2025年的流感季比过去3年来得都猛——根据国家疾控中心（CDC）发布的最新中国流感流行情况概要，南北方报告流感样病例百分比均高于过去3年。 近日，《每日经济新闻》记者走访广州市部分三甲医院了解到，医院方面都能平稳应对流感患者增加的情况，不过，在流感特效药销量大涨的同时，国内流 感疫苗的接种仍然不够火热。 根据CDC在2022年的调查结果，中国18岁~59岁人群流感疫苗接种率只有0.52%，60岁以上人群接种率为4.63%，离世界卫生组织（WHO）设定的老年人和 慢性病患者的接种覆盖率达到75%的差距较大。 值得注意的是，在智利，2025年流感季接种的约830万剂流感疫苗，基本来自中国，重点人群接种率高达85%。疫苗产品是类似的，为何民众接种率差距这 么大？来自智利发展大学医学院教授的观察，又有哪些启示？ 南方流感病毒检测阳性率仍在上升，北方出现下降趋势 根据中国疾病预防控制中心2025年第49周流感监测周报，截至2025年12月7日，南方省份流感病毒检测阳性率上升，个别省份下降；北方部分省份流感病毒 检测阳性率出现下降。全国共报告1219起流感样病例暴发疫情，其中914起为H2N3毒株。 广东省疾控中心发布 ...

Core Viewpoint - The article highlights the increasing incidence of shingles among younger individuals, particularly in high-stress professions, and emphasizes the low vaccination rates in China, which poses a significant public health risk [1][2][3]. Group 1: Shingles Incidence and Impact - Shingles, caused by the varicella-zoster virus, is commonly associated with individuals over 50, but recent cases among younger celebrities indicate a rising trend in younger populations, particularly those with high-stress jobs [2][5]. - The pain associated with shingles is severe, with reports indicating that it can reach levels comparable to childbirth, leading to a lack of public awareness regarding its severity and the importance of vaccination [7][9]. Group 2: Vaccination Rates and Challenges - The vaccination rate for shingles in China is alarmingly low, with only 0.79% of adults aged 40 and above vaccinated as of September 2024, compared to higher rates in the U.S. [6]. - The high cost of vaccines, with imported vaccines priced at 3,260 yuan and domestic vaccines around 1,400 yuan, significantly hinders vaccination efforts, especially among retirees with limited income [9][10]. Group 3: Market Dynamics and Pricing Strategies - The vaccine market has seen a price war since 2025, with prices for imported vaccines dropping from 3,260 yuan to 1,652 yuan, and domestic vaccines being offered at half price, which may lead to long-term sustainability issues for vaccine manufacturers [3][11]. - Companies are facing inventory challenges, with a significant drop in vaccine issuance in 2025, indicating a mismatch between supply and demand [11]. Group 4: Public Awareness and Marketing Strategies - There is a notable gap in public awareness regarding shingles and its vaccine, particularly among older adults who are the primary target demographic [13]. - Vaccine companies are utilizing social media and other platforms for marketing, focusing on educating the public about the disease and the availability of vaccines, despite regulatory restrictions on direct advertising [12][14].

Core Viewpoint - Hualan Biological's revenue increased by 68.77% in the first half of 2025, despite a challenging environment for the vaccine industry, primarily driven by significant sales of rabies vaccines and a doubling of flu vaccine revenue [1][2][3]. Revenue Performance - Hualan Biological achieved a revenue of 59.96 million yuan in the first half of 2025, marking a year-on-year growth of 68.77% [1]. - The company's net profit attributable to shareholders was 20.80 million yuan, a decrease of 17.71% compared to the previous year [1]. - The flu vaccine revenue grew by 132.94%, contributing approximately 40% to the total revenue [2][3]. Market Dynamics - The domestic vaccine industry is undergoing a deep adjustment period due to price wars, particularly in the HPV vaccine segment, which has led to significant revenue declines for several companies [2]. - Hualan Biological's proactive sales efforts and increased market promotion have resulted in a notable rise in sales, especially for rabies vaccines [1][3]. Sales and Marketing Strategy - Sales expenses increased by 30.78% to 28.99 million yuan, reflecting the company's efforts to enhance market penetration and awareness [4]. - Hualan Biological's sales network covers over 30 provincial regions and more than 2,500 disease control centers, achieving a coverage rate of over 70% [4]. Future Growth Prospects - The company is focusing on expanding its product pipeline, with ongoing clinical trials for new vaccines, including a freeze-dried Hib vaccine and mRNA vaccines for flu and RSV [5]. - Hualan Biological aims to increase the sales revenue and market share of its rabies vaccine while enhancing public awareness of flu vaccination [5].

Core Viewpoint - The price reduction trend for self-paid vaccines has reached the shingles vaccine, with significant price cuts observed in various regions of China, aiming to increase vaccination rates among the population [1][2]. Price Reduction and Promotional Activities - Since March 2023, the price of shingles vaccines in regions like Inner Mongolia, Shandong, Henan, and Chongqing has been halved compared to last year, with some areas offering "buy one get one free" promotions [2]. - The "2025 Domestic Shingles Vaccine Benefit Project" offers a half-price vaccination for residents over 40, reducing the original price from 1389 yuan to 704.5 yuan, saving 684.5 yuan [3]. - A promotional activity allows individuals to complete the first dose between May and August 2025 and the second dose by December 31, 2025, reducing the total cost from 3260 yuan to 1652 yuan [4][6]. Market Competition and Pricing Discrepancies - The two available shingles vaccines in China, one imported from GlaxoSmithKline and one domestic from Baike Biological, are experiencing inconsistent price reductions, leading to regional competition [7]. - In some areas, only the imported vaccine has seen a price drop, while the domestic vaccine remains at its original price [7]. Vaccination Rates and Challenges - The vaccination rate for shingles among adults aged 40 and older in China is extremely low, at only 0.79% as of September 2024, compared to 41.1% in the U.S. for those aged 60 and above [12][13]. - High self-paid prices are a significant barrier to increasing vaccination rates, with the cost of the imported vaccine previously equating to nearly a month's pension for retirees in cities like Guangzhou [14]. - There is a lack of awareness and understanding of shingles and its vaccine among the elderly, further limiting vaccination uptake [12][15]. Inventory and Sales Performance - Baike Biological has faced challenges with unsold inventory, leading to a significant increase in accounts receivable and inventory levels, indicating poor sales performance [8][9]. - GlaxoSmithKline's vaccine has seen a decline in expected sales, with procurement agreements being extended to 2029 due to underperformance [10][11]. Healthcare Infrastructure and Service Limitations - The current healthcare infrastructure for adult vaccination is inadequate, with insufficient resources and a lack of clear guidelines for adult immunization services [16]. - Many vaccination centers are not equipped to handle adult vaccinations, leading to a conservative approach in recommending vaccines to the elderly [16].