潘建伟 ，中国科学院院士，主要从事量子光学、量子信息和量子力学基础问题检验等方面的研究。因其在 多粒子干涉度量学和自由空间量子传输方面的开创性实验工作，使得全球化安全量子通信和量子计算优越 性成为现实可能。 编辑丨王多鱼 排版丨水成文 2025 年 12 月 6 日， 2025 腾冲科学大奖 揭晓 ： 潘建伟 院士 获得这项千万奖金大奖。 此外，今年首次设立并颁发了 腾冲青年科学家奖 ，该 奖项围绕数学物理与天文科学、材料科学、生命科 学、医学医药科学、信息与智能科学、先进制造科学、生态环境与地球科学、航空航天科学、艺术与交叉 科学和科学普及 10 个分领域颁发。 北京大学物理学院博雅特聘教授 王剑威 ，上海交通大学机械与动力工程学院特聘教授 钱小石 ，中国科学 院昆明动物所研究员 吴东东 ，中国科学院深圳先进技术研究院研究员 李汉杰 ，西安交通大学自动化科学 与工程学院教授 徐占伯 ，浙江大学航空航天学院交叉力学中心教授 李铁风 ，中国科学院地质与地球物理 研究所研究员 蔡书慧 ，北京宇航系统工程研究所研究员 梁欣欣 ，南京大学化学化工学院特聘研究员 黄小 强 ，获得 腾冲青年科学家奖。 中山大学物理学院教 ...

Summary of Guardant Health FY Conference Call Company Overview - **Company**: Guardant Health (NasdaqGS:GH) - **Industry**: Life Sciences, Tools, and Diagnostics Key Financial Targets - **Revenue Target**: $2.2 billion by 2028, with a potential aspiration of $5 billion [2][4] - **Oncology Revenue**: Expected to be $1.4 billion by 2028, accounting for over 60% of total revenue [4][6] - **Biopharma Revenue**: Forecasted to grow from $200 million to $300 million by 2028 [5] - **Screening Revenue**: Projected to reach $500 million by 2028, representing approximately 25% of total revenue [6] Product Performance and Growth - **Guardant360**: Continues to grow at approximately 30% year-over-year, driven by increased orders per oncologist and new SMART apps [7][10] - **Reveal**: Fastest-growing oncology product, with potential for new indications and therapy monitoring applications [5][12] - **Shield**: Expected to contribute significantly to revenue, with a target of $500 million by 2028 [6] Market Dynamics - **Oncology Market**: Guardant360 has penetrated the oncology market well, with over 10,000 oncologists ordering the test annually [7] - **Liquid Biopsy**: The company believes that centralized lab business will remain dominant due to the complexity of services offered compared to hospital labs [24] Regulatory and Reimbursement Strategies - **ADLT Submission for Reveal**: Ongoing process with potential upside if approved, targeting an ASP of $1,000 by 2028 [14][16] - **Medicare Reimbursement**: Critical for achieving ASP targets and driving revenue growth [16] Operational Efficiency and Cost Management - **Cost of Goods Sold (COGS)**: Targeting $200 per test for Shield, with current costs below $500 [17][29] - **Gross Margin Targets**: Expecting gross margins of 65-70% across the product portfolio by 2028 [29][30] Sales and Marketing Strategy - **Sales Force Expansion**: Currently over 250 sales representatives, with plans for continued ramp-up [35] - **Partnership with Quest**: Aims to leverage Quest's extensive network to enhance market penetration [35] Future Outlook and Strategic Initiatives - **Breakeven Target**: Committed to achieving breakeven by the end of 2027, with no changes to the plan despite recent funding [26][27] - **M&A Opportunities**: Focused on acquiring technologies that enhance product offerings, with a preference for smaller deals [39][40] Clinical Trials and Product Development - **SERENA-6 Protocol**: Anticipated to be a significant catalyst for product adoption and market expansion [37][38] Conclusion - Guardant Health is positioned for strong growth in the oncology diagnostics market, with a clear strategy for revenue generation, operational efficiency, and market expansion through innovative products and strategic partnerships. The company remains focused on achieving its financial targets while navigating regulatory landscapes and enhancing its product offerings.

Core Insights - The article discusses the development of SVAtlas, a comprehensive single extracellular vesicle (EV) omics resource that addresses the challenges of analyzing EV heterogeneity and facilitates clinical applications in disease diagnostics [3][10]. Group 1: Background and Importance of EVs - Extracellular vesicles (EVs) are nano-sized particles secreted by cells, carrying important biomolecules like proteins and nucleic acids, and play a significant role in intercellular communication and disease progression [2]. - The presence of EVs in easily accessible bodily fluids such as blood and urine makes them ideal candidates for liquid biopsy in cancer and neurodegenerative disease research [2]. Group 2: Challenges in EV Research - Traditional bulk analysis techniques struggle to capture the molecular characteristics of individual EVs due to the high heterogeneity within EV populations, which obscures critical disease signals and hinders clinical application [2][5]. - The lack of standardized technology and fragmented data has limited the clinical application of EV biomarkers [2][5]. Group 3: Development of SVAtlas - The research team from Shandong University, led by Hou Qingzhen, constructed the first cross-disease, cross-body fluid, and cross-species single EV multi-omics atlas, named SVAtlas, published in Nucleic Acids Research [3][5]. - SVAtlas integrates self-sequencing data with results from 276 global research projects, covering 31 major diseases, 32 types of tissues and organs, and 10 types of biological fluids, including data from over 137 million single EVs [5]. Group 4: Features and Functionality of SVAtlas - The platform supports analysis of tissue/organ heterogeneity and disease-specific subgroups, providing global clustering, high-heterogeneity subgroup selection, and differential heatmaps to display single EV distribution and characteristics [7]. - SVAtlas includes a dynamic analysis platform with built-in computational biology tools for data browsing, preprocessing, clustering analysis, and interactive visualization, aiding in the identification of disease-specific biomarkers [8]. - The platform features an AI question-and-answer tool based on large language models (LLM) to assist users in navigating complex single EV characterization methods [8]. Group 5: Future Implications - The establishment of SVAtlas marks a new phase in single EV research, enabling standardized and multi-omics integration, allowing researchers to explore EV heterogeneity and discover potential biomarkers on a unified platform [10]. - With the addition of more data and novel omics, SVAtlas is expected to become a crucial tool in liquid biopsy, precision medicine, and disease diagnostics [10].

Financial Data and Key Metrics Changes - Total revenue grew 20% year over year to $851 million, exceeding guidance by $43 million [4] - Adjusted EBITDA increased by $37 million, or 37% year over year, reaching $135 million, with adjusted EBITDA margins expanding by 200 basis points to 16% [4][6] - Free cash flow for the quarter was $190 million, an increase of $77 million, with year-to-date free cash flow at $236 million, up 270% year over year [5] Business Line Data and Key Metrics Changes - Screening revenue increased 22% year over year to $666 million, driven by strong Cologuard growth [4] - Precision oncology revenue rose 12% year over year to $183 million, supported by Oncotype DX expansion [4] Market Data and Key Metrics Changes - Cologuard brand awareness is recognized by over 90% of consumers, contributing to increased adoption among the 55 million Americans not up to date with colorectal cancer screening [8] - Cologuard Plus demonstrated 95% sensitivity and 94% specificity, leading to a 40% reduction in false positives compared to the original Cologuard [8] Company Strategy and Development Direction - The company is focused on expanding access to Cologuard Plus and driving adoption of CancerGuard, a multi-cancer early detection test [3][11] - The strategy includes deepening relationships with payers and health systems to close gaps in cancer screening [3][9] - The company plans to sunset Cologuard in favor of Cologuard Plus, which is recognized as a superior test [31] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving 2027 financial targets, citing strong momentum and operational leverage [7] - The company is raising full-year revenue guidance to between $3.22 billion and $3.235 billion, reflecting a positive outlook for growth [5][6] - Management noted that the current quarter marks an inflection point for the business, with expectations for continued growth [7] Other Important Information - The company is investing in direct-to-consumer marketing for CancerGuard, leveraging its established brand [12] - The launch of CancerGuard is expected to address the low screening rates for various cancers, with plans for extensive provider education [11][12] Q&A Session Summary Question: What drove the strong screening performance in Q3? - Management attributed the performance to improved relationships with health systems, targeted messaging, and strong execution from the sales team [19] Question: What is the outlook for 2026? - Management indicated that guidance for 2026 will be provided in the next earnings call, but noted a long-term growth target of 15% CAGR from 2022 to 2027 [21] Question: How will care gap strength impact margins? - Management expects an uptick in gross margins in Q4 due to fewer care gap shipments compared to Q3 [24] Question: What is the strategy for CancerGuard with payers? - Management emphasized a long-term approach to securing coverage with payers, focusing on the positive impact of screening [25] Question: What is the status of the Freedom test timelines? - Management confirmed no changes to the Freedom V2 timelines, with data expected to be presented at a scientific conference soon [28] Question: How is the Cologuard Plus contributing to growth? - Management noted that Cologuard Plus contributed approximately 2-300 basis points to overall screening growth in Q3, with expectations for 3-400 basis points in Q4 [37] Question: What are the expectations for OncoDetect and CancerGuard in 2026? - Management does not expect OncoDetect to be a material contributor in 2025 but anticipates significant growth potential in the future [34]

Financial Data and Key Metrics Changes - Total revenue for Q3 2025 grew 39% year-over-year to $265.2 million, marking the first time annualized revenue surpassed $1 billion [6][25] - Non-GAAP gross margin improved to 66% in Q3 2025, up from 63% in the prior year, driven by reduced costs [29] - Adjusted EBITDA loss was $45.5 million, an improvement from a loss of $56.2 million in Q3 2024 [30] Business Line Data and Key Metrics Changes - Oncology revenue increased 31% to $184.4 million, with approximately 74,000 tests performed, reflecting a 40% growth in volume [8][25] - Screening revenue from Shield totaled $24.1 million, generated from 24,000 tests, with an average selling price (ASP) of approximately $880 [28] - Biopharma and data revenue grew 18% year-over-year to $54.7 million, supported by two companion diagnostic approvals [27] Market Data and Key Metrics Changes - The screening business is tracking at an annual run rate of approximately $100 million, one year into the commercial launch of the FDA-approved product [6] - Shield tests have shown high adherence rates, with over 90% of ordered cases resulting in completed blood samples [18] Company Strategy and Development Direction - The company aims to expand its commercial infrastructure for Shield, leveraging partnerships with Quest Diagnostics and Path Group to enhance access [19][20] - Continued investment in commercial initiatives and the introduction of new smart applications are expected to drive future growth [14][15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential inclusion of Shield in American Cancer Society guidelines, which could enhance commercial coverage [40][41] - The company raised its full-year 2025 revenue guidance to $965-$970 million, reflecting stronger-than-expected performance [31][32] Other Important Information - The company surpassed 1 million cumulative clinical patients tested, highlighting the impact of its tests in clinical practice [7] - The submission of the PMA application to the FDA for Guardant360 Liquid is expected to streamline the product offering and enhance market adoption [11] Q&A Session Summary Question: Can you walk us through the Shield ASP dynamics exiting the year? - Management indicated that the ASP for Shield is currently around $1,495, with expectations for continued strong payment from Medicare Advantage [36][37] Question: Is guideline inclusion by the American Cancer Society a real possibility by year-end? - Management remains optimistic about the potential inclusion and its positive impact on reimbursement rates, although it will take time to translate into payments [40][41] Question: How should we think about 2026 growth for Shield? - Management is confident about long-term growth but refrained from providing specific guidance for 2026 at this time [45][46] Question: Can you provide any KPIs around average testing frequency per physician? - Management reported high adherence rates, with over 90% of ordered Shield tests being completed [80]

Core Insights - The article discusses the challenges of drug resistance and recurrence in cancer treatment, particularly focusing on ovarian cancer and the advancements in liquid biopsy technology to monitor tumor evolution and resistance [2][3][4]. Group 1: Ovarian Cancer and Treatment Challenges - Ovarian cancer has one of the highest recurrence rates among cancers, with over 70% of patients experiencing relapse after treatment [4]. - The standard treatment for ovarian cancer typically involves surgery followed by chemotherapy, which may initially be effective but often leads to drug resistance and recurrence [5][6]. Group 2: Research Advancements - A recent study published in the journal "Nature" introduced a novel method called CloneSeq-SV, combining single-cell gene sequencing and liquid biopsy to analyze the evolutionary patterns of drug-resistant ovarian cancer [3][7]. - The study found that signals of drug resistance could be detected in circulating tumor DNA (ctDNA) before imaging tests indicated tumor recurrence, potentially allowing for earlier intervention [9][13]. Group 3: Case Studies and Findings - In the case of patient 009, ctDNA levels rose significantly before imaging confirmed recurrence, suggesting that early intervention could be beneficial [11][13]. - Patient 044, who initially responded well to treatment, later exhibited a drug-resistant tumor that was genetically distinct from the original tumor, highlighting the importance of re-evaluating genetic profiles post-recurrence [29][30]. Group 4: Future Directions in Cancer Treatment - The article emphasizes a shift from reactive to predictive treatment strategies, where interventions are based on early signals from ctDNA rather than waiting for significant tumor growth [35][40]. - The potential for personalized treatment based on the specific characteristics of resistant tumors is discussed, with the hope that advancements in technology will lead to more effective and timely interventions [36][39].

Core Insights - The 2025 China International Service Trade Fair (CIFTIS) commenced in September in Beijing, featuring a forum on "Innovations in Tumor Treatment and New Trends in Drug Development" as a key academic activity [1] - The forum aims to create a high-end communication platform for policy interpretation, results release, industry connection, and international cooperation in the field of tumor prevention and treatment [1][3] Group 1: Forum Objectives and Themes - The forum is centered around the theme "Gathering Global Wisdom to Build a New Future in Cancer Prevention" and focuses on promoting disease prevention research and accelerating the transformation of scientific achievements [3] - The event emphasizes the importance of collaboration among government, industry, academia, and research institutions to enhance tumor prevention and treatment [3][4] Group 2: Scientific and Technological Innovations - Keynote speakers highlighted that technological innovation is crucial for the development of precision medicine in oncology, integrating multi-omics technologies, gene editing, liquid biopsy, and artificial intelligence [4] - The proportion of innovative drugs in development, such as cell therapy and bispecific antibodies, has reached 39% in China, marking a significant shift from generic to innovative drug development [4] Group 3: Challenges and Solutions in Cancer Treatment - Experts discussed the challenges in cancer prevention, including low HPV vaccination rates and insufficient screening coverage, particularly in remote areas and among young women [5][6] - A new model for cervical cancer prevention and control was presented, focusing on a multi-dimensional approach that includes immunology, protein, and gene strategies [6] Group 4: Collaborative Research Initiatives - The forum witnessed the launch of a strategic cooperation agreement for a research project aimed at establishing a standardized system for clinical applications of tumor biotherapy [6] - The project involves multiple institutions and aims to create technical standards and clinical pathways to facilitate the safe and compliant transformation of cutting-edge technologies in the industry [6]

Core Viewpoint - Early cancer detection is crucial for reducing mortality rates among cancer patients, and the study highlights the potential of phosphatidylserine-positive extracellular vesicles (PS+ EV) as a specific biomarker for multiple operable cancers [2][10]. Group 1: Importance of Early Cancer Detection - Most cancers are diagnosed at advanced stages, limiting treatment options and chances of cure [4]. - Current cancer diagnostics rely heavily on imaging techniques and histopathological analysis, which have inherent risks and insufficient sensitivity for early-stage cancers [4][5]. - There is a critical need for sensitive and accessible screening methods to detect various cancer types at earlier, more treatable stages [4]. Group 2: Liquid Biopsy and Extracellular Vesicles - Liquid biopsy is a minimally invasive and sensitive detection method that can identify cancer at earlier stages [5]. - Blood is the primary biological fluid for analyzing circulating tumor-derived components, including circulating tumor cells (CTC), extracellular vesicles (EV), and various acellular molecules [5][6]. - Tumor-derived EVs are released by metabolically active and proliferating cancer cells, providing a promising avenue for early diagnosis and clinical decision-making [6][7]. Group 3: Research Findings - The study identified phosphatidylserine (PS) as a tumor-specific EV biomarker, leading to the development of a blood biopsy method called "PSEV-MultiCancer" [7][11]. - In a clinical sample of 1869, including 1269 cancer patients, PSEV-MultiCancer achieved an area under the curve (AUC) of 0.932, with a positive detection rate of 84.7% [7]. - For early-stage (I-II) cancers, the sensitivity reached 74.7% and specificity was 89.8% [7]. Group 4: Validation and Implications - The method underwent blind validation in three independent clinical cohorts, yielding AUC values of 0.97, 0.99, and 0.89, with an average sensitivity of 84.1% and average specificity of 97.3% [8]. - These findings support PSEV-MultiCancer as a promising non-invasive early cancer detection tool, aiding timely therapeutic interventions for patients [10][11].

Quanterix (QTRX) FY Conference Summary Company Overview - Quanterix operates in the life sciences tools and diagnostics industry, focusing on ultra-sensitive protein measurement platforms based on digital ELISA [2][4] Key Points and Arguments Financial Guidance and Performance - The company anticipates a significant decline in its core Calynterex business for 2025 [2] - Despite macroeconomic pressures, the consumables business generated approximately $100 million, showing resilience compared to the previous year [4] - Diagnostics revenues tripled, indicating growth potential despite being a small segment [5] - Academic revenues were expected to decline by 20% to 30%, with an actual decline of 18% [6] - The Accelerator business saw a year-over-year revenue drop of 60%, with $4 million in revenue for the quarter [9][10] Business Segments - The Accelerator business had strong performance in previous years but is currently facing pressure due to smaller project sizes and budget constraints [11][12] - The Akoya business is projected to generate $30 million in the second half of the year, down from $82 million last year, primarily due to CDx business milestones [15] Strategic Initiatives - Quanterix aims to create a unified company structure post-Akoya acquisition, focusing on assay development and expanding consumables [19][24] - The company is targeting $85 million in annualized synergies by the end of next year, with 75% already implemented [23] - R&D investment is projected to be 30% of total revenues, emphasizing the importance of innovation [24] Product Development and Market Trends - The upcoming launch of the SMO-one platform aims to enhance sensitivity and multiplexing capabilities for liquid biopsy testing in neurology and oncology [28][29] - The Lucent AD Complete test is positioned as a significant advancement in Alzheimer's diagnostics, with plans for FDA submission and reimbursement efforts [34][36] - The company is actively working on integrating new biomarkers into its tests, enhancing diagnostic capabilities [39] Market Position and Future Outlook - Quanterix is optimistic about the translational market, particularly in understanding spatially resolved biomarkers in tissue [21] - The company believes that the integration of Akoya will enhance its oncology capabilities and expand its customer base [44] - The goal for 2026 includes achieving cash flow breakeven and maintaining a strong balance sheet with over $100 million [52] Additional Important Insights - The company is focused on increasing throughput and efficiency in its operations, leveraging existing technologies without requiring new instruments [50] - Quanterix is committed to developing a diverse range of assays to meet market demands and drive revenue growth [47] - The management expresses confidence in achieving its strategic goals and delivering value to shareholders despite current market challenges [52][53]

Core Viewpoint - The article discusses the complexities and limitations of cancer screening, emphasizing that not all screening methods are effective and that many can lead to false positives and false negatives [1][2][3]. Group 1: Limitations of Current Screening Methods - Effective cancer screening should improve survival rates, but many existing methods do not meet this standard [2][4]. - False negatives (missed tumors) and false positives (incorrectly identified tumors) are significant issues in cancer screening, leading to unnecessary anxiety and financial burden [7][8]. - Many commonly used tumor markers are not recommended for healthy individuals due to high rates of false results [7][10]. Group 2: Recommended Screening Methods - Recommended screening methods include colonoscopy for colorectal cancer, gastroscopy for gastric cancer, low-dose spiral CT for high-risk lung cancer, mammography and ultrasound for breast cancer, and cytology and HPV testing for cervical cancer [8][11]. - The age at which screening should begin varies by cancer type, with guidelines suggesting starting at 45 for colorectal cancer and 40 for breast cancer [11][12]. Group 3: Future Directions in Cancer Screening - There is ongoing research into new screening methods, including liquid biopsies that detect cancer-related DNA in blood and the use of artificial intelligence for early tumor detection through imaging [12][13].