2026 年 3 月 16 日，中国科学院 分子细胞科学卓越创新中心/复 旦大学 陈飞 团队 、 复旦大学附属肿瘤 医院 俞晓立 、 郭小毛 和 沈敏洪 团队 合作 （ 复旦大学附属肿瘤医院 饶欣欣 、 王静雯 为论文共同第一 作者 ） ， 在 Cell Stem Cell 期刊 发表了题为： Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis 的研究论文。 该研究首次建立了大规模乳腺癌原发肿瘤、癌旁正常组织及淋巴结转移灶的配对的 患者来源类器官 （PDO） 生物样本库，结合基因组、转录组和染色质可及性等多组学分析，系统揭示了乳腺癌进展过程中 的表观遗传重编程规律，定义了全新的 表观遗传聚类 体系，并阐明了 转录因子 协同网络驱动淋巴结转移 的关键分子机制，为突破传统乳腺癌分型局限、推进精准治疗提供了新的理论依据和实验平台。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 乳腺癌 在临床表现上具有显著的异质性，并且在肿瘤进展过程中会出现 ...

Core Viewpoint - The research highlights the critical role of the maternal transcription factor OTX2 in initiating human embryonic genome activation (EGA) and its implications for early human development [2][6]. Group 1: Research Findings - OTX2 is identified as an essential maternal PRD-like homeobox protein transcription factor necessary for EGA and early development in humans [5]. - At the 4-cell stage, OTX2 activates key EGA genes, including TPRX1 and TPRX2, as well as EGA-related repetitive sequences HERVL-int and MLT2A1 [5]. - OTX2 directly binds to promoters and presumed enhancers at EGA target sites, many of which overlap with OTX2 motif-containing Alu and MaLR repetitive elements, enhancing chromatin accessibility [5]. Group 2: Implications and Significance - The findings establish OTX2 as a key maternal transcription factor that awakens the genome at the beginning of human life, providing insights into molecular regulatory mechanisms in developmental biology and reproductive medicine [6]. - A related article in Nature Genetics emphasizes the largely unknown transcription factors responsible for initiating EGA in humans, underscoring the significance of the new research on OTX2 [6].

Core Viewpoint - The research team led by Professor Zhu Fangjie from Fujian Agriculture and Forestry University has decoded the functional differentiation of MYB family transcription factors, providing new insights into the "specificity paradox" in higher plant research, which may accelerate the application of grass in new energy and materials [1][2]. Group 1: Research Findings - The study analyzed the DNA sequence specificity of 40 MYB family transcription factors, revealing a new mechanism for functional differentiation among transcription factors that originated from a common ancestor [1][2]. - The research identified key MYB factors that regulate cellulose synthesis in grass, which is crucial for its agronomic traits and production performance [2]. Group 2: Implications for Industry - The findings are expected to enhance the application of grass in the fields of new energy and new materials, particularly as biomass materials [2]. - The research integrates basic scientific research with industrial transformation, leveraging the advantages of the Straits Joint Research Institute and the National Grass Engineering Technology Research Center [2].