整理 | GLP1减重宝典内容团队 近日，合肥海关所属庐州海关关员在对进境邮件进行CT机检查验时，发现图像异常，经开箱查验，发现大量用透明塑料袋封装的减肥 药品。该批药品色泽鲜艳、大小不一，无生产日期、无质量合格证明、无生产厂家。经现场快速检测，该批药品中含有违禁成分甲基 安非他明，共计600粒。 JOIN GLP-1 CLUB 甲基安非他明是一种强效的中枢神经系统兴奋剂，是冰毒的有效成分，被列为第一类精神药品，具有成瘾性。根据《中华人民共和国 药品管理法》规定，进口、出口麻醉药品和国家规定范围内的精神药品，应当持有国务院药品监督管理部门颁发的进口准许证、出口 准许证。目前，海关已依法对该批减肥药品予以暂扣。 版权声明：所有「GLP1减重宝典」的原创文章，转载须联系授权，并在文首/文末注明来源、作者、微信ID，否则减重宝典将向其追究法律责 任。部分文章推送时未能与原作者或公众号平台取得联系。若涉及版权问题，敬请原作者联系我们。合作事宜，请添加微信：andyxu365 加入专家库与我们深度讨论 「GLP-1俱乐部」覆盖数百位专业人士，构建了围绕GLP-1产业链上下游、覆盖多个板块的专家库，成为了业内顶尖专业人士 ...

Core Viewpoint - The article emphasizes the importance of adhering to the recommended administration guidelines for oral semaglutide to achieve optimal therapeutic effects in weight loss and blood sugar control [2][13]. Administration Guidelines - The recommended way to take oral semaglutide is to consume it with no more than 4 ounces (approximately 120 milliliters) of water before breakfast, ensuring at least a 30-minute interval before eating or drinking anything else [2]. - Taking the medication before any meal or after any meal is less effective due to shorter fasting periods, which can lead to lower plasma concentrations of semaglutide [3]. - If a person only eats lunch and dinner, taking the medication before lunch is acceptable; similarly, if only breakfast and dinner are consumed, taking it before dinner is also permissible [4]. - Taking the medication after meals is not recommended as it significantly diminishes its effectiveness [5]. Timing Considerations - Taking the medication before bedtime is contingent on the fasting duration; if dinner is skipped, it can be taken before sleep, but it is not advisable if dinner is consumed due to insufficient fasting time [7][8]. - The amount of water used to take the medication should not exceed 120 mL, as excessive water can hinder the drug's absorption [9]. - It is crucial to wait at least 30 minutes after taking the medication before consuming breakfast or any other oral medications to avoid interference with absorption [10]. Impact of Non-compliance - Occasional deviations from the recommended administration (e.g., forgetting to take the medication or taking it with too much water) generally have a minimal impact on overall efficacy; however, consistent non-compliance can adversely affect therapeutic outcomes [11][12]. Efficacy Comparison - Oral semaglutide (Rybelsus) and injectable semaglutide (Ozempic) have been shown to have comparable efficacy in clinical trials, with similar reductions in A1C levels and weight loss observed in both [14].