来源：央视网 你或身边的人，有没有突然像变了个人？情绪失控、记性变差、一点就炸……别总以为是"压力 大"或"更年期"，有时候这可能是身体在发出求救信号！ 66岁的上海王老伯也有类似的遭遇。前段时间，他突然变得嗅觉、味觉下降，甚至出现尿裤子、走路摇 晃的情况。家人原以为是衰老迹象，直到一次突发高热寒颤并伴有间断性头痛，家人紧急送医后，检查 结果震惊全家——颅底竟埋藏着一个直径超6厘米的巨大脑膜瘤！这个比乒乓球还大的肿瘤，已悄然压 迫大脑组织长达三年。 上海冬雷脑科医院神经外科主任张学军接诊后分析指出，王老伯的一系列症状正是肿瘤压迫不同脑区 的"报警信号"：额叶受压导致情感淡漠、性格改变和尿失禁；顶叶受累引发味觉失灵、身体感知异常； 巨大的肿瘤体积效应则造成头痛、肢体乏力，最终导致卧床不起。 脾气变差 一查竟是肿瘤作祟 近日，48岁的周先生（化名）总感觉自己"不太对劲"。一开始只是早上经常头痛，靠止痛药还能扛一 扛；慢慢地，他发现自己的记性越来越差，刚说过的话转头就忘，工作中频频出错。 更让家人担心的是，他的脾气明显变坏了，一点小事就烦躁易怒，和从前简直判若两人。 家里人以为他是工作压力大，到了"中年危机"，劝他 ...

Core Insights - Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults, with a median survival of only 12-18 months post-diagnosis, and current treatments have limited efficacy in extending life expectancy [2][3] - A recent study published by Zhao Wei's team in Nature Cell Biology identifies HOXB3 condensation in the core regulatory circuitry (CRC) of GBM as a potential therapeutic target, suggesting that targeting HOXB3 with the peptide P621-R9 can selectively reduce tumorigenic potential in patient-derived xenograft models [2][5] Research Findings - The study utilized single-cell CUT&Tag analysis to investigate H3K27ac modifications, revealing significant heterogeneity within the GBM core regulatory circuitry [5] - The research highlighted the heterogeneous condensation state of HOXB3, influenced by its intrinsic disordered region (IDR) and interaction with RUNX1, which drives phenotypic expression [5] - The synthesized peptide P621-R9 effectively disrupts HOXB3 condensation, alters chromatin structure, and reduces transcription at super-enhancer-associated oncogenic loci in GBM cells exhibiting HOXB3 condensation [5][6] Implications for Treatment - These findings underscore the critical role of condensation in the heterogeneity of GBM and suggest that peptide-based targeted therapies for different GBM subgroups may represent a promising new direction for treatment [6] - A concurrent article in Nature Cell Biology discusses the potential origins of GBM heterogeneity from the activation of various gene core regulatory circuits, emphasizing HOXB3's central role in GBM CRC and the therapeutic potential of peptide-mediated targeting [6]

Core Viewpoint - The study highlights the impact of gut microbiota dysbiosis induced by brain tumors on the efficacy of immunotherapy, suggesting that dietary supplementation with tryptophan can restore gut microbiota and significantly enhance the immune response through T cell circulation [2][11][14]. Group 1: Research Background - The influence of gut microbiota on various tumors, particularly gastrointestinal tumors, is recognized, but its effects on brain tumors remain largely unexplored [2][6]. - Glioblastoma (GBM) is known for its poor prognosis and limited survival rate improvements despite various treatments, attributed to unique characteristics of the tumor microenvironment [4][5]. Group 2: Research Findings - The research utilized a GBM mouse model and employed 16S rRNA sequencing to analyze changes in gut microbiota during tumor progression, finding that tryptophan supplementation could reverse these changes [9]. - Tryptophan supplementation not only restored gut microbiota balance but also significantly improved survival rates in mouse models and enhanced the effectiveness of immunotherapy [9][13]. Group 3: Key Microbial Insights - Among the gut bacteria responding positively to tryptophan, Duncaniella dubosii emerged as a key contributor to the immune modulation effects of tryptophan [10][13]. - The study emphasizes the potential of targeting gut microbiota modulation to improve cancer immunotherapy outcomes, particularly through mechanisms involving T cell regulation [14].