Macro Dynamics - The State Administration for Market Regulation will convert the pilot commission into a formal commission for conducting antitrust reviews of certain operator concentrations from August 1, 2025, after a successful pilot period from August 1, 2022, to July 31, 2025 [1] Financial Institutions - Zheng Yu has officially taken on the roles of Party Secretary, Chairman, and General Manager of Wukuang Securities, having previously served in various positions within the company [5] - Qingdao Bank reported a net profit of 3.065 billion yuan for the first half of 2025, representing a year-on-year increase of 16.05%, with total operating income of 7.662 billion yuan, up 7.5% [6] Market Data - On July 31, the three major indices fell by over 1%, with the Shanghai Composite Index down 1.18%, the Shenzhen Component Index down 1.73%, and the ChiNext Index down 1.66%. The total market turnover approached 2 trillion yuan, with over 4,200 stocks declining [7] - The financing balance of the two markets increased by 2.168 billion yuan, with the Shanghai Stock Exchange's balance at 1,001.228 billion yuan and the Shenzhen Stock Exchange's balance at 963.026 billion yuan [9] Company Dynamics - Industrial Fulian announced that there have been no significant changes in its main customers and products amid recent stock price fluctuations [13] - Sinopec expects a net profit of 20.1 billion to 21.6 billion yuan for the first half of 2025, a decrease of 39.5% to 43.7% year-on-year, due to factors such as a significant drop in international oil prices and intense market competition [14] - Heng Rui Medicine received approval for clinical trials of HRS-5041, a new drug for prostate cancer treatment, which shows potential in overcoming resistance compared to second-generation AR inhibitors [16]

HRS-5041是公司开发的新型、高效、选择性的AR-PROTAC(雄激素受体-蛋白降解靶向嵌合体)小分子， 拟用于治疗前列腺癌。HRS-5041对野生型及各类突变体的AR蛋白有显著的降解作用，与二代AR抑制 剂相比，有克服耐药的潜力。经查询，目前国内外暂无同类产品获批上市。截至目前，HRS-5041片相 关项目累计研发投入约6,919万元。 智通财经APP讯，恒瑞医药(600276.SH)发布公告，近日，公司及子公司成都盛迪医药有限公司收到国 家药品监督管理局(以下简称"国家药监局")核准签发关于HRS-5041片的《药物临床试验批准通知书》， 将于近期开展临床试验。 ...