Core Insights - Fosun Pharma has signed a licensing agreement with Aikono for the exclusive rights to research, develop, manufacture, register, and commercialize AC-201 in China and Hong Kong, aimed at treating autoimmune diseases [1][2] - AC-201, an oral small molecule JAK inhibitor developed by Aikono, has shown promising results in Phase II clinical trials for moderate to severe plaque psoriasis, demonstrating good safety and tolerability [1] - The global sales of JAK inhibitors are projected to reach approximately $16.8 billion in 2024, indicating a significant market opportunity for AC-201 [1] Company Overview - Aikono, established in December 2017 and based in Suzhou, Jiangsu Province, focuses on the research and development of small molecule innovative drugs, with three products currently in clinical research [2] - Aikono's registered capital is $43 million, and it is fully owned by Aikono Biopharmaceuticals (Hong Kong) Limited, with Xiaohu Zhang as the actual controller [2] Financial Terms - Fosun Pharma will pay Aikono up to RMB 156 million (including upfront and milestone payments) for the licensing agreement [2] Strategic Implications - This collaboration aims to leverage Fosun Pharma's strengths in drug clinical development, registration, production, and commercialization, enhancing its product pipeline in the autoimmune disease sector and strengthening its competitive position in the market [2]

Core Viewpoint - Yaojie Ankang successfully listed on the Hong Kong Stock Exchange, marking it as the first company from Nanjing to go public this year, bringing the total number of listed companies in the city to 163 [1][3] Company Overview - Yaojie Ankang focuses on the research and development of small molecule innovative drugs, particularly targeting oncology, inflammation, and cardiovascular diseases [1] - The company has established a pipeline of six clinical-stage candidates and one preclinical candidate, most of which have innovative potential [1] Product Development - The core product, Tinengotinib, is a multi-target kinase inhibitor that aims to block faulty cellular signals to exert anti-tumor effects [1] - Tinengotinib is currently undergoing multiple clinical trials in China and the U.S. for various solid tumors, including cholangiocarcinoma, prostate cancer, and breast cancer [1] - The product has received breakthrough therapy designation from the National Medical Products Administration and orphan drug designation from the FDA for cholangiocarcinoma treatment [1] Financial and Market Position - Yaojie Ankang has completed nine rounds of financing, raising over 1.7 billion yuan [2] - The successful listing on the Hong Kong Stock Exchange is seen as a new starting point for the company in the capital market [2] Support and Policy Environment - The Nanjing Jiangbei New Area has established an overseas listing industry investment fund to support companies like Yaojie Ankang in their listing endeavors [2] - The fund has a total scale of 1 billion yuan and aims to invest in companies planning to list overseas [2] Local Market Context - The listing of Yaojie Ankang is part of a broader trend, with Nanjing having 31 companies listed on the Hong Kong Stock Exchange, making it the capital market with the most new listings in recent years [3] - There are currently four companies in the pipeline for listing, seven that have submitted applications for overseas listings, and 34 companies receiving guidance, indicating a robust local market for IPOs [3]