撰文丨王聪 编辑丨王多鱼 排版丨水成文 3D 生物打印 是一种三维生物制造技术，用于精确地排列细胞和含细胞生物材料 （生物墨水） ，以构建具有所需功能的立体生物组织。通常，生物墨水依靠水凝 胶基质在生物打印之前、期间或之后稳定并交联构建体。尽管此类方法推进了仿生学的发展，但其难以实现体内细胞的高密度，且大量水凝胶成分可能会阻碍细 胞间相互作用，导致表型丧失并降低组织功能。 近年来，无支架的 3D 生物打印技术被提出以解决细胞密度问题，但这类方法通常依赖于挤出式生物打印，难以无法达到复杂组织所需的分辨率和复杂度。 2025 年 12 月 8 日， 哈佛医学院 张宇 教授团队在国际大奖学术期刊 Cell 上发表了题为： Biomaterial-minimalistic photoactivated bioprinting of cell- dense tissues 的研究论文。 王冕 （现为同济大学研究员） 、 李婉露 （现为 上海交通大学 助理教授） 、 郝晋 （现为上海交通大学助理研究员） 、 蔡玲 为 论文共同第一作者 。 该研究开发了一种去材料化、无支架的 高细胞密度生物墨水 （ Cell-dense ...

Industry Overview - The collagen protein food industry in China is experiencing significant growth, with a retail market size projected to reach 30.1 billion yuan in 2024, reflecting a year-on-year increase of 13.37% [1][6] - The demand for collagen protein foods is driven by consumer interest in skin care, bone health, and anti-aging, particularly among younger generations who prefer dietary sources for health and beauty [1][6] Industry Chain - The upstream of the collagen protein food industry includes raw materials such as skins, tendons, and bones from terrestrial livestock (cattle, pigs) and aquatic sources (fish skins, scales) [4][5] - The midstream involves the production and manufacturing of collagen protein foods, while the downstream focuses on the food sector [4][5] Market Size - The global retail market for collagen protein foods is expected to reach USD 20.48 billion in 2024, with a year-on-year growth of 1.79% [6] - The abundant supply of raw materials in China, due to large-scale livestock and fish production, supports the growth of the collagen protein food sector [6] Key Companies Performance - Tongrentang has made significant strides in the collagen protein food sector, launching products with innovative formulations and high-quality ingredients, such as collagen peptides derived from cod skin [7][8] - Kangnabei has also achieved notable success, offering high-content collagen peptide drinks and protein powders, with a focus on safety and quality standards [8] Industry Development Trends 1. Technological advancements are driving product innovation and industry upgrades, with breakthroughs in recombinant collagen technology leading to cost reductions and enhanced bioactivity [9] 2. Market demand is diversifying, with a growing interest in functional skincare products among younger consumers and increased demand for joint health solutions among older adults [10] 3. The rise of online sales channels and social media marketing is becoming crucial for industry growth, with companies leveraging e-commerce platforms for product promotion and consumer engagement [11][12]