Core Insights - The article highlights the significant contributions of Chinese scholars in top international academic journals, with 8 out of 18 papers published in Nature on October 1, 2025, authored by Chinese researchers [2][5][6][7][8][10][12][14]. - A notable paper from Yale University discusses a new method in spatial transcriptomics, RAEFISH, which achieves whole-genome coverage and single-molecule resolution, marking a significant advancement in the field [16][19]. - A study from the National Laboratory of Yacheng Bay reveals the genetic selection trajectories in soybean domestication, providing new insights into breeding strategies and genetic resources [20][23][24]. Group 1: Contributions to Nature - On October 1, 2025, multiple papers authored by Chinese scholars were published in Nature, including significant studies on T cell exhaustion, dietary impacts on intestinal stemness, and new paradigms in protein biogenesis [2][5][6][7][8][10]. - The research from Ohio State University on T cell exhaustion highlights the role of proteotoxic stress in immune evasion [2]. - The study from MIT explores how dietary cysteine enhances intestinal stemness through CD8 T cell-derived IL-22 [5]. Group 2: Innovations in Spatial Transcriptomics - The Yale University team developed RAEFISH, a new spatial transcriptomics method that allows for whole-genome coverage and single-molecule resolution, addressing previous limitations in the field [16][19]. - This advancement provides a powerful tool for various biological research areas, including developmental biology and drug discovery [19]. Group 3: Soybean Genetic Research - The research team at Yacheng Bay National Laboratory studied 8,105 soybean accessions, revealing key genetic selections during domestication and improvement processes [20][23]. - The findings indicate the existence of two independent centers of soybean domestication and highlight the importance of black soybean in this process [23]. - The study also provides insights into the changing breeding priorities in China, emphasizing high protein content in the early years and more recently focusing on yield, oil content, and stress resistance [23][24].

Core Insights - The article discusses the domestication, dissemination, and improvement trajectories of soybean, highlighting its significance as a major source of protein and oil for human consumption and animal feed [3][4][6]. Group 1: Research Findings - The study analyzed genomic information from 8,105 soybean accessions, including wild types, local varieties, and modern cultivars, revealing the genetic selection trajectories during domestication and improvement [4][6]. - Black soybean is identified as a key intermediate type in the domestication process, with findings suggesting that domestication traits were selected gradually [6][7]. - The research proposes the existence of two independent centers of soybean domestication in China: one in the Huang-Huai-Hai region and another in the northwest [6][7]. Group 2: Implications for Breeding - The study provides new molecular targets for future soybean quality improvement by identifying selected genes that facilitated trait enhancement and environmental adaptation during global dissemination [6][9]. - It highlights the shift in breeding focus in China from high-protein soybean varieties in the early years to an emphasis on high yield, high oil content, and stress resistance in recent years [6][9]. - A high-density soybean genome variation map and quantitative trait nucleotide (QTN) database were established, providing valuable resources for the global research community [7][9].