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和誉-B(02256.HK):匹米替尼具备BIC潜力 多项管线推进顺利
Ge Long Hui· 2025-08-10 03:31
Core Insights - The company reported a total revenue of 657 million yuan for H1 2025, representing a 20% year-on-year increase, with net profit rising by 59% to 328 million yuan [1] - The company has implemented cost reduction and efficiency improvement measures, including a stock buyback program that has repurchased 9.545 million shares, accounting for 1.4% of the total shares issued at the beginning of the year [1] - The drug Pimiatinib has shown potential as a breakthrough therapy and has received regulatory recognition in China, the US, and Europe [1][2] Financial Performance - For H1 2025, the company's revenue was 612 million yuan, a 23% increase year-on-year, with R&D expenses amounting to 228 million yuan, representing a 37.25% R&D expense ratio, down by 6 percentage points [1] - Administrative expenses were 35.41 million yuan, with an administrative expense ratio of 5.78%, down by 2.3 percentage points [1] - The company expects revenues of 630 million yuan, 684 million yuan, and 634 million yuan for 2025-2027, with net profits projected at 45 million yuan, 68 million yuan, and 98 million yuan respectively [4] Drug Development and Partnerships - Pimiatinib has been licensed to Merck for commercialization in China, with a total deal value potentially reaching 605.5 million USD, of which the company has already received 155 million USD [2] - The drug ABSK011 has initiated a registration clinical study for treating FGF19 overexpressing HCC, with breakthrough therapy designation granted [2][3] - ABSK011 has shown promising efficacy in clinical trials, with an overall response rate (ORR) of 52.9% in pre-treated patients, significantly better than existing therapies [3] Pipeline and Future Prospects - The company is actively developing other drug candidates, including oral PD-L1 inhibitor ABSK043 and FGFR2/3 inhibitor ABSK061, with positive initial data reported [3] - The company has initiated a phase II clinical study for ABSK043 in combination with EGFR TKI for NSCLC patients, and is exploring potential collaborations for treating KRAS G12C mutation NSCLC patients [3]