Core Viewpoint - The development of organ-on-a-chip technology by Wuhan First Hospital significantly reduces the drug research and development cycle and experimental costs while improving the accuracy of experimental data [4][5][10]. Group 1: Organ-on-a-Chip Technology - The organ-on-a-chip technology can simulate various human organs, including blood vessels, skin, liver, intestines, and kidneys, allowing for preclinical research that replaces traditional cell models and animal testing [2][5]. - The multi-organ chip integrates multiple organ models and can simulate complex physiological and pathological processes, such as blood circulation, thereby enhancing the efficiency of drug development [5][9]. - The single-organ chip, such as the skin chip, can grow skin tissue with a layered structure from a small sample, providing a more accurate model for testing cosmetic products and drug efficacy [5][8]. Group 2: Applications in Drug Development - The organ-on-a-chip technology allows for real-time observation of cancer cell behavior and drug interactions, facilitating personalized treatment approaches, especially for cancer patients [9]. - The technology has been successfully used to create disease models for over 20 conditions, including atopic dermatitis and drug-induced liver injury, enhancing the understanding of disease mechanisms [9]. - The introduction of skin chips has improved the efficiency of testing cosmetic products, allowing for direct observation of collagen fiber growth and pigment deposition without relying on animal models [10].