潘建伟 ，中国科学院院士，主要从事量子光学、量子信息和量子力学基础问题检验等方面的研究。因其在 多粒子干涉度量学和自由空间量子传输方面的开创性实验工作，使得全球化安全量子通信和量子计算优越 性成为现实可能。 编辑丨王多鱼 排版丨水成文 2025 年 12 月 6 日， 2025 腾冲科学大奖 揭晓 ： 潘建伟 院士 获得这项千万奖金大奖。 此外，今年首次设立并颁发了 腾冲青年科学家奖 ，该 奖项围绕数学物理与天文科学、材料科学、生命科 学、医学医药科学、信息与智能科学、先进制造科学、生态环境与地球科学、航空航天科学、艺术与交叉 科学和科学普及 10 个分领域颁发。 北京大学物理学院博雅特聘教授 王剑威 ，上海交通大学机械与动力工程学院特聘教授 钱小石 ，中国科学 院昆明动物所研究员 吴东东 ，中国科学院深圳先进技术研究院研究员 李汉杰 ，西安交通大学自动化科学 与工程学院教授 徐占伯 ，浙江大学航空航天学院交叉力学中心教授 李铁风 ，中国科学院地质与地球物理 研究所研究员 蔡书慧 ，北京宇航系统工程研究所研究员 梁欣欣 ，南京大学化学化工学院特聘研究员 黄小 强 ，获得 腾冲青年科学家奖。 中山大学物理学院教 ...

Core Viewpoint - The research led by Professor Lu Yuming highlights the impact of chromatin accessibility on the clearance rate of plasma DNA through the kidneys, suggesting new diagnostic methods for diseases with renal manifestations [3][9]. Group 1: Liquid Biopsy and Non-Invasive Testing - Professor Lu Yuming is recognized as a pioneer in the field of liquid biopsy, particularly in non-invasive prenatal testing, having discovered fetal cell-free DNA in maternal blood as early as 1997 [2]. - The non-invasive prenatal diagnostic technology based on DNA analysis has been widely adopted in over 100 countries, benefiting approximately 10 million pregnant women annually [2]. - The recent development of the FRAGMA technology enables the detection of multiple cancers through blood tests, advancing liquid biopsy into the whole-genome era [2]. Group 2: Research Findings on Urinary Cell-Free DNA (ucfDNA) - The study published in the journal Med reveals that chromatin accessibility states affect the renal clearance of plasma DNA, potentially through size limitations of the glomerular barrier [3][9]. - The research identifies two types of ucfDNA: renal ucfDNA (filtered through the kidneys) and urinary tract ucfDNA, highlighting their distinct characteristics [5]. - Analysis of 136 ucfDNA samples from various groups (healthy controls, pregnant women, chronic kidney disease patients, and bladder cancer patients) provided insights into fragmentomic features, including fragment size and 5' end motifs [5][6]. Group 3: Implications for Disease Detection - Renal ucfDNA is primarily derived from open chromatin regions, while urinary tract ucfDNA exhibits unique fragmentomic characteristics [6][7]. - The study indicates that in patients with proteinuria (e.g., preeclampsia, chronic kidney disease), levels of ucfDNA from heterochromatin regions increase, suggesting a correlation with glomerular permeability [6]. - The effectiveness of bladder cancer detection is significantly enhanced by analyzing low methylation signals from heterochromatin regions, achieving an AUC of 0.93 [6]. Group 4: Broader Impact and Recognition - Professor Lu Yuming's contributions to medical science have garnered international accolades, including election to the Royal Society and the National Academy of Sciences, as well as prestigious awards such as the Future Science Prize and the Lasker Award [14]. - His research is considered a strong contender for the Nobel Prize, with significant implications for cancer screening and risk prediction [14].