撰文丨王聪 编辑丨王多鱼 排版丨水成文 在 慢性压力 （ Chronic Stress ） 状态下，细胞必须同时维持组织功能和自身的存活。肝细胞承担着代 谢、合成和解毒等作用，但长期的营养失衡会导致肝细胞死亡，并引发 代谢功能障碍相关脂肪性肝炎 （MASH） 。尽管此前的研究已经确定了应激压力诱导肝细胞死亡的驱动因素，但慢性压力对存活细胞的 功能影响仍不清楚。 2025 年 12 月 22 日，麻省理工学院、哈佛大学医学院的研究人员在国际顶尖学术期刊 Cell 上发表了题 为： Hepatic adaptation to chronic metabolic stress primes tumorigenesis 的研究论文。 该研究表明，高脂饮食 （HFD） 不只会导致脂肪肝，其带来的慢性代谢压力会导致干细胞发生深刻变化， 肝细胞对这种 慢性代谢压力的适应会促进肿瘤发生。 肝脏 是身体的"化工厂"，负责代谢、解毒和蛋白质合成。但当我们长期暴露于 高脂饮食 （HFD） 等代谢 压力下，肝细胞会面临一个艰难选择：是优先保证自身生存，还是维持器官功能？ 这这项最新研究中，研究团队通过跨物 种的多组学分析，发现肝细胞 ...

Core Insights - Congenital heart disease is the most common type of birth defect in newborns, and recent research by Chinese scientists has identified an organ primordium determination zone that provides a crucial theoretical basis for the prevention and treatment of congenital heart disease and other birth defects [1][3] - The study, published in the international academic journal "Cell," utilized single-cell spatial omics analysis to capture the dynamic process of organ formation in mouse embryos, focusing on the early stages of development [1][3] Research Findings - The research team discovered a unique signaling "depression" known as the organ primordium determination zone (PDZ) at 7.75 days of mouse embryonic development, characterized by low signal activity and the expression of various receptor signaling genes [3] - The PDZ area is surrounded by high concentrations of inhibitory and activating signaling molecules, creating a microenvironment conducive to the coordinated development of the heart and foregut [3] - This study provides a new methodology for understanding organ regeneration and tumorigenesis, offering precise scientific evidence for the prevention and treatment of congenital heart disease and related conditions [3]