整理 | GLP1减重宝典内容团队 在中国市场，司美格鲁肽受到肥胖患者的青睐，销售额不断攀升。 国产司美格鲁肽的研发也在加速，多家企业布局了司美格鲁肽的仿 制药。 司美格鲁肽是一种新型降糖减重 药物，其通过模拟人体天然激素GLP-1，不仅能够调节血糖水平，还能辅助减重。 然而，司美格鲁肽作为药品，仍然存在药物禁忌及副作用。在考虑使用司美格鲁肽之前，个人需对自己的身体状况进行健康评估，以确 定该药物是否适合自己的健康状况。很多人也会进一步产生一个疑问： 如果使用司美格鲁肽，需要做什么检查？ ▍ 有 家族甲状腺疾病病史或既往病史的患者，以及胰腺炎高发患 者 通常不适宜使用司美格鲁肽 甲状腺功能检查 ：检查甲状腺功能，包括甲状腺彩超，以评估甲状腺 C 细胞肿瘤风险。关于司美格鲁肽对甲状腺功能的影响，现有研 究表明，司美格鲁肽与人体的甲状腺功能并无直接关联，且没有明确的证据表明它对甲状腺有负面影响。 如果使用者或使用者家人中有人患有或曾经患有 MTC 或多发性内分泌肿瘤综合征 2 型 (MEN 2； 导致体内多个腺体出现肿瘤的疾 病)，请告知保健医生。 如果是这样，保健医生可能会告诉患者不要使用 司美格鲁肽 注射液。 ...

Core Insights - The article highlights the discovery of a large quantity of illegal weight loss drugs containing methamphetamine, a controlled substance, by customs officials in Hefei [2][4]. Group 1: Regulatory Issues - Methamphetamine is classified as a first-class psychoactive drug in China, known for its addictive properties and is the active ingredient in ice drugs [4]. - According to the Drug Administration Law of the People's Republic of China, the import and export of narcotic drugs and certain psychoactive substances require permits issued by the State Drug Administration [4]. Group 2: Industry Context - The article emphasizes the growing concern over the illegal trade of weight loss drugs, particularly those containing harmful substances, which poses risks to public health [2][4]. - The GLP-1 drug class is mentioned as a new category of weight loss and diabetes management medications, which work by enhancing insulin secretion and suppressing appetite [11].

Core Viewpoint - The article emphasizes the importance of adhering to the recommended administration guidelines for oral semaglutide to achieve optimal therapeutic effects in weight loss and blood sugar control [2][13]. Administration Guidelines - The recommended way to take oral semaglutide is to consume it with no more than 4 ounces (approximately 120 milliliters) of water before breakfast, ensuring at least a 30-minute interval before eating or drinking anything else [2]. - Taking the medication before any meal or after any meal is less effective due to shorter fasting periods, which can lead to lower plasma concentrations of semaglutide [3]. - If a person only eats lunch and dinner, taking the medication before lunch is acceptable; similarly, if only breakfast and dinner are consumed, taking it before dinner is also permissible [4]. - Taking the medication after meals is not recommended as it significantly diminishes its effectiveness [5]. Timing Considerations - Taking the medication before bedtime is contingent on the fasting duration; if dinner is skipped, it can be taken before sleep, but it is not advisable if dinner is consumed due to insufficient fasting time [7][8]. - The amount of water used to take the medication should not exceed 120 mL, as excessive water can hinder the drug's absorption [9]. - It is crucial to wait at least 30 minutes after taking the medication before consuming breakfast or any other oral medications to avoid interference with absorption [10]. Impact of Non-compliance - Occasional deviations from the recommended administration (e.g., forgetting to take the medication or taking it with too much water) generally have a minimal impact on overall efficacy; however, consistent non-compliance can adversely affect therapeutic outcomes [11][12]. Efficacy Comparison - Oral semaglutide (Rybelsus) and injectable semaglutide (Ozempic) have been shown to have comparable efficacy in clinical trials, with similar reductions in A1C levels and weight loss observed in both [14].