Investment Rating - The industry investment rating is "Positive" (maintained) [2] Core Insights - The report highlights the acquisition of Capstan Therapeutics by AbbVie for up to $2.1 billion, focusing on in vivo CAR-T therapy development [6][15] - The report emphasizes the growing interest and investment in in vivo CAR-T technology, with multiple companies actively pursuing diverse delivery systems [7][26] - The pharmaceutical and biotechnology sector saw a weekly increase of 3.64%, outperforming the CSI 300 index by 2.1 percentage points, ranking 4th among 31 sub-industries [8][31] Summary by Sections 1. AbbVie Acquisition of Capstan - AbbVie announced the acquisition of Capstan Therapeutics for a maximum of $2.1 billion, focusing on in vivo CAR-T therapies [6][15] - Capstan's main asset, CPTX2309, is an RNA delivery candidate for anti-CD19 CAR-T therapy, currently in Phase I clinical trials [15][20] 2. MNC's Active Layout in In Vivo CAR-T Technology - MNC has been actively investing in in vivo CAR-T technology through collaborations and acquisitions, focusing on both lentiviral and lipid nanoparticle delivery systems [7][26] - The report notes that over 20 disclosed mRNA technology projects in in vivo CAR-T are primarily concentrated in the lipid nanoparticle direction [22][30] 3. Weekly Performance of the Pharmaceutical Sector - The pharmaceutical sector increased by 3.64% in the first week of July, outperforming the CSI 300 index [31] - Among sub-sectors, other biological products saw the highest increase of 8.28%, while medical equipment experienced the largest decline of 0.21% [35][36] 4. Recommended Stocks - Recommended stocks include major pharmaceutical and biotechnology companies such as Heng Rui Medicine, East China Medicine, and others [9]

体内 CAR-T：全球竞赛已打响，关注云顶新耀和石药集团 20250701 摘要 体内 CAR-T 技术获产业催化，艾伯维 21 亿美元收购 Capstan 标志性 事件。云顶新耀和石药集团等国内企业在该领域具备稀缺性，mRNA 平 台安全性已获验证，有望成新突破点。 现有自体 CAR-T 疗法因成本高昂应用受限，全球销售额不足 45 亿美元。 体内 CAR-T 疗法旨在降低成本，提高可及性。《Nature》预测其成本 将比自体 CAR-T 低一个数量级。 基于 mRNA 的体内 CAR-T 通过 LNP 包裹 mRNA 载体，使 T 细胞表达 CAR，具有高效、安全优势，能快速表达蛋白质，且副作用可迅速恢复。 阿斯利康和艾伯维均通过收购布局该领域。 阿斯利康的 P3B3A CAR-T 技术针对多发性骨髓瘤和自身免疫疾病， CD20 CAR-T 技术针对 B 细胞淋巴瘤，已获 FDA 一期临床批准。 Interose 公司 CD2 CAR-T 技术已在澳大利亚和欧洲启动一期临床。 mRNA 平台在 CAR-T 疗法中应用前景广阔，研发周期短、成本低，可 通过替换 mRNA 序列研究不同肿瘤药物。Capston ...