for 2025, 2026, and 2027 are estimated at 750 million, 890 million, and 1.06 billion yuan respectively [4]