Core Insights - A new antibiotic, pre-methenamine C lactone, has been discovered by chemists from the University of Warwick and Monash University, showing over 100 times higher antibacterial activity against various resistant pathogens compared to the known antibiotic methenamine A [1][2] - The discovery was made during the synthesis of methenamine A, where previously untested intermediates exhibited significant antibacterial properties, particularly against MRSA and VRE [1] Group 1 - The new antibiotic demonstrates significant efficacy against MRSA, a superbug resistant to multiple common antibiotics, and VRE, which can resist the strongest antibiotic vancomycin [1] - Pre-methenamine C lactone showed no signs of resistance in enterococci during experiments, unlike vancomycin, which induced resistance under the same conditions [1] - The findings suggest that pre-methenamine C lactone could be a potential new candidate drug for combating VRE infections [1] Group 2 - Pre-methenamine C lactone is characterized by its simple structure, strong activity, low likelihood of developing resistance, and ease of synthesis, positioning it as a promising candidate for a new generation of antibiotics [2] - This discovery offers hope to the approximately 1.1 million people who lose their lives each year due to antibiotic resistance [2]

Market Overview - The A-share market showed mixed performance today, with the Shanghai Composite Index rising by 0.39% to close at 3457.75 points, while the Shenzhen Component Index increased by 0.11% to 10476.29 points. However, the Sci-Tech Innovation 50 Index fell by 0.86% to 994.80 points, and the ChiNext Index decreased by 0.24% to 2147.92 points. Overall, 2628 stocks rose, 2542 fell, and 247 remained unchanged across the market [1]. - The total trading volume in the Shanghai and Shenzhen markets was 14660 billion, a decrease of 208.42 billion compared to the previous trading day [1]. Industry Performance - Among the Shenwan first-level industries, sectors such as comprehensive, pharmaceutical biology, banking, non-ferrous metals, public utilities, and building materials led the gains, while computer, retail, telecommunications, media, power equipment, and real estate sectors experienced declines [1]. Sector Highlights - The top-performing concept sectors today included China Shipbuilding System, innovative drugs, antibiotics, vitamins, generic drugs, low-priced stocks in the ChiNext, hydropower, biotechnology, advanced packaging, superhard materials, pet economy, CRO, medical material exports, selected banks, and brain-computer interfaces [1].

Market Overview - The A-share market showed mixed performance today, with the Shanghai Composite Index rising by 0.21% to close at 3387.57 points, while the Shenzhen Component Index increased by 0.44% to 10294.22 points. The ChiNext Index fell by 0.22% to 995.49 points, and the Growth Enterprise Market Index rose by 0.83% to 2065.39 points. Overall, there were more decliners than advancers, with 3599 stocks declining and 1615 stocks advancing across the market. The total trading volume in the Shanghai and Shenzhen markets reached 11734 billion yuan, an increase of 37.64 billion yuan compared to the previous trading day [1]. Industry Performance - Among the primary industries, coal, non-ferrous metals, electric equipment, banking, pharmaceutical biology, and transportation sectors led the gains, while beauty care, electronics, media, social services, machinery equipment, and retail sectors experienced declines [1]. - The top-performing concept sectors included gold and jewelry, selected air transport, power batteries, coal mining, central enterprise coal, lithium battery anodes, lithium iron phosphate batteries, solid-state batteries, sodium-ion batteries, complete vehicles, cobalt mines, battery recycling, new energy vehicles, germanium-gallium-antimony ink, and antibiotics [2].