Investment Rating - The industry investment rating is "Positive" (maintained) [2] Core Insights - The report highlights the acquisition of Capstan Therapeutics by AbbVie for up to $2.1 billion, focusing on in vivo CAR-T therapy development [6][15] - The report emphasizes the growing interest and investment in in vivo CAR-T technology, with multiple companies actively pursuing diverse delivery systems [7][26] - The pharmaceutical and biotechnology sector saw a weekly increase of 3.64%, outperforming the CSI 300 index by 2.1 percentage points, ranking 4th among 31 sub-industries [8][31] Summary by Sections 1. AbbVie Acquisition of Capstan - AbbVie announced the acquisition of Capstan Therapeutics for a maximum of $2.1 billion, focusing on in vivo CAR-T therapies [6][15] - Capstan's main asset, CPTX2309, is an RNA delivery candidate for anti-CD19 CAR-T therapy, currently in Phase I clinical trials [15][20] 2. MNC's Active Layout in In Vivo CAR-T Technology - MNC has been actively investing in in vivo CAR-T technology through collaborations and acquisitions, focusing on both lentiviral and lipid nanoparticle delivery systems [7][26] - The report notes that over 20 disclosed mRNA technology projects in in vivo CAR-T are primarily concentrated in the lipid nanoparticle direction [22][30] 3. Weekly Performance of the Pharmaceutical Sector - The pharmaceutical sector increased by 3.64% in the first week of July, outperforming the CSI 300 index [31] - Among sub-sectors, other biological products saw the highest increase of 8.28%, while medical equipment experienced the largest decline of 0.21% [35][36] 4. Recommended Stocks - Recommended stocks include major pharmaceutical and biotechnology companies such as Heng Rui Medicine, East China Medicine, and others [9]

Investment Rating - The industry investment rating is "Positive" (maintained) [1] Core Insights - The report highlights recent positive developments in the high-quality weight loss sector, particularly focusing on myostatin pathway clinical trial results from Regeneron and Scholar Rock, which demonstrate significant reductions in lean body mass loss when combined with GLP-1 medications [4][12] - The pharmaceutical and biotechnology sector experienced a decline of 4.35% in the third week of June 2025, underperforming the CSI 300 index by 3.9 percentage points, ranking 29th among 31 sub-industries [5][16] - The report emphasizes the potential of Activin receptor drugs, such as Eli Lilly's Bimagrumab and Lai Kai's LAE-102, to retain lean body mass and even promote muscle gain, with promising safety and pharmacokinetic data [4][12] Summary by Sections 1. Recent Developments in Weight Loss Sector - Regeneron's myostatin antibody Trevogrumab combined with semaglutide showed a 50.8% reduction in lean body mass loss over 24 weeks, compared to a 7.9 lbs loss with semaglutide alone [4][12] - Scholar Rock's myostatin antibody Apitegromab combined with Tirzepatide demonstrated a 54.9% reduction in lean body mass loss [4][12] 2. Market Performance - The pharmaceutical and biotechnology sector's decline of 4.35% in June's third week was the largest among all sectors, with the vaccine sector experiencing the smallest drop of 0.4% [5][21] - Other sub-sectors, such as blood products and medical consumables, also faced declines, with the largest drop seen in other biological products at 6.7% [5][21] 3. Recommended Stocks - Recommended stocks include major pharmaceutical and biotechnology companies such as Heng Rui Medicine, East China Medicine, and Innovent Biologics, among others [6]

医药生物 2025 年 06 月 15 日 投资评级：看好（维持） 行业走势图 数据来源：聚源 -19% -10% 0% 10% 19% 29% 2024-06 2024-10 2025-02 医药生物 沪深300 相关研究报告 《关注 Protac 自免赛道积极进展—行 业周报》-2025.6.8 《重视Pharma估值重塑的机会—行业 周报》-2025.6.2 《经营拐点显现，动保业务有望贡献 较大业绩弹性，推荐国邦医药—行业 周报》-2025.5.25 SYS6010:广谱抗肿瘤大品种，早期 NSCLC 数据优异 ——行业周报 | 余汝意（分析师） | 余克清（分析师） | 聂媛媛（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | nieyuanyuan@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790525010002 | 证书编号：S0790124050002 | SYS6010（EGFR ADC）：广谱抗肿瘤大品种，早期 NSCLC 数据优异 截至 2025 年 6 月，全 ...

数据来源：聚源 -19% -10% 0% 10% 19% 29% 2024-06 2024-10 2025-02 医药生物 沪深300 相关研究报告 《重视Pharma估值重塑的机会—行业 周报》-2025.6.2 《经营拐点显现，动保业务有望贡献 较大业绩弹性，推荐国邦医药—行业 周报》-2025.5.25 医药生物 2025 年 06 月 08 日 投资评级：看好（维持） 行业走势图 《医药商业 2024 及 2025Q1 总结，关 注龙头企稳恢复 — 行 业 周 报 》 -2025.5.18 关注 Protac 自免赛道积极进展 ——行业周报 | 余汝意（分析师） | | 余克清（分析师） | | --- | --- | --- | | yuruyi@kysec.cn | | yukeqing@kysec.cn | | 证书编号：S0790523070002 | | 证书编号：S0790525010002 | |  关注 Protac | 自免赛道积极进展 | | 近期，Kymera 公司的 STAT6 degrader 分子 KT-621 的 1 期健康人数据读出。所 有≥50mg 的剂量组都实现了 ...

医药生物 2025 年 06 月 08 日 投资评级：看好（维持） 行业走势图 数据来源：聚源 -19% -10% 0% 10% 19% 29% 2024-06 2024-10 2025-02 医药生物 沪深300 相关研究报告 《重视Pharma估值重塑的机会—行业 周报》-2025.6.2 《经营拐点显现，动保业务有望贡献 较大业绩弹性，推荐国邦医药—行业 周报》-2025.5.25 风险提示：政策落地不及预期、行业整合不及预期、行业竞争格局恶化 《医药商业 2024 及 2025Q1 总结，关 注龙头企稳恢复 — 行 业 周 报 》 -2025.5.18 关注 Protac 自免赛道积极进展 ——行业周报 | 余汝意（分析师） | | 余克清（分析师） | | --- | --- | --- | | yuruyi@kysec.cn | | yukeqing@kysec.cn | | 证书编号：S0790523070002 | | 证书编号：S0790525010002 | |  关注 Protac | 自免赛道积极进展 | | 近期，Kymera 公司的 STAT6 degrader 分子 KT-62 ...

医药生物 2025 年 05 月 11 日 投资评级：看好（维持） 行业走势图 TCE 实体瘤赛道更新，关注 Janux 和 Vir 积极进展 数据来源：聚源 -24% -12% 0% 12% 24% 2024-05 2024-09 2025-01 医药生物 沪深300 相关研究报告 《首选创新药，关注消费复苏—医药 行业 2025 年度中期投资策略 》 -2025.5.7 《关注左侧中药板块的结构性机会— 行业周报》-2025.4.27 《Orforglipron 产业链被低估，国内相 关公司有望长周期受益—行业点评报 告》-2025.4.26 TCE 实体瘤赛道更新，关注 Janux 和 Vir 积极进展 ——行业周报 | 余汝意（分析师） | 余克清（分析师） | 石启正（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | shiqizheng@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790525010002 | 证书编号：S0790125020004 | Janux 和 Vir ...

医药生物 2025 年 05 月 11 日 投资评级：看好（维持） 行业走势图 数据来源：聚源 -24% -12% 0% 12% 24% 2024-05 2024-09 2025-01 医药生物 沪深300 《首选创新药，关注消费复苏—医药 行业 2025 年度中期投资策略 》 -2025.5.7 《关注左侧中药板块的结构性机会— 行业周报》-2025.4.27 《Orforglipron 产业链被低估，国内相 关公司有望长周期受益—行业点评报 告》-2025.4.26 TCE 实体瘤赛道更新，关注 Janux 和 Vir 积极进展 ——行业周报 | 余汝意（分析师） | 余克清（分析师） | 石启正（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | shiqizheng@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790525010002 | 证书编号：S0790125020004 | TCE 实体瘤赛道更新，关注 Janux 和 Vir 积极进展 Janux 和 Vir 更新了其 T ...