英国华威大学与澳大利亚莫纳什大学化学家发现一种超强抗生素——前甲烯霉素C内酯。它对多种耐药 病原体的抗菌活性比已知抗生素甲烯霉素A高出100倍以上，尤其对耐甲氧西林金黄色葡萄球菌 （MRSA）和耐万古霉素肠球菌（VRE）表现出显著杀菌效果。相关成果发表于新一期《美国化学会会 刊》。 此次发现的新抗生素原本只是合成已知抗生素甲烯霉素A过程中的中间化合物。甲烯霉素A早在50年前 就已发现，但其合成中间体从未被测试过抗菌活性。通过基因操作，研究团队意外发现两个此前未知的 中间体，其抗菌活性远超甲烯霉素A。 实验显示，前甲烯霉素C内酯对多种革兰氏阳性菌的活性比甲烯霉素A高出100倍，其中就包括MRSA和 VRE。MRSA是一种对多种常用抗生素高度耐药、易导致严重感染的超级细菌。VRE能抵抗最强抗生素 万古霉素，极易导致院内感染，是世界卫生组织重点关注的高危病原体。 值得注意的是，肠球菌在实验中未出现对前甲烯霉素C内酯的耐药现象，而在相同条件下，万古霉素却 会诱发耐药。这一发现表明，前甲烯霉素C内酯可能成为对抗VRE感染的潜在新候选药物。 凭借结构简单、活性强、难以产生耐药性且易于合成等优势，前甲烯霉素C内酯有望成为新 ...

Market Overview - The A-share market showed mixed performance today, with the Shanghai Composite Index rising by 0.39% to close at 3457.75 points, while the Shenzhen Component Index increased by 0.11% to 10476.29 points. However, the Sci-Tech Innovation 50 Index fell by 0.86% to 994.80 points, and the ChiNext Index decreased by 0.24% to 2147.92 points. Overall, 2628 stocks rose, 2542 fell, and 247 remained unchanged across the market [1]. - The total trading volume in the Shanghai and Shenzhen markets was 14660 billion, a decrease of 208.42 billion compared to the previous trading day [1]. Industry Performance - Among the Shenwan first-level industries, sectors such as comprehensive, pharmaceutical biology, banking, non-ferrous metals, public utilities, and building materials led the gains, while computer, retail, telecommunications, media, power equipment, and real estate sectors experienced declines [1]. Sector Highlights - The top-performing concept sectors today included China Shipbuilding System, innovative drugs, antibiotics, vitamins, generic drugs, low-priced stocks in the ChiNext, hydropower, biotechnology, advanced packaging, superhard materials, pet economy, CRO, medical material exports, selected banks, and brain-computer interfaces [1].

Market Overview - The A-share market showed mixed performance today, with the Shanghai Composite Index rising by 0.21% to close at 3387.57 points, while the Shenzhen Component Index increased by 0.44% to 10294.22 points. The ChiNext Index fell by 0.22% to 995.49 points, and the Growth Enterprise Market Index rose by 0.83% to 2065.39 points. Overall, there were more decliners than advancers, with 3599 stocks declining and 1615 stocks advancing across the market. The total trading volume in the Shanghai and Shenzhen markets reached 11734 billion yuan, an increase of 37.64 billion yuan compared to the previous trading day [1]. Industry Performance - Among the primary industries, coal, non-ferrous metals, electric equipment, banking, pharmaceutical biology, and transportation sectors led the gains, while beauty care, electronics, media, social services, machinery equipment, and retail sectors experienced declines [1]. - The top-performing concept sectors included gold and jewelry, selected air transport, power batteries, coal mining, central enterprise coal, lithium battery anodes, lithium iron phosphate batteries, solid-state batteries, sodium-ion batteries, complete vehicles, cobalt mines, battery recycling, new energy vehicles, germanium-gallium-antimony ink, and antibiotics [2].