Core Viewpoint - The company demonstrates strong financial performance with sustainable growth potential, driven by its core product, ABKS021 (Pimicitinib), and strategic partnerships, particularly with Merck [1][4] Financial Performance - In the first half of 2025, the company reported revenue of 657 million RMB (up 20% year-on-year) and a net profit of 328 million RMB (up 59% year-on-year) [1] - The company holds cash reserves of 2.3 billion RMB, providing a solid foundation for future R&D and operations [1] Product Development - Pimicitinib's global commercialization option was exercised by Merck, with an upfront payment of 85 million USD [1] - The NDA for Pimicitinib has been accepted in China and is expected to be submitted in the U.S. within the year, with potential approvals in both markets by mid-2026 [1] - Clinical trial data for Pimicitinib shows a 54% objective response rate (ORR) at week 25, significantly outperforming placebo and other similar products [1] Pipeline and Research - The company is advancing its pipeline with ABSK011, a potential first-in-class FGFR4 inhibitor, which has shown superior efficacy in preclinical studies compared to earlier entrants [1] - ABSK011 is currently in clinical trials for FGF19+ hepatocellular carcinoma, with promising early results [1] - The company is also developing ABSK043, an oral PD-L1 inhibitor, which has shown a 19.6% ORR in early trials for NSCLC [2] Market Position and Competitive Advantage - The company’s product ABSK061, an FGFR2/3 inhibitor, is positioned to compete with existing therapies due to its oral administration route, contrasting with the injectable nature of competitors [3] - The company has a rich pipeline including KRAS inhibitors and ADCs, indicating a well-structured approach to drug development [3] Shareholder Engagement - The company has been actively repurchasing shares, indicating a commitment to shareholder returns, with a total of 9.545 million shares repurchased by June 30, 2025 [3] - Notable foreign investors, including Allianz SE and Morgan Stanley, have increased their stakes, reflecting confidence in the company's growth prospects [4] Revenue and Profit Forecast - Revenue projections for 2025-2027 are 680 million RMB, 620 million RMB, and 790 million RMB, with net profits of 40 million RMB, 60 million RMB, and 80 million RMB respectively [4]

Investment Rating - The report maintains a "Buy" rating for the company, expecting a relative performance increase of over 15% against the benchmark index in the next 6 to 12 months [2][11]. Core Insights - The company has shown strong financial performance with a revenue of 657 million RMB in the first half of 2025, representing a year-on-year growth of 20%, and a net profit of 328 million RMB, up 59% year-on-year [4]. - The company has a robust cash reserve of 2.3 billion RMB, providing solid support for future R&D and operations [4]. - The core product, Pimiatinib (ABSK021), has successfully entered the global commercialization phase with Merck exercising its option and paying a fee of 85 million USD [4]. - The company is expected to achieve significant sales milestones with Pimiatinib's global approval and ongoing sales revenue sharing [4]. - The company is actively repurchasing shares, indicating a focus on shareholder returns, with a total of 9.545 million shares repurchased by June 30, 2025 [7]. Financial Performance and Projections - Revenue projections for 2025-2027 are estimated at 678 million RMB, 621 million RMB, and 786 million RMB respectively, with net profits of 42 million RMB, 64 million RMB, and 80 million RMB [2][6]. - The company anticipates a peak sales potential of 1.5 billion USD for Pimiatinib targeting TGCT and 1 billion USD for cGVHD [6]. - The report highlights a significant increase in revenue growth rate from 2,544% in 2023 to 35% in 2024, followed by a slight decline of 8% in 2025, and a rebound of 27% in 2026 [9][10]. Product Pipeline and Market Potential - The company is advancing its pipeline with ABSK011, a potential first-in-class FGFR4 inhibitor, which has shown promising preclinical efficacy and is currently in registration clinical trials [5]. - ABSK043, an oral PD-L1 inhibitor, is also in development, showing a 19.6% objective response rate in early trials, with potential for significant market impact in the NSCLC segment [7]. - The company has a rich pipeline with various candidates, including KRAS inhibitors and ADCs, indicating a strong future growth trajectory [7].

Core Viewpoint - The stock price of He Yu-B (02256) has surged nearly 200% year-to-date, driven by favorable policies and a warming investment climate in the Hong Kong innovative drug sector, leading to increased investor focus on the commercialization capabilities of innovative drug companies [1][2]. Group 1: Stock Performance and Market Recognition - On August 11, He Yu-B's stock price surpassed its IPO price of 12.46 HKD, closing up 5.93%, and reached a new high of 13.67 HKD the following day [1]. - The company was included in the MSCI Global Small Cap Index, which tracks over $17 trillion in assets, enhancing its market liquidity and international visibility [4]. Group 2: Innovation and Product Development - The key driver of He Yu-B's value is its innovative product, Pimicotinib, which is the first Chinese-developed CSF-1R inhibitor entering global Phase III clinical trials [4]. - Pimicotinib has received breakthrough therapy designation from multiple regulatory agencies, indicating its potential in various indications beyond TGCT [5][6]. Group 3: Financial Strength and Cash Flow - He Yu-B has secured a significant partnership with Merck, which includes a $70 million upfront payment and potential for future milestone payments, positioning the company for its first profitable year in 2024 [5][6]. - The company has maintained around 2 billion HKD in cash reserves over the past three years, ensuring financial stability during challenging market conditions [7]. Group 4: Pipeline and Future Prospects - He Yu-B's pipeline includes multiple promising candidates, such as Irpagratinib, which has been designated as a breakthrough therapy for advanced liver cancer, indicating strong potential for future revenue [8]. - The company has established 22 differentiated innovative research pipelines, focusing on precision oncology and immunotherapy, with several candidates showing "best-in-class" or "first-in-class" potential [7][8]. Group 5: Shareholder Returns and Valuation - He Yu-B has engaged in share buybacks, returning value to shareholders while maintaining a low price-to-sales (PS) ratio of 13.38, suggesting significant growth potential compared to peers [9]. - Analysts believe that He Yu-B's current valuation is low, considering the high certainty of its late-stage candidates and the potential for licensing agreements [9].

Core Insights - The company reported a total revenue of 657 million yuan for H1 2025, representing a 20% year-on-year increase, with net profit rising by 59% to 328 million yuan [1] - The company has implemented cost reduction and efficiency improvement measures, including a stock buyback program that has repurchased 9.545 million shares, accounting for 1.4% of the total shares issued at the beginning of the year [1] - The drug Pimiatinib has shown potential as a breakthrough therapy and has received regulatory recognition in China, the US, and Europe [1][2] Financial Performance - For H1 2025, the company's revenue was 612 million yuan, a 23% increase year-on-year, with R&D expenses amounting to 228 million yuan, representing a 37.25% R&D expense ratio, down by 6 percentage points [1] - Administrative expenses were 35.41 million yuan, with an administrative expense ratio of 5.78%, down by 2.3 percentage points [1] - The company expects revenues of 630 million yuan, 684 million yuan, and 634 million yuan for 2025-2027, with net profits projected at 45 million yuan, 68 million yuan, and 98 million yuan respectively [4] Drug Development and Partnerships - Pimiatinib has been licensed to Merck for commercialization in China, with a total deal value potentially reaching 605.5 million USD, of which the company has already received 155 million USD [2] - The drug ABSK011 has initiated a registration clinical study for treating FGF19 overexpressing HCC, with breakthrough therapy designation granted [2][3] - ABSK011 has shown promising efficacy in clinical trials, with an overall response rate (ORR) of 52.9% in pre-treated patients, significantly better than existing therapies [3] Pipeline and Future Prospects - The company is actively developing other drug candidates, including oral PD-L1 inhibitor ABSK043 and FGFR2/3 inhibitor ABSK061, with positive initial data reported [3] - The company has initiated a phase II clinical study for ABSK043 in combination with EGFR TKI for NSCLC patients, and is exploring potential collaborations for treating KRAS G12C mutation NSCLC patients [3]