液-液相分离(LLPS)

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云南大学最新Nature子刊:线粒体上的相分离,维持线粒体稳态并延长寿命
生物世界· 2025-09-14 04:05
Core Viewpoint - The research published by Professor Yang Chonglin's team from Yunnan University reveals that the mitochondria-associated condensates (MATO) formed by the RNA-binding protein LARP-1 through liquid-liquid phase separation (LLPS) play a crucial role in maintaining mitochondrial homeostasis and promoting lifespan extension [3][5]. Group 1 - The study demonstrates that MATO mediates the local synthesis of proteins necessary for maintaining mitochondrial structure and function [5]. - In Caenorhabditis elegans, LARP-1 coordinates the translation mechanism and the fusion of various RNA-binding proteins to form MATO, which is dependent on the mitochondrial outer membrane complex transport enzyme [5]. - A deficiency in LARP-1 significantly reduces mitochondrial protein levels, disrupts the organization of mitochondrial cristae, and affects ATP production [5]. Group 2 - The research identifies that the synthesis of MICOS subunit IMMT-1 (MIC60) and ATP synthase β subunit ATP-2, which are critical for mitochondrial cristae organization, is decreased in LARP-1 deficient worms [5]. - During aging and starvation, LARP-1 MATO dissociates from the mitochondria; however, its persistent presence in mitochondria can protect mitochondrial health and greatly extend lifespan [5][7].
Nature子刊:武汉大学普颖颖团队等揭示细菌新型细胞器保护mRNA的机制
生物世界· 2025-08-20 04:43
Core Viewpoint - The research reveals that aggresomes, a type of non-membrane organelle in Escherichia coli, play a crucial role in protecting mRNA integrity under stress, thereby enhancing bacterial survival and recovery efficiency in adverse conditions [4][7][9]. Group 1: Research Findings - The study published in Nature Microbiology demonstrates that aggresomes selectively protect mRNA through electrostatic repulsion mechanisms, which is vital for the survival of persister cells under stress [4][8]. - Long-term stress leads to ATP depletion, resulting in increased formation and accumulation of aggresomes, along with specific mRNA enrichment within these structures [8]. - The research indicates that mRNA stored in aggresomes facilitates rapid reactivation of translation, contributing to a reduction in lag phase during bacterial growth after stress removal [8][9]. Group 2: Implications - Understanding the role of aggresomes in mRNA protection provides insights into bacterial resistance mechanisms, potentially guiding the development of novel antibacterial strategies targeting persister cells [4][7]. - The findings highlight the significance of non-membrane organelles in bacterial stress responses, which could influence future research in microbiology and antibiotic resistance [4][9].